๐ฅ Full CVA Clinical Scenario โ Harold Meston, 68M
๐จ PHASE 1: EMERGENCY PRESENTATION
Setting: Emergency Department, 07:42 AM
The Ambulance Call
Paramedic hands you the report:
*"68-year-old male, found by wife at 07:15 AM slumped in bathroom. Last seen normal at 06:30 AM. GCS 13 on scene (E4V3M6). BP 186/104, HR 88 irregular, SpO2 96% on room air. Right-sided weakness noted. Brought in by blue light."
Harold is wheeled in. He looks frightened.
(right arm flaccid, face drooping on right, trying to speak)
"I... I can't... my arm... what's... happening to me?"
โ YOUR FIRST DECISION:
What do you do FIRST?
A) Stabilize airway, breathing, circulation (ABC)
B) Order CT head immediately
C) Take full history from wife
D) Check blood glucose
E) Call the stroke team
โ
CORRECT APPROACH - All of the below happen simultaneously (Stroke Protocol):
| Action | Finding |
|---|
| ABC | Airway patent, RR 18, SpO2 96% - no O2 needed |
| Blood glucose | 7.2 mmol/L - rules out hypoglycaemia mimicking stroke |
| IV access + bloods | FBC, U&E, coag, troponin, lipids sent |
| 12-lead ECG | Atrial fibrillation - rate ~88 bpm |
| Stroke team activated | Target: CT within 25 minutes of arrival |
| Onset time confirmed | Last known well = 06:30 AM (75 minutes ago) |
๐ง PHASE 2: NIHSS ASSESSMENT
You perform the NIH Stroke Scale on Harold:
| Domain | Finding | Score |
|---|
| Level of consciousness | Alert, but slow to respond | 1 |
| LOC Questions (age/month) | Gets 1 wrong | 1 |
| LOC Commands | Follows 1 of 2 | 1 |
| Gaze | No deviation | 0 |
| Visual fields | Possible right homonymous hemianopia | 1 |
| Facial palsy | Partial right lower face droop | 1 |
| Left arm motor | Normal | 0 |
| Right arm motor | Drifts, falls within 10 seconds | 2 |
| Left leg motor | Normal | 0 |
| Right leg motor | Some effort against gravity | 2 |
| Limb ataxia | None | 0 |
| Sensory | Mild right-sided reduction | 1 |
| Language/Aphasia | Mild-moderate expressive aphasia | 2 |
| Dysarthria | Mild slurring | 1 |
| Extinction/Neglect | None | 0 |
NIHSS Total = 13 โ Moderate-Severe Stroke
๐ฅ๏ธ PHASE 3: IMAGING
CT Head (Non-contrast) โ 08:05 AM
Radiology report:
"No intracranial haemorrhage. No established infarct visible. Hyperdense MCA sign on left. ASPECTS score = 9/10 (subtle loss of grey-white differentiation in left insular cortex). No midline shift."
โ DECISION POINT 2: Thrombolysis?
Is Harold eligible for IV tPA (alteplase)?
You mentally run through the checklist:
| Criteria | Harold | Eligible? |
|---|
| Ischaemic stroke confirmed | Yes - no bleed on CT | โ
|
| Onset within 4.5 hours | 75 min (well within) | โ
|
| Age โฅ18 | 68 | โ
|
| NIHSS 4-25 | NIHSS 13 | โ
|
| BP <185/110 after treatment | Currently 186/104 - borderline | โ ๏ธ |
| Blood glucose normal | 7.2 - normal | โ
|
| No recent surgery/bleeding | None reported | โ
|
| Not on anticoagulants | Wife confirms - no warfarin/DOAC | โ
|
BP given 10mg IV labetalol โ repeat BP 174/98 โ
โ
DECISION: IV Alteplase given at 08:18 AM
- Dose: 0.9 mg/kg (max 90mg) โ Harold gets 75mg
- 10% as IV bolus, 90% over 60 minutes
- Door-to-needle time: 36 minutes โ
(target <60 min)
๐ญ PHASE 4: CT ANGIOGRAPHY
Done immediately after tPA:
"Proximal left M1 MCA occlusion confirmed. Good collateral circulation. Thrombectomy-eligible anatomy."
โ DECISION POINT 3: Mechanical Thrombectomy?
| Criteria | Harold |
|---|
| Large vessel occlusion | Yes - M1 MCA |
| NIHSS โฅ6 | Yes (13) |
| ASPECTS โฅ6 | Yes (9) |
| Within 6 hours of onset | Yes (90 min) |
| Pre-morbid mRS 0-1 | Wife confirms independent at baseline |
โ
DECISION: Thrombectomy performed at 08:52 AM
- TICI 2b reperfusion achieved (>50% territory reperfused)
- Door-to-groin time: 70 minutes โ
๐ PHASE 5: INVESTIGATIONS RESULTS
| Test | Result | Significance |
|---|
| ECG | AF, rate 88 | Cardioembolic source! |
| Echo (TTE) | LA enlargement, no thrombus visible | AF-related remodelling |
| HbA1c | 48 mmol/mol (6.5%) | Borderline - pre-diabetes |
| LDL | 3.8 mmol/L | High - atherosclerosis risk |
| BP (mean over 24h) | 158/96 | Poorly controlled HTN |
| FBC | Normal | |
| Coag | Normal INR | |
| Renal function | Creatinine 98 - normal | Important for anticoagulation |
๐ PHASE 6: ACUTE MANAGEMENT
Immediate Orders:
| Medication | Rationale |
|---|
| Aspirin 300mg (hold 24h post-tPA) | Antiplatelet - bridge until anticoagulation |
| Atorvastatin 40-80mg | High-intensity statin for LDL + plaque stability |
| Antihypertensives | Hold aggressive treatment acutely (permissive hypertension) |
| DVT prophylaxis | TED stockings, LMWH after 24h |
| NBM initially | Swallow assessment before oral intake |
| Glucose monitoring | Target 4-11 mmol/L |
Anticoagulation Decision:
Harold has AF = cardioembolic stroke
When to start anticoagulation?
| Stroke size | Timing |
|---|
| TIA | Immediately |
| Minor stroke | Day 3-4 |
| Moderate stroke (Harold) | Day 6-8 |
| Severe stroke | Day 12-14 |
Plan: Start Apixaban 5mg BD on Day 7 (AF + no contraindications)
๐ง PHASE 7: REHABILITATION
Specialist Referrals Made:
| Team | Goal |
|---|
| Physiotherapy | Right-sided weakness, gait retraining |
| Occupational Therapy | ADL assessment, home modifications |
| Speech & Language Therapy | Aphasia rehab, swallow assessment |
| Dietitian | Dysphagia diet if needed, metabolic risk |
| Stroke Psychologist | Emotional lability, depression screening |
| Pharmacist | Medication reconciliation, adherence counselling |
Harold's Rehabilitation Goals (Week 1):
๐ PHASE 8: PROGNOSIS
Modified Rankin Scale at Admission:
mRS = 4 (moderately severe - unable to walk without assistance, needs help with ADLs)
Expected Trajectory:
| Timeframe | Expected Recovery |
|---|
| 1 week | Improved alertness, some word retrieval |
| 1 month | Walking with aid, partial arm movement |
| 3 months | ~40% chance of mRS โค2 (functionally independent) |
| 6 months | Plateau of most neurological recovery |
| 1 year | Language may continue improving (aphasia) |
Recurrence Risk:
- Without treatment: 10-15% stroke in first 90 days
- With anticoagulation (AF): Reduced by ~65%
- With statin + BP control: Further 25-30% RRR
๐ฌ PHASE 9: PATIENT CONVERSATION โ Prognosis Discussion
Day 3. Harold is more alert. His wife Margaret is present.
You: "Harold, Margaret - I want to talk about what happened and what comes next. How are you feeling today, Harold?"
Harold: (slowly) "Better... than... before. But still... this arm. Will it... come back?"
You: "The good news is we were able to open the blocked vessel quickly. That gives you the best possible chance of recovery. Most recovery happens in the first 3 months..."
Margaret: (tearful) "Will he be able to come home? Will he be... normal again?"
You: "Our goal is absolutely to get Harold home. He may need some help at home - we'll assess that carefully. His speech is already improving. The arm... takes more time, but physiotherapy will start tomorrow."
Harold: (quietly, eyes wet) "I'm... scared I'll be a... burden."
You: (lean forward, make eye contact) "Harold, that's a very normal feeling. But you're not a burden - you're a person who had a medical emergency and is fighting back. We're going to support both of you through this."
๐ PHASE 10: DISCHARGE PLANNING (Day 8)
| Item | Plan |
|---|
| Discharge mRS | 3 (moderate disability - some help needed) |
| Destination | Home with community stroke rehab |
| Medications | Apixaban 5mg BD, Atorvastatin 80mg, Ramipril 5mg, Amlodipine 5mg |
| Follow-up | Stroke clinic 4 weeks, GP 1 week |
| Red flags given | FAST symptoms, chest pain, bleeding |
| Carer support | Margaret referred to carer support group |
| Driving | Not for minimum 1 month, DVLA notification |
๐ฏ LEARNING SUMMARY
| Key Lesson | Detail |
|---|
| Time is brain | 1.9 million neurons die per minute in stroke |
| AF = anticoagulate | Not antiplatelet - anticoagulation for cardioembolic |
| tPA window | 4.5 hours from last known well |
| Thrombectomy | Up to 24h in selected patients |
| Permissive hypertension | Allow BP up to 220/120 acutely (unless thrombolysis) |
| Swallow first | Always assess swallow before oral medications/food |
| Rehab starts day 1 | Early mobilisation improves outcomes |
Would you like to:
- ๐ Replay any phase with different decisions?
- ๐ Quiz mode on CVA management?
- ๐ฃ๏ธ Practice the family communication again?
- ๐ Go deeper into any specific treatment?