Systemic circulation: hypoxia usually causes vasodilation to increase local blood flow and oxygen delivery, particularly in the brain and exercising muscle.
Pulmonary circulation: alveolar hypoxia causes vasoconstriction. This diverts blood away from poorly ventilated alveoli toward better-ventilated areas, improving V/Q matching.
With widespread or chronic lung hypoxia, pulmonary vasoconstriction can raise pulmonary arterial pressure and contribute to pulmonary hypertension. Pulmonary circulation review
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