Glimepiride for type 2 diabetes is usually taken once daily with breakfast or with the first main meal of the day. It should not be taken after finishing the meal.

Taking it with food helps reduce the risk of low blood sugar (hypoglycemia). If you skip that meal, generally skip the glimepiride dose rather than taking it without food, unless your prescriber has given you different instructions. The FDA prescribing information specifies administration with breakfast or the first main meal.

Follow the timing and dose on your own prescription, especially if you also use insulin or other diabetes medicines.