A detailed medical visual memory aid / study poster about Pre-Eclampsia Pathophysiology. The poster has a dark navy background with bright color-coded sections. TOP SECTION - Title: "PRE-ECLAMPSIA PATHOPHYSIOLOGY" in large bold white text SECTION 1 (Red box): "CORE CONCEPT" - Two large arrows pointing to a central damaged blood vessel icon: LEFT side labeled "ENDOTHELIAL DYSFUNCTION" (caused by: Oxidative stress, Cytokines TNF-α IL-6, Antiangiogenic factors sFlt-1 & Endoglin) | RIGHT side labeled "VASOSPASM" (caused by: ↑TXA2, ↑Angiotensin-II, ↑Endothelin-1, ↓PGI2, ↓Nitric Oxide) SECTION 2 (Orange box): "PROSTAGLANDIN IMBALANCE" - Two-column table: NORMAL: PGI2 ↑Vasodilation, ↓Platelet aggregation | PRE-ECLAMPSIA: TXA2 ↑Vasoconstriction, ↑Platelet aggregation SECTION 3 (Yellow box): "ORGAN DAMAGE - 5 organs as icons with bullet points: 🫀 PLACENTA: Failed trophoblast invasion beyond decidua-myometrial junction → IUGR 🫘 KIDNEY: Glomerular endotheliosis → GFR↓25%, Proteinuria, Bilateral renal cortical necrosis 🧠 BRAIN: Vasospasm → Seizures, PRES (bilateral occipital edema on MRI) 🫀 LIVER: Periportal hemorrhagic necrosis, Subcapsular hematoma 💔 BLOOD VESSELS: Intense vasospasm → vasa vasorum damage" SECTION 4 (Green box): "CLINICAL TRIAD EXPLAINED" - Three arrows: HYPERTENSION ← Vasospasm + ↑ pressor sensitivity EDEMA ← Endothelial injury → ↑capillary permeability + ↓oncotic pressure PROTEINURIA ← Glomerular endotheliosis → protein leak (50-60% albumin, 10-15% α-globulin) SECTION 5 (Purple box): "HELLP SYNDROME" - Bold acronym breakdown: H = Hemolysis (schistocytes, burr cells) EL = Elevated Liver enzymes (AST/ALT >70 IU/L, LDH >600 IU/L) LP = Low Platelets (<1,00,000/mm³) Note: "Occurs in 10-15% of pre-eclampsia cases. May develop WITHOUT hypertension." SECTION 6 (Blue box): "MANAGEMENT HIGHLIGHTS" • Antiseizure: Magnesium sulfate • Delivery: Cesarean (common mode) • Epidural safe if platelets >1,00,000/mm³ • Platelet transfusion if <50,000/mm³ • Steroids: Improve pulmonary maturity, ↑thrombocyte count • ICU monitoring: BP, platelets, urine output, liver enzymes SECTION 7 (Teal box): "MATERNAL COMPLICATIONS" as icons list: Abruptio placentae | DIC | Acute renal failure | Pulmonary edema | ARDS | Subcapsular liver hematoma | Death Bottom footer: "HELLP Mortality: Perinatal 5-60% | Maternal up to 25%" Clean medical poster style with icons, arrows, color coding, easy to memorize layout