from reportlab.lib.pagesizes import A4
from reportlab.lib import colors
from reportlab.lib.units import cm, mm
from reportlab.platypus import (SimpleDocTemplate, Paragraph, Spacer, Table,
                                 TableStyle, HRFlowable, KeepTogether)
from reportlab.lib.styles import getSampleStyleSheet, ParagraphStyle
from reportlab.lib.enums import TA_CENTER, TA_LEFT, TA_JUSTIFY
from reportlab.platypus import PageBreak

OUTPUT = "/home/daytona/workspace/lit-review-study/PSM_Quick_Reference.pdf"

# ── Color Palette ──────────────────────────────────────────────
DARK_BLUE   = colors.HexColor("#1a237e")
MED_BLUE    = colors.HexColor("#1565c0")
LIGHT_BLUE  = colors.HexColor("#e3f2fd")
TEAL        = colors.HexColor("#00695c")
LIGHT_TEAL  = colors.HexColor("#e0f2f1")
ORANGE      = colors.HexColor("#e65100")
LIGHT_ORANGE= colors.HexColor("#fff3e0")
PURPLE      = colors.HexColor("#6a1b9a")
LIGHT_PURPLE= colors.HexColor("#f3e5f5")
GREEN       = colors.HexColor("#2e7d32")
LIGHT_GREEN = colors.HexColor("#e8f5e9")
RED         = colors.HexColor("#b71c1c")
LIGHT_RED   = colors.HexColor("#ffebee")
YELLOW      = colors.HexColor("#f9a825")
LIGHT_YELLOW= colors.HexColor("#fffde7")
GREY_BG     = colors.HexColor("#f5f5f5")
WHITE       = colors.white
BLACK       = colors.HexColor("#212121")

doc = SimpleDocTemplate(
    OUTPUT, pagesize=A4,
    leftMargin=1.5*cm, rightMargin=1.5*cm,
    topMargin=1.5*cm, bottomMargin=1.5*cm
)

styles = getSampleStyleSheet()

def S(name, parent='Normal', **kw):
    return ParagraphStyle(name, parent=styles[parent], **kw)

# Style definitions
title_style = S('MyTitle', fontSize=20, textColor=WHITE, alignment=TA_CENTER,
                fontName='Helvetica-Bold', spaceAfter=4)
subtitle_style = S('MySub', fontSize=11, textColor=WHITE, alignment=TA_CENTER,
                   fontName='Helvetica', spaceAfter=2)
section_style = S('Section', fontSize=13, textColor=WHITE, alignment=TA_LEFT,
                  fontName='Helvetica-Bold', leftPadding=6, spaceAfter=2)
body_style = S('Body', fontSize=9, textColor=BLACK, fontName='Helvetica',
               leading=13, spaceAfter=2)
bold_body = S('BoldBody', fontSize=9, textColor=BLACK, fontName='Helvetica-Bold',
              leading=13, spaceAfter=2)
small_style = S('Small', fontSize=8, textColor=BLACK, fontName='Helvetica',
                leading=11, spaceAfter=1)
small_bold = S('SmallBold', fontSize=8, textColor=BLACK, fontName='Helvetica-Bold',
               leading=11)
tip_style = S('Tip', fontSize=8.5, textColor=ORANGE, fontName='Helvetica-Bold',
              alignment=TA_CENTER, leading=12)
analogy_style = S('Analogy', fontSize=8.5, textColor=DARK_BLUE,
                  fontName='Helvetica-Oblique', leading=12, leftIndent=6)
white_body = S('WhiteBody', fontSize=9, textColor=WHITE, fontName='Helvetica',
               leading=13)
white_bold = S('WhiteBold', fontSize=9.5, textColor=WHITE, fontName='Helvetica-Bold',
               leading=14)
heading_cell = S('HeadCell', fontSize=9, textColor=WHITE, fontName='Helvetica-Bold',
                 alignment=TA_CENTER, leading=12)
q_style = S('Q', fontSize=8.5, textColor=DARK_BLUE, fontName='Helvetica-Bold',
            leading=12, spaceAfter=1)
a_style = S('A', fontSize=8.5, textColor=BLACK, fontName='Helvetica',
            leading=12, spaceAfter=4, leftIndent=8)

def section_header(text, color):
    tbl = Table([[Paragraph(text, section_style)]], colWidths=[17.5*cm])
    tbl.setStyle(TableStyle([
        ('BACKGROUND', (0,0), (-1,-1), color),
        ('ROUNDEDCORNERS', [4,4,4,4]),
        ('TOPPADDING',  (0,0), (-1,-1), 5),
        ('BOTTOMPADDING', (0,0), (-1,-1), 5),
        ('LEFTPADDING',  (0,0), (-1,-1), 8),
    ]))
    return tbl

def colored_table(headers, rows, col_widths, header_color, alt_color):
    header_cells = [Paragraph(h, heading_cell) for h in headers]
    data = [header_cells]
    for i, row in enumerate(rows):
        bg = alt_color if i % 2 == 0 else WHITE
        data.append([Paragraph(str(c), small_style) for c in row])
    tbl = Table(data, colWidths=col_widths)
    style = [
        ('BACKGROUND', (0,0), (-1,0), header_color),
        ('ROWBACKGROUNDS', (0,1), (-1,-1), [alt_color, WHITE]),
        ('GRID', (0,0), (-1,-1), 0.5, colors.HexColor("#cccccc")),
        ('TOPPADDING',  (0,0), (-1,-1), 4),
        ('BOTTOMPADDING', (0,0), (-1,-1), 4),
        ('LEFTPADDING',  (0,0), (-1,-1), 5),
        ('VALIGN', (0,0), (-1,-1), 'MIDDLE'),
    ]
    tbl.setStyle(TableStyle(style))
    return tbl

def pill_box(text, bg, text_color=WHITE):
    p = ParagraphStyle('pill', fontSize=9, textColor=text_color,
                       fontName='Helvetica-Bold', alignment=TA_CENTER, leading=12)
    tbl = Table([[Paragraph(text, p)]], colWidths=[3.2*cm])
    tbl.setStyle(TableStyle([
        ('BACKGROUND', (0,0), (-1,-1), bg),
        ('ROUNDEDCORNERS', [6,6,6,6]),
        ('TOPPADDING', (0,0), (-1,-1), 4),
        ('BOTTOMPADDING', (0,0), (-1,-1), 4),
    ]))
    return tbl

story = []

# ══════════════════════════════════════════════════════════════
# TITLE BANNER
# ══════════════════════════════════════════════════════════════
banner_data = [[
    Paragraph("📚  PSM PRACTICA QUICK REFERENCE", title_style),
    Paragraph("Literature Review  •  Validity  •  Reliability", subtitle_style),
]]
banner = Table([[
    Paragraph("📚  PSM PRACTICA QUICK REFERENCE", title_style),
]], colWidths=[17.5*cm])
banner.setStyle(TableStyle([
    ('BACKGROUND', (0,0), (-1,-1), DARK_BLUE),
    ('ROUNDEDCORNERS', [6,6,6,6]),
    ('TOPPADDING',  (0,0), (-1,-1), 10),
    ('BOTTOMPADDING', (0,0), (-1,-1), 4),
]))
subtitle_banner = Table([[
    Paragraph("Literature Review  •  Validity  •  Reliability", subtitle_style),
]], colWidths=[17.5*cm])
subtitle_banner.setStyle(TableStyle([
    ('BACKGROUND', (0,0), (-1,-1), MED_BLUE),
    ('TOPPADDING',  (0,0), (-1,-1), 4),
    ('BOTTOMPADDING', (0,0), (-1,-1), 8),
]))
story.append(banner)
story.append(subtitle_banner)
story.append(Spacer(1, 6))

# ══════════════════════════════════════════════════════════════
# SECTION 1: DEFINITION
# ══════════════════════════════════════════════════════════════
story.append(section_header("📖  WHAT IS A LITERATURE REVIEW?", MED_BLUE))
story.append(Spacer(1, 4))
def_box = Table([[
    Paragraph(
        '<i>"A survey of scholarly sources on a specific topic — to identify '
        'relevant theories, methods, and <b>gaps</b> in existing research."</i>',
        analogy_style)
]], colWidths=[17.5*cm])
def_box.setStyle(TableStyle([
    ('BACKGROUND', (0,0), (-1,-1), LIGHT_BLUE),
    ('BOX', (0,0), (-1,-1), 1, MED_BLUE),
    ('TOPPADDING',  (0,0), (-1,-1), 6),
    ('BOTTOMPADDING', (0,0), (-1,-1), 6),
    ('LEFTPADDING',  (0,0), (-1,-1), 10),
]))
story.append(def_box)
story.append(Spacer(1, 6))

# Purposes
story.append(Paragraph("<b>5 PURPOSES of Literature Review:</b>", bold_body))
purposes = [
    ("1", "Show familiarity with the topic and scholarly context"),
    ("2", "Develop theoretical framework and methodology"),
    ("3", "Position your work among other researchers"),
    ("4", "Show your research fills a gap or contributes to debate"),
    ("5", "Evaluate current state of research & scholarly debates"),
]
for num, text in purposes:
    row_data = [[
        Paragraph(f"<b>{num}</b>", S('Num', fontSize=10, textColor=WHITE,
                                      fontName='Helvetica-Bold', alignment=TA_CENTER)),
        Paragraph(text, small_style)
    ]]
    row_tbl = Table(row_data, colWidths=[0.7*cm, 16.8*cm])
    bg = [DARK_BLUE, MED_BLUE, TEAL, PURPLE, ORANGE][int(num)-1]
    row_tbl.setStyle(TableStyle([
        ('BACKGROUND', (0,0), (0,0), bg),
        ('BACKGROUND', (1,0), (1,0), GREY_BG),
        ('TOPPADDING',  (0,0), (-1,-1), 3),
        ('BOTTOMPADDING', (0,0), (-1,-1), 3),
        ('LEFTPADDING', (0,0), (0,0), 2),
        ('LEFTPADDING', (1,0), (1,0), 6),
        ('VALIGN', (0,0), (-1,-1), 'MIDDLE'),
        ('LINEBELOW', (0,0), (-1,-1), 0.3, colors.HexColor("#dddddd")),
    ]))
    story.append(row_tbl)
story.append(Spacer(1, 8))

# ══════════════════════════════════════════════════════════════
# SECTION 2: 5 STEPS
# ══════════════════════════════════════════════════════════════
story.append(section_header("⭐  5 KEY STEPS OF LITERATURE REVIEW  (Most Important!)", TEAL))
story.append(Spacer(1, 4))

steps = [
    (TEAL,   "STEP 1", "SEARCH",   "Search for Relevant Literature",
     "PubMed • Google Scholar • Scopus • Books • Journals • Conference papers"),
    (MED_BLUE,"STEP 2", "EVALUATE", "Evaluate Sources",
     "Use Wh Questions • Take notes • Cite in APA or Vancouver style"),
    (PURPLE,  "STEP 3", "IDENTIFY", "Identify Themes, Debates & Gaps",
     "What themes recur? Where do researchers agree/disagree? What's unstudied?"),
    (ORANGE,  "STEP 4", "OUTLINE",  "Outline the Structure",
     "Choose: Chronological / Thematic / Methodological / Theoretical"),
    (GREEN,   "STEP 5", "WRITE",    "Write Your Literature Review",
     "Intro (focus & purpose) → Body (summarize + synthesize + analyze) → Conclusion"),
]

for color, step_lbl, short, full, detail in steps:
    row = Table([[
        Paragraph(step_lbl, S('SL', fontSize=7.5, textColor=WHITE,
                               fontName='Helvetica-Bold', alignment=TA_CENTER, leading=10)),
        Paragraph(short,    S('SH', fontSize=11, textColor=color,
                               fontName='Helvetica-Bold', leading=13)),
        Paragraph(f"<b>{full}</b><br/><font size='8'>{detail}</font>",
                  S('SD', fontSize=8.5, textColor=BLACK, fontName='Helvetica', leading=12)),
    ]], colWidths=[1.5*cm, 2.8*cm, 13.2*cm])
    row.setStyle(TableStyle([
        ('BACKGROUND', (0,0), (0,0), color),
        ('BACKGROUND', (1,0), (1,0), colors.HexColor("#f0f0f0")),
        ('BACKGROUND', (2,0), (2,0), WHITE),
        ('BOX', (0,0), (-1,-1), 0.5, color),
        ('LINEBELOW', (0,0), (-1,-1), 0.3, colors.HexColor("#dddddd")),
        ('TOPPADDING',  (0,0), (-1,-1), 5),
        ('BOTTOMPADDING', (0,0), (-1,-1), 5),
        ('LEFTPADDING', (1,0), (1,0), 6),
        ('LEFTPADDING', (2,0), (2,0), 8),
        ('VALIGN', (0,0), (-1,-1), 'MIDDLE'),
    ]))
    story.append(row)
story.append(Spacer(1, 4))

memory = Table([[
    Paragraph("🧠  Memory Code:  <b>S - E - I - O - W</b>  "
              "(Search → Evaluate → Identify → Outline → Write)", tip_style)
]], colWidths=[17.5*cm])
memory.setStyle(TableStyle([
    ('BACKGROUND', (0,0), (-1,-1), LIGHT_YELLOW),
    ('BOX', (0,0), (-1,-1), 1, YELLOW),
    ('TOPPADDING',  (0,0), (-1,-1), 6),
    ('BOTTOMPADDING', (0,0), (-1,-1), 6),
]))
story.append(memory)
story.append(Spacer(1, 8))

# ══════════════════════════════════════════════════════════════
# SECTION 3: BOOLEAN OPERATORS
# ══════════════════════════════════════════════════════════════
story.append(section_header("🔍  BOOLEAN OPERATORS  (How to Search)", PURPLE))
story.append(Spacer(1, 4))

bool_headers = ["Operator", "Effect", "Example", "Results"]
bool_rows = [
    ["AND", "Narrows (both terms)", "Fever AND Joint Pain", "4,432"],
    ["OR",  "Broadens (either term)", "Fever OR Joint Pain", "317,869"],
    ["NOT", "Excludes a term", "Typhoid fever NOT children", "10,758"],
    ['"  "', "Exact phrase", 'Fever AND "Joint Pain"', "780"],
    ["(  )", "Groups terms", "Fever AND (joint pain OR chills)", "8,064"],
]
story.append(colored_table(bool_headers, bool_rows,
    [2.5*cm, 4*cm, 7*cm, 4*cm], PURPLE, LIGHT_PURPLE))
story.append(Spacer(1, 4))

bool_mem = Table([[
    Paragraph("AND = Less results (narrow)  |  OR = More results (broad)  |  NOT = Removes results", tip_style)
]], colWidths=[17.5*cm])
bool_mem.setStyle(TableStyle([
    ('BACKGROUND', (0,0), (-1,-1), LIGHT_PURPLE),
    ('BOX', (0,0), (-1,-1), 1, PURPLE),
    ('TOPPADDING',  (0,0), (-1,-1), 5),
    ('BOTTOMPADDING', (0,0), (-1,-1), 5),
]))
story.append(bool_mem)
story.append(Spacer(1, 8))

# ══════════════════════════════════════════════════════════════
# SECTION 4: HOW TO READ AN ARTICLE
# ══════════════════════════════════════════════════════════════
story.append(section_header("📑  HOW TO READ AN ARTICLE  (5 Reading Steps)", MED_BLUE))
story.append(Spacer(1, 4))

read_steps = [
    ("1", "ABSTRACT",      "Decide whether article is worth reading in detail"),
    ("2", "INTRODUCTION",  "Understand why the study is important; background literature"),
    ("3", "METHODS",       "Focus on: participants, measures, procedures (read critically)"),
    ("4", "RESULTS",       "Are conclusions logical? Can you detect any researcher bias?"),
    ("5", "DISCUSSION",    "Take with a grain of salt — note limitations carefully"),
]
cols = [0.7*cm, 3.2*cm, 13.6*cm]
read_data = [["#", "Section", "What to Look For"]]
for n, sec, desc in read_steps:
    read_data.append([n, sec, desc])

read_tbl = Table([[Paragraph(c, heading_cell if i == 0 else small_bold if j == 1
                              else small_style, )
                   for j, c in enumerate(row)]
                  for i, row in enumerate(read_data)],
                 colWidths=cols)
# simpler approach
read_data2 = [
    [Paragraph("#", heading_cell), Paragraph("Section", heading_cell), Paragraph("What to Look For", heading_cell)],
]
for n, sec, desc in read_steps:
    read_data2.append([Paragraph(n, small_bold), Paragraph(f"<b>{sec}</b>", small_bold), Paragraph(desc, small_style)])

read_tbl2 = Table(read_data2, colWidths=cols)
read_tbl2.setStyle(TableStyle([
    ('BACKGROUND', (0,0), (-1,0), MED_BLUE),
    ('ROWBACKGROUNDS', (0,1), (-1,-1), [LIGHT_BLUE, WHITE]),
    ('GRID', (0,0), (-1,-1), 0.4, colors.HexColor("#bbbbbb")),
    ('TOPPADDING',  (0,0), (-1,-1), 4),
    ('BOTTOMPADDING', (0,0), (-1,-1), 4),
    ('LEFTPADDING',  (0,0), (-1,-1), 5),
    ('VALIGN', (0,0), (-1,-1), 'MIDDLE'),
    ('ALIGN', (0,0), (0,-1), 'CENTER'),
]))
story.append(read_tbl2)
story.append(Spacer(1, 8))

# ══════════════════════════════════════════════════════════════
# SECTION 5: STRUCTURES + WHERE IN THESIS
# ══════════════════════════════════════════════════════════════
two_col = Table([[
    # Left: 4 structures
    Table([
        [Paragraph("🏗  4 STRUCTURES", S('H', fontSize=10, textColor=WHITE,
                    fontName='Helvetica-Bold', alignment=TA_CENTER))],
        [Table([
            [Paragraph("Chronological", small_bold), Paragraph("Time (old→new)", small_style)],
            [Paragraph("<b>Thematic ★</b>", small_bold), Paragraph("Topic/theme (PSM favourite)", small_style)],
            [Paragraph("Methodological", small_bold), Paragraph("Research methods", small_style)],
            [Paragraph("Theoretical", small_bold), Paragraph("Frameworks/theories", small_style)],
        ], colWidths=[3.5*cm, 4.5*cm],
        style=TableStyle([
            ('ROWBACKGROUNDS', (0,0), (-1,-1), [LIGHT_TEAL, WHITE]),
            ('GRID', (0,0), (-1,-1), 0.3, colors.HexColor("#cccccc")),
            ('TOPPADDING',  (0,0), (-1,-1), 4),
            ('BOTTOMPADDING', (0,0), (-1,-1), 4),
            ('LEFTPADDING',  (0,0), (-1,-1), 5),
        ])],
    ]], colWidths=[8.2*cm],
    style=TableStyle([
        ('BACKGROUND', (0,0), (0,0), TEAL),
        ('TOPPADDING', (0,0), (0,0), 5),
        ('BOTTOMPADDING', (0,0), (0,0), 5),
        ('TOPPADDING', (0,1), (0,1), 0),
        ('LEFTPADDING', (0,0), (-1,-1), 4),
    ])),

    Spacer(0.3*cm, 1),

    # Right: Where in thesis
    Table([
        [Paragraph("📍  WHERE IN THESIS?", S('H2', fontSize=10, textColor=WHITE,
                    fontName='Helvetica-Bold', alignment=TA_CENTER))],
        [Paragraph(
            "Introduction → <b>Literature Review</b> → Theoretical Framework → Methodology\n\n"
            "• Comes near the <b>beginning</b> of thesis\n"
            "• After introduction\n"
            "• Leads to theoretical framework / methodology",
            S('TBox', fontSize=8.5, textColor=BLACK, fontName='Helvetica', leading=13)
        )],
    ], colWidths=[8.5*cm],
    style=TableStyle([
        ('BACKGROUND', (0,0), (0,0), ORANGE),
        ('BACKGROUND', (0,1), (0,1), LIGHT_ORANGE),
        ('TOPPADDING', (0,0), (0,0), 5),
        ('BOTTOMPADDING', (0,0), (0,0), 5),
        ('TOPPADDING', (0,1), (0,1), 8),
        ('BOTTOMPADDING', (0,1), (0,1), 8),
        ('LEFTPADDING', (0,0), (-1,-1), 8),
        ('BOX', (0,0), (-1,-1), 0.5, ORANGE),
    ])),
]], colWidths=[8.2*cm, 0.3*cm, 9*cm])
story.append(two_col)
story.append(Spacer(1, 8))

# ══════════════════════════════════════════════════════════════
# PAGE BREAK → VALIDITY & RELIABILITY
# ══════════════════════════════════════════════════════════════
story.append(PageBreak())

# Title strip page 2
p2_banner = Table([[
    Paragraph("✅  VALIDITY  &  RELIABILITY  —  QUICK REFERENCE", title_style),
]], colWidths=[17.5*cm])
p2_banner.setStyle(TableStyle([
    ('BACKGROUND', (0,0), (-1,-1), DARK_BLUE),
    ('TOPPADDING',  (0,0), (-1,-1), 8),
    ('BOTTOMPADDING', (0,0), (-1,-1), 8),
]))
story.append(p2_banner)
story.append(Spacer(1, 6))

# ── VALIDITY ──────────────────────────────────────────────────
story.append(section_header("🎯  VALIDITY  =  'Does the test measure what it claims to measure?'", TEAL))
story.append(Spacer(1, 4))

analogy1 = Table([[
    Paragraph(
        "🔑 <b>Analogy:</b> Using a weighing scale to measure height = NOT valid. "
        "A valid test measures <i>exactly</i> what it is supposed to measure.",
        analogy_style)
]], colWidths=[17.5*cm])
analogy1.setStyle(TableStyle([
    ('BACKGROUND', (0,0), (-1,-1), LIGHT_TEAL),
    ('BOX', (0,0), (-1,-1), 1, TEAL),
    ('TOPPADDING', (0,0), (-1,-1), 5),
    ('BOTTOMPADDING', (0,0), (-1,-1), 5),
    ('LEFTPADDING', (0,0), (-1,-1), 10),
]))
story.append(analogy1)
story.append(Spacer(1, 5))

validity_types = [
    (TEAL,   "1. Content Validity",
     "Covers ALL aspects of the topic",
     "Biology exam must include ALL subjects taught — not just one topic"),
    (MED_BLUE, "2. Construct Validity\n(Convergent)",
     "Related things ARE related",
     "Two IQ tests should correlate with each other"),
    (MED_BLUE, "2. Construct Validity\n(Discriminant)",
     "Unrelated things are NOT related",
     "IQ test should NOT correlate with personality traits"),
    (PURPLE, "3. Criterion — Predictive",
     "Predicts a FUTURE outcome",
     "High SAT score → High college GPA"),
    (PURPLE, "3. Criterion — Concurrent",
     "Correlates with existing test NOW",
     "New depression test ≈ results of established depression scale"),
    (ORANGE, "4. Face Validity",
     "Looks appropriate (subjective)",
     "Diet questionnaire asks about food intake, meal frequency, types of food"),
]

v_data = [
    [Paragraph("Type", heading_cell), Paragraph("Meaning", heading_cell),
     Paragraph("Example", heading_cell)]
]
colors_cycle = [LIGHT_TEAL, LIGHT_BLUE, LIGHT_BLUE, LIGHT_PURPLE, LIGHT_PURPLE, LIGHT_ORANGE]
for i, (clr, typ, meaning, example) in enumerate(validity_types):
    v_data.append([
        Paragraph(f"<b>{typ}</b>", S('VT', fontSize=8, textColor=clr,
                                      fontName='Helvetica-Bold', leading=11)),
        Paragraph(meaning, small_style),
        Paragraph(f"<i>{example}</i>", small_style),
    ])

v_tbl = Table(v_data, colWidths=[4.2*cm, 5.3*cm, 8*cm])
v_style = [
    ('BACKGROUND', (0,0), (-1,0), TEAL),
    ('GRID', (0,0), (-1,-1), 0.4, colors.HexColor("#bbbbbb")),
    ('TOPPADDING',  (0,0), (-1,-1), 4),
    ('BOTTOMPADDING', (0,0), (-1,-1), 4),
    ('LEFTPADDING',  (0,0), (-1,-1), 5),
    ('VALIGN', (0,0), (-1,-1), 'MIDDLE'),
]
for i, c in enumerate(colors_cycle):
    v_style.append(('BACKGROUND', (0, i+1), (-1, i+1), c))
v_tbl.setStyle(TableStyle(v_style))
story.append(v_tbl)
story.append(Spacer(1, 4))

val_mem = Table([[
    Paragraph("🧠  Memory:  <b>C - C - C - F</b>  (Content • Construct • Criterion • Face)", tip_style)
]], colWidths=[17.5*cm])
val_mem.setStyle(TableStyle([
    ('BACKGROUND', (0,0), (-1,-1), LIGHT_TEAL),
    ('BOX', (0,0), (-1,-1), 1, TEAL),
    ('TOPPADDING',  (0,0), (-1,-1), 5),
    ('BOTTOMPADDING', (0,0), (-1,-1), 5),
]))
story.append(val_mem)
story.append(Spacer(1, 8))

# ── RELIABILITY ───────────────────────────────────────────────
story.append(section_header("🔁  RELIABILITY  =  'Does the test give consistent results?'", PURPLE))
story.append(Spacer(1, 4))

analogy2 = Table([[
    Paragraph(
        "🔑 <b>Analogy:</b> Weigh yourself 3 times — get 3 different readings = NOT reliable. "
        "A reliable test gives the <i>same result every time</i> under same conditions.",
        analogy_style)
]], colWidths=[17.5*cm])
analogy2.setStyle(TableStyle([
    ('BACKGROUND', (0,0), (-1,-1), LIGHT_PURPLE),
    ('BOX', (0,0), (-1,-1), 1, PURPLE),
    ('TOPPADDING', (0,0), (-1,-1), 5),
    ('BOTTOMPADDING', (0,0), (-1,-1), 5),
    ('LEFTPADDING', (0,0), (-1,-1), 10),
]))
story.append(analogy2)
story.append(Spacer(1, 5))

reliability_types = [
    (PURPLE, "1. Test-Retest",
     "Same test, same people, different times — results should be similar",
     "Personality test now and again in 2 weeks → similar scores"),
    (MED_BLUE, "2. Inter-Rater",
     "Different raters assessing the same thing should agree",
     "Two teachers grade same essay → similar marks"),
    (TEAL, "3. Parallel-Forms",
     "Two versions of same test → similar results",
     "Math Test Version A ≈ Math Test Version B"),
    (GREEN, "4. Internal Consistency\n(Split-Half)",
     "Two halves of the test give similar scores",
     "20-item anxiety test: Q1–10 score ≈ Q11–20 score"),
    (ORANGE, "4. Internal Consistency\n(Cronbach's Alpha)",
     "Statistical measure (0–1) of how correlated items are",
     "α = 0.85 = HIGH reliability ✓  |  α < 0.7 = LOW reliability ✗"),
]

r_data = [
    [Paragraph("Type", heading_cell), Paragraph("Meaning", heading_cell),
     Paragraph("Example", heading_cell)]
]
r_colors = [LIGHT_PURPLE, LIGHT_BLUE, LIGHT_TEAL, LIGHT_GREEN, LIGHT_ORANGE]
for i, (clr, typ, meaning, example) in enumerate(reliability_types):
    r_data.append([
        Paragraph(f"<b>{typ}</b>", S('RT', fontSize=8, textColor=clr,
                                      fontName='Helvetica-Bold', leading=11)),
        Paragraph(meaning, small_style),
        Paragraph(f"<i>{example}</i>", small_style),
    ])

r_tbl = Table(r_data, colWidths=[4.2*cm, 6*cm, 7.3*cm])
r_style = [
    ('BACKGROUND', (0,0), (-1,0), PURPLE),
    ('GRID', (0,0), (-1,-1), 0.4, colors.HexColor("#bbbbbb")),
    ('TOPPADDING',  (0,0), (-1,-1), 4),
    ('BOTTOMPADDING', (0,0), (-1,-1), 4),
    ('LEFTPADDING',  (0,0), (-1,-1), 5),
    ('VALIGN', (0,0), (-1,-1), 'MIDDLE'),
]
for i, c in enumerate(r_colors):
    r_style.append(('BACKGROUND', (0, i+1), (-1, i+1), c))
r_tbl.setStyle(TableStyle(r_style))
story.append(r_tbl)
story.append(Spacer(1, 4))

rel_mem = Table([[
    Paragraph("🧠  Memory:  <b>T - I - P - I</b>  (Test-retest • Inter-rater • Parallel-forms • Internal consistency)", tip_style)
]], colWidths=[17.5*cm])
rel_mem.setStyle(TableStyle([
    ('BACKGROUND', (0,0), (-1,-1), LIGHT_PURPLE),
    ('BOX', (0,0), (-1,-1), 1, PURPLE),
    ('TOPPADDING',  (0,0), (-1,-1), 5),
    ('BOTTOMPADDING', (0,0), (-1,-1), 5),
]))
story.append(rel_mem)
story.append(Spacer(1, 6))

# ── COMPARISON TABLE ──────────────────────────────────────────
story.append(section_header("⚖  VALIDITY  vs  RELIABILITY", MED_BLUE))
story.append(Spacer(1, 4))

comp_data = [
    [Paragraph("", heading_cell),
     Paragraph("VALIDITY", heading_cell),
     Paragraph("RELIABILITY", heading_cell)],
    [Paragraph("<b>Means</b>", small_bold),
     Paragraph("Accuracy — measures the right thing", small_style),
     Paragraph("Consistency — same results every time", small_style)],
    [Paragraph("<b>Importance</b>", small_bold),
     Paragraph("Makes results meaningful & applicable", small_style),
     Paragraph("Makes results dependable & repeatable", small_style)],
    [Paragraph("<b>Key rule</b>", small_bold),
     Paragraph("❌ Cannot be valid without being reliable", small_style),
     Paragraph("✅ Can be reliable without being valid", small_style)],
]
comp_tbl = Table(comp_data, colWidths=[3*cm, 7.25*cm, 7.25*cm])
comp_tbl.setStyle(TableStyle([
    ('BACKGROUND', (0,0), (-1,0), MED_BLUE),
    ('BACKGROUND', (1,1), (1,-1), LIGHT_TEAL),
    ('BACKGROUND', (2,1), (2,-1), LIGHT_PURPLE),
    ('GRID', (0,0), (-1,-1), 0.5, colors.HexColor("#bbbbbb")),
    ('TOPPADDING',  (0,0), (-1,-1), 5),
    ('BOTTOMPADDING', (0,0), (-1,-1), 5),
    ('LEFTPADDING',  (0,0), (-1,-1), 6),
    ('VALIGN', (0,0), (-1,-1), 'MIDDLE'),
]))
story.append(comp_tbl)
story.append(Spacer(1, 4))

clock_box = Table([[
    Paragraph(
        "🕐 <b>Clock Analogy:</b>  Clock always 10 min fast = <b>RELIABLE ✓  but NOT Valid ✗</b>  |  "
        "Clock showing random times = <b>Neither Reliable nor Valid ✗</b>",
        S('CB', fontSize=8.5, textColor=RED, fontName='Helvetica-Bold',
          alignment=TA_CENTER, leading=12))
]], colWidths=[17.5*cm])
clock_box.setStyle(TableStyle([
    ('BACKGROUND', (0,0), (-1,-1), LIGHT_RED),
    ('BOX', (0,0), (-1,-1), 1, RED),
    ('TOPPADDING', (0,0), (-1,-1), 6),
    ('BOTTOMPADDING', (0,0), (-1,-1), 6),
]))
story.append(clock_box)
story.append(Spacer(1, 6))

# ── PRE-TESTING ───────────────────────────────────────────────
story.append(section_header("🧪  PRE-TESTING  (Pilot Testing)", ORANGE))
story.append(Spacer(1, 3))
pre_box = Table([[
    Paragraph(
        "Done BEFORE the main study to check if your questionnaire works. "
        "Identifies: unclear questions • format problems • validity and reliability issues.",
        body_style)
]], colWidths=[17.5*cm])
pre_box.setStyle(TableStyle([
    ('BACKGROUND', (0,0), (-1,-1), LIGHT_ORANGE),
    ('BOX', (0,0), (-1,-1), 1, ORANGE),
    ('TOPPADDING', (0,0), (-1,-1), 6),
    ('BOTTOMPADDING', (0,0), (-1,-1), 6),
    ('LEFTPADDING', (0,0), (-1,-1), 10),
]))
story.append(pre_box)
story.append(Spacer(1, 6))

# ── EXAM Q&A ──────────────────────────────────────────────────
story.append(section_header("❓  LIKELY EXAM QUESTIONS & ANSWERS", RED))
story.append(Spacer(1, 4))

qa = [
    ("What is a literature review?",
     "A survey of scholarly sources on a specific topic to identify relevant theories, methods, and gaps in existing research."),
    ("Write the 5 steps of literature review.",
     "1. Search for relevant literature  2. Evaluate sources  3. Identify themes/debates/gaps  4. Outline the structure  5. Write your review"),
    ("What are Boolean operators? Give examples.",
     "AND (narrows — Fever AND Pain), OR (broadens — Fever OR Pain), NOT (excludes — Fever NOT children). Use \" \" for exact phrase, ( ) to group."),
    ("Define validity. Name its types.",
     "Validity = test measures what it claims to. Types: Content, Construct (convergent + discriminant), Criterion (predictive + concurrent), Face."),
    ("Define reliability. Name its types.",
     "Reliability = consistency of a measure. Types: Test-retest, Inter-rater, Parallel-forms, Internal consistency (split-half, Cronbach's alpha)."),
    ("Difference between validity & reliability?",
     "Validity = accuracy (measures right thing). Reliability = consistency (same result every time). A test can be reliable but NOT valid."),
    ("What is Cronbach's Alpha?",
     "A statistic (0–1) measuring internal consistency. Value ≥ 0.7–0.8 = good reliability. It shows how correlated test items are."),
    ("Where does literature review go in a thesis?",
     "Near the beginning — after the introduction, before the methodology/theoretical framework."),
]

qa_data = []
for q, a in qa:
    qa_data.append([
        Paragraph(f"Q: {q}", q_style),
        Paragraph(f"A: {a}", a_style),
    ])

qa_tbl = Table(qa_data, colWidths=[6*cm, 11.5*cm])
qa_tbl.setStyle(TableStyle([
    ('ROWBACKGROUNDS', (0,0), (-1,-1), [LIGHT_RED, WHITE]),
    ('GRID', (0,0), (-1,-1), 0.3, colors.HexColor("#dddddd")),
    ('TOPPADDING',  (0,0), (-1,-1), 4),
    ('BOTTOMPADDING', (0,0), (-1,-1), 4),
    ('LEFTPADDING',  (0,0), (-1,-1), 5),
    ('VALIGN', (0,0), (-1,-1), 'TOP'),
]))
story.append(qa_tbl)
story.append(Spacer(1, 6))

# ── FINAL MEMORY STRIP ────────────────────────────────────────
final_strip = Table([[
    Paragraph("S-E-I-O-W", S('FS', fontSize=10, textColor=WHITE,
               fontName='Helvetica-Bold', alignment=TA_CENTER)),
    Paragraph("5 Steps", S('FL', fontSize=8, textColor=WHITE,
               fontName='Helvetica', alignment=TA_CENTER)),
    Paragraph("AND·OR·NOT", S('FS2', fontSize=10, textColor=WHITE,
               fontName='Helvetica-Bold', alignment=TA_CENTER)),
    Paragraph("Boolean", S('FL2', fontSize=8, textColor=WHITE,
               fontName='Helvetica', alignment=TA_CENTER)),
    Paragraph("C-C-C-F", S('FS3', fontSize=10, textColor=WHITE,
               fontName='Helvetica-Bold', alignment=TA_CENTER)),
    Paragraph("Validity", S('FL3', fontSize=8, textColor=WHITE,
               fontName='Helvetica', alignment=TA_CENTER)),
    Paragraph("T-I-P-I", S('FS4', fontSize=10, textColor=WHITE,
               fontName='Helvetica-Bold', alignment=TA_CENTER)),
    Paragraph("Reliability", S('FL4', fontSize=8, textColor=WHITE,
               fontName='Helvetica', alignment=TA_CENTER)),
]], colWidths=[2.5*cm, 1.9*cm, 3*cm, 1.9*cm, 2.5*cm, 1.9*cm, 2.5*cm, 1.7*cm])
final_strip.setStyle(TableStyle([
    ('BACKGROUND', (0,0), (1,-1), TEAL),
    ('BACKGROUND', (2,0), (3,-1), PURPLE),
    ('BACKGROUND', (4,0), (5,-1), MED_BLUE),
    ('BACKGROUND', (6,0), (7,-1), ORANGE),
    ('TOPPADDING',  (0,0), (-1,-1), 5),
    ('BOTTOMPADDING', (0,0), (-1,-1), 5),
    ('ALIGN', (0,0), (-1,-1), 'CENTER'),
    ('VALIGN', (0,0), (-1,-1), 'MIDDLE'),
]))
story.append(final_strip)

# BUILD
doc.build(story)
print("PDF created successfully:", OUTPUT)

Successfully replaced 1 instance(s) of the string in '/home/daytona/workspace/lit-review-study/make_reference_pdf.py'

Successfully replaced 1 instance(s) of the string in '/home/daytona/workspace/lit-review-study/make_reference_pdf.py'

from reportlab.lib.pagesizes import A4
from reportlab.lib import colors
from reportlab.lib.units import cm
from reportlab.platypus import (SimpleDocTemplate, Paragraph, Spacer, Table,
                                TableStyle, PageBreak)
from reportlab.lib.styles import ParagraphStyle
from reportlab.lib.enums import TA_CENTER, TA_LEFT

OUTPUT = "/home/daytona/workspace/psm-topics/PSM_3Topics_QuickRevision.pdf"

# ── Colour Palette ─────────────────────────────────────────────
C = {
    # Chikungunya - warm orange/red
    "chik_dark":   colors.HexColor("#bf360c"),
    "chik_mid":    colors.HexColor("#e64a19"),
    "chik_light":  colors.HexColor("#fbe9e7"),
    "chik_accent": colors.HexColor("#ff8a65"),
    # Malaria - deep teal/green
    "mal_dark":    colors.HexColor("#1b5e20"),
    "mal_mid":     colors.HexColor("#2e7d32"),
    "mal_light":   colors.HexColor("#e8f5e9"),
    "mal_accent":  colors.HexColor("#66bb6a"),
    # Congenital - deep purple/indigo
    "con_dark":    colors.HexColor("#4a148c"),
    "con_mid":     colors.HexColor("#6a1b9a"),
    "con_light":   colors.HexColor("#f3e5f5"),
    "con_accent":  colors.HexColor("#ab47bc"),
    # Shared
    "navy":        colors.HexColor("#0d1b2a"),
    "dark_blue":   colors.HexColor("#1a237e"),
    "gold":        colors.HexColor("#f9a825"),
    "gold_light":  colors.HexColor("#fffde7"),
    "grey":        colors.HexColor("#f5f5f5"),
    "dgrey":       colors.HexColor("#757575"),
    "white":       colors.white,
    "black":       colors.HexColor("#212121"),
    "red_warn":    colors.HexColor("#c62828"),
    "red_light":   colors.HexColor("#ffebee"),
}

W = 17.7 * cm   # usable page width

doc = SimpleDocTemplate(
    OUTPUT, pagesize=A4,
    leftMargin=1.4*cm, rightMargin=1.4*cm,
    topMargin=1.3*cm, bottomMargin=1.3*cm
)

# ── Style helpers ──────────────────────────────────────────────
def PS(name, **kw):
    base = kw.pop("parent", "Normal")
    defaults = dict(fontName="Helvetica", fontSize=9, leading=13,
                    textColor=C["black"], spaceAfter=0)
    defaults.update(kw)
    return ParagraphStyle(name, **defaults)

# Common styles
TITLE  = PS("title",  fontName="Helvetica-Bold", fontSize=22, textColor=C["white"],
            alignment=TA_CENTER, leading=28)
SUB    = PS("sub",    fontName="Helvetica",      fontSize=11, textColor=C["white"],
            alignment=TA_CENTER, leading=16)
SEC    = PS("sec",    fontName="Helvetica-Bold", fontSize=12, textColor=C["white"],
            alignment=TA_LEFT,   leading=16)
BODY   = PS("body",   fontSize=8.5, leading=12)
BOLD   = PS("bold",   fontName="Helvetica-Bold", fontSize=8.5, leading=12)
SMALL  = PS("small",  fontSize=8,   leading=11)
SMBOLD = PS("smbold", fontName="Helvetica-Bold", fontSize=8, leading=11)
TIP    = PS("tip",    fontName="Helvetica-Bold", fontSize=9,
            textColor=C["gold"], alignment=TA_CENTER, leading=13)
WHITE_B= PS("wb",     fontName="Helvetica-Bold", fontSize=8.5,
            textColor=C["white"], leading=12)
WHITE_N= PS("wn",     fontSize=8.5, textColor=C["white"], leading=12)
HCELL  = PS("hcell",  fontName="Helvetica-Bold", fontSize=8.5,
            textColor=C["white"], alignment=TA_CENTER, leading=12)
WARN   = PS("warn",   fontName="Helvetica-Bold", fontSize=8.5,
            textColor=C["red_warn"], alignment=TA_CENTER, leading=12)

# ── Reusable builders ──────────────────────────────────────────
def section_bar(text, dark, mid):
    t = Table([[Paragraph(text, SEC)]], colWidths=[W])
    t.setStyle(TableStyle([
        ("BACKGROUND", (0,0), (-1,-1), dark),
        ("TOPPADDING",    (0,0), (-1,-1), 6),
        ("BOTTOMPADDING", (0,0), (-1,-1), 6),
        ("LEFTPADDING",   (0,0), (-1,-1), 10),
    ]))
    return t

def info_box(text_para, bg, border):
    t = Table([[text_para]], colWidths=[W])
    t.setStyle(TableStyle([
        ("BACKGROUND", (0,0), (-1,-1), bg),
        ("BOX",        (0,0), (-1,-1), 1.2, border),
        ("TOPPADDING",    (0,0), (-1,-1), 6),
        ("BOTTOMPADDING", (0,0), (-1,-1), 6),
        ("LEFTPADDING",   (0,0), (-1,-1), 10),
        ("RIGHTPADDING",  (0,0), (-1,-1), 10),
    ]))
    return t

def color_table(headers, rows, col_w, hdr_color, alt_color):
    data = [[Paragraph(h, HCELL) for h in headers]]
    for i, row in enumerate(rows):
        bg = alt_color if i % 2 == 0 else C["white"]
        data.append([Paragraph(str(c), SMALL) for c in row])
    t = Table(data, colWidths=col_w)
    t.setStyle(TableStyle([
        ("BACKGROUND",   (0,0), (-1,0), hdr_color),
        ("ROWBACKGROUNDS",(0,1),(-1,-1),[alt_color, C["white"]]),
        ("GRID",         (0,0), (-1,-1), 0.4, colors.HexColor("#cccccc")),
        ("TOPPADDING",    (0,0), (-1,-1), 4),
        ("BOTTOMPADDING", (0,0), (-1,-1), 4),
        ("LEFTPADDING",   (0,0), (-1,-1), 5),
        ("VALIGN",        (0,0), (-1,-1), "MIDDLE"),
    ]))
    return t

def numbered_rows(items, num_color):
    rows = []
    for i, (label, detail) in enumerate(items):
        num_p  = Paragraph(f"<b>{i+1}</b>",
                           PS(f"n{i}", fontName="Helvetica-Bold", fontSize=10,
                              textColor=C["white"], alignment=TA_CENTER))
        body_p = Paragraph(f"<b>{label}</b> — {detail}", BODY)
        row = Table([[num_p, body_p]], colWidths=[0.7*cm, W - 0.7*cm])
        row.setStyle(TableStyle([
            ("BACKGROUND",    (0,0),(0,0), num_color),
            ("BACKGROUND",    (1,0),(1,0), C["grey"] if i%2==0 else C["white"]),
            ("VALIGN",        (0,0),(-1,-1), "MIDDLE"),
            ("TOPPADDING",    (0,0),(-1,-1), 4),
            ("BOTTOMPADDING", (0,0),(-1,-1), 4),
            ("LEFTPADDING",   (1,0),(1,0), 7),
            ("LINEBELOW",     (0,0),(-1,-1), 0.3, colors.HexColor("#dddddd")),
        ]))
        rows.append(row)
    return rows

def memory_box(text, bg=C["gold_light"], border=C["gold"]):
    t = Table([[Paragraph(f"🧠  {text}", TIP)]], colWidths=[W])
    t.setStyle(TableStyle([
        ("BACKGROUND", (0,0),(-1,-1), bg),
        ("BOX",        (0,0),(-1,-1), 1.2, border),
        ("TOPPADDING",    (0,0),(-1,-1), 6),
        ("BOTTOMPADDING", (0,0),(-1,-1), 6),
    ]))
    return t

def sp(h=4):
    return Spacer(1, h)

# ══════════════════════════════════════════════════════════════
story = []

# ─── COVER BANNER ────────────────────────────────────────────
cover = Table([
    [Paragraph("PSM QUICK REVISION", TITLE)],
    [Paragraph("Chikungunya Fever  •  Malaria  •  Congenital Anomalies", SUB)],
    [Paragraph("Based on Park's Textbook of Preventive &amp; Social Medicine", 
               PS("cv3", fontSize=9, textColor=colors.HexColor("#bbdefb"),
                  alignment=TA_CENTER, leading=13))],
], colWidths=[W])
cover.setStyle(TableStyle([
    ("BACKGROUND", (0,0),(0,0), C["navy"]),
    ("BACKGROUND", (0,1),(0,1), C["dark_blue"]),
    ("BACKGROUND", (0,2),(0,2), colors.HexColor("#1565c0")),
    ("TOPPADDING",    (0,0),(0,0), 12),
    ("BOTTOMPADDING", (0,0),(0,0), 4),
    ("TOPPADDING",    (0,1),(0,1), 4),
    ("BOTTOMPADDING", (0,1),(0,1), 4),
    ("TOPPADDING",    (0,2),(0,2), 4),
    ("BOTTOMPADDING", (0,2),(0,2), 10),
]))
story.append(cover)
story.append(sp(8))

# ══════════════════════════════════════════════════════════════
# TOPIC 1 — CHIKUNGUNYA FEVER
# ══════════════════════════════════════════════════════════════
story.append(section_bar("🦟  TOPIC 1 — CHIKUNGUNYA FEVER", C["chik_dark"], C["chik_mid"]))
story.append(sp(4))

# Definition box
story.append(info_box(
    Paragraph('<b>Definition:</b> A dengue-like viral fever caused by <b>Chikungunya virus</b> '
              '(RNA virus, Alphavirus, Togaviridae family), transmitted by <b>Aedes mosquitoes</b>. '
              'Hallmark = severe joint pain. '
              '"Chikungunya" = <i>Kimakonde language</i> (Tanzania) = <b>"to become contorted / doubled up"</b> '
              'due to excruciating joint pain. First isolated: <b>Tanzania, 1952–53</b>.',
              BODY), C["chik_light"], C["chik_mid"]))
story.append(sp(5))

# 2-column: Agent + Epi
agent_tbl = Table([
    [Paragraph("AGENT", HCELL)],
    [Paragraph("• <b>Virus:</b> Single-stranded RNA virus<br/>• <b>Family:</b> Togaviridae<br/>"
               "• <b>Genus:</b> Alphavirus<br/>• Also called Group A Arbovirus", SMALL)],
], colWidths=[5.8*cm])
agent_tbl.setStyle(TableStyle([
    ("BACKGROUND",(0,0),(0,0),C["chik_mid"]),
    ("BACKGROUND",(0,1),(0,1),C["chik_light"]),
    ("TOPPADDING",(0,0),(-1,-1),5),("BOTTOMPADDING",(0,0),(-1,-1),5),
    ("LEFTPADDING",(0,0),(-1,-1),6),
    ("BOX",(0,0),(-1,-1),0.5,C["chik_mid"]),
]))

epi_tbl = Table([
    [Paragraph("EPIDEMIOLOGY", HCELL)],
    [Paragraph("• <b>Vector:</b> <i>Aedes aegypti</i> &amp; <i>Aedes albopictus</i><br/>"
               "• <b>Incubation:</b> 4–7 days (range 1–12 days)<br/>"
               "• <b>Season:</b> Rainy season (peak vector population)<br/>"
               "• <b>India:</b> Endemic in 24 states + 6 UTs<br/>"
               "• Re-emerged in India in <b>2006</b>", SMALL)],
], colWidths=[11.5*cm])
epi_tbl.setStyle(TableStyle([
    ("BACKGROUND",(0,0),(0,0),C["chik_mid"]),
    ("BACKGROUND",(0,1),(0,1),C["chik_light"]),
    ("TOPPADDING",(0,0),(-1,-1),5),("BOTTOMPADDING",(0,0),(-1,-1),5),
    ("LEFTPADDING",(0,0),(-1,-1),6),
    ("BOX",(0,0),(-1,-1),0.5,C["chik_mid"]),
]))

story.append(Table([[agent_tbl, epi_tbl]], colWidths=[5.8*cm, 11.9*cm],
    style=[("VALIGN",(0,0),(-1,-1),"TOP"),("LEFTPADDING",(1,0),(1,0),4)]))
story.append(sp(5))

# Clinical features
story.append(Paragraph("<b>CLINICAL FEATURES</b>", BOLD))
story.append(sp(3))
feat_rows = [
    ("High Fever + Chills", "Sudden onset, temperature typically >39°C"),
    ("Severe Arthropathy ★", "Bilateral symmetric joint pain — hands, wrists, elbows, shoulders, knees, ankles. Appears Day 3–5. Can last MONTHS–YEARS"),
    ("Morbilliform Rash", "60–80% of patients; on trunk + limbs; can recur every 3–7 days"),
    ("Headache + Lumbago", "Cephalalgia (headache), backache, conjunctivitis, adenopathy"),
    ("Other", "Coffee-coloured vomiting, epistaxis, petechiae"),
]
feat_data = [[Paragraph("Feature", HCELL), Paragraph("Details", HCELL)]]
for i, (f, d) in enumerate(feat_rows):
    bg = C["chik_light"] if i%2==0 else C["white"]
    feat_data.append([
        Paragraph(f"<b>{f}</b>", SMBOLD),
        Paragraph(d, SMALL),
    ])
feat_tbl = Table(feat_data, colWidths=[4.5*cm, 13.2*cm])
feat_tbl.setStyle(TableStyle([
    ("BACKGROUND",(0,0),(-1,0),C["chik_mid"]),
    ("ROWBACKGROUNDS",(0,1),(-1,-1),[C["chik_light"],C["white"]]),
    ("GRID",(0,0),(-1,-1),0.4,colors.HexColor("#cccccc")),
    ("TOPPADDING",(0,0),(-1,-1),4),("BOTTOMPADDING",(0,0),(-1,-1),4),
    ("LEFTPADDING",(0,0),(-1,-1),5),("VALIGN",(0,0),(-1,-1),"MIDDLE"),
]))
story.append(feat_tbl)
story.append(sp(4))

# Diagnosis + Treatment side by side
dx_tbl = Table([
    [Paragraph("DIAGNOSIS", HCELL)],
    [Paragraph("• <b>Week 1:</b> RT-PCR (gold standard)<br/>"
               "• <b>After week 1:</b> IgM antibodies<br/>"
               "  (persist 30–90 days)<br/>"
               "• <b>Reference:</b> Plaque-Reduction<br/>"
               "  Neutralization Test (PRNT)", SMALL)],
], colWidths=[5.8*cm])
dx_tbl.setStyle(TableStyle([
    ("BACKGROUND",(0,0),(0,0),C["chik_mid"]),
    ("BACKGROUND",(0,1),(0,1),C["chik_light"]),
    ("TOPPADDING",(0,0),(-1,-1),5),("BOTTOMPADDING",(0,0),(-1,-1),5),
    ("LEFTPADDING",(0,0),(-1,-1),6),
    ("BOX",(0,0),(-1,-1),0.5,C["chik_mid"]),
]))

tx_tbl = Table([
    [Paragraph("TREATMENT &amp; PREVENTION", HCELL)],
    [Paragraph("• <b>NO specific antiviral</b> — supportive care only<br/>"
               "• Paracetamol / Diclofenac for fever + joint pain<br/>"
               "• <b>AVOID: Aspirin &amp; Steroids</b><br/>"
               "• NSAIDs only after ruling out dengue<br/>"
               "• Methotrexate/Hydroxychloroquine for severe arthritis<br/>"
               "• <b>Prevention:</b> No vaccine. Aedes control,<br/>"
               "  repellents, long sleeves, screened houses", SMALL)],
], colWidths=[11.5*cm])
tx_tbl.setStyle(TableStyle([
    ("BACKGROUND",(0,0),(0,0),C["chik_mid"]),
    ("BACKGROUND",(0,1),(0,1),C["chik_light"]),
    ("TOPPADDING",(0,0),(-1,-1),5),("BOTTOMPADDING",(0,0),(-1,-1),5),
    ("LEFTPADDING",(0,0),(-1,-1),6),
    ("BOX",(0,0),(-1,-1),0.5,C["chik_mid"]),
]))

story.append(Table([[dx_tbl, tx_tbl]], colWidths=[5.8*cm, 11.9*cm],
    style=[("VALIGN",(0,0),(-1,-1),"TOP"),("LEFTPADDING",(1,0),(1,0),4)]))
story.append(sp(4))

# Warn box
warn_tbl = Table([[Paragraph(
    "⚠  AVOID ASPIRIN &amp; STEROIDS in Chikungunya!  |  "
    "No deaths reported  |  Not transmitted through breastfeeding  |  "
    "Reportable disease (NVBDCP / CDC ArboNET)",
    PS("wchk", fontName="Helvetica-Bold", fontSize=8.5,
       textColor=C["chik_dark"], alignment=TA_CENTER, leading=12)
)]], colWidths=[W])
warn_tbl.setStyle(TableStyle([
    ("BACKGROUND",(0,0),(-1,-1),colors.HexColor("#fff3e0")),
    ("BOX",(0,0),(-1,-1),1.2,C["chik_dark"]),
    ("TOPPADDING",(0,0),(-1,-1),5),("BOTTOMPADDING",(0,0),(-1,-1),5),
]))
story.append(warn_tbl)
story.append(sp(4))
story.append(memory_box(
    "Memory: CHIK = Contorted (name), High fever, Insect=Aedes, Knees/Joints  "
    "|  Incubation: 4–7 days  |  No deaths  |  No vaccine"))
story.append(sp(10))

# ══════════════════════════════════════════════════════════════
# TOPIC 2 — MALARIA
# ══════════════════════════════════════════════════════════════
story.append(section_bar("🦟  TOPIC 2 — MALARIA", C["mal_dark"], C["mal_mid"]))
story.append(sp(4))

story.append(info_box(
    Paragraph('<b>Definition:</b> A <b>protozoal disease</b> caused by parasites of genus '
              '<b>Plasmodium</b>, transmitted by the bite of infected <b>female Anopheles mosquito</b>. '
              'A typical attack has 3 stages: <b>Cold → Hot → Sweating</b>. '
              'Febrile paroxysms repeat every <b>3rd day (tertian)</b> or <b>4th day (quartan)</b> '
              'depending on the species.',
              BODY), C["mal_light"], C["mal_mid"]))
story.append(sp(5))

# Species table
story.append(Paragraph("<b>4 SPECIES OF PLASMODIUM</b>", BOLD))
story.append(sp(3))
sp_data = [
    [Paragraph("Species", HCELL), Paragraph("Fever Pattern", HCELL),
     Paragraph("Key Feature", HCELL), Paragraph("Danger", HCELL)],
    [Paragraph("<b>P. falciparum ★</b>", SMBOLD),
     Paragraph("Sub-tertian / quotidian (36–48 hrs)", SMALL),
     Paragraph("Cerebral malaria, Blackwater fever, drug resistance", SMALL),
     Paragraph("MOST DANGEROUS", PS("d1",fontName="Helvetica-Bold",fontSize=8,textColor=C["red_warn"],leading=11))],
    [Paragraph("<b>P. vivax</b>", SMBOLD),
     Paragraph("Tertian (every 48 hrs)", SMALL),
     Paragraph("Most common in India; relapses due to hypnozoites", SMALL),
     Paragraph("Moderate", SMALL)],
    [Paragraph("<b>P. malariae</b>", SMBOLD),
     Paragraph("Quartan (every 72 hrs)", SMALL),
     Paragraph("Nephrotic syndrome (rare)", SMALL),
     Paragraph("Mild", SMALL)],
    [Paragraph("<b>P. ovale</b>", SMBOLD),
     Paragraph("Tertian (every 48 hrs)", SMALL),
     Paragraph("Rare; hypnozoites like vivax", SMALL),
     Paragraph("Mild", SMALL)],
]
sp_tbl = Table(sp_data, colWidths=[3.8*cm, 4.2*cm, 6.2*cm, 3.5*cm])
sp_tbl.setStyle(TableStyle([
    ("BACKGROUND",(0,0),(-1,0),C["mal_mid"]),
    ("BACKGROUND",(0,1),(-1,1),C["mal_light"]),
    ("BACKGROUND",(0,2),(-1,2),C["white"]),
    ("BACKGROUND",(0,3),(-1,3),C["mal_light"]),
    ("BACKGROUND",(0,4),(-1,4),C["white"]),
    ("GRID",(0,0),(-1,-1),0.4,colors.HexColor("#cccccc")),
    ("TOPPADDING",(0,0),(-1,-1),4),("BOTTOMPADDING",(0,0),(-1,-1),4),
    ("LEFTPADDING",(0,0),(-1,-1),5),("VALIGN",(0,0),(-1,-1),"MIDDLE"),
]))
story.append(sp_tbl)
story.append(sp(5))

# Paroxysm + Epidemiology 2-col
parox_tbl = Table([
    [Paragraph("MALARIAL PAROXYSM", HCELL)],
    [Paragraph(
        "<b>Stage 1 — Cold (15–60 min)</b><br/>"
        "Severe chills, shivering, rigors<br/><br/>"
        "<b>Stage 2 — Hot (2–6 hrs)</b><br/>"
        "High fever, headache, nausea, vomiting<br/><br/>"
        "<b>Stage 3 — Sweating (2–4 hrs)</b><br/>"
        "Profuse sweating, fever breaks<br/>"
        "Patient feels WELL until next paroxysm", SMALL)],
], colWidths=[5.8*cm])
parox_tbl.setStyle(TableStyle([
    ("BACKGROUND",(0,0),(0,0),C["mal_mid"]),
    ("BACKGROUND",(0,1),(0,1),C["mal_light"]),
    ("TOPPADDING",(0,0),(-1,-1),5),("BOTTOMPADDING",(0,0),(-1,-1),5),
    ("LEFTPADDING",(0,0),(-1,-1),7),
    ("BOX",(0,0),(-1,-1),0.5,C["mal_mid"]),
]))

comp_tbl = Table([
    [Paragraph("COMPLICATIONS (P. falciparum)", HCELL)],
    [Paragraph(
        "• <b>Cerebral malaria</b> — convulsions, coma (most dangerous)<br/>"
        "• <b>Blackwater fever</b> — massive hemolysis → black urine<br/>"
        "• <b>Severe anemia</b> — RBC destruction<br/>"
        "• <b>Hypoglycemia</b> — especially in children + pregnant women<br/>"
        "• <b>Algid malaria</b> — collapse, shock<br/>"
        "• <b>Pulmonary edema</b> — ARDS<br/>"
        "• <b>In pregnancy</b> — miscarriage, low birth weight, maternal death",
        SMALL)],
], colWidths=[11.5*cm])
comp_tbl.setStyle(TableStyle([
    ("BACKGROUND",(0,0),(0,0),C["mal_mid"]),
    ("BACKGROUND",(0,1),(0,1),C["mal_light"]),
    ("TOPPADDING",(0,0),(-1,-1),5),("BOTTOMPADDING",(0,0),(-1,-1),5),
    ("LEFTPADDING",(0,0),(-1,-1),7),
    ("BOX",(0,0),(-1,-1),0.5,C["mal_mid"]),
]))

story.append(Table([[parox_tbl, comp_tbl]], colWidths=[5.8*cm, 11.9*cm],
    style=[("VALIGN",(0,0),(-1,-1),"TOP"),("LEFTPADDING",(1,0),(1,0),4)]))
story.append(sp(5))

# Diagnosis
story.append(Paragraph("<b>DIAGNOSIS</b>", BOLD))
story.append(sp(3))
dx_data = [
    [Paragraph("Test", HCELL), Paragraph("Details", HCELL), Paragraph("Purpose", HCELL)],
    [Paragraph("<b>Thick blood smear</b>", SMBOLD),
     Paragraph("Gold standard; done during fever", SMALL),
     Paragraph("Parasite detection", SMALL)],
    [Paragraph("<b>Thin blood smear</b>", SMBOLD),
     Paragraph("Species identification", SMALL),
     Paragraph("Species typing", SMALL)],
    [Paragraph("<b>RDT (HRP-2 Ag)</b>", SMBOLD),
     Paragraph("Rapid diagnostic test for P. falciparum", SMALL),
     Paragraph("Field diagnosis", SMALL)],
    [Paragraph("<b>PCR</b>", SMBOLD),
     Paragraph("Most sensitive", SMALL),
     Paragraph("Reference/research", SMALL)],
    [Paragraph("<b>Indices: API, ABER, SPR</b>", SMBOLD),
     Paragraph("API = Annual Parasite Incidence; ABER = Annual Blood Exam Rate (should be >10%); SPR = Slide Positivity Rate", SMALL),
     Paragraph("Programme monitoring", SMALL)],
]
dx_tbl2 = Table(dx_data, colWidths=[4.5*cm, 8*cm, 5.2*cm])
dx_tbl2.setStyle(TableStyle([
    ("BACKGROUND",(0,0),(-1,0),C["mal_mid"]),
    ("ROWBACKGROUNDS",(0,1),(-1,-1),[C["mal_light"],C["white"]]),
    ("GRID",(0,0),(-1,-1),0.4,colors.HexColor("#cccccc")),
    ("TOPPADDING",(0,0),(-1,-1),4),("BOTTOMPADDING",(0,0),(-1,-1),4),
    ("LEFTPADDING",(0,0),(-1,-1),5),("VALIGN",(0,0),(-1,-1),"MIDDLE"),
]))
story.append(dx_tbl2)
story.append(sp(5))

# Treatment
story.append(Paragraph("<b>TREATMENT</b>", BOLD))
story.append(sp(3))
tx_data = [
    [Paragraph("Species", HCELL), Paragraph("Treatment", HCELL)],
    [Paragraph("<b>P. falciparum</b>", SMBOLD),
     Paragraph("<b>ACT = Artemisinin-based Combination Therapy</b> (e.g., Artesunate + Amodiaquine)<br/>"
               "Severe malaria: IV Artesunate or IV Quinine", SMALL)],
    [Paragraph("<b>P. vivax</b>", SMBOLD),
     Paragraph("<b>Chloroquine</b> (14 days) + <b>Primaquine</b> for radical cure "
               "(kills liver hypnozoites, prevents relapse)", SMALL)],
    [Paragraph("<b>All species</b>", SMBOLD),
     Paragraph("Note: Chloroquine resistance widespread for P. falciparum in South-East Asia → Always use ACT", SMALL)],
]
tx_tbl2 = Table(tx_data, colWidths=[4.5*cm, 13.2*cm])
tx_tbl2.setStyle(TableStyle([
    ("BACKGROUND",(0,0),(-1,0),C["mal_mid"]),
    ("ROWBACKGROUNDS",(0,1),(-1,-1),[C["mal_light"],C["white"],C["mal_light"]]),
    ("GRID",(0,0),(-1,-1),0.4,colors.HexColor("#cccccc")),
    ("TOPPADDING",(0,0),(-1,-1),4),("BOTTOMPADDING",(0,0),(-1,-1),4),
    ("LEFTPADDING",(0,0),(-1,-1),5),("VALIGN",(0,0),(-1,-1),"MIDDLE"),
]))
story.append(tx_tbl2)
story.append(sp(4))

# Prevention
story.append(Paragraph("<b>PREVENTION &amp; CONTROL (PSM Key Topic)</b>", BOLD))
story.append(sp(3))
prev_data = [
    [Paragraph("Method", HCELL), Paragraph("Details", HCELL)],
    [Paragraph("<b>IRS</b>", SMBOLD),
     Paragraph("Indoor Residual Spraying — DDT, Malathion sprayed on walls", SMALL)],
    [Paragraph("<b>ITN / LLIN</b>", SMBOLD),
     Paragraph("Insecticide-Treated Nets / Long-Lasting Insecticidal Nets", SMALL)],
    [Paragraph("<b>Larval control</b>", SMBOLD),
     Paragraph("Anti-larval measures, Gambusia fish, drain stagnant water, oil on water surface", SMALL)],
    [Paragraph("<b>Chemoprophylaxis</b>", SMBOLD),
     Paragraph("Chloroquine / Doxycycline / Mefloquine for travellers to endemic areas", SMALL)],
    [Paragraph("<b>Vaccine</b>", SMBOLD),
     Paragraph("<b>RTS,S/AS01 (Mosquirix)</b> — first WHO-approved malaria vaccine (2021); "
               "for P. falciparum; for children in sub-Saharan Africa", SMALL)],
    [Paragraph("<b>Programme</b>", SMBOLD),
     Paragraph("<b>NVBDCP</b> = National Vector Borne Disease Control Programme "
               "(controls malaria, dengue, chikungunya, kala-azar, filaria, JE)", SMALL)],
]
prev_tbl = Table(prev_data, colWidths=[3.5*cm, 14.2*cm])
prev_tbl.setStyle(TableStyle([
    ("BACKGROUND",(0,0),(-1,0),C["mal_mid"]),
    ("ROWBACKGROUNDS",(0,1),(-1,-1),[C["mal_light"],C["white"]]),
    ("GRID",(0,0),(-1,-1),0.4,colors.HexColor("#cccccc")),
    ("TOPPADDING",(0,0),(-1,-1),4),("BOTTOMPADDING",(0,0),(-1,-1),4),
    ("LEFTPADDING",(0,0),(-1,-1),5),("VALIGN",(0,0),(-1,-1),"MIDDLE"),
]))
story.append(prev_tbl)
story.append(sp(4))
story.append(memory_box(
    "Memory: FACT = Falciparum most dangerous, Anopheles female transmits, "
    "Cold→Hot→Sweating (3 stages), Treatment = ACT  |  Species: FVMO"))
story.append(sp(10))

# ══════════════════════════════════════════════════════════════
# TOPIC 3 — CONGENITAL ANOMALIES
# ══════════════════════════════════════════════════════════════
story.append(section_bar("👶  TOPIC 3 — CONGENITAL ANOMALIES (BIRTH DEFECTS)", C["con_dark"], C["con_mid"]))
story.append(sp(4))

story.append(info_box(
    Paragraph('<b>Definition (WHO 1972):</b> <b>Congenital malformation</b> = structural defects only at birth. '
              '<b>Congenital anomaly</b> (broader term) = <b>ALL structural + biochemical + functional '
              'disorders present at birth</b>. '
              'Some obvious at birth (cleft palate); some detected later (PDA, CDH).',
              BODY), C["con_light"], C["con_mid"]))
story.append(sp(5))

# Stats row
stats_tbl = Table([[
    Table([
        [Paragraph("1 in 33", PS("s1",fontName="Helvetica-Bold",fontSize=18,
                                  textColor=C["con_mid"],alignment=TA_CENTER,leading=22))],
        [Paragraph("infants affected", PS("s1b",fontSize=8,alignment=TA_CENTER,leading=11))],
    ], colWidths=[5.5*cm], style=[("BACKGROUND",(0,0),(-1,-1),C["con_light"]),
                                   ("BOX",(0,0),(-1,-1),1,C["con_mid"]),
                                   ("TOPPADDING",(0,0),(-1,-1),5),
                                   ("BOTTOMPADDING",(0,0),(-1,-1),5)]),
    Table([
        [Paragraph("3.2 Million", PS("s2",fontName="Helvetica-Bold",fontSize=18,
                                      textColor=C["con_mid"],alignment=TA_CENTER,leading=22))],
        [Paragraph("disabilities per year", PS("s2b",fontSize=8,alignment=TA_CENTER,leading=11))],
    ], colWidths=[5.7*cm], style=[("BACKGROUND",(0,0),(-1,-1),C["con_light"]),
                                   ("BOX",(0,0),(-1,-1),1,C["con_mid"]),
                                   ("TOPPADDING",(0,0),(-1,-1),5),
                                   ("BOTTOMPADDING",(0,0),(-1,-1),5)]),
    Table([
        [Paragraph("270,000", PS("s3",fontName="Helvetica-Bold",fontSize=18,
                                  textColor=C["con_mid"],alignment=TA_CENTER,leading=22))],
        [Paragraph("neonatal deaths/year", PS("s3b",fontSize=8,alignment=TA_CENTER,leading=11))],
    ], colWidths=[5.7*cm], style=[("BACKGROUND",(0,0),(-1,-1),C["con_light"]),
                                   ("BOX",(0,0),(-1,-1),1,C["con_mid"]),
                                   ("TOPPADDING",(0,0),(-1,-1),5),
                                   ("BOTTOMPADDING",(0,0),(-1,-1),5)]),
]], colWidths=[5.9*cm, 5.9*cm, 5.9*cm]])
stats_tbl.setStyle(TableStyle([
    ("VALIGN",(0,0),(-1,-1),"MIDDLE"),
    ("LEFTPADDING",(1,0),(2,0),4),
]))
story.append(stats_tbl)
story.append(sp(4))
story.append(Paragraph(
    "<b>Most common serious anomalies:</b>  1. Heart defects  •  2. Neural tube defects  •  3. Down syndrome",
    BODY))
story.append(sp(5))

# Causes 2-col
gen_tbl = Table([
    [Paragraph("GENETIC CAUSES", HCELL)],
    [Paragraph(
        "<b>Chromosomal:</b><br/>"
        "• Down syndrome (extra chr 21)<br/>"
        "• Klinefelter syndrome (XXY)<br/>"
        "• Turner syndrome (XO)<br/><br/>"
        "<b>Inborn errors of metabolism:</b><br/>"
        "• PKU, Tay-Sachs, Galactosaemia<br/><br/>"
        "<b>Single gene defects:</b><br/>"
        "• Haemophilia, Sickle cell disease",
        SMALL)],
], colWidths=[5.8*cm])
gen_tbl.setStyle(TableStyle([
    ("BACKGROUND",(0,0),(0,0),C["con_mid"]),
    ("BACKGROUND",(0,1),(0,1),C["con_light"]),
    ("TOPPADDING",(0,0),(-1,-1),5),("BOTTOMPADDING",(0,0),(-1,-1),5),
    ("LEFTPADDING",(0,0),(-1,-1),7),
    ("BOX",(0,0),(-1,-1),0.5,C["con_mid"]),
]))

env_tbl = Table([
    [Paragraph("ENVIRONMENTAL CAUSES (TERATOGENS)", HCELL)],
    [Paragraph(
        "<b>Infections (TORCH):</b> Toxoplasma, Other (Syphilis/HIV), <b>Rubella</b>, CMV, Herpes; Varicella<br/>"
        "<b>Drugs:</b> <b>Thalidomide</b> (phocomelia), Anti-convulsants, Stilboestrol,<br/>"
        "&nbsp;&nbsp;high-dose Vit A, <b>Alcohol</b>, Tobacco, Anaesthetics<br/>"
        "<b>Maternal disease:</b> Diabetes, Cardiac failure<br/>"
        "<b>Physical:</b> X-rays, Irradiation, Pesticides<br/>"
        "<b>Nutritional:</b> <b>Folic acid deficiency</b> → Neural tube defects",
        SMALL)],
], colWidths=[11.5*cm])
env_tbl.setStyle(TableStyle([
    ("BACKGROUND",(0,0),(0,0),C["con_mid"]),
    ("BACKGROUND",(0,1),(0,1),C["con_light"]),
    ("TOPPADDING",(0,0),(-1,-1),5),("BOTTOMPADDING",(0,0),(-1,-1),5),
    ("LEFTPADDING",(0,0),(-1,-1),7),
    ("BOX",(0,0),(-1,-1),0.5,C["con_mid"]),
]))

story.append(Paragraph("<b>CAUSES OF CONGENITAL ANOMALIES</b>", BOLD))
story.append(sp(3))
story.append(Table([[gen_tbl, env_tbl]], colWidths=[5.8*cm, 11.9*cm],
    style=[("VALIGN",(0,0),(-1,-1),"TOP"),("LEFTPADDING",(1,0),(1,0),4)]))
story.append(sp(5))

# Risk factors
story.append(Paragraph("<b>RISK FACTORS</b>", BOLD))
story.append(sp(3))
rf_data = [
    [Paragraph("Risk Factor", HCELL), Paragraph("Details", HCELL)],
    [Paragraph("<b>Advanced maternal age</b>", SMBOLD),
     Paragraph("Main risk for Down syndrome. Overall risk = 1:800. At age 40–45 = 1:67", SMALL)],
    [Paragraph("<b>Consanguinity</b>", SMBOLD),
     Paragraph("First-cousin / uncle-niece marriages → high rate of mental retardation + malformations", SMALL)],
    [Paragraph("<b>Previous malformed child</b>", SMBOLD),
     Paragraph("Risk in next pregnancy is <b>10x higher</b>", SMALL)],
    [Paragraph("<b>Drug use in pregnancy</b>", SMBOLD),
     Paragraph("Especially first trimester — thalidomide, anti-convulsants, alcohol", SMALL)],
    [Paragraph("<b>Infections (TORCH)</b>", SMBOLD),
     Paragraph("Especially first trimester rubella, CMV, toxoplasmosis", SMALL)],
]
rf_tbl = Table(rf_data, colWidths=[5.2*cm, 12.5*cm])
rf_tbl.setStyle(TableStyle([
    ("BACKGROUND",(0,0),(-1,0),C["con_mid"]),
    ("ROWBACKGROUNDS",(0,1),(-1,-1),[C["con_light"],C["white"]]),
    ("GRID",(0,0),(-1,-1),0.4,colors.HexColor("#cccccc")),
    ("TOPPADDING",(0,0),(-1,-1),4),("BOTTOMPADDING",(0,0),(-1,-1),4),
    ("LEFTPADDING",(0,0),(-1,-1),5),("VALIGN",(0,0),(-1,-1),"MIDDLE"),
]))
story.append(rf_tbl)
story.append(sp(5))

# Prenatal diagnosis + Prevention side by side
pnd_tbl = Table([
    [Paragraph("PRENATAL DIAGNOSIS", HCELL)],
    [Paragraph(
        "<b>AFP (Alpha Fetoprotein)</b><br/>"
        "→ Neural tube defects<br/>"
        "→ Elevated in maternal blood + amniotic fluid<br/><br/>"
        "<b>Ultrasound</b><br/>"
        "→ Many structural abnormalities<br/><br/>"
        "<b>Amniocentesis</b><br/>"
        "→ After 12 weeks (2nd trimester)<br/>"
        "→ Down syndrome, NTDs, chromosomes<br/><br/>"
        "<b>CVS (Chorionic Villus Sampling)</b><br/>"
        "→ <b>9–11 weeks</b> (EARLIER than amnio!)<br/>"
        "→ Chromosome status",
        SMALL)],
], colWidths=[5.8*cm])
pnd_tbl.setStyle(TableStyle([
    ("BACKGROUND",(0,0),(0,0),C["con_mid"]),
    ("BACKGROUND",(0,1),(0,1),C["con_light"]),
    ("TOPPADDING",(0,0),(-1,-1),5),("BOTTOMPADDING",(0,0),(-1,-1),5),
    ("LEFTPADDING",(0,0),(-1,-1),7),
    ("BOX",(0,0),(-1,-1),0.5,C["con_mid"]),
]))

prv_tbl = Table([
    [Paragraph("PREVENTION — 3 APPROACHES (Park's)", HCELL)],
    [Paragraph(
        "<b>1. Discourage further reproduction</b> after a malformed child<br/>"
        "&nbsp;&nbsp;&nbsp;(next pregnancy risk = 10x higher)<br/><br/>"
        "<b>2. Avoid pregnancy in high-risk conditions:</b><br/>"
        "&nbsp;&nbsp;&nbsp;• Advanced maternal age (Down syndrome)<br/>"
        "&nbsp;&nbsp;&nbsp;• Consanguineous marriages<br/><br/>"
        "<b>3. Identify &amp; remove teratogens:</b><br/>"
        "&nbsp;&nbsp;&nbsp;• Avoid drugs in 1st trimester<br/>"
        "&nbsp;&nbsp;&nbsp;• <b>Folic acid</b> supplementation (prevents NTDs)<br/>"
        "&nbsp;&nbsp;&nbsp;• <b>Rubella vaccine</b> (routine immunization)<br/>"
        "&nbsp;&nbsp;&nbsp;• Avoid alcohol, X-rays, pesticides<br/>"
        "&nbsp;&nbsp;&nbsp;• Treat TORCH infections",
        SMALL)],
], colWidths=[11.5*cm])
prv_tbl.setStyle(TableStyle([
    ("BACKGROUND",(0,0),(0,0),C["con_mid"]),
    ("BACKGROUND",(0,1),(0,1),C["con_light"]),
    ("TOPPADDING",(0,0),(-1,-1),5),("BOTTOMPADDING",(0,0),(-1,-1),5),
    ("LEFTPADDING",(0,0),(-1,-1),7),
    ("BOX",(0,0),(-1,-1),0.5,C["con_mid"]),
]))

story.append(Table([[pnd_tbl, prv_tbl]], colWidths=[5.8*cm, 11.9*cm],
    style=[("VALIGN",(0,0),(-1,-1),"TOP"),("LEFTPADDING",(1,0),(1,0),4)]))
story.append(sp(4))
story.append(memory_box(
    "Memory: GEMS = Genetic + Environmental infection (TORCH) + Maternal disease + Substances/drugs  |  "
    "TORCH = Toxoplasma, Other, Rubella, CMV, Herpes  |  CVS earlier (9–11 wks) than Amnio (after 12 wks)"))
story.append(sp(10))

# ══════════════════════════════════════════════════════════════
# FINAL: COMPARISON + EXAM Q&A
# ══════════════════════════════════════════════════════════════
story.append(section_bar("⚡  QUICK COMPARISON + EXAM Q&amp;A", C["dark_blue"], colors.HexColor("#1565c0")))
story.append(sp(5))

# Comparison table
story.append(Paragraph("<b>CHIKUNGUNYA vs MALARIA — AT A GLANCE</b>", BOLD))
story.append(sp(3))
cmp_data = [
    [Paragraph("Feature", HCELL),
     Paragraph("Chikungunya", PS("hch", fontName="Helvetica-Bold", fontSize=8.5,
                                  textColor=C["white"], alignment=TA_CENTER, leading=12)),
     Paragraph("Malaria", PS("hmal", fontName="Helvetica-Bold", fontSize=8.5,
                               textColor=C["white"], alignment=TA_CENTER, leading=12))],
    [Paragraph("Causative agent", SMBOLD), Paragraph("Chikungunya virus (RNA)", SMALL), Paragraph("Plasmodium protozoa", SMALL)],
    [Paragraph("Vector", SMBOLD), Paragraph("Aedes mosquito", SMALL), Paragraph("Female Anopheles mosquito", SMALL)],
    [Paragraph("Hallmark symptom", SMBOLD), Paragraph("Severe joint pain (arthropathy)", SMALL), Paragraph("Cold→Hot→Sweating paroxysm", SMALL)],
    [Paragraph("Fever pattern", SMBOLD), Paragraph("Continuous, high fever", SMALL), Paragraph("Periodic (3rd/4th day)", SMALL)],
    [Paragraph("Rash", SMBOLD), Paragraph("Common (60–80%)", SMALL), Paragraph("Uncommon", SMALL)],
    [Paragraph("Deaths", SMBOLD), Paragraph("NONE reported", SMALL), Paragraph("Yes (P. falciparum)", SMALL)],
    [Paragraph("Treatment", SMBOLD), Paragraph("Supportive only (no antiviral)", SMALL), Paragraph("ACT for falciparum; Chloroquine+Primaquine for vivax", SMALL)],
    [Paragraph("Vaccine", SMBOLD), Paragraph("None available", SMALL), Paragraph("RTS,S (Mosquirix) — 2021", SMALL)],
    [Paragraph("Programme", SMBOLD), Paragraph("NVBDCP", SMALL), Paragraph("NVBDCP", SMALL)],
]
cmp_tbl = Table(cmp_data, colWidths=[4.5*cm, 6.6*cm, 6.6*cm])
cmp_tbl.setStyle(TableStyle([
    ("BACKGROUND",(0,0),(0,0),colors.HexColor("#1565c0")),
    ("BACKGROUND",(1,0),(1,0),C["chik_mid"]),
    ("BACKGROUND",(2,0),(2,0),C["mal_mid"]),
    ("ROWBACKGROUNDS",(0,1),(-1,-1),[C["grey"],C["white"]]),
    ("GRID",(0,0),(-1,-1),0.4,colors.HexColor("#cccccc")),
    ("TOPPADDING",(0,0),(-1,-1),4),("BOTTOMPADDING",(0,0),(-1,-1),4),
    ("LEFTPADDING",(0,0),(-1,-1),5),("VALIGN",(0,0),(-1,-1),"MIDDLE"),
]))
story.append(cmp_tbl)
story.append(sp(6))

# Q&A
story.append(Paragraph("<b>MOST LIKELY EXAM QUESTIONS &amp; ANSWERS</b>", BOLD))
story.append(sp(3))
qa = [
    ("What does 'Chikungunya' mean? Where was it first isolated?",
     "Kimakonde language = 'to become contorted/doubled up' due to joint pain. First isolated: Tanzania, 1952–53."),
    ("Vector of chikungunya? Incubation period?",
     "Aedes aegypti and Aedes albopictus. Incubation = 4–7 days."),
    ("Treatment of chikungunya. What to avoid?",
     "Supportive: Paracetamol, Diclofenac, fluids. AVOID Aspirin and Steroids."),
    ("Define malaria. Name causative agents.",
     "Protozoal disease caused by Plasmodium (falciparum, vivax, malariae, ovale), transmitted by female Anopheles."),
    ("3 stages of malarial paroxysm?",
     "Cold stage → Hot stage → Sweating stage."),
    ("Most dangerous species of malaria? Why?",
     "P. falciparum — causes cerebral malaria, blackwater fever, multi-drug resistance."),
    ("Treatment of P. falciparum malaria?",
     "ACT = Artemisinin-based Combination Therapy. Severe: IV Artesunate."),
    ("What is NVBDCP?",
     "National Vector Borne Disease Control Programme — controls malaria, dengue, chikungunya, kala-azar, filaria, JE."),
    ("WHO definition of congenital anomaly?",
     "All structural + biochemical + functional disorders present at birth."),
    ("Incidence of congenital anomalies?",
     "1 in 33 infants; 3.2 million disabilities/year; 270,000 neonatal deaths/year."),
    ("3 prevention approaches for congenital anomalies (Park's)?",
     "1. Discourage reproduction after malformed child.  2. Avoid pregnancy in high-risk.  3. Remove teratogens."),
    ("CVS vs Amniocentesis — difference?",
     "CVS at 9–11 weeks (earlier). Amniocentesis after 12 weeks."),
    ("Risk of Down syndrome with age?",
     "Overall = 1:800. At age 40–45 = 1:67. Advanced maternal age is the main risk factor."),
    ("Name teratogens causing congenital anomalies.",
     "Thalidomide, Rubella, Alcohol, Folic acid deficiency, X-rays, Anti-convulsants, CMV, Toxoplasma."),
]
qa_data = [[Paragraph("Q", HCELL), Paragraph("Question", HCELL), Paragraph("Answer", HCELL)]]
for i, (q, a) in enumerate(qa):
    bg = colors.HexColor("#e3f2fd") if i%2==0 else C["white"]
    qa_data.append([
        Paragraph(f"<b>{i+1}</b>",
                  PS(f"qn{i}", fontName="Helvetica-Bold", fontSize=9,
                     textColor=C["white"], alignment=TA_CENTER)),
        Paragraph(q, PS(f"qq{i}", fontName="Helvetica-Bold", fontSize=8,
                        textColor=colors.HexColor("#1a237e"), leading=12)),
        Paragraph(a, SMALL),
    ])
qa_tbl = Table(qa_data, colWidths=[0.7*cm, 7.5*cm, 9.5*cm])
qa_styles = [
    ("BACKGROUND",(0,0),(-1,0),colors.HexColor("#1a237e")),
    ("GRID",(0,0),(-1,-1),0.4,colors.HexColor("#cccccc")),
    ("TOPPADDING",(0,0),(-1,-1),4),("BOTTOMPADDING",(0,0),(-1,-1),4),
    ("LEFTPADDING",(0,0),(-1,-1),5),("VALIGN",(0,0),(-1,-1),"MIDDLE"),
]
# colour number cells by topic
for i in range(1, 15):
    if i <= 3:    bg = C["chik_mid"]
    elif i <= 8:  bg = C["mal_mid"]
    else:          bg = C["con_mid"]
    qa_styles.append(("BACKGROUND",(0,i),(0,i), bg))
    row_bg = C["chik_light"] if i<=3 else C["mal_light"] if i<=8 else C["con_light"]
    if i%2==0:
        qa_styles.append(("BACKGROUND",(1,i),(2,i), row_bg))
qa_tbl.setStyle(TableStyle(qa_styles))
story.append(qa_tbl)
story.append(sp(6))

# Footer memory strip
mem_strip = Table([[
    Paragraph("CHIK: CHIK mnemonic | No deaths | No vaccine | Avoid Aspirin",
              PS("ms1", fontName="Helvetica-Bold", fontSize=7.5,
                 textColor=C["white"], alignment=TA_CENTER, leading=10)),
    Paragraph("MALARIA: FACT | Cold→Hot→Sweat | ACT for Pf | NVBDCP",
              PS("ms2", fontName="Helvetica-Bold", fontSize=7.5,
                 textColor=C["white"], alignment=TA_CENTER, leading=10)),
    Paragraph("CONGENITAL: GEMS | TORCH | CVS 9–11wks | AFP for NTD | Folic acid",
              PS("ms3", fontName="Helvetica-Bold", fontSize=7.5,
                 textColor=C["white"], alignment=TA_CENTER, leading=10)),
]], colWidths=[5.9*cm, 5.9*cm, 5.9*cm])
mem_strip.setStyle(TableStyle([
    ("BACKGROUND",(0,0),(0,0),C["chik_mid"]),
    ("BACKGROUND",(1,0),(1,0),C["mal_mid"]),
    ("BACKGROUND",(2,0),(2,0),C["con_mid"]),
    ("TOPPADDING",(0,0),(-1,-1),6),("BOTTOMPADDING",(0,0),(-1,-1),6),
    ("VALIGN",(0,0),(-1,-1),"MIDDLE"),
]))
story.append(mem_strip)

doc.build(story)
print("PDF created:", OUTPUT)

Successfully replaced 1 instance(s) of the string in '/home/daytona/workspace/psm-topics/make_psm_pdf.py'

from reportlab.lib.pagesizes import A4
from reportlab.lib import colors
from reportlab.lib.units import cm
from reportlab.platypus import SimpleDocTemplate, Paragraph, Spacer, Table, TableStyle, PageBreak
from reportlab.lib.styles import ParagraphStyle
from reportlab.lib.enums import TA_CENTER, TA_LEFT

OUTPUT = "/home/daytona/workspace/psm-topics/YellowFever_QuickRevision.pdf"
W = 17.7 * cm

# ── Colour Palette ─────────────────────────────────
YD  = colors.HexColor("#e65100")   # deep orange (dark)
YM  = colors.HexColor("#f57c00")   # orange (mid)
YL  = colors.HexColor("#fff3e0")   # orange (light bg)
YA  = colors.HexColor("#ffb74d")   # amber accent
TB  = colors.HexColor("#0d1b2a")   # title bg navy
DB  = colors.HexColor("#1a237e")   # dark blue
MB  = colors.HexColor("#1565c0")   # medium blue
LB  = colors.HexColor("#e3f2fd")   # light blue
GD  = colors.HexColor("#1b5e20")   # dark green
GM  = colors.HexColor("#2e7d32")   # mid green
GL  = colors.HexColor("#e8f5e9")   # light green
RD  = colors.HexColor("#b71c1c")   # dark red
RL  = colors.HexColor("#ffebee")   # light red
PD  = colors.HexColor("#4a148c")   # dark purple
PM  = colors.HexColor("#6a1b9a")   # mid purple
PL  = colors.HexColor("#f3e5f5")   # light purple
TM  = colors.HexColor("#00695c")   # teal mid
TL  = colors.HexColor("#e0f2f1")   # teal light
GLD = colors.HexColor("#f9a825")   # gold
GLL = colors.HexColor("#fffde7")   # gold light
GRY = colors.HexColor("#f5f5f5")   # grey
WH  = colors.white
BK  = colors.HexColor("#212121")

def PS(name, **kw):
    d = dict(fontName="Helvetica", fontSize=9, leading=13, textColor=BK)
    d.update(kw)
    return ParagraphStyle(name, **d)

TITLE = PS("T",  fontName="Helvetica-Bold", fontSize=24, textColor=WH, alignment=TA_CENTER, leading=30)
SUB   = PS("S",  fontName="Helvetica",      fontSize=11, textColor=WH, alignment=TA_CENTER, leading=15)
SEC   = PS("Sc", fontName="Helvetica-Bold", fontSize=12, textColor=WH, leading=15)
BODY  = PS("B",  fontSize=9,  leading=13)
BOLD  = PS("Bd", fontName="Helvetica-Bold", fontSize=9, leading=13)
SM    = PS("Sm", fontSize=8,  leading=11)
SMB   = PS("Sb", fontName="Helvetica-Bold", fontSize=8, leading=11)
HC    = PS("Hc", fontName="Helvetica-Bold", fontSize=8.5, textColor=WH, alignment=TA_CENTER, leading=12)
TIP   = PS("Tp", fontName="Helvetica-Bold", fontSize=9, textColor=GLD, alignment=TA_CENTER, leading=13)
WB    = PS("Wb", fontName="Helvetica-Bold", fontSize=9, textColor=WH, leading=12)
WN    = PS("Wn", fontSize=9, textColor=WH, leading=12)

def sp(h=4): return Spacer(1, h)

def sec_bar(text, color):
    t = Table([[Paragraph(text, SEC)]], colWidths=[W])
    t.setStyle(TableStyle([
        ("BACKGROUND",(0,0),(-1,-1),color),
        ("TOPPADDING",(0,0),(-1,-1),6), ("BOTTOMPADDING",(0,0),(-1,-1),6),
        ("LEFTPADDING",(0,0),(-1,-1),10),
    ]))
    return t

def ibox(para, bg, border):
    t = Table([[para]], colWidths=[W])
    t.setStyle(TableStyle([
        ("BACKGROUND",(0,0),(-1,-1),bg),
        ("BOX",(0,0),(-1,-1),1.2,border),
        ("TOPPADDING",(0,0),(-1,-1),7), ("BOTTOMPADDING",(0,0),(-1,-1),7),
        ("LEFTPADDING",(0,0),(-1,-1),10), ("RIGHTPADDING",(0,0),(-1,-1),10),
    ]))
    return t

def ctable(headers, rows, cw, hc, alt):
    data = [[Paragraph(h, HC) for h in headers]]
    for i, row in enumerate(rows):
        bg = alt if i % 2 == 0 else WH
        data.append([Paragraph(str(c), SM) for c in row])
    t = Table(data, colWidths=cw)
    t.setStyle(TableStyle([
        ("BACKGROUND",(0,0),(-1,0),hc),
        ("ROWBACKGROUNDS",(0,1),(-1,-1),[alt,WH]),
        ("GRID",(0,0),(-1,-1),0.4,colors.HexColor("#cccccc")),
        ("TOPPADDING",(0,0),(-1,-1),4), ("BOTTOMPADDING",(0,0),(-1,-1),4),
        ("LEFTPADDING",(0,0),(-1,-1),5), ("VALIGN",(0,0),(-1,-1),"MIDDLE"),
    ]))
    return t

def mem_box(text):
    t = Table([[Paragraph(f"🧠  {text}", TIP)]], colWidths=[W])
    t.setStyle(TableStyle([
        ("BACKGROUND",(0,0),(-1,-1),GLL),
        ("BOX",(0,0),(-1,-1),1.2,GLD),
        ("TOPPADDING",(0,0),(-1,-1),6), ("BOTTOMPADDING",(0,0),(-1,-1),6),
    ]))
    return t

def side_box(title, content_para, cw, hc, bg):
    t = Table([[Paragraph(title, HC)], [content_para]], colWidths=[cw])
    t.setStyle(TableStyle([
        ("BACKGROUND",(0,0),(0,0),hc),
        ("BACKGROUND",(0,1),(0,1),bg),
        ("BOX",(0,0),(-1,-1),0.5,hc),
        ("TOPPADDING",(0,0),(-1,-1),5), ("BOTTOMPADDING",(0,0),(-1,-1),5),
        ("LEFTPADDING",(0,0),(-1,-1),7),
    ]))
    return t

# ══════════════════════════════════════════════════
story = []

# ── COVER ──────────────────────────────────────────
cover = Table([
    [Paragraph("🟡  YELLOW FEVER", TITLE)],
    [Paragraph("PSM Quick Revision  •  Park's Textbook of Preventive & Social Medicine", SUB)],
    [Paragraph("Flavivirus fibricus  |  Arbovirus  |  Togavirus Family  |  Aedes aegypti", 
               PS("cv3", fontSize=9, textColor=colors.HexColor("#ffe0b2"), alignment=TA_CENTER, leading=13))],
], colWidths=[W])
cover.setStyle(TableStyle([
    ("BACKGROUND",(0,0),(0,0),colors.HexColor("#bf360c")),
    ("BACKGROUND",(0,1),(0,1),YD),
    ("BACKGROUND",(0,2),(0,2),YM),
    ("TOPPADDING",(0,0),(0,0),12), ("BOTTOMPADDING",(0,0),(0,0),4),
    ("TOPPADDING",(0,1),(0,1),5), ("BOTTOMPADDING",(0,1),(0,1),5),
    ("TOPPADDING",(0,2),(0,2),4), ("BOTTOMPADDING",(0,2),(0,2),10),
]))
story += [cover, sp(7)]

# ── DEFINITION ─────────────────────────────────────
story.append(sec_bar("📖  DEFINITION", YD))
story += [sp(4), ibox(Paragraph(
    '<b>Yellow Fever</b> is a <b>zoonotic viral haemorrhagic fever</b> caused by '
    '<b>Flavivirus fibricus</b> (Group B arbovirus, Togavirus family). It affects monkeys and other vertebrates '
    'in tropical Africa and America, and is transmitted to man by <b>culicine mosquitoes</b>. '
    'It is characterized by <b>fever, jaundice (yellow skin), black vomit, and severe liver + kidney damage</b>. '
    'Case fatality rate can reach <b>80%</b> in severe cases. Survivors get <b>lifelong immunity</b>.', BODY),
    YL, YM), sp(5)]

# ── PROBLEM STATEMENT ──────────────────────────────
story.append(sec_bar("🌍  PROBLEM STATEMENT (Global Burden)", YM))
story += [sp(4)]

stat_items = [
    ("47 countries", "At risk (Africa + Latin America)", YD),
    (">900 million", "Population at risk worldwide", YM),
    ("84,000–170,000", "Estimated cases per year (2013)", colors.HexColor("#ef6c00")),
    ("29,000–60,000", "Estimated deaths per year (2013)", RD),
]
stat_cells = []
for val, lbl, clr in stat_items:
    cell = Table([
        [Paragraph(val, PS(f"sv{val}", fontName="Helvetica-Bold", fontSize=14,
                           textColor=clr, alignment=TA_CENTER, leading=18))],
        [Paragraph(lbl, PS(f"sl{val}", fontSize=7.5, alignment=TA_CENTER, leading=10))],
    ], colWidths=[4.2*cm])
    cell.setStyle(TableStyle([
        ("BACKGROUND",(0,0),(-1,-1),YL),
        ("BOX",(0,0),(-1,-1),1,clr),
        ("TOPPADDING",(0,0),(-1,-1),5), ("BOTTOMPADDING",(0,0),(-1,-1),5),
    ]))
    stat_cells.append(cell)
stat_row = Table([stat_cells], colWidths=[4.4*cm, 4.4*cm, 4.4*cm, 4.4*cm])
stat_row.setStyle(TableStyle([("LEFTPADDING",(1,0),(3,0),4), ("VALIGN",(0,0),(-1,-1),"MIDDLE")]))
story += [stat_row, sp(4)]
story.append(ibox(Paragraph(
    '<b>Highest risk countries in Americas:</b> Bolivia, Brazil, Colombia, Ecuador, Peru  |  '
    '<b>Asia:</b> Disease never reported but REGION IS AT RISK (conditions present)', SM), YL, YM))
story += [sp(7)]

# ── EPIDEMIOLOGICAL TRIAD ──────────────────────────
story.append(sec_bar("🔬  EPIDEMIOLOGICAL TRIAD", DB))
story += [sp(5)]

# Agent box
agent_box = side_box("AGENT FACTORS", Paragraph(
    '<b>Causative Agent:</b> Flavivirus fibricus — Group B Arbovirus — Togavirus family<br/>'
    '<b>Related to:</b> Dengue, West Nile virus (shares antigens)<br/>'
    '<b>Reservoir:</b> Monkeys + forest mosquitoes (jungle);  Man + Aedes aegypti (urban)<br/>'
    '<b>Communicability in Man:</b> Blood infective for first <b>3–4 days</b> of illness<br/>'
    '<b>Communicability in Mosquito:</b> Infective after <b>8–12 days</b> extrinsic incubation;<br/>'
    '&nbsp;&nbsp;once infective, mosquito remains so for <b>LIFE</b><br/>'
    '<b>Special:</b> Transovarian transmission in mosquitoes during adverse conditions (dry season)', SM),
    W, MB, LB)
story += [agent_box, sp(4)]

# Host + Environment side by side
host_box = side_box("HOST FACTORS", Paragraph(
    '<b>Age &amp; Sex:</b> All ages, both sexes susceptible<br/>'
    '<b>Occupation at HIGH RISK:</b> Loggers, woodcutters, hunters (forest workers)<br/>'
    '<b>Immunity:</b> One attack = <b>LIFELONG immunity</b>; second attacks UNKNOWN<br/>'
    '<b>Maternal antibodies:</b> Infants of immune mothers protected for <b>up to 6 months</b>', SM),
    8.65*cm, TM, TL)
env_box = side_box("ENVIRONMENTAL FACTORS", Paragraph(
    '<b>Temperature:</b> ≥<b>24°C</b> required for virus multiplication in mosquito<br/>'
    '<b>Humidity:</b> Relative humidity ><b>60%</b> required for mosquito survival<br/>'
    '<b>Urbanization:</b> Encroachment on jungle brings humans into jungle cycles<br/>'
    '<b>Travel:</b> International travel spreads virus from endemic → receptive areas', SM),
    8.65*cm, YD, YL)
story += [Table([[host_box, env_box]], colWidths=[8.85*cm, 8.85*cm],
    style=[("VALIGN",(0,0),(-1,-1),"TOP"),("LEFTPADDING",(1,0),(1,0),4)]), sp(7)]

# ── INCUBATION + CLINICAL FEATURES ─────────────────
story.append(sec_bar("🤒  INCUBATION PERIOD &amp; CLINICAL FEATURES", colors.HexColor("#c62828")))
story += [sp(4)]

inc_box = side_box("INCUBATION PERIOD", Paragraph(
    '<b>3 to 6 days</b><br/>(6 days recognized under <b>IHR</b> — International Health Regulations)', BODY),
    5.8*cm, RD, RL)

stage_box = side_box("3 STAGES OF YELLOW FEVER", Paragraph(
    '<b>Stage 1 — Infection (Days 1–3):</b> Sudden high fever, headache, backache, nausea, vomiting<br/>'
    '<b>Stage 2 — Remission:</b> Fever drops briefly; most patients RECOVER here<br/>'
    '<b>Stage 3 — Intoxication (Toxic Phase — SEVERE):</b><br/>'
    '&nbsp;&nbsp;• <b>Jaundice</b> (gives disease its name — "Yellow" Fever)<br/>'
    '&nbsp;&nbsp;• <b>"Black Vomit"</b> = vomiting of digested blood (HALLMARK!)<br/>'
    '&nbsp;&nbsp;• Epistaxis (nosebleed), Melena (blood in stool)<br/>'
    '&nbsp;&nbsp;• <b>Albuminuria / Anuria</b> (kidney failure)<br/>'
    '&nbsp;&nbsp;• Shock, agitation, stupor, <b>coma, death</b><br/>'
    '• <b>Death:</b> Between <b>5th–10th day</b> of illness<br/>'
    '• <b>CFR:</b> Up to <b>80%</b> in severe cases', SM),
    11.5*cm, RD, RL)
story += [Table([[inc_box, stage_box]], colWidths=[6*cm, 11.7*cm],
    style=[("VALIGN",(0,0),(-1,-1),"TOP"),("LEFTPADDING",(1,0),(1,0),4)]), sp(4)]

warn = Table([[Paragraph(
    '⚠  KEY FEATURES: Jaundice + Black Vomit + Kidney failure (albuminuria)  |  '
    'CFR up to 80%  |  Death on Day 5–10  |  Survivors get LIFELONG immunity',
    PS("w1", fontName="Helvetica-Bold", fontSize=8.5, textColor=RD, alignment=TA_CENTER, leading=12)
)]], colWidths=[W])
warn.setStyle(TableStyle([
    ("BACKGROUND",(0,0),(-1,-1),RL),
    ("BOX",(0,0),(-1,-1),1.2,RD),
    ("TOPPADDING",(0,0),(-1,-1),5), ("BOTTOMPADDING",(0,0),(-1,-1),5),
]))
story += [warn, sp(7)]

# ── 3 TRANSMISSION CYCLES ──────────────────────────
story.append(sec_bar("🔄  3 CYCLES OF TRANSMISSION  (Very Important!)", GD))
story += [sp(4)]

cycles = [
    (GD,   "1. JUNGLE\n(Sylvatic)", "Tropical rainforests",
     "Monkeys → Humans (mainly young men / loggers / woodcutters)",
     "Wild forest mosquitoes",
     "UNCONTROLLABLE — no practical control measures"),
    (TM,   "2. INTERMEDIATE\n(Savannah)", "Humid/semi-humid Africa",
     "Monkeys + Humans in nearby villages",
     "Semi-domestic mosquitoes (breed in wild AND near homes)",
     "MOST COMMON outbreak type in Africa; can escalate to urban"),
    (YD,   "3. URBAN", "Densely populated cities",
     "Human → Human (infected person brings virus to city)",
     "Aedes aegypti (domestic)",
     "LARGEST EPIDEMICS; most dangerous; controlled by vaccination + vector control"),
]
cyc_data = [[Paragraph(h, HC) for h in ["Cycle","Location","Who","Vector","Key Note"]]]
for clr, name, loc, who, vec, note in cycles:
    cyc_data.append([
        Paragraph(f"<b>{name}</b>", PS(f"cn{name}", fontName="Helvetica-Bold", fontSize=8,
                                        textColor=WH, alignment=TA_CENTER, leading=11)),
        Paragraph(loc, SM), Paragraph(who, SM), Paragraph(vec, SM),
        Paragraph(note, PS(f"nt{name}", fontSize=7.5, textColor=clr,
                            fontName="Helvetica-Bold", leading=11)),
    ])
cyc_tbl = Table(cyc_data, colWidths=[3*cm, 3.2*cm, 4.5*cm, 3.5*cm, 3.5*cm])
cyc_styles = [
    ("BACKGROUND",(0,0),(-1,0),GD),
    ("GRID",(0,0),(-1,-1),0.4,colors.HexColor("#cccccc")),
    ("TOPPADDING",(0,0),(-1,-1),4), ("BOTTOMPADDING",(0,0),(-1,-1),4),
    ("LEFTPADDING",(0,0),(-1,-1),5), ("VALIGN",(0,0),(-1,-1),"MIDDLE"),
    ("BACKGROUND",(0,1),(0,1),GD), ("BACKGROUND",(0,2),(0,2),TM), ("BACKGROUND",(0,3),(0,3),YD),
    ("BACKGROUND",(1,1),(-1,1),GL), ("BACKGROUND",(1,2),(-1,2),TL), ("BACKGROUND",(1,3),(-1,3),YL),
]
cyc_tbl.setStyle(TableStyle(cyc_styles))
story += [cyc_tbl, sp(4),
          mem_box("J–I–U: Jungle (uncontrollable) → Intermediate (most common in Africa) → Urban (Aedes aegypti, person-to-person)"),
          sp(7)]

# ── 17D VACCINE ────────────────────────────────────
story.append(sec_bar("💉  17D VACCINE  (Most Effective Control)", PM))
story += [sp(4)]

vac_box = side_box("VACCINE DETAILS", Paragraph(
    '<b>Name:</b> 17D vaccine (approved for international use)<br/>'
    '<b>Type:</b> <b>Live attenuated</b> vaccine (17D strain — non-virulent)<br/>'
    '<b>Prepared in:</b> Chick embryo → freeze-dried (lyophilized)<br/>'
    '<b>Dose:</b> <b>0.5 ml, subcutaneous</b>, at deltoid insertion<br/>'
    '<b>Number of doses:</b> Single dose, irrespective of age<br/>'
    '<b>Immunity onset:</b> Begins on <b>7th day</b> after vaccination<br/>'
    '<b>Immunity duration:</b> <b>LIFETIME</b> (since 2016; was 10 years before)<br/>'
    '<b>Storage:</b> +5°C to −30°C (preferably below 0°C); <b>HEAT SENSITIVE!</b><br/>'
    '<b>Reconstituted vaccine:</b> Keep on ice; discard after <b>30 minutes</b>', SM),
    8.65*cm, PM, PL)

contra_box = side_box("CONTRAINDICATIONS (Who NOT to vaccinate)", Paragraph(
    '<b>1.</b> Children <b>&lt;9 months</b> routine; <b>&lt;6 months</b> during epidemic<br/>'
    '<b>2.</b> <b>Pregnant women</b> (except high-risk outbreak situation)<br/>'
    '<b>3.</b> Severe <b>egg protein allergy</b><br/>'
    '<b>4.</b> Severe <b>immunodeficiency</b> (HIV/AIDS, thymus disorder)<br/><br/>'
    '<b>Side effects:</b> Mild reactions (myalgia, headache, low fever)<br/>'
    'in 2–5% of vaccinees, appearing <b>5–10 days</b> after vaccination<br/><br/>'
    '<b>⚠ IMPORTANT:</b> Cholera + Yellow fever vaccines given together<br/>'
    'or within <b>3 weeks = INTERFERE</b> — give <b>≥3 weeks apart!</b>', SM),
    8.65*cm, RD, RL)
story += [Table([[vac_box, contra_box]], colWidths=[8.85*cm, 8.85*cm],
    style=[("VALIGN",(0,0),(-1,-1),"TOP"),("LEFTPADDING",(1,0),(1,0),4)]), sp(4),
    mem_box("17D = Live attenuated | 0.5ml SC | Immunity: Day 7 | LIFETIME validity (2016) | Discard reconstituted vaccine in 30 min | HEAT SENSITIVE"),
    sp(7)]

# ── INDIA + IHR ────────────────────────────────────
story.append(sec_bar("🇮🇳  INDIA &amp; INTERNATIONAL MEASURES (IHR)", MB))
story += [sp(4)]

india_box = side_box("INDIA = RECEPTIVE AREA", Paragraph(
    '<b>Definition:</b> "An area in which yellow fever does not exist,<br/>'
    'but where conditions would permit its development if introduced"<br/><br/>'
    '<b>Why is India receptive?</b><br/>'
    '✓ Population unvaccinated and susceptible<br/>'
    '✓ Aedes aegypti found in ABUNDANCE<br/>'
    '✓ Climate favourable in most parts<br/>'
    '✓ Common monkey (Macacus spp.) is susceptible<br/>'
    '✗ Only MISSING LINK = the virus itself (not present in India)<br/><br/>'
    '<b>How virus could enter India:</b><br/>'
    '1. Infected travellers (clinical + subclinical)<br/>'
    '2. Infected mosquitoes on aircraft/ships', SM),
    8.65*cm, MB, LB)

ihr_box = side_box("INTERNATIONAL MEASURES (IHR)", Paragraph(
    '<b>For Travellers:</b><br/>'
    '• Must have valid <b>International Certificate of Vaccination</b><br/>'
    '• Without certificate: <b>Quarantine for 6 days</b> (mosquito-proof ward)<br/>'
    '• Certificate valid from <b>10 days after vaccination</b><br/>'
    '• Since <b>11 July 2016:</b> Certificate valid for <b>LIFETIME</b> (was 10 years)<br/>'
    '• Required even if traveller was only <b>in transit</b><br/>'
    '• India requires for infants <b>≥9 months</b><br/><br/>'
    '<b>For Aircraft/Ships from endemic areas:</b><br/>'
    '• <b>Aerosol spraying</b> with insecticides on arrival<br/>'
    '• Airports/seaports kept vector-free for <b>400 metres</b> around perimeter<br/>'
    '• <b>Aedes aegypti index kept below 1%</b>', SM),
    8.65*cm, MB, LB)
story += [Table([[india_box, ihr_box]], colWidths=[8.85*cm, 8.85*cm],
    style=[("VALIGN",(0,0),(-1,-1),"TOP"),("LEFTPADDING",(1,0),(1,0),4)]), sp(4)]

# Aedes index highlight
ae_tbl = Table([[
    Paragraph("📏  Aedes aegypti Index", PS("aei", fontName="Helvetica-Bold", fontSize=10,
               textColor=MB, alignment=TA_CENTER, leading=13)),
    Paragraph(
        '"The percentage of houses and their premises in a defined area showing actual '
        'breeding of Aedes aegypti larvae"  |  Must be <b>&lt;1%</b> in towns and seaports in endemic areas',
        PS("aed", fontSize=8.5, leading=12)),
]], colWidths=[5*cm, 12.7*cm])
ae_tbl.setStyle(TableStyle([
    ("BACKGROUND",(0,0),(0,0),LB), ("BACKGROUND",(1,0),(1,0),LB),
    ("BOX",(0,0),(-1,-1),1,MB),
    ("TOPPADDING",(0,0),(-1,-1),6), ("BOTTOMPADDING",(0,0),(-1,-1),6),
    ("LEFTPADDING",(0,0),(-1,-1),6), ("VALIGN",(0,0),(-1,-1),"MIDDLE"),
]))
story += [ae_tbl, sp(7)]

# ── VECTOR CONTROL + TREATMENT ─────────────────────
story.append(sec_bar("🦟  VECTOR CONTROL  &amp;  TREATMENT", GD))
story += [sp(4)]

vc_box = side_box("VECTOR CONTROL", Paragraph(
    '• Control <b>Aedes aegypti</b> (peri-domestic mosquito)<br/>'
    '• Anti-adult measures (adulticidal insecticides)<br/>'
    '• Anti-larval measures (eliminate breeding sites)<br/>'
    '• <b>Source reduction</b> = long-term policy (remove breeding places)<br/>'
    '• Health education for community<br/>'
    '• Keep <b>Aedes aegypti index &lt;1%</b> in seaports/towns', SM),
    8.65*cm, GD, GL)

tx_box = side_box("TREATMENT", Paragraph(
    '<b>NO specific antiviral treatment available</b><br/><br/>'
    'Only <b>supportive care:</b><br/>'
    '• Treat dehydration (IV fluids)<br/>'
    '• Fever management<br/>'
    '• Antibiotics for secondary bacterial infections<br/>'
    '• ICU support in severe cases<br/><br/>'
    '<b>Prevention &gt;&gt; Treatment</b><br/>'
    'Vaccination is the most effective strategy', SM),
    8.65*cm, YD, YL)
story += [Table([[vc_box, tx_box]], colWidths=[8.85*cm, 8.85*cm],
    style=[("VALIGN",(0,0),(-1,-1),"TOP"),("LEFTPADDING",(1,0),(1,0),4)]), sp(7)]

# ── EYE STRATEGY ───────────────────────────────────
story.append(sec_bar("🎯  EYE STRATEGY  (Elimination Yellow Fever Epidemics)", TM))
story += [sp(4)]

eye_box = side_box("EYE STRATEGY — WHO + UNICEF + GAVI", Paragraph(
    '<b>3 Strategic Objectives:</b><br/>'
    '1. Protect at-risk populations<br/>'
    '2. Prevent international spread of yellow fever<br/>'
    '3. Contain outbreaks rapidly<br/><br/>'
    '<b>5 Competencies for Success:</b><br/>'
    '1. Affordable vaccines and sustained vaccine market<br/>'
    '2. Strong political commitment (global + regional + country)<br/>'
    '3. High-level governance with long-term partnerships<br/>'
    '4. Synergies with other health programmes<br/>'
    '5. Research and development for better tools', SM),
    8.65*cm, TM, TL)

diag_box = side_box("DIAGNOSIS", Paragraph(
    '<b>RT-PCR:</b> Within first <b>5 days</b> (acute/viremic phase)<br/>'
    '<b>Virus isolation:</b> From blood in first 4 days<br/>'
    '<b>Serology (ELISA):</b> IgM + IgG after day 5<br/><br/>'
    '<b>WHO recommendation:</b><br/>'
    'Every at-risk country must have at least<br/>'
    '<b>one national laboratory</b> for basic YF blood tests<br/><br/>'
    '<b>Confirmed case</b> in unvaccinated population<br/>= potential outbreak = emergency vaccination', SM),
    8.65*cm, TM, TL)
story += [Table([[eye_box, diag_box]], colWidths=[8.85*cm, 8.85*cm],
    style=[("VALIGN",(0,0),(-1,-1),"TOP"),("LEFTPADDING",(1,0),(1,0),4)]), sp(7)]

# ── QUICK REFERENCE TABLE ──────────────────────────
story.append(sec_bar("⚡  COMPLETE QUICK REFERENCE  (One-Page Glance)", DB))
story += [sp(4)]
ref_rows = [
    ("<b>Causative agent</b>",      "Flavivirus fibricus — Group B Arbovirus — Togavirus family"),
    ("<b>Reservoir</b>",            "Monkeys + forest mosquitoes (jungle);  Man + Aedes aegypti (urban)"),
    ("<b>Vector</b>",               "Culicine mosquitoes (jungle);  Aedes aegypti (urban/intermediate)"),
    ("<b>Incubation period</b>",    "3–6 days  (IHR recognizes 6 days)"),
    ("<b>Period of communicability (man)</b>", "Blood infective for first 3–4 days of illness"),
    ("<b>Extrinsic incubation</b>",  "8–12 days in mosquito; mosquito then infective for LIFE"),
    ("<b>3 transmission cycles</b>", "Jungle (sylvatic) → Intermediate → Urban (Aedes aegypti)"),
    ("<b>Hallmark symptoms</b>",     "Fever → Jaundice → Black Vomit → Kidney failure → Shock → Coma"),
    ("<b>Case fatality rate</b>",    "Up to 80% in severe cases"),
    ("<b>Death occurs</b>",          "Between 5th–10th day of illness"),
    ("<b>Immunity after infection</b>","LIFELONG; second attacks unknown"),
    ("<b>Treatment</b>",             "Supportive only — no antiviral; IV fluids, antipyretics, antibiotics"),
    ("<b>Vaccine</b>",               "17D — Live attenuated — 0.5 ml SC — single dose — chick embryo"),
    ("<b>Vaccine immunity onset</b>","7th day after vaccination"),
    ("<b>Vaccine validity</b>",      "LIFETIME (since 11 July 2016; previously 10 years)"),
    ("<b>Vaccine storage</b>",       "+5°C to −30°C; heat sensitive; discard reconstituted vaccine in 30 min"),
    ("<b>Vaccine contraindications</b>","<9 months, pregnant, egg allergy, immunodeficiency"),
    ("<b>Cholera + YF vaccine</b>",  "Give ≥3 weeks apart — they INTERFERE if given together"),
    ("<b>India's status</b>",        "RECEPTIVE AREA — has vector + climate + susceptible hosts, but NO virus"),
    ("<b>Quarantine (no certificate)</b>","6 days in mosquito-proof ward"),
    ("<b>Certificate valid from</b>","10 days after vaccination"),
    ("<b>Airport vector-free zone</b>","400 metres around perimeter"),
    ("<b>Aedes aegypti index</b>",   "<1% in towns and seaports in endemic areas"),
    ("<b>EYE Strategy</b>",          "WHO + UNICEF + GAVI — 3 objectives: protect, prevent spread, contain"),
    ("<b>Programme</b>",             "IHR (WHO) + NVBDCP (India)"),
]
ref_data = [[Paragraph("Feature", HC), Paragraph("Details", HC)]]
for i, (f, d) in enumerate(ref_rows):
    bg = YL if i % 2 == 0 else WH
    ref_data.append([Paragraph(f, SMB), Paragraph(d, SM)])
ref_tbl = Table(ref_data, colWidths=[5.5*cm, 12.2*cm])
ref_styles = [
    ("BACKGROUND",(0,0),(-1,0),DB),
    ("GRID",(0,0),(-1,-1),0.4,colors.HexColor("#cccccc")),
    ("TOPPADDING",(0,0),(-1,-1),4), ("BOTTOMPADDING",(0,0),(-1,-1),4),
    ("LEFTPADDING",(0,0),(-1,-1),5), ("VALIGN",(0,0),(-1,-1),"MIDDLE"),
]
for i in range(1, len(ref_rows)+1):
    ref_styles.append(("BACKGROUND",(0,i),(-1,i), YL if i%2==1 else WH))
ref_tbl.setStyle(TableStyle(ref_styles))
story += [ref_tbl, sp(6)]

# ── EXAM Q&A ───────────────────────────────────────
story.append(sec_bar("❓  MOST LIKELY EXAM QUESTIONS &amp; ANSWERS", RD))
story += [sp(4)]
qa = [
    ("Define yellow fever.",
     "Zoonotic viral haemorrhagic fever caused by Flavivirus fibricus (Group B arbovirus, Togavirus). Transmitted by culicine mosquitoes. Characterized by fever, jaundice, black vomit, severe liver+kidney damage. CFR up to 80%."),
    ("What is the causative agent?",
     "Flavivirus fibricus — Group B Arbovirus — Togavirus family. Related to dengue and West Nile virus."),
    ("What are the 3 cycles of transmission?",
     "1. Jungle/Sylvatic (monkeys→humans, forest mosquitoes) 2. Intermediate (monkeys+humans, semi-domestic mosquitoes) 3. Urban (human→human, Aedes aegypti)."),
    ("What is the incubation period?",
     "3–6 days. 6 days recognized under IHR."),
    ("Describe the 17D vaccine.",
     "Live attenuated vaccine, 0.5 ml SC, single dose. Grown in chick embryo, freeze-dried. Immunity starts Day 7, lasts LIFETIME (since 2016). Store at +5°C to −30°C. Discard reconstituted vaccine in 30 minutes."),
    ("What is the validity of the YF vaccination certificate?",
     "LIFETIME — since 11 July 2016 (IHR amendment, May 2014). Previously was 10 years."),
    ("Why is India a 'receptive area' for yellow fever?",
     "Has all conditions: abundant Aedes aegypti, suitable climate, susceptible unvaccinated population, susceptible monkeys (Macacus spp.) — but the virus itself is not present in India."),
    ("What is the quarantine period? What are the conditions?",
     "6 days in a mosquito-proof ward, from date of leaving infected area."),
    ("What is the Aedes aegypti index?",
     "% of houses in a defined area showing actual Aedes aegypti larvae breeding. Must be <1% in towns/seaports of endemic areas."),
    ("Who should NOT receive yellow fever vaccine?",
     "Children <9 months (routine)/<6 months (epidemic), pregnant women, severe egg allergy, severe immunodeficiency (HIV/AIDS, thymus disorder)."),
    ("What is the EYE Strategy?",
     "Elimination Yellow Fever Epidemics — by WHO+UNICEF+GAVI. 3 objectives: protect at-risk populations, prevent international spread, contain outbreaks rapidly."),
    ("What is the treatment of yellow fever?",
     "No specific antiviral. Supportive only: IV fluids, antipyretics, antibiotics for bacterial co-infection."),
]
qa_data = [[Paragraph("#", HC), Paragraph("Question", HC), Paragraph("Answer", HC)]]
for i, (q, a) in enumerate(qa):
    bg = YL if i%2==0 else WH
    qa_data.append([
        Paragraph(str(i+1), PS(f"qn{i}", fontName="Helvetica-Bold", fontSize=9,
                               textColor=WH, alignment=TA_CENTER)),
        Paragraph(q, PS(f"qq{i}", fontName="Helvetica-Bold", fontSize=8,
                        textColor=YD, leading=12)),
        Paragraph(a, SM),
    ])
qa_tbl = Table(qa_data, colWidths=[0.7*cm, 6.5*cm, 10.5*cm])
qa_styles = [
    ("BACKGROUND",(0,0),(-1,0),RD),
    ("GRID",(0,0),(-1,-1),0.4,colors.HexColor("#cccccc")),
    ("TOPPADDING",(0,0),(-1,-1),4), ("BOTTOMPADDING",(0,0),(-1,-1),4),
    ("LEFTPADDING",(0,0),(-1,-1),5), ("VALIGN",(0,0),(-1,-1),"MIDDLE"),
]
for i in range(1, len(qa)+1):
    qa_styles.append(("BACKGROUND",(0,i),(0,i), YD))
    qa_styles.append(("BACKGROUND",(1,i),(2,i), YL if i%2==1 else WH))
qa_tbl.setStyle(TableStyle(qa_styles))
story += [qa_tbl, sp(6)]

# ── MEMORY FOOTER ──────────────────────────────────
mem_strip = Table([[
    Paragraph("Agent: Flavivirus fibricus\nTogavirus | Group B Arbovirus",
              PS("m1", fontName="Helvetica-Bold", fontSize=7.5, textColor=WH,
                 alignment=TA_CENTER, leading=10)),
    Paragraph("3 Cycles: J→I→U\nJungle | Intermediate | Urban",
              PS("m2", fontName="Helvetica-Bold", fontSize=7.5, textColor=WH,
                 alignment=TA_CENTER, leading=10)),
    Paragraph("17D Vaccine: Live attenuated\nImmunity Day 7 | LIFETIME",
              PS("m3", fontName="Helvetica-Bold", fontSize=7.5, textColor=WH,
                 alignment=TA_CENTER, leading=10)),
    Paragraph("India = Receptive Area\nQuarantine = 6 days",
              PS("m4", fontName="Helvetica-Bold", fontSize=7.5, textColor=WH,
                 alignment=TA_CENTER, leading=10)),
    Paragraph("Aedes Index <1%\n400m vector-free zone",
              PS("m5", fontName="Helvetica-Bold", fontSize=7.5, textColor=WH,
                 alignment=TA_CENTER, leading=10)),
]], colWidths=[3.54*cm, 3.54*cm, 3.54*cm, 3.54*cm, 3.54*cm])
mem_strip.setStyle(TableStyle([
    ("BACKGROUND",(0,0),(0,0),colors.HexColor("#bf360c")),
    ("BACKGROUND",(1,0),(1,0),GD),
    ("BACKGROUND",(2,0),(2,0),PM),
    ("BACKGROUND",(3,0),(3,0),MB),
    ("BACKGROUND",(4,0),(4,0),TM),
    ("TOPPADDING",(0,0),(-1,-1),7), ("BOTTOMPADDING",(0,0),(-1,-1),7),
    ("VALIGN",(0,0),(-1,-1),"MIDDLE"),
]))
story.append(mem_strip)

# BUILD
doc = SimpleDocTemplate(OUTPUT, pagesize=A4,
    leftMargin=1.4*cm, rightMargin=1.4*cm,
    topMargin=1.3*cm, bottomMargin=1.3*cm)
doc.build(story)
print("PDF created:", OUTPUT)

from reportlab.lib.pagesizes import A4
from reportlab.lib import colors
from reportlab.lib.units import cm
from reportlab.platypus import SimpleDocTemplate, Paragraph, Spacer, Table, TableStyle
from reportlab.lib.styles import ParagraphStyle
from reportlab.lib.enums import TA_CENTER, TA_LEFT

OUTPUT = "/home/daytona/workspace/psm-topics/Immunization_vs_Vaccination.pdf"
W = 17.7 * cm

# ── Colour Palette ──────────────────────────────────
NAVY   = colors.HexColor("#0d1b2a")
DB     = colors.HexColor("#1a237e")
MB     = colors.HexColor("#1565c0")
LB     = colors.HexColor("#e3f2fd")
TEAL_D = colors.HexColor("#00695c")
TEAL_M = colors.HexColor("#00897b")
TEAL_L = colors.HexColor("#e0f2f1")
GD     = colors.HexColor("#1b5e20")
GM     = colors.HexColor("#2e7d32")
GL     = colors.HexColor("#e8f5e9")
OD     = colors.HexColor("#e65100")
OM     = colors.HexColor("#f57c00")
OL     = colors.HexColor("#fff3e0")
PD     = colors.HexColor("#4a148c")
PM     = colors.HexColor("#6a1b9a")
PL     = colors.HexColor("#f3e5f5")
RD     = colors.HexColor("#b71c1c")
RL     = colors.HexColor("#ffebee")
GLD    = colors.HexColor("#f9a825")
GLLD   = colors.HexColor("#fffde7")
GRY    = colors.HexColor("#f5f5f5")
WH     = colors.white
BK     = colors.HexColor("#212121")
PINK_D = colors.HexColor("#880e4f")
PINK_L = colors.HexColor("#fce4ec")
CYAN_D = colors.HexColor("#006064")
CYAN_L = colors.HexColor("#e0f7fa")

def PS(name, **kw):
    d = dict(fontName="Helvetica", fontSize=9, leading=13, textColor=BK)
    d.update(kw)
    return ParagraphStyle(name, **d)

TITLE = PS("T",  fontName="Helvetica-Bold", fontSize=22, textColor=WH, alignment=TA_CENTER, leading=28)
SUB   = PS("S",  fontName="Helvetica",      fontSize=10, textColor=WH, alignment=TA_CENTER, leading=14)
SEC   = PS("Sc", fontName="Helvetica-Bold", fontSize=11.5, textColor=WH, leading=15)
BODY  = PS("B",  fontSize=9, leading=13)
BOLD  = PS("Bd", fontName="Helvetica-Bold", fontSize=9, leading=13)
SM    = PS("Sm", fontSize=8, leading=11)
SMB   = PS("Sb", fontName="Helvetica-Bold", fontSize=8, leading=11)
HC    = PS("Hc", fontName="Helvetica-Bold", fontSize=8.5, textColor=WH, alignment=TA_CENTER, leading=12)
TIP   = PS("Tp", fontName="Helvetica-Bold", fontSize=9, textColor=GLD, alignment=TA_CENTER, leading=13)
WB    = PS("Wb", fontName="Helvetica-Bold", fontSize=9, textColor=WH, leading=12)

def sp(h=4): return Spacer(1, h)

def sec_bar(text, color):
    t = Table([[Paragraph(text, SEC)]], colWidths=[W])
    t.setStyle(TableStyle([
        ("BACKGROUND",(0,0),(-1,-1),color),
        ("TOPPADDING",(0,0),(-1,-1),6), ("BOTTOMPADDING",(0,0),(-1,-1),6),
        ("LEFTPADDING",(0,0),(-1,-1),10),
    ]))
    return t

def ibox(para, bg, border):
    t = Table([[para]], colWidths=[W])
    t.setStyle(TableStyle([
        ("BACKGROUND",(0,0),(-1,-1),bg),
        ("BOX",(0,0),(-1,-1),1.2,border),
        ("TOPPADDING",(0,0),(-1,-1),7), ("BOTTOMPADDING",(0,0),(-1,-1),7),
        ("LEFTPADDING",(0,0),(-1,-1),10), ("RIGHTPADDING",(0,0),(-1,-1),10),
    ]))
    return t

def mem_box(text):
    t = Table([[Paragraph(f"🧠  {text}", TIP)]], colWidths=[W])
    t.setStyle(TableStyle([
        ("BACKGROUND",(0,0),(-1,-1),GLLD),
        ("BOX",(0,0),(-1,-1),1.2,GLD),
        ("TOPPADDING",(0,0),(-1,-1),5), ("BOTTOMPADDING",(0,0),(-1,-1),5),
    ]))
    return t

def side_box(title, content_para, cw, hc, bg):
    t = Table([[Paragraph(title, HC)], [content_para]], colWidths=[cw])
    t.setStyle(TableStyle([
        ("BACKGROUND",(0,0),(0,0),hc),
        ("BACKGROUND",(0,1),(0,1),bg),
        ("BOX",(0,0),(-1,-1),0.5,hc),
        ("TOPPADDING",(0,0),(-1,-1),5), ("BOTTOMPADDING",(0,0),(-1,-1),5),
        ("LEFTPADDING",(0,0),(-1,-1),7),
    ]))
    return t

def ctable(headers, rows, cw, hc, alt):
    data = [[Paragraph(h, HC) for h in headers]]
    for i, row in enumerate(rows):
        data.append([Paragraph(str(c), SM) for c in row])
    t = Table(data, colWidths=cw)
    styles = [
        ("BACKGROUND",(0,0),(-1,0),hc),
        ("ROWBACKGROUNDS",(0,1),(-1,-1),[alt, WH]),
        ("GRID",(0,0),(-1,-1),0.4,colors.HexColor("#cccccc")),
        ("TOPPADDING",(0,0),(-1,-1),4), ("BOTTOMPADDING",(0,0),(-1,-1),4),
        ("LEFTPADDING",(0,0),(-1,-1),5), ("VALIGN",(0,0),(-1,-1),"MIDDLE"),
    ]
    t.setStyle(TableStyle(styles))
    return t

# ══════════════════════════════════════════════════
story = []

# ── COVER ──────────────────────────────────────────
cover = Table([
    [Paragraph("💉  IMMUNIZATION vs VACCINATION", TITLE)],
    [Paragraph("PSM Quick Revision  •  Park's Textbook of Preventive & Social Medicine", SUB)],
    [Paragraph("Active Immunization  •  Passive Immunization  •  Types of Vaccines  •  Herd Immunity  •  Cold Chain  •  UIP", 
               PS("cv3", fontSize=8.5, textColor=colors.HexColor("#bbdefb"), alignment=TA_CENTER, leading=12))],
], colWidths=[W])
cover.setStyle(TableStyle([
    ("BACKGROUND",(0,0),(0,0),NAVY),
    ("BACKGROUND",(0,1),(0,1),DB),
    ("BACKGROUND",(0,2),(0,2),MB),
    ("TOPPADDING",(0,0),(0,0),12), ("BOTTOMPADDING",(0,0),(0,0),4),
    ("TOPPADDING",(0,1),(0,1),5), ("BOTTOMPADDING",(0,1),(0,1),5),
    ("TOPPADDING",(0,2),(0,2),4), ("BOTTOMPADDING",(0,2),(0,2),10),
]))
story += [cover, sp(7)]

# ── DEFINITIONS ────────────────────────────────────
story.append(sec_bar("📖  KEY DEFINITIONS  (Start Here!)", DB))
story += [sp(4)]

def_data = [
    [Paragraph("Term", HC), Paragraph("Simple Meaning", HC), Paragraph("Technical Meaning (Park's)", HC)],
    [Paragraph("<b>VACCINE</b>", SMB),
     Paragraph("The substance injected / given", SM),
     Paragraph('"An immuno-biological substance designed to produce specific protection against a given disease. It stimulates the production of protective antibody and other immune mechanisms."', SM)],
    [Paragraph("<b>VACCINATION</b>", SMB),
     Paragraph("The ACT of giving a vaccine", SM),
     Paragraph("Physical act of administering a vaccine (injection, oral drop, spray). Done by a healthcare worker.", SM)],
    [Paragraph("<b>IMMUNIZATION</b>", SMB),
     Paragraph("The process of BECOMING immune", SM),
     Paragraph("Biological process by which an individual becomes resistant to a disease — through vaccination OR natural infection. BROADER term than vaccination.", SM)],
]
def_tbl = Table(def_data, colWidths=[3.5*cm, 4*cm, 10.2*cm])
def_tbl.setStyle(TableStyle([
    ("BACKGROUND",(0,0),(-1,0),DB),
    ("ROWBACKGROUNDS",(0,1),(-1,-1),[LB,WH,LB]),
    ("GRID",(0,0),(-1,-1),0.4,colors.HexColor("#cccccc")),
    ("TOPPADDING",(0,0),(-1,-1),5), ("BOTTOMPADDING",(0,0),(-1,-1),5),
    ("LEFTPADDING",(0,0),(-1,-1),5), ("VALIGN",(0,0),(-1,-1),"TOP"),
]))
story += [def_tbl, sp(5)]

# ── BIG DIFFERENCE TABLE ───────────────────────────
story.append(sec_bar("⚖  VACCINATION  vs  IMMUNIZATION  —  KEY DIFFERENCE", MB))
story += [sp(4)]

diff_data = [
    [Paragraph("Feature", HC), Paragraph("VACCINATION", HC), Paragraph("IMMUNIZATION", HC)],
    [Paragraph("<b>Meaning</b>", SMB), Paragraph("Act of giving a vaccine", SM), Paragraph("Process of becoming immune", SM)],
    [Paragraph("<b>Nature</b>", SMB), Paragraph("Physical act", SM), Paragraph("Biological process", SM)],
    [Paragraph("<b>Who performs it</b>", SMB), Paragraph("Healthcare worker", SM), Paragraph("The body's own immune system", SM)],
    [Paragraph("<b>Always leads to protection?</b>", SMB), Paragraph("Not necessarily (some may not respond)", SM), Paragraph("Yes — by definition", SM)],
    [Paragraph("<b>Can happen naturally?</b>", SMB), Paragraph("No — only through deliberate act", SM), Paragraph("Yes — through natural infection too", SM)],
    [Paragraph("<b>Example</b>", SMB), Paragraph("Giving BCG injection to a newborn", SM), Paragraph("Newborn developing immunity against TB", SM)],
    [Paragraph("<b>Which is broader?</b>", SMB), Paragraph("Narrower term", SM), Paragraph("BROADER term (includes vaccination + natural infection)", SM)],
]
diff_tbl = Table(diff_data, colWidths=[4.5*cm, 6.2*cm, 7*cm])
diff_tbl.setStyle(TableStyle([
    ("BACKGROUND",(0,0),(0,0),MB),
    ("BACKGROUND",(1,0),(1,0),TEAL_D),
    ("BACKGROUND",(2,0),(2,0),GM),
    ("ROWBACKGROUNDS",(0,1),(-1,-1),[LB,WH]),
    ("GRID",(0,0),(-1,-1),0.4,colors.HexColor("#cccccc")),
    ("TOPPADDING",(0,0),(-1,-1),4), ("BOTTOMPADDING",(0,0),(-1,-1),4),
    ("LEFTPADDING",(0,0),(-1,-1),5), ("VALIGN",(0,0),(-1,-1),"MIDDLE"),
]))
story += [diff_tbl, sp(4)]
story.append(ibox(Paragraph(
    '<b>Analogy:</b> Vaccination = planting a seed.  Immunization = tree grown and bearing fruit (protection). '
    'You plant the seed (vaccinate) but the tree must grow on its own (immune response = immunization). '
    'Not every seed always grows — similarly not everyone responds to every vaccine!', BODY), LB, MB))
story += [sp(7)]

# ── TYPES OF IMMUNIZATION ─────────────────────────
story.append(sec_bar("🔄  TYPES OF IMMUNIZATION", TEAL_D))
story += [sp(4)]

# Active box
active_box = side_box("ACTIVE IMMUNIZATION", Paragraph(
    '<b>Body makes its OWN antibodies</b><br/><br/>'
    '<b>How:</b> Give vaccine → body produces antibodies<br/>'
    '<b>Onset:</b> Delayed (days to weeks)<br/>'
    '<b>Duration:</b> Long-lasting / <b>Lifelong</b><br/>'
    '<b>Types:</b><br/>'
    '&nbsp;&nbsp;• <b>Naturally acquired</b> — through actual infection<br/>'
    '&nbsp;&nbsp;• <b>Artificially acquired</b> — through vaccination<br/><br/>'
    '<b>Examples:</b> BCG, OPV, DPT, Measles, Hepatitis B<br/><br/>'
    'Park\'s: <i>"One of the most powerful and cost-effective weapons of modern medicine"</i>', SM),
    8.65*cm, TEAL_D, TEAL_L)

passive_box = side_box("PASSIVE IMMUNIZATION", Paragraph(
    '<b>READY-MADE antibodies given from outside</b><br/><br/>'
    '<b>How:</b> Immunoglobulins/antisera injected<br/>'
    '<b>Onset:</b> <b>Immediate</b><br/>'
    '<b>Duration:</b> Short — <b>only 1–6 weeks</b><br/>'
    '<b>3 Types of preparations:</b><br/>'
    '&nbsp;&nbsp;1. Normal human immunoglobulin<br/>'
    '&nbsp;&nbsp;2. Specific (hyperimmune) human immunoglobulin<br/>'
    '&nbsp;&nbsp;3. Antisera or anti-toxins (animal-derived)<br/><br/>'
    '<b>Examples:</b> Anti-tetanus serum, Anti-rabies Ig<br/>'
    '<b>Limitation:</b> Limited value in mass disease control', SM),
    8.65*cm, PM, PL)
story += [Table([[active_box, passive_box]], colWidths=[8.85*cm, 8.85*cm],
    style=[("VALIGN",(0,0),(-1,-1),"TOP"),("LEFTPADDING",(1,0),(1,0),4)]), sp(5)]

# Active vs Passive comparison
act_pass_data = [
    [Paragraph("Feature", HC), Paragraph("ACTIVE Immunization", HC), Paragraph("PASSIVE Immunization", HC)],
    [Paragraph("<b>Who makes antibodies?</b>", SMB), Paragraph("The person themselves", SM), Paragraph("Given from outside (another person/animal)", SM)],
    [Paragraph("<b>Onset of protection</b>", SMB), Paragraph("Delayed (days to weeks)", SM), Paragraph("Immediate", SM)],
    [Paragraph("<b>Duration</b>", SMB), Paragraph("Long-lasting / Lifelong", SM), Paragraph("Short — 1 to 6 weeks only", SM)],
    [Paragraph("<b>Examples</b>", SMB), Paragraph("BCG, OPV, DPT, MMR, Hep B", SM), Paragraph("ATS, Anti-rabies Ig, Normal Ig", SM)],
    [Paragraph("<b>Use in mass control</b>", SMB), Paragraph("Primary strategy", SM), Paragraph("Limited value (short duration)", SM)],
    [Paragraph("<b>Reactions</b>", SMB), Paragraph("Generally mild", SM), Paragraph("Can occur (esp. animal antisera)", SM)],
    [Paragraph("<b>Combined use</b>", SMB), Paragraph("Tetanus: TT + ATS together for immediate + long-term", SM), Paragraph("Given at different sites from vaccine", SM)],
]
ap_tbl = Table(act_pass_data, colWidths=[4.5*cm, 6.2*cm, 7*cm])
ap_tbl.setStyle(TableStyle([
    ("BACKGROUND",(0,0),(0,0),TEAL_D),
    ("BACKGROUND",(1,0),(1,0),TEAL_D),
    ("BACKGROUND",(2,0),(2,0),PM),
    ("ROWBACKGROUNDS",(0,1),(-1,-1),[TEAL_L,WH]),
    ("GRID",(0,0),(-1,-1),0.4,colors.HexColor("#cccccc")),
    ("TOPPADDING",(0,0),(-1,-1),4), ("BOTTOMPADDING",(0,0),(-1,-1),4),
    ("LEFTPADDING",(0,0),(-1,-1),5), ("VALIGN",(0,0),(-1,-1),"MIDDLE"),
]))
story += [ap_tbl, sp(4)]
story.append(ibox(Paragraph(
    '⚠  <b>Important Rule:</b> Immunoglobulin should NOT be given within <b>3 weeks BEFORE</b> or until '
    '<b>2 weeks AFTER</b> a live attenuated vaccine — they INTERFERE with each other!<br/>'
    'Exception: Hepatitis B vaccine + Hepatitis B immunoglobulin CAN be given together.',
    PS("warn", fontName="Helvetica-Bold", fontSize=8.5, textColor=RD, leading=12)), RL, RD))
story += [sp(4), mem_box(
    "Active = A = Antibodies made by yourself | Passive = P = Pre-made antibodies given | "
    "Active = Delayed but LONG | Passive = Immediate but SHORT (1–6 weeks)"), sp(7)]

# ── TYPES OF VACCINES ──────────────────────────────
story.append(sec_bar("🧪  TYPES OF VACCINES", OD))
story += [sp(4)]

vax_data = [
    [Paragraph("Type", HC), Paragraph("How Prepared", HC), Paragraph("Examples", HC), Paragraph("Key Feature", HC)],
    [Paragraph("<b>A. Live Attenuated</b>", SMB),
     Paragraph("Weakened live organisms (passed in lab repeatedly)", SM),
     Paragraph("BCG, OPV, MMR, Measles, Yellow Fever (17D), Varicella, Rotavirus", SM),
     Paragraph("Single dose; mimics natural infection; strongest immunity; heat-sensitive", SM)],
    [Paragraph("<b>B. Killed / Inactivated</b>", SMB),
     Paragraph("Dead organisms or their parts", SM),
     Paragraph("DPT, IPV, Hepatitis A, Typhoid (Vi), Influenza, Cholera, Rabies", SM),
     Paragraph("Multiple doses needed; safe in pregnancy; stable at room temp", SM)],
    [Paragraph("<b>C. Toxoids</b>", SMB),
     Paragraph("Bacterial toxin chemically treated to be harmless (but still immunogenic)", SM),
     Paragraph("Tetanus Toxoid (TT), Diphtheria Toxoid (in DPT)", SM),
     Paragraph("Antibodies made against the TOXIN not the organism", SM)],
    [Paragraph("<b>D. Subunit / Recombinant</b>", SMB),
     Paragraph("Only a piece/protein of the organism; made by genetic engineering", SM),
     Paragraph("Hepatitis B (HBsAg), HPV vaccine, Acellular pertussis (DTaP)", SM),
     Paragraph("Very safe; no live organism; newer technology", SM)],
]
vax_tbl = Table(vax_data, colWidths=[4*cm, 4.5*cm, 5.2*cm, 4*cm])
vax_tbl.setStyle(TableStyle([
    ("BACKGROUND",(0,0),(-1,0),OD),
    ("BACKGROUND",(0,1),(-1,1),OL),
    ("BACKGROUND",(0,2),(-1,2),WH),
    ("BACKGROUND",(0,3),(-1,3),OL),
    ("BACKGROUND",(0,4),(-1,4),WH),
    ("GRID",(0,0),(-1,-1),0.4,colors.HexColor("#cccccc")),
    ("TOPPADDING",(0,0),(-1,-1),4), ("BOTTOMPADDING",(0,0),(-1,-1),4),
    ("LEFTPADDING",(0,0),(-1,-1),5), ("VALIGN",(0,0),(-1,-1),"MIDDLE"),
]))
story += [vax_tbl, sp(5)]

# Live vs Killed comparison (Park's Table 30)
story.append(Paragraph("<b>LIVE vs KILLED VACCINE — Park's Comparison Table (Table 30)</b>", BOLD))
story += [sp(3)]
lk_data = [
    [Paragraph("Feature", HC), Paragraph("KILLED Vaccine", HC), Paragraph("LIVE Attenuated Vaccine", HC)],
    [Paragraph("Number of doses", SMB), Paragraph("Multiple (need boosters)", SM), Paragraph("Single dose usually enough", SM)],
    [Paragraph("Need for adjuvant", SMB), Paragraph("Yes", SM), Paragraph("No", SM)],
    [Paragraph("Duration of immunity", SMB), Paragraph("Shorter", SM), Paragraph("Longer", SM)],
    [Paragraph("Effectiveness", SMB), Paragraph("Lower", SM), Paragraph("Greater (mimics natural infection)", SM)],
    [Paragraph("Immunoglobulins produced", SMB), Paragraph("IgG only", SM), Paragraph("IgA + IgG", SM)],
    [Paragraph("Mucosal immunity", SMB), Paragraph("Poor", SM), Paragraph("Yes", SM)],
    [Paragraph("Cell-mediated immunity", SMB), Paragraph("Poor", SM), Paragraph("Yes", SM)],
    [Paragraph("Reversion to virulence", SMB), Paragraph("No", SM), Paragraph("Possible (e.g., VAPP from OPV)", SM)],
    [Paragraph("Stability at room temp", SMB), Paragraph("High", SM), Paragraph("Low (heat-sensitive!)", SM)],
    [Paragraph("Safe in pregnancy", SMB), Paragraph("Yes", SM), Paragraph("Contraindicated", SM)],
    [Paragraph("Safe in immunocompromised", SMB), Paragraph("Yes", SM), Paragraph("Contraindicated", SM)],
    [Paragraph("Two live vaccines rule", SMB), Paragraph("N/A", SM), Paragraph("Same time at different sites OR ≥3 weeks apart", SM)],
]
lk_tbl = Table(lk_data, colWidths=[5*cm, 5.5*cm, 7.2*cm])
lk_styles = [
    ("BACKGROUND",(0,0),(0,0),OD),
    ("BACKGROUND",(1,0),(1,0),GM),
    ("BACKGROUND",(2,0),(2,0),MB),
    ("GRID",(0,0),(-1,-1),0.4,colors.HexColor("#cccccc")),
    ("TOPPADDING",(0,0),(-1,-1),4), ("BOTTOMPADDING",(0,0),(-1,-1),4),
    ("LEFTPADDING",(0,0),(-1,-1),5), ("VALIGN",(0,0),(-1,-1),"MIDDLE"),
]
for i in range(1, len(lk_data)):
    lk_styles.append(("BACKGROUND",(0,i),(-1,i), OL if i%2==1 else WH))
lk_tbl.setStyle(TableStyle(lk_styles))
story += [lk_tbl, sp(4),
    mem_box("Live vaccines: BCG-MOVR (BCG, Measles, OPV, Varicella, Rotavirus) + YF, MMR | "
            "Killed: DIT-HCI (DPT, IPV, Typhoid, Hep A, Cholera, Influenza)"), sp(7)]

# ── HERD IMMUNITY ──────────────────────────────────
story.append(sec_bar("🐄  HERD IMMUNITY  (Community Immunity)", GM))
story += [sp(4)]

herd_box = side_box("DEFINITION (Park's)", Paragraph(
    '"Herd immunity describes a type of immunity that occurs when the vaccination of a '
    '<b>portion of the population</b> provides protection to <b>unprotected individuals</b>. '
    'When large numbers are immune, it is difficult to maintain a chain of infection — '
    'the lower the likelihood a susceptible person will contact an infectious agent."<br/><br/>'
    '<b>Elements of herd immunity:</b><br/>'
    '1. Clinical + subclinical infection in the herd<br/>'
    '2. Immunization of the herd<br/>'
    '3. Herd structure (births, deaths, migration)', SM),
    8.65*cm, GM, GL)

thresh_box = side_box("HERD IMMUNITY THRESHOLD", Paragraph(
    '"The proportion of immune individuals above which a disease may <b>no longer persist</b>"<br/><br/>'
    'Varies with:<br/>'
    '• Virulence of the disease<br/>'
    '• Efficacy of the vaccine<br/>'
    '• Contact parameter (how infectious)<br/><br/>'
    '<b>Approximate thresholds:</b><br/>'
    '• Measles: ~<b>95%</b> needed<br/>'
    '• Polio: ~<b>80–85%</b><br/>'
    '• Smallpox: ~<b>80–85%</b><br/><br/>'
    '<b>Note:</b> In <b>tetanus</b>, herd immunity does <b>NOT</b> protect the<br/>'
    'individual (tetanus comes from soil, not person-to-person)', SM),
    8.65*cm, GM, GL)
story += [Table([[herd_box, thresh_box]], colWidths=[8.85*cm, 8.85*cm],
    style=[("VALIGN",(0,0),(-1,-1),"TOP"),("LEFTPADDING",(1,0),(1,0),4)]), sp(4)]
story.append(ibox(Paragraph(
    '<b>Simple explanation:</b> When enough people are immune → the disease cannot find susceptible people easily → '
    'chain of infection breaks → even <b>unvaccinated people are protected</b> (babies, immunocompromised). '
    'Example: Measles in Faroe Islands (1854) — virgin population, near 100% attack rate. '
    'Epidemic stopped as herd immunity built up. Determined by <b>serological surveys</b>.', BODY), GL, GM))
story += [sp(7)]

# ── COLD CHAIN ─────────────────────────────────────
story.append(sec_bar("❄  COLD CHAIN", CYAN_D))
story += [sp(4)]

cc_def = side_box("DEFINITION (Park's)", Paragraph(
    '"The cold chain is a system of storage and transport of vaccines at <b>low temperature</b> '
    'from the <b>manufacturer to the actual vaccination site</b>."<br/><br/>'
    '<b>Why needed:</b> Vaccine failure occurs if temperature not maintained. '
    'Once vaccine potency is lost, it <b>CANNOT be regained</b>.<br/><br/>'
    '<b>6 RIGHTS of Supply Chain:</b><br/>'
    '1. Right <b>Vaccine</b><br/>'
    '2. Right <b>Quantity</b><br/>'
    '3. Right <b>Place</b><br/>'
    '4. Right <b>Time</b><br/>'
    '5. Right <b>Condition</b> (no temperature break)<br/>'
    '6. Right <b>Cost</b>', SM),
    8.65*cm, CYAN_D, CYAN_L)

temp_box = side_box("TEMPERATURE REQUIREMENTS", Paragraph(
    '<b>Most vaccines:</b> +2°C to +8°C<br/>'
    '<b>Yellow Fever (17D):</b> +5°C to −30°C (can be frozen)<br/><br/>'
    '<b>Vaccines SENSITIVE TO FREEZING (DO NOT FREEZE!):</b><br/>'
    '• Hepatitis B<br/>'
    '• DPT / Pentavalent<br/>'
    '• Tetanus Toxoid (TT)<br/>'
    '• IPV (injectable polio)<br/>'
    '• Cholera, HPV, Influenza<br/><br/>'
    '<b>Most heat-sensitive:</b> Live vaccines (BCG, OPV, measles, YF)<br/><br/>'
    '<b>Multi-dose vial after opening:</b><br/>'
    'Use within <b>4 hours</b> OR keep at +2°C to +8°C', SM),
    8.65*cm, CYAN_D, CYAN_L)
story += [Table([[cc_def, temp_box]], colWidths=[8.85*cm, 8.85*cm],
    style=[("VALIGN",(0,0),(-1,-1),"TOP"),("LEFTPADDING",(1,0),(1,0),4)]), sp(4),
    mem_box("6 Rights = VQP-TCC: Vaccine, Quantity, Place, Time, Condition, Cost | "
            "DO NOT FREEZE: Hep B, DPT, TT, IPV | Use opened multi-dose vial within 4 hours"), sp(7)]

# ── UIP + EPI ──────────────────────────────────────
story.append(sec_bar("🏥  UIP &amp; EPI  —  National Immunization Programme", PINK_D))
story += [sp(4)]

epi_uip_data = [
    [Paragraph("Programme", HC), Paragraph("Details", HC)],
    [Paragraph("<b>EPI — Expanded Programme on Immunization</b>", SMB),
     Paragraph("Launched globally by WHO in <b>May 1974</b>. Goal: protect all children against 6 diseases by 2000. "
               "Launched in India in <b>January 1978</b>. "
               "6 original diseases: <b>Diphtheria, Whooping cough, Tetanus, Polio, TB (BCG), Measles</b>", SM)],
    [Paragraph("<b>Universal Child Immunization</b>", SMB),
     Paragraph("Name given by UNICEF in <b>October 1985</b> (UN's 40th anniversary). Aimed to add impetus to global EPI.", SM)],
    [Paragraph("<b>UIP — Universal Immunization Programme (India)</b>", SMB),
     Paragraph("Launched in India on <b>November 19, 1985</b>. Dedicated to memory of <b>Smt. Indira Gandhi</b>. "
               "Goal: achieve universal immunization coverage by 1990.", SM)],
]
epi_tbl = Table(epi_uip_data, colWidths=[5.5*cm, 12.2*cm])
epi_tbl.setStyle(TableStyle([
    ("BACKGROUND",(0,0),(-1,0),PINK_D),
    ("ROWBACKGROUNDS",(0,1),(-1,-1),[PINK_L, WH, PINK_L]),
    ("GRID",(0,0),(-1,-1),0.4,colors.HexColor("#cccccc")),
    ("TOPPADDING",(0,0),(-1,-1),4), ("BOTTOMPADDING",(0,0),(-1,-1),4),
    ("LEFTPADDING",(0,0),(-1,-1),5), ("VALIGN",(0,0),(-1,-1),"MIDDLE"),
]))
story += [epi_tbl, sp(5)]

# NIS Schedule
story.append(Paragraph("<b>NATIONAL IMMUNIZATION SCHEDULE (NIS) — Key Vaccines</b>", BOLD))
story += [sp(3)]
nis_data = [
    [Paragraph("Age", HC), Paragraph("Vaccines Given", HC)],
    [Paragraph("<b>At BIRTH</b>", SMB), Paragraph("BCG  •  OPV-0 (birth dose)  •  Hepatitis B (birth dose)", SM)],
    [Paragraph("<b>6 weeks</b>", SMB), Paragraph("OPV-1  •  Pentavalent-1 (DPT+HepB+Hib)  •  IPV-1", SM)],
    [Paragraph("<b>10 weeks</b>", SMB), Paragraph("OPV-2  •  Pentavalent-2  •  IPV-2", SM)],
    [Paragraph("<b>14 weeks</b>", SMB), Paragraph("OPV-3  •  Pentavalent-3  •  IPV-3", SM)],
    [Paragraph("<b>9 months</b>", SMB), Paragraph("Measles / MR-1", SM)],
    [Paragraph("<b>16–24 months</b>", SMB), Paragraph("OPV Booster  •  DPT Booster  •  MR-2", SM)],
    [Paragraph("<b>5 years</b>", SMB), Paragraph("DPT Booster  •  OPV Booster", SM)],
    [Paragraph("<b>10 years, 16 years</b>", SMB), Paragraph("TT / Td (Tetanus-diphtheria)", SM)],
    [Paragraph("<b>Pregnant women</b>", SMB), Paragraph("TT — 2 doses 1 month apart (or booster if previously immunized)", SM)],
]
nis_tbl = Table(nis_data, colWidths=[4*cm, 13.7*cm])
nis_styles = [
    ("BACKGROUND",(0,0),(-1,0),PINK_D),
    ("GRID",(0,0),(-1,-1),0.4,colors.HexColor("#cccccc")),
    ("TOPPADDING",(0,0),(-1,-1),4), ("BOTTOMPADDING",(0,0),(-1,-1),4),
    ("LEFTPADDING",(0,0),(-1,-1),5), ("VALIGN",(0,0),(-1,-1),"MIDDLE"),
]
for i in range(1, len(nis_data)):
    nis_styles.append(("BACKGROUND",(0,i),(-1,i), PINK_L if i%2==1 else WH))
nis_tbl.setStyle(TableStyle(nis_styles))
story += [nis_tbl, sp(4)]
story.append(ibox(Paragraph(
    '<b>Pentavalent vaccine</b> = DPT + Hepatitis B + Hib combined. '
    'Replaces DPT + Hep B + Hib individually in NIS.<br/>'
    '<b>Good immunization schedule criteria:</b> (1) Epidemiologically relevant  '
    '(2) Immunologically effective  (3) Operationally feasible  (4) Socially acceptable',
    SM), PINK_L, PINK_D))
story += [sp(4),
    mem_box("UIP = Nov 19, 1985 (India) | EPI = 1974 WHO (India 1978) | "
            "EPI 6 diseases = DPMT-WP: Diphtheria, Pertussis, Measles, Tetanus, TB, Polio"), sp(7)]

# ── EXAM Q&A ───────────────────────────────────────
story.append(sec_bar("❓  MOST LIKELY EXAM QUESTIONS &amp; ANSWERS", RD))
story += [sp(4)]
qa = [
    ("Difference between vaccination and immunization?",
     "Vaccination = physical act of giving a vaccine. Immunization = biological process of becoming immune (broader term — includes vaccination + natural infection)."),
    ("Define active immunization. Give examples.",
     "Body produces its OWN antibodies. Delayed onset but LIFELONG protection. Examples: BCG, OPV, DPT, Measles, Hepatitis B."),
    ("Define passive immunization. Give examples.",
     "Ready-made antibodies given from outside. IMMEDIATE onset but SHORT duration (1–6 weeks). Examples: Anti-tetanus serum (ATS), Anti-rabies immunoglobulin."),
    ("Compare active vs passive immunization.",
     "Active = own antibodies, delayed, lifelong. Passive = given antibodies, immediate, 1–6 weeks only."),
    ("Compare live vs killed vaccines (4 differences).",
     "Live: single dose, longer immunity, IgA+IgG, mucosal immunity, heat-sensitive, may revert to virulence. Killed: multiple doses, shorter immunity, IgG only, stable, safe in pregnancy."),
    ("What are toxoids? Examples.",
     "Bacterial toxin treated chemically to remove toxicity but retain antigenicity. Examples: Tetanus toxoid (TT), Diphtheria toxoid."),
    ("Define herd immunity.",
     "Immunity that occurs when vaccination of a portion of population protects unprotected individuals. Chain of infection breaks when enough are immune."),
    ("What is the cold chain? What are the 6 rights?",
     "System of storage + transport of vaccines at low temperature from manufacturer to vaccination site. 6 Rights: Vaccine, Quantity, Place, Time, Condition, Cost."),
    ("Which vaccines must NOT be frozen?",
     "Hepatitis B, DPT/Pentavalent, TT, IPV, Cholera, HPV, Influenza — protect from sub-zero temperatures."),
    ("What is UIP? When launched in India?",
     "Universal Immunization Programme. Launched November 19, 1985. Dedicated to Smt. Indira Gandhi. EPI launched globally 1974; in India January 1978."),
    ("What are the 6 original EPI diseases?",
     "Diphtheria, Whooping cough (Pertussis), Measles, Tetanus, Tuberculosis (BCG), Poliomyelitis."),
    ("Rule for giving two live vaccines?",
     "Give simultaneously at different sites OR with a gap of at least 3 weeks. NEVER in between. Immunoglobulin: not within 3 weeks before or 2 weeks after a live vaccine."),
]
qa_data = [[Paragraph("#", HC), Paragraph("Question", HC), Paragraph("Answer", HC)]]
for i, (q, a) in enumerate(qa):
    bg = LB if i%2==0 else WH
    qa_data.append([
        Paragraph(str(i+1), PS(f"qn{i}", fontName="Helvetica-Bold", fontSize=9,
                               textColor=WH, alignment=TA_CENTER)),
        Paragraph(q, PS(f"qq{i}", fontName="Helvetica-Bold", fontSize=8,
                        textColor=DB, leading=12)),
        Paragraph(a, SM),
    ])
qa_tbl = Table(qa_data, colWidths=[0.7*cm, 6.5*cm, 10.5*cm])
qa_styles = [
    ("BACKGROUND",(0,0),(-1,0),RD),
    ("GRID",(0,0),(-1,-1),0.4,colors.HexColor("#cccccc")),
    ("TOPPADDING",(0,0),(-1,-1),4), ("BOTTOMPADDING",(0,0),(-1,-1),4),
    ("LEFTPADDING",(0,0),(-1,-1),5), ("VALIGN",(0,0),(-1,-1),"MIDDLE"),
]
for i in range(1, len(qa)+1):
    qa_styles.append(("BACKGROUND",(0,i),(0,i), DB))
    qa_styles.append(("BACKGROUND",(1,i),(2,i), LB if i%2==1 else WH))
qa_tbl.setStyle(TableStyle(qa_styles))
story += [qa_tbl, sp(6)]

# ── MEMORY FOOTER STRIP ────────────────────────────
labels = [
    (DB,    "Vaccination = ACT\nImmunization = PROCESS"),
    (TEAL_D,"Active = Own Abs\nPassive = Given Abs"),
    (OD,    "Live: BCG-MOVR\nKilled: DIT-HCI"),
    (GM,    "Herd = Community\nprotects all"),
    (CYAN_D,"6 Rights: VQP-TCC\nNo freeze: HepB DPT TT"),
    (PINK_D,"UIP: Nov 19, 1985\nEPI: 1974 WHO"),
]
mem_cells = [[
    Paragraph(lbl, PS(f"mf{i}", fontName="Helvetica-Bold", fontSize=7.5,
                      textColor=WH, alignment=TA_CENTER, leading=10))
    for i, (_, lbl) in enumerate(labels)
]]
mem_strip = Table(mem_cells, colWidths=[W/len(labels)]*len(labels))
ms_style = [
    ("TOPPADDING",(0,0),(-1,-1),6), ("BOTTOMPADDING",(0,0),(-1,-1),6),
    ("VALIGN",(0,0),(-1,-1),"MIDDLE"),
]
for i, (clr, _) in enumerate(labels):
    ms_style.append(("BACKGROUND",(i,0),(i,0),clr))
mem_strip.setStyle(TableStyle(ms_style))
story.append(mem_strip)

doc = SimpleDocTemplate(OUTPUT, pagesize=A4,
    leftMargin=1.4*cm, rightMargin=1.4*cm,
    topMargin=1.3*cm, bottomMargin=1.3*cm)
doc.build(story)
print("PDF created:", OUTPUT)