From only the uploaded reference material (do not use external knowledge), identify all important diagrams, figures, flowcharts, graphs, tables, radiographs, clinical photographs, histopathology images, classification charts, and schematic illustrations related to " Host microbe interaction in periodontology " that are useful for answering an MDS Periodontology university theory examination question. For each item, provide: 1. Title/Name of the diagram/figure 2. Page number 3. Type (Diagram/Figure/Flowchart/Graph/Table/Radiograph/Clinical photograph/Histology/Schematic) 4. Importance (Very High/High/Moderate for university exams) 5. Why it is important in theory exams (1–2 lines) Output requirements: • Use only the uploaded references. • Do not summarize the chapter. • Do not explain Aggressive Periodontitis. • Do not include diagrams from other topics unless they are directly relevant. • List every important visual element found in the uploaded references • Present the output as a table sorted by exam importance, with Very High items first.
Search the following uploaded text files for ALL figures, diagrams, tables, flowcharts, graphs, schematics, clinical photographs, histopathology images, radiographs, and classification charts related to "host-microbe interaction" in periodontology. The files are: 1. /home/daytona/workspace/attachments/6db9eaaf-cd48-497d-8ff7-d68d98ce0d5c/14 th ed Newman_and_Carranza's_Clinical_Periodontology_and_Implantology, - Copy - Copy.txt 2. /home/daytona/workspace/attachments/6db9eaaf-cd48-497d-8ff7-d68d98ce0d5c/Carranza's Clinical Periodontology, 10th Edition - Copy.txt 3. /home/daytona/workspace/attachments/6db9eaaf-cd48-497d-8ff7-d68d98ce0d5c/Clinical Periodontology and Implant Dentistry 6th Edition - Copy.txt 4. /home/daytona/workspace/attachments/6db9eaaf-cd48-497d-8ff7-d68d98ce0d5c/Periodontics Medicine Surgery Implants.txt Search each file for: - Keywords: "Figure", "Fig.", "Table", "Flowchart", "Diagram", "Schematic", "Graph", "Chart", "Illustration", "Photograph", "Radiograph", "Histology", "Histopathology" - Combined with: "host", "microbe", "microbial", "bacteria", "immune", "inflammation", "cytokine", "neutrophil", "macrophage", "complement", "antibody", "innate", "adaptive", "virulence", "pathogen", "biofilm", "periodontal", "invasion", "evasion", "defense", "host response", "pathogenesis", "plaque" For each figure/table/diagram found, record: - Exact title/caption (copy verbatim from the text) - Page number or chapter reference - Type (Figure/Table/Diagram/Flowchart etc.) - Source book name Use grep tool to search for patterns like "Fig", "Figure", "TABLE", "Table" in each file. Read sections around each match to get full captions. Be thorough - read multiple sections of each file. Return a comprehensive list of ALL visual elements found with their exact captions and page/location references.
~/attachments/6db9eaaf-cd48-497d-8ff7-d68d98ce0d5c
"Fig" in ~/attachments/6db9eaaf-cd48-497d-8ff7-d68d98ce0d5c
"Table" in ~/attachments/6db9eaaf-cd48-497d-8ff7-d68d98ce0d5c
"Fig. 8" in ~/attachments/6db9eaaf-cd48-497d-8ff7-d68d98ce0d5c
"Fig. 11" in ~/attachments/6db9eaaf-cd48-497d-8ff7-d68d98ce0d5c
"Fig. 12" in ~/attachments/6db9eaaf-cd48-497d-8ff7-d68d98ce0d5c
"Fig" in ~/attachments/6db9eaaf-cd48-497d-8ff7-d68d98ce0d5c
"Table" in ~/attachments/6db9eaaf-cd48-497d-8ff7-d68d98ce0d5c
"Fig" in ~/attachments/6db9eaaf-cd48-497d-8ff7-d68d98ce0d5c
"host" in ~/attachments/6db9eaaf-cd48-497d-8ff7-d68d98ce0d5c
"Fig" in ~/attachments/6db9eaaf-cd48-497d-8ff7-d68d98ce0d5c
"Table 8" in .../6db9eaaf-cd48-497d-8ff7-d68d98ce0d5c/Clinical Periodontology and Implant Dentistry 6th Edition - Copy.txt
"Table 13" in .../6db9eaaf-cd48-497d-8ff7-d68d98ce0d5c/Clinical Periodontology and Implant Dentistry 6th Edition - Copy.txt
"Table 10-" in .../6db9eaaf-cd48-497d-8ff7-d68d98ce0d5c/Clinical Periodontology and Implant Dentistry 6th Edition - Copy.txt
"Table 15-" in .../6db9eaaf-cd48-497d-8ff7-d68d98ce0d5c/Clinical Periodontology and Implant Dentistry 6th Edition - Copy.txt
"Fig. 12-" in .../6db9eaaf-cd48-497d-8ff7-d68d98ce0d5c/Clinical Periodontology and Implant Dentistry 6th Edition - Copy.txt
"Fig. 13-" in .../6db9eaaf-cd48-497d-8ff7-d68d98ce0d5c/Clinical Periodontology and Implant Dentistry 6th Edition - Copy.txt
"Fig. 10-1" in .../6db9eaaf-cd48-497d-8ff7-d68d98ce0d5c/Clinical Periodontology and Implant Dentistry 6th Edition - Copy.txt
"Figure 5-" in .../6db9eaaf-cd48-497d-8ff7-d68d98ce0d5c/Periodontics Medicine Surgery Implants.txt
"Figure 6-" in .../6db9eaaf-cd48-497d-8ff7-d68d98ce0d5c/Periodontics Medicine Surgery Implants.txt
"Figure 18-" in .../6db9eaaf-cd48-497d-8ff7-d68d98ce0d5c/Periodontics Medicine Surgery Implants.txt
answer
Search the following uploaded text/markdown files for ALL figures, diagrams, tables, flowcharts, graphs, schematics, clinical photographs, histopathology images, radiographs, and classification charts related to "host-microbe interaction" in periodontology. Files to search: 1. /home/daytona/workspace/attachments/6db9eaaf-cd48-497d-8ff7-d68d98ce0d5c/Essential_Microbiology_for_Dentistry_Lakshman_Samaranayake_5th_Ed (1).md 2. /home/daytona/workspace/attachments/6db9eaaf-cd48-497d-8ff7-d68d98ce0d5c/Janeway's Immunobiology 9th Ed - 2017.txt 3. /home/daytona/workspace/attachments/6db9eaaf-cd48-497d-8ff7-d68d98ce0d5c/Richard_J_Lamont_George_Hajishengallis_Hyun_Koo_Howard_F_Jenkinson.txt 4. /home/daytona/workspace/attachments/6db9eaaf-cd48-497d-8ff7-d68d98ce0d5c/Essentials of_Clinical Periodontology and Periodontics.md 5. /home/daytona/workspace/attachments/6db9eaaf-cd48-497d-8ff7-d68d98ce0d5c/Biomarkers in Periodontal Health and Disease.md For EACH file: 1. Use the grep tool to search for patterns: "Fig", "Figure", "TABLE", "Table", "Flowchart", "Diagram", "Schematic", "Graph", "Chart", "Box", "Illustration" 2. For each match found, read the surrounding lines (about 10 lines before and after) to get the full caption/title 3. Only include items RELEVANT to host-microbe interaction topics: innate immunity, adaptive immunity, complement, neutrophils, cytokines, TLRs, PRRs, RANKL, bone resorption, bacterial virulence, biofilm-host interaction, pathogenesis, inflammation, tissue destruction, evasion of host defenses, GCF, antimicrobial peptides, MMPs For each visual element found, record: - Exact figure/table number and title (copy verbatim) - Page number or section location - Type (Figure/Table/Diagram/Schematic/Flowchart/Graph/Histology etc.) - Source book name Be thorough - use grep multiple times with different search terms. Read large sections of each file. Return a comprehensive list of ALL relevant visual elements found with their exact captions, locations, and source books.
"Fig" in ~/attachments/6db9eaaf-cd48-497d-8ff7-d68d98ce0d5c
"Fig" in ~/attachments/6db9eaaf-cd48-497d-8ff7-d68d98ce0d5c
"Fig" in ~/attachments/6db9eaaf-cd48-497d-8ff7-d68d98ce0d5c
"Fig" in ~/attachments/6db9eaaf-cd48-497d-8ff7-d68d98ce0d5c
"Fig" in ~/attachments/6db9eaaf-cd48-497d-8ff7-d68d98ce0d5c
"Table" in ~/attachments/6db9eaaf-cd48-497d-8ff7-d68d98ce0d5c
"Table" in ~/attachments/6db9eaaf-cd48-497d-8ff7-d68d98ce0d5c
"Table" in ~/attachments/6db9eaaf-cd48-497d-8ff7-d68d98ce0d5c
"Table" in ~/attachments/6db9eaaf-cd48-497d-8ff7-d68d98ce0d5c
"Flowchart" in ~/attachments/6db9eaaf-cd48-497d-8ff7-d68d98ce0d5c
"Box" in ~/attachments/6db9eaaf-cd48-497d-8ff7-d68d98ce0d5c
"Box" in ~/attachments/6db9eaaf-cd48-497d-8ff7-d68d98ce0d5c
"Figure" in ~/attachments/6db9eaaf-cd48-497d-8ff7-d68d98ce0d5c
"FIGURE" in ~/attachments/6db9eaaf-cd48-497d-8ff7-d68d98ce0d5c
"figure" in ~/attachments/6db9eaaf-cd48-497d-8ff7-d68d98ce0d5c
"figure" in ~/attachments/6db9eaaf-cd48-497d-8ff7-d68d98ce0d5c
"Table" in ~/attachments/6db9eaaf-cd48-497d-8ff7-d68d98ce0d5c
"TABLE" in ~/attachments/6db9eaaf-cd48-497d-8ff7-d68d98ce0d5c
~/attachments/6db9eaaf-cd48-497d-8ff7-d68d98ce0d5c
ls "/home/daytona/workspace/attachments/6db9eaaf-cd48-497d-8ff7-d68d98ce0d5c/" |…
grep -i "figure\|table\|box\|panel\|diagram\|flowchart" "/home/daytona/workspace…
file "/home/daytona/workspace/attachments/6db9eaaf-cd48-497d-8ff7-d68d98ce0d5c/J…
ls -la "/home/daytona/workspace/attachments/6db9eaaf-cd48-497d-8ff7-d68d98ce0d5c…
ls -la "/home/daytona/workspace/attachments/6db9eaaf-cd48-497d-8ff7-d68d98ce0d5c…
cd "/home/daytona/workspace/attachments/6db9eaaf-cd48-497d-8ff7-d68d98ce0d5c/" &…
cd "/home/daytona/workspace/attachments/6db9eaaf-cd48-497d-8ff7-d68d98ce0d5c/" &…
cd "/home/daytona/workspace/attachments/6db9eaaf-cd48-497d-8ff7-d68d98ce0d5c/" &…
cd "/home/daytona/workspace/attachments/6db9eaaf-cd48-497d-8ff7-d68d98ce0d5c/" &…
cd "/home/daytona/workspace/attachments/6db9eaaf-cd48-497d-8ff7-d68d98ce0d5c/" &…
cd "/home/daytona/workspace/attachments/6db9eaaf-cd48-497d-8ff7-d68d98ce0d5c/" &…
cd "/home/daytona/workspace/attachments/6db9eaaf-cd48-497d-8ff7-d68d98ce0d5c/" &…
cd "/home/daytona/workspace/attachments/6db9eaaf-cd48-497d-8ff7-d68d98ce0d5c/" &…
answer
Host-Microbe Interaction in Periodontology
Visual Elements from Uploaded References - MDS Perio University Theory Exam
VERY HIGH IMPORTANCE
| # | Title / Name of Diagram/Figure | Source & Location | Type | Importance | Why Important in Theory Exams |
|---|---|---|---|---|---|
| 1 | FIGURE 4 (Ch.15) - Complex network of innate and adaptive immune interactions in periodontitis (neutrophils, Th17, Th1, Th2, Treg, RANKL, macrophages, B cells, complement C3a/C5a, DC, IL-1, TNF, MMPs, ROS, bone resorption) | Lamont, Hajishengallis, Koo & Jenkinson - Ch. 15 | Schematic/Master Diagram | Very High | The single most comprehensive figure integrating all arms of host-microbe interaction in periodontitis; answers virtually any long-answer question on immunopathogenesis |
| 2 | Fig. 8.5 - Cytokine networks in periodontal diseases (PRRs→MAMPs, NF-κB, Th1/Th2/Th17/Treg, RANKL, TNF-α, IL-10, osteoclastogenesis) | Newman & Carranza 14th Ed. - Ch. 8 | Schematic Diagram | Very High | Directly answers questions on cytokine cascades, T-helper cell polarization, and bone loss mechanisms in periodontitis |
| 3 | Fig. 11.1 - Multiple pattern-recognition receptors (PRRs) in host-microbial interactions (TLRs, NLRs, inflammasome, MAMPs, NF-κB, cytokine production) | Newman & Carranza 14th Ed. - Ch. 11 | Schematic Diagram | Very High | Core diagram for innate immunity questions; covers TLR signaling, NF-κB pathway, and downstream inflammatory response in one figure |
| 4 | Fig. 11.4 - Dynamics of host response in periodontal disease (bacteria → epithelium → innate pathways #1 neutrophils #2 macrophages/DCs/γδ T cells → adaptive immunity → osteoclastogenesis via RANKL, TNF, IL-6, IL-17, MMPs) | Newman & Carranza 14th Ed. - Ch. 11 | Schematic/Flowchart | Very High | Step-by-step pathogenesis flowchart from bacterial challenge to bone destruction; essential for structured long-answer writing |
| 5 | Fig. 11.3 - Complement activation and periodontal disease (classical, lectin, alternative pathways; C3a, C5a, C3b, MAC; cross-talk with TLRs; tissue breakdown) | Newman & Carranza 14th Ed. - Ch. 11 | Schematic Diagram | Very High | Complement is a high-frequency exam topic; this figure covers all three pathways and links them directly to periodontal tissue destruction |
| 6 | Fig. 2.3 - Complex interactions between pathogens and host response in periodontitis (LPS → NF-κB → TNF-α, IL-8, GM-CSF → PMNL → ROS → TIMPs/MMPs → oxidative stress → tissue destruction) | Biomarkers in Periodontal Health & Disease - Ch. 2 | Central Pathogenesis Schematic | Very High | Key LPS-to-tissue destruction pathway diagram; answers questions on bacterial endotoxin, NF-κB activation, and MMP-mediated destruction |
| 7 | Fig. 10.24 / Fig. 10-6 - Socransky Microbial Complexes (colour-coded complexes; red = P. gingivalis, T. forsythia, T. denticola; orange bridges early colonisers to red complex; pyramid form) | Newman & Carranza 14th Ed. Ch. 10; Lindhe 6th Ed. Ch. 10; Lamont Ch. 13 | Cluster Diagram | Very High | Most frequently cited figure in periodontal microbiology; directly asked in exams on periodontal pathogens, microbial succession, and keystone pathogens |
| 8 | Fig. 10.25 - Ecologic Plaque Hypothesis (plaque accumulation → gingivitis → environmental shift → gram-negative anaerobes → dysbiosis → tissue destruction; Eh, GCF) | Newman & Carranza 14th Ed. - Ch. 10 | Flowchart/Schematic | Very High | Directly asked in theory exams on pathogenesis of periodontal disease and the ecological basis of host-microbe dysbiosis |
| 9 | FIGURE 1 (Ch.15) - Forms of periodontal disease and mechanisms of dysbiosis (health → gingivitis → periodontitis; keystone pathogens, dysbiosis cycle, GCF as nutrient source) | Lamont, Hajishengallis, Koo & Jenkinson - Ch. 15 | Pathogenesis Schematic | Very High | Illustrates the symbiosis-to-dysbiosis transition; central to questions on ecological pathogenesis and keystone pathogen concept |
| 10 | FIGURE 3 (Ch.15) - Periodontitis as disrupted host-microbe homeostasis (symbiosis vs. dysbiosis paradigm; community virulence concept) | Lamont, Hajishengallis, Koo & Jenkinson - Ch. 15 | Conceptual Diagram | Very High | Directly tests the shift from Page-Kornman model to dysbiosis/community virulence model - a standard MDS theory question |
| 11 | FIGURE 5 (Ch.15) - P. gingivalis subversion of neutrophils (TLR1-TLR2 crosstalk, C5aR signalling, MyD88 degradation, PI3K activation, phagocytosis inhibition, sustained inflammatory cytokines) | Lamont, Hajishengallis, Koo & Jenkinson - Ch. 15 | Molecular Signalling Diagram | Very High | Explains the keystone pathogen concept mechanistically; directly answers questions on immune evasion by P. gingivalis and complement-TLR crosstalk |
| 12 | FIGURE 7 (Ch.15) - RANKL/OPG pathway and osteoclastogenesis (RANK/RANKL/OPG triad, T cells, B cells, plasma cells, osteoblasts → osteoclast activation → bone resorption) | Lamont, Hajishengallis, Koo & Jenkinson - Ch. 15 | RANKL/OPG Pathway Diagram | Very High | RANKL/OPG is one of the most commonly examined mechanisms in MDS perio theory; this figure covers the full cellular source network |
| 13 | Fig. 8.8 - Biologic systems model of periodontitis (Person Level: subgingival biofilm, risk factors; Genetic/Epigenetic Level: age, sex, gene polymorphisms, DNA methylation; Biologic Phenotype; Clinical Phenotype - modified from Offenbacher 2008) | Newman & Carranza 14th Ed. - Ch. 8 | Conceptual Systems Diagram | Very High | Frequently asked in questions on host susceptibility, genetic risk, and the multifactorial model of periodontitis |
| 14 | Figure 5-4 - Model of periodontal immunopathogenesis (innate + adaptive → immunopathogenic progression or disease abrogation; role of smoking, genetic bias, systemic diseases, stress) | Periodontics: Medicine Surgery Implants - Ch. 5 | Conceptual Model | Very High | Classic immunopathogenesis model (Armitage); tests understanding of bidirectional host-microbe outcomes and modifying factors |
| 15 | Fig. 8.4 - Invasion of epithelial cells by Fusobacterium nucleatum (SEM; coaggregation with S. cristatus; epithelial cell penetration) | Newman & Carranza 14th Ed. - Ch. 8 | Electron Micrograph/Clinical Photo | Very High | Bacterial invasion of host tissues is a direct exam question; this electron micrograph provides structural evidence for tissue penetration |
| 16 | Fig. 16.1 / Figure 13-1 (10th Ed.) - Detailed assessment of host response in periodontal pathogenesis (integrates microbial challenge, innate/adaptive immune responses, cytokine networks, tissue-destructive outcomes) | Carranza 10th Ed. - Ch. 16 | Comprehensive Flowchart/Schematic | Very High | Comprehensive pathogenesis diagram integrating all components; standard reference for structured long-answer questions |
| 17 | Fig. 12.3 / Figure 12-3 - Complement system: C3 activation, classical pathway, alternative pathway | Carranza 10th Ed. - Ch. 12; Lindhe 6th Ed. | Pathway Diagram | Very High | Complement is directly asked in host response questions; covering C3 activation routes and effector functions is mandatory |
| 18 | Table 10-3 / Table 13-3 - Selected virulence determinants of periodontal bacteria (P. gingivalis: gingipains RgpA/RgpB/Kgp, lipid A, fimbriae, capsule, OMVs; A. actinomycetemcomitans: leukotoxin LtxA, CDT; T. forsythia: BspA; T. denticola: dentilisin/PrtP) | Lindhe 6th Ed. - Ch. 10; Carranza 10th Ed. Ch. 13 | Table | Very High | Virulence factors are directly examined in theory papers; this table covers all major periodontal pathogens with mechanisms |
| 19 | Figs 2.13-2.15 - Complement system: three pathways overview and functional outcomes (classical, lectin, alternative; opsonisation, inflammation, lysis) | Janeway's Immunobiology 9th Ed. - Ch. 2 | Pathway Diagrams (series) | Very High | Standard immunology reference for complement; used when answering detailed mechanism questions on complement in periodontitis |
| 20 | Fig. 3.10 + Fig. 3.13 - TLR ligand specificity and TLR4-MD2-LPS complex (TLR1-TLR10 ligands; TLR4 structure with MD-2 and LPS; downstream NF-κB) | Janeway's Immunobiology 9th Ed. - Ch. 3 | Schematic/Structural Diagram | Very High | TLR-LPS recognition is a core exam topic in periodontal host response; Janeway gives the most detailed structural basis |
| 21 | Fig. 6 (Ch.13) - Overview of pathogenesis of periodontitis (Page & Kornman 1997) (bacteria → inflammation → risk factors → tissue destruction → ecological feedback loop) | Lamont, Hajishengallis, Koo & Jenkinson - Ch. 13 | Pathogenesis Overview Diagram | Very High | The Page & Kornman model is a classic examination question; this figure presents it in its original integrative form |
| 22 | Figs 8.1-8.3 / Histopathology series (Health → Gingivitis → Periodontitis) (photomicrographs: healthy gingiva, sequential stages of gingivitis, periodontitis with bone loss) | Newman & Carranza 14th Ed. - Ch. 8 | Histopathology Series | Very High | Histopathologic progression is directly asked in theory exams; these three figures are the standard reference for initial, early, established, and advanced lesions |
| 23 | Figures 5-1, 5-2, 5-3 (series) - Histopathology: health → gingivitis → periodontitis (monkey/beagle/human biopsies; PMN infiltrate, lymphocytes, plasma cells, ulcerated PE; schematic + photomicrographs) | Periodontics: Medicine Surgery Implants - Ch. 5 | Histopathology Series + Schematic | Very High | Directly used in questions on histopathology of periodontal lesions and cellular composition of the periodontal infiltrate |
HIGH IMPORTANCE
| # | Title / Name of Diagram/Figure | Source & Location | Type | Importance | Why Important in Theory Exams |
|---|---|---|---|---|---|
| 24 | Fig. 11.2 - Dynamics of the immune/inflammatory response in periodontal disease (balance between pro-inflammatory and pro-reparative microenvironments; MMPs, OPG, RANKL, TIMPs) | Newman & Carranza 14th Ed. - Ch. 11 | Schematic Diagram | High | Covers the balance concept in host response; used for questions on stable vs. progressive lesions and host modulation |
| 25 | Table 11.1 - PRRs and their MAMPs in the periodontal microenvironment (TLR-2: lipoproteins/peptidoglycan; TLR-4: LPS; TLR-5: flagellin; TLR-9: CpG DNA) | Newman & Carranza 14th Ed. - Ch. 11 | Table | High | TLR-ligand pairing is a standard short-note question; this table provides ready-made structured answers |
| 26 | Table 11.2 - Inflammatory mediators causing periodontal tissue destruction (cytokines, prostaglandins, MMPs and their tissue-destructive effects) | Newman & Carranza 14th Ed. - Ch. 11 | Table | High | One of the most cited tables in periodontal pathogenesis questions; covers all major inflammatory mediators in one place |
| 27 | Table 8.1 + 8.2 - Matrix metalloproteinases (MMPs): nomenclature, classification, substrates + biologic effects in periodontitis | Newman & Carranza 14th Ed. - Ch. 8 | Tables | High | MMP questions are common in MDS perio theory; these two tables together provide complete answers on MMP nomenclature and function |
| 28 | Fig. 10.17 - Metabolic interactions among bacterial species and between plaque bacteria and host (CO₂, H₂, NH₄⁺ exchange; survival mechanisms; bacteria-host metabolic cross-talk) | Newman & Carranza 14th Ed. - Ch. 10 | Schematic Diagram | High | Tests understanding of biofilm ecology and host-biofilm metabolic interactions; useful for ecological plaque questions |
| 29 | Fig. 10.2 - Subgingival plaque (diagram of plaque-bacteria association; SEM of cross-section; histologic structure - gram-positive attached zone vs. gram-negative unattached zone; epithelium-associated bacteria) | Newman & Carranza 14th Ed. - Ch. 10 | Composite Diagram + SEM + Histology | High | Subgingival plaque structure is a foundational topic; this multi-panel figure is the standard reference for structural organisation questions |
| 30 | Fig. 10.3 - Bacterial penetration into the periodontal pocket wall (bacteria through pocket epithelium and basement lamina into connective tissue; electron micrograph) | Newman & Carranza 14th Ed. - Ch. 10 | Histology/Electron Micrograph | High | Tissue invasion by bacteria is a key mechanism in periodontitis pathogenesis; electron micrograph provides direct visual evidence |
| 31 | Figure 12-4 - Leukocyte transendothelial migration (rolling, signalling, arrest, transmigration; adhesion molecules) | Carranza 10th Ed. - Ch. 12 | Schematic Diagram | High | Leukocyte trafficking is tested in questions on acute inflammation and neutrophil function in periodontitis |
| 32 | Figure 12-5 / Fig. 8.1 (Essentials) - Neutrophil chemotaxis and chemotactic receptors | Carranza 10th Ed. - Ch. 12; Essentials Ch. 8 | Schematic Diagram | High | Neutrophil chemotaxis and receptor-mediated migration are standard content in host response questions |
| 33 | Figures 12-6 / Fig. 8.3 (Essentials) - Phagocytic killing: oxidative burst and lysosomal enzymes | Carranza 10th Ed. - Ch. 12; Essentials Ch. 8 | Schematic Diagram | High | Phagocytic killing mechanisms are directly asked; oxidative vs. non-oxidative killing is a classic comparison question |
| 34 | Figure 12-7 - MHC class II antigen presentation (APC processing and presentation of periodontal bacterial antigens to CD4+ T cells) | Carranza 10th Ed. - Ch. 12 | Schematic Diagram | High | Antigen presentation is foundational to adaptive immunity questions; required for answers on T cell activation in periodontitis |
| 35 | Figure 12-10 - Cytokine production by T cells: Th1, Th2, Th17 profiles | Carranza 10th Ed. - Ch. 12 | Schematic Diagram | High | Th1/Th2/Th17 balance in periodontitis is a recurring exam topic; directly used in answers on T-helper cell subsets |
| 36 | Table 12-1 - Cells of the immune system (neutrophils, monocytes, DCs, eosinophils, basophils, mast cells, CD4+ T cells; surface receptors and functions) | Carranza 10th Ed. - Ch. 12 | Table | High | Provides structured content for immune cell identification and function questions |
| 37 | Table 12-5 - TNF superfamily molecules (RANKL, OPG, TRAIL; roles in periodontal bone loss and immune regulation) | Carranza 10th Ed. - Ch. 12 | Table | High | RANKL/OPG/TRAIL axis is directly examined; this table lists all relevant TNF superfamily members in the periodontal context |
| 38 | Table 13-1 - Select Bacterial Adhesins and Target Substrates (P. gingivalis fimbriae, A. actinomycetemcomitans adhesins; tooth surface, tissue, and connective tissue substrates) | Carranza 10th Ed. - Ch. 13 | Table | High | Bacterial adhesion mechanisms are tested in virulence factor questions; table is directly quotable |
| 39 | Table 13-4 - Bacterial products perturbing the complement system (mechanisms used by periodontal pathogens to evade complement-mediated killing) | Carranza 10th Ed. - Ch. 13 | Table | High | Complement evasion by periodontal bacteria is a specific and commonly tested concept in MDS exams |
| 40 | Fig. 8.9 (Samaranayake) - Natural defense mechanisms of the oral cavity (TLRs, IgG, PMNLs, saliva AMPs as first-line defenses) | Essential Microbiology for Dentistry - Ch. 8 | Schematic Diagram | High | Comprehensive overview of oral innate defense; used for questions on first-line host defense mechanisms |
| 41 | Fig. 9.5 (Samaranayake) - TH1 vs. TH2 cytokine secretion profiles | Essential Microbiology for Dentistry - Ch. 9 | Diagram | High | T-helper polarisation and cytokine profiles are standard exam content in adaptive immunity and periodontitis |
| 42 | Table 9.1 (Samaranayake) - Main producers and major actions of cytokines (IL-1β, IL-6, IL-8, IL-17, TNF-α, IFN-γ, TGF-β) | Essential Microbiology for Dentistry - Ch. 9 | Table | High | Comprehensive cytokine table; provides structured, exam-ready content for cytokine-related questions |
| 43 | Tables 8.1-8.4 (Samaranayake) - Antigen-non-specific defense chemicals; Cathelicidins/defensins; Non-specific host defense; Cell death responses | Essential Microbiology for Dentistry - Ch. 8 | Tables (series) | High | AMPs and innate defense molecules are tested in questions on the first line of host defense against periodontal bacteria |
| 44 | Fig. 3.14 (Janeway) - TLR signalling via MyD88 and TRIF adaptor pathways (TLR downstream signalling; NF-κB and IRF3 activation) | Janeway's Immunobiology 9th Ed. - Ch. 3 | Signalling Diagram | High | MyD88-dependent and independent TLR signalling is a high-level MDS question; Janeway gives the most authoritative illustration |
| 45 | Fig. 3.19 + 3.20 (Janeway) - NLRP3 inflammasome assembly and IL-1β/IL-18 production | Janeway's Immunobiology 9th Ed. - Ch. 3 | Structural/Pathway Diagram | High | Inflammasome activation by periodontal bacteria is an emerging exam topic; directly relevant to IL-1β-mediated bone loss |
| 46 | Fig. 3.27 + 3.33 (Janeway) - Cytokines/chemokines by DCs and macrophages; TNF-α, IL-1β, IL-6 spectrum of activities | Janeway's Immunobiology 9th Ed. - Ch. 3 | Summary Table-Figures | High | Provides detailed cytokine biology for long-answer questions on innate inflammatory mediators in periodontitis |
| 47 | Fig. 2.38 (Janeway) - Complement evasion proteins produced by pathogens | Janeway's Immunobiology 9th Ed. - Ch. 2 | Summary Table-Figure | High | Microbial complement evasion is directly relevant to P. gingivalis keystone pathogen questions |
| 48 | Figs 24.2-24.6 (Essentials) - Osteoclastogenesis sequence (preosteoclast formation → maturation → OPG inhibition → osteoblast-osteoclast crosstalk → resorption at bone surface) | Essentials of Clinical Periodontology - Ch. 24 | Diagram Series | High | Bone resorption mechanisms are directly tested; these five sequential figures together build a complete answer on alveolar bone loss |
| 49 | Flowcharts 24.1 + 24.2 (Essentials) - Changes in bone during gingival inflammation; Sequence of events in bone resorption (RANKL/OPG imbalance → osteoclastogenesis → alveolar bone loss) | Essentials of Clinical Periodontology - Ch. 24 | Flowcharts | High | Flowchart format directly mirrors how students are expected to answer bone resorption questions in theory exams |
| 50 | Tables 12.1 + 12.2 (Essentials) - Virulence factors of P. gingivalis and A. actinomycetemcomitans | Essentials of Clinical Periodontology - Ch. 12 | Tables | High | The two primary pathogens of periodontitis and their virulence mechanisms are a core exam question; both tables are directly quotable |
| 51 | Flowchart 6.1 (Essentials) - Mechanism and tissue damage caused by dental plaque (plaque → LPS/antigens → host response cascade → tissue destruction) | Essentials of Clinical Periodontology - Ch. 6 | Flowchart | High | Direct cause-to-destruction flowchart answering how plaque mediates host tissue injury; classic short-note answer |
| 52 | Flowchart 15.2 (Essentials) - Pathological events with host modifying factors (integrated host-modifying factors → pathological cascade) | Essentials of Clinical Periodontology - Ch. 15 | Flowchart | High | Integrates environmental/systemic modifiers with inflammatory pathway; used in questions on multifactorial pathogenesis |
| 53 | Table 8.1 (Essentials) - Important cytokines and their effects (IL-1, IL-2, IL-4, IL-6, IL-8, IFN-γ, TNF-α: origin, target, effect) | Essentials of Clinical Periodontology - Ch. 8 | Table | High | Classic cytokine reference table for exam answers; covers all major cytokines in a structured format |
| 54 | Tables 12.3-12.7 (Essentials) - Host response influence on PD; Microorganism impact on inflammation; Epithelial/CT changes; Hypersensitivity | Essentials of Clinical Periodontology - Ch. 12 | Tables (series) | High | These tables systematically cover all aspects of how bacteria interact with host tissues; useful for structured long answers |
| 55 | Figs 12.1-12.8 / Figs 13.1-13.9 (Lindhe) - Histopathology of gingivitis and periodontitis (PMN infiltrate, lymphocyte/macrophage infiltrate, CD4:CD8 ratio 2:1, Langerhans cells, MHC-DR T cells, B cells, plasma cell predominance, APC interactions) | Lindhe 6th Ed. - Chs 12 & 13 | Histopathology + Immunohistochemistry Series | High | Immunohistochemical evidence for cellular composition is asked in questions on experimental gingivitis and periodontitis lesion histology |
| 56 | Fig. 10-16 (Lindhe) - P. gingivalis remodels oral commensal microbiota (immune subversion: IL-8 paralysis, complement modulation, TLR4 manipulation → dysbiosis → pathologic inflammation and bone loss) | Lindhe 6th Ed. - Ch. 10 | Schematic Diagram | High | Keystone pathogen concept with mechanistic detail; directly answers questions on P. gingivalis immune subversion |
| 57 | Fig. 10-14 (Lindhe) - Essential components of the parasite life cycle (colonisation, attachment, multiplication, nutrition, evasion, invasion, exit; gene products required at each step) | Lindhe 6th Ed. - Ch. 10 | Schematic Diagram | High | Provides a complete virulence framework for bacterial pathogenicity; tests understanding of sequential pathogen requirements |
| 58 | Fig. 13-9 (Lindhe) - Immune regulation components in periodontitis (APC, IL, IFN, Treg, TCR, TNF, plasma cells interactions) | Lindhe 6th Ed. - Ch. 13 | Schematic Diagram | High | Adaptive immune regulation in periodontitis; covers T cell-APC interaction, cytokine feedback, and regulatory mechanisms |
| 59 | Fig. 2.4 (Biomarkers) - Cytokines and chemokines in bone resorption (IL-1, IL-6, IL-17, TNF-α, RANKL/OPG, osteoclast progenitor, chemokines) | Biomarkers in Periodontal Health & Disease - Ch. 2 | Cytokine-Bone Diagram | High | Directly connects the cytokine network to osteoclastogenesis and bone resorption; useful for both pathogenesis and biomarker questions |
| 60 | Table 16.3 + 16.4 (Essentials) + Tables 33.2 / 31.2 (Samaranayake) - GCF composition: immunoglobulins, complement, PMNLs, cytokines, MMPs | Essentials Ch. 16; Samaranayake Ch. 33 | Tables | High | GCF as a host response mirror is a common exam question; these tables provide structured content on GCF biomarkers |
| 61 | Fig. 8 (Ch.15, Lamont) - Biological functions of IL-17 in periodontitis (IL-17 → G-CSF, CXCL chemokines, Del-1 downregulation, neutrophil recruitment, MMP-3/9/13, RANKL, β-defensin, S100 proteins) | Lamont, Hajishengallis, Koo & Jenkinson - Ch. 15 | Multi-Pathway Diagram | High | IL-17 is increasingly asked in MDS theory; this figure covers its dual role (protective vs. destructive) with specific molecular targets |
| 62 | Fig. 9 (Ch.15, Lamont) - B cell roles in periodontitis (antibody production, RANKL expression, CXCL13-driven neutrophil recruitment, bone resorption) | Lamont, Hajishengallis, Koo & Jenkinson - Ch. 15 | Diagram | High | B-lineage cell dominance in periodontitis lesions is a specific exam point; RANKL from plasma cells is a high-yield concept |
| 63 | Fig. 6 (Ch.10, Lamont) - Epithelial innate immune responses to oral bacteria (TLR signalling, AMP production by epithelium) | Lamont, Hajishengallis, Koo & Jenkinson - Ch. 10 | Diagram | High | Epithelial innate immunity is a foundational concept tested in questions on first-line host defense |
| 64 | Figs 23.1-23.3 (Lindhe) - Mechanisms linking periodontal infections to atherosclerosis/plaque formation/plaque rupture (endothelial invasion, monocyte activation, foam cell formation, MMP-mediated rupture) | Lindhe 6th Ed. - Chs 23 | Schematic Diagrams (series) | High | Periodontal-cardiovascular link is a common long-answer question; these three figures cover the complete mechanistic chain |
| 65 | Fig. 12-2 (Carranza 10th) / Fig. 12-1 (Lindhe) - Leukocyte types and stages of inflammation | Carranza 10th Ed.; Lindhe 6th Ed. | Schematic Diagram | High | Provides cellular sequence of the inflammatory response for structured answer writing |
MODERATE IMPORTANCE
| # | Title / Name of Diagram/Figure | Source & Location | Type | Importance | Why Important in Theory Exams |
|---|---|---|---|---|---|
| 66 | Fig. 12.1-12.5 (Newman 14th) - Resolution mediators: acute inflammation, chemical structures of SPMs, DEL-1, genetic/microbial model, healing | Newman & Carranza 14th Ed. - Ch. 12 | Schematic Diagrams (series) | Moderate | Resolution of inflammation is an emerging topic; tested in questions on host modulation and SPMs (lipoxins, resolvins, protectins, maresins) |
| 67 | Table 12.1 (Newman 14th) - Resolution mediators (SPMs) in periodontology | Newman & Carranza 14th Ed. - Ch. 12 | Table | Moderate | Specialized pro-resolving mediators are a newer topic tested in advanced MDS questions |
| 68 | Table 8.3 (Newman 14th) - Saliva molecular components contributing to host defenses | Newman & Carranza 14th Ed. - Ch. 8 | Table | Moderate | Salivary defense molecules (mucins, lysozyme, lactoferrin, sIgA) may appear in questions on innate host defense |
| 69 | Fig. 10-11 (Lindhe) - Genome organisation of P. gingivalis strains W83, ATCC33277, TDC60 (pathogenicity islands, genetic variation) | Lindhe 6th Ed. - Ch. 10 | Genome Diagram | Moderate | Relevant for questions on strain variation and genetic basis of P. gingivalis virulence |
| 70 | Figs 10-12, 10-13 (Lindhe) - Histologic sections of supra/subgingival plaque; CLSM in vitro biofilm with species-specific staining | Lindhe 6th Ed. - Ch. 10 | Histology/CLSM | Moderate | Visual evidence for biofilm structure and species organisation; supports biofilm architecture questions |
| 71 | Fig. 10-15 (Lindhe) - 3D reconstruction of intracellular bacteria in buccal epithelial cells (A. actinomycetemcomitans in vivo invasion) | Lindhe 6th Ed. - Ch. 10 | 3D Fluorescence Reconstruction | Moderate | Provides in vivo evidence for intracellular bacterial invasion; supports pathogenesis questions on tissue invasion |
| 72 | Figs 3, 4, 6, 7, 8 (Ch.14, Lamont) - P. gingivalis gingipain structure, substrate specificity, OMVs, T9SS | Lamont, Hajishengallis, Koo & Jenkinson - Ch. 14 | Structural Diagrams/SEM | Moderate | Detailed virulence mechanism figures for gingipains and OMVs; tested in advanced MDS questions on P. gingivalis |
| 73 | TABLE 2 (Ch.14, Lamont) - Proteolytic enzymes of T. denticola, T. forsythia, P. intermedia (KLIKK proteases, dentilisin, karilysin, interpain) | Lamont, Hajishengallis, Koo & Jenkinson - Ch. 14 | Table | Moderate | Red/orange complex virulence enzymes are tested in detailed pathogen virulence questions |
| 74 | Figs 3.5, 3.6 (Janeway) - Respiratory burst (NADPH oxidase/ROS) and Neutrophil Extracellular Traps (NETs) | Janeway's Immunobiology 9th Ed. - Ch. 3 | Diagrams | Moderate | NETs and ROS-mediated killing are increasingly asked in advanced MDS questions on neutrophil biology |
| 75 | Fig. 3.29, 3.31 (Janeway) - Adhesion molecules in leukocyte extravasation; neutrophil diapedesis (selectins, integrins, ICAMs) | Janeway's Immunobiology 9th Ed. - Ch. 3 | Diagrams | Moderate | Molecular basis of neutrophil migration; tested in detailed questions on acute periodontal inflammation |
| 76 | Figs 10-7, 10-8, 10-9 (Lindhe) - Bacterial counts at attachment level change categories; HOMIM bar-code array; correspondence analysis of subgingival communities | Lindhe 6th Ed. - Ch. 10 | Graph/Array/CA Plot | Moderate | Data-based evidence for dysbiosis and microbial community shifts; supports evidence-based exam answers |
| 77 | Fig. 10.2 (Biomarkers) - Multifactorial pathogenic mechanisms in periodontitis (bacteria + susceptible host + environment → periodontitis) | Biomarkers in Periodontal Health & Disease - Ch. 2 | Overview Diagram | Moderate | Reinforces multifactorial model; useful as a supporting figure in long-answer questions |
| 78 | Figs 8.1-8.3 (Essentials) - Neutrophil chemotaxis, phagocytosis, oxidative/non-oxidative killing | Essentials of Clinical Periodontology - Ch. 8 | Diagrams | Moderate | Sequential neutrophil function figures; useful for step-by-step question answers on PMNL in host defense |
| 79 | Figs 8.5-8.9 (Essentials) - B/T/NK cell derivation; humoral response; local cellular response; antibody production; hypersensitivity types I-IV | Essentials of Clinical Periodontology - Ch. 8 | Diagrams | Moderate | Adaptive immunity figures for medium-length questions on cellular and humoral host defense in periodontitis |
| 80 | Figs 6.1-6.11 (Essentials) - Biofilm structure, bacterial adhesion mechanisms, coaggregation, mature plaque, Socransky complexes | Essentials of Clinical Periodontology - Ch. 6 | Diagram/Micrograph Series | Moderate | Biofilm biology and microbial ecology; supportive for comprehensive pathogenesis answers |
| 81 | Figs 23.2A-G (Essentials) - Sequential 7-stage development from health to periodontal pocket (plaque → sulcus extension → JE detachment → neutrophil action → ulceration → pocket) | Essentials of Clinical Periodontology - Ch. 23 | Sequential Diagram | Moderate | Visual step-by-step pocket pathogenesis; supports answers on periodontal pocket formation |
| 82 | Flowcharts 17.1, 25.2 (Essentials) - Progression from health to periodontitis; Host status in chronic periodontitis | Essentials of Clinical Periodontology - Chs 17 & 25 | Flowcharts | Moderate | Progression flowcharts support structured answers on disease staging and host susceptibility |
| 83 | Fig. 14-1 (Lindhe) - Mechanisms linking diabetes and periodontal disease (hyperglycaemia, inflammatory amplification, bidirectional relationship) | Lindhe 6th Ed. - Ch. 14 | Schematic Diagram | Moderate | Systemic disease link is a standard exam topic; this figure provides mechanistic rather than merely associative content |
| 84 | Tables 15.1-15.4 (Lindhe) - Heritability of periodontal disease; twin studies; genetic loci for inflammatory diseases | Lindhe 6th Ed. - Ch. 15 | Tables | Moderate | Genetic susceptibility evidence tables; support answers on host susceptibility and genetic risk factors |
| 85 | Fig. 18-2 + 18-3 (Periodontics Med/Surg) - Oral microbiology testing report; IL-1 gene cluster polymorphism test | Periodontics: Medicine Surgery Implants - Ch. 18 | Laboratory Report/Genetic Test | Moderate | Periodontal diagnostics and genetic susceptibility testing; relevant for questions on disease risk assessment |
| 86 | Figs 8.4-8.7 (Samaranayake) - Alternative, classical, and terminal (MAC) complement pathways; biological effects of complement | Essential Microbiology for Dentistry - Ch. 8 | Pathway Diagrams | Moderate | Stepwise complement pathway diagrams from a microbiology perspective; useful as supporting reference |
| 87 | Fig. 9.4 (Samaranayake) - Antigen processing and presentation (MHC I and II) | Essential Microbiology for Dentistry - Ch. 9 | Diagram | Moderate | MHC antigen presentation is foundational adaptive immunity content; reinforces APC-T cell interaction |
| 88 | Table 5.2-5.4 (Samaranayake) - Surface virulence factors (capsule, LPS, fimbriae); exotoxins vs. endotoxins; bacterial exotoxins and mode of action | Essential Microbiology for Dentistry - Ch. 5 | Tables | Moderate | General virulence factor tables applicable to periodontal pathogens; support comparison questions |
| 89 | Fig. 6 (Ch.15, Lamont) + Fig. 5 (Ch.10, Lamont) - DEL-1 as endogenous inhibitor of leukocyte adhesion (LFA-1-ICAM axis; neutrophil recruitment control) | Lamont, Hajishengallis, Koo & Jenkinson - Chs 10 & 15 | Diagrams | Moderate | DEL-1 is an emerging concept in neutrophil regulation and resolution; tested in advanced MDS questions |
| 90 | Figs 2.10-2.11 (Janeway) - Defensin structure and mechanism; AMP activation by proteolysis (cathelicidins, LL-37, β-defensins) | Janeway's Immunobiology 9th Ed. - Ch. 2 | Structural Diagrams | Moderate | AMPs at the host-microbe interface; relevant for questions on epithelial innate defense and host-microbe homeostasis |
| 91 | Tables 5.1-5.3 (Biomarkers) - Microbiological/genetic tests available; Candidate biomarkers in saliva; POC diagnostic kits | Biomarkers in Periodontal Health & Disease - Ch. 5 | Tables | Moderate | Periodontal diagnostics and biomarkers; useful for questions on disease activity monitoring and chairside tests |
| 92 | Fig. 5.2 + 5.3 (Biomarkers) - Inflammatory cell interactions network; IL-17 in neutrophil-bacteria interaction | Biomarkers in Periodontal Health & Disease - Ch. 5 | Network Diagrams | Moderate | Cytokine-cellular interaction network in biomarker context; useful for advanced immunology questions |