const pptxgen = require("pptxgenjs");
const { execSync } = require("child_process");
const fs = require("fs");

// ── Helper: fetch images as base64 ───────────────────────────────────────────
function fetchImgs(urls) {
  try {
    const result = execSync(
      `node /home/daytona/skills/shared/scripts/fetch_images.js ${urls.map(u => `"${u}"`).join(" ")}`,
      { timeout: 60000 }
    ).toString();
    return JSON.parse(result);
  } catch (e) {
    console.error("Image fetch error:", e.message);
    return urls.map(u => ({ url: u, base64: null, error: e.message }));
  }
}

// ── Image URLs (Kanski textbook clinical images) ─────────────────────────────
const IMG_URLS = [
  // serpiginous early active (peripapilar white lesion)
  "https://cdn.orris.care/cdss_images/6c9ce0eb1ece304a020b0404aa0fadba164390e9d415378f8a1b1b0abed5bd7e.png",
  // serpiginous advanced scarring with RPE changes
  "https://cdn.orris.care/cdss_images/ee030616e6bbe3d5efcbab9ee62c40725effddf051be5f5a54cbf624e311f3d9.png",
  // MFC inactive lesions fundus
  "https://cdn.orris.care/cdss_images/e9d838a582b02386b0abc10c5df05931c14c00c131b5b7702cf1ad16f4201c62.png",
  // fungal (candida/aspergillus) choroiditis panel
  "https://cdn.orris.care/cdss_images/828ec6e4b716df6b35caf32a210b3ff2baf83ed4244b69b7b3ebf2f93e18b05a.png",
  // serpiginous advanced chorioretinal atrophy
  "https://cdn.orris.care/cdss_images/7753836a09dd5069bfd64e9c4213ef40143e55bfe7ef0c95d9fcfb7bd7187467.png",
];

console.log("Fetching images...");
const imgs = fetchImgs(IMG_URLS);
const img = (i) => imgs[i] && imgs[i].base64 ? imgs[i].base64 : null;

// ── Presentation setup ────────────────────────────────────────────────────────
const pres = new pptxgen();
pres.layout = "LAYOUT_16x9";
pres.title = "Choroiditis – A Complete Review";
pres.author = "Medical Education";

// ── Design constants (matching Retinitis_Complete.pptx exactly) ──────────────
const C_BG      = "FFFFFF";
const C_NAVY    = "1E3A5F";
const C_HEAD    = "1A1A1A";
const C_TEXT    = "2C2C2C";
const C_ACCENT  = "D4E6F1";  // light blue for flowchart boxes
const C_BOX2    = "EAF4FB";  // lighter blue
const C_ARROW   = "1E3A5F";
const FONT      = "Calibri";
const W         = 10;         // slide width inches
const H         = 5.625;      // slide height inches

// ─────────────────────────────────────────────────────────────────────────────
// HELPER FUNCTIONS
// ─────────────────────────────────────────────────────────────────────────────

function applyBg(slide) {
  slide.background = { color: C_BG };
}

/** Standard content slide: heading + divider line */
function addHeading(slide, title) {
  // heading text
  slide.addText(title, {
    x: 0.33, y: 0.1, w: 9.34, h: 0.62,
    fontSize: 24, bold: true, color: C_HEAD, fontFace: FONT,
    valign: "middle", margin: 0,
  });
  // divider line
  slide.addShape(pres.ShapeType.rect, {
    x: 0.33, y: 0.75, w: 9.34, h: 0.03,
    fill: { color: C_NAVY }, line: { color: C_NAVY, width: 0 },
  });
}

/** Add bullet list (max 6 items) */
function addBullets(slide, items, opts = {}) {
  const defaults = { x: 0.43, y: 0.85, w: 9.2, h: 4.65, fontSize: 17, color: C_TEXT, fontFace: FONT };
  const cfg = { ...defaults, ...opts };
  const textArr = items.map((item, i) => ({
    text: item,
    options: {
      bullet: { indent: 15 },
      breakLine: i < items.length - 1,
      fontSize: cfg.fontSize,
      color: cfg.color,
      fontFace: cfg.fontFace,
    }
  }));
  slide.addText(textArr, { x: cfg.x, y: cfg.y, w: cfg.w, h: cfg.h, valign: "top" });
}

/** Two-column layout: bullets left, image right */
function addBulletsWithImage(slide, items, imgData, imgCaption = "") {
  const textArr = items.map((item, i) => ({
    text: item,
    options: {
      bullet: { indent: 15 },
      breakLine: i < items.length - 1,
      fontSize: 16,
      color: C_TEXT,
      fontFace: FONT,
    }
  }));
  slide.addText(textArr, { x: 0.43, y: 0.85, w: 5.7, h: 4.65, valign: "top" });
  if (imgData) {
    slide.addImage({ data: imgData, x: 6.25, y: 0.88, w: 3.5, h: 3.3 });
    if (imgCaption) {
      slide.addText(imgCaption, {
        x: 6.25, y: 4.22, w: 3.5, h: 0.35,
        fontSize: 10, color: "888888", fontFace: FONT, italic: true, align: "center"
      });
    }
  }
}

/** Flowchart box */
function addFcBox(slide, label, x, y, w = 2.6, h = 0.52, fill = C_ACCENT, textColor = C_NAVY, sz = 13) {
  slide.addShape(pres.ShapeType.roundRect, {
    x, y, w, h,
    fill: { color: fill },
    line: { color: C_NAVY, width: 1.5 },
    rectRadius: 0.1,
  });
  slide.addText(label, {
    x, y, w, h,
    fontSize: sz, bold: true, color: textColor, fontFace: FONT,
    align: "center", valign: "middle", margin: 0,
  });
}

/** Downward arrow between flowchart boxes */
function addFcArrow(slide, x, y1, y2) {
  slide.addShape(pres.ShapeType.line, {
    x: x + 0.02, y: y1, w: 0, h: y2 - y1,
    line: { color: C_NAVY, width: 1.5, endArrowType: "triangle" },
  });
}

// ─────────────────────────────────────────────────────────────────────────────
// SLIDE 1 – TITLE SLIDE
// ─────────────────────────────────────────────────────────────────────────────
{
  const s = pres.addSlide();
  applyBg(s);
  // top bar
  s.addShape(pres.ShapeType.rect, { x: 0, y: 0, w: W, h: 0.2, fill: { color: C_NAVY }, line: { color: C_NAVY } });
  // bottom bar
  s.addShape(pres.ShapeType.rect, { x: 0, y: 5.4, w: W, h: 0.22, fill: { color: C_NAVY }, line: { color: C_NAVY } });
  // Main title
  s.addText("CHOROIDITIS", {
    x: 0.5, y: 0.42, w: 9, h: 1.2,
    fontSize: 54, bold: true, color: C_HEAD, fontFace: FONT, align: "center", valign: "middle",
  });
  // Subtitle
  s.addText("Complete Review: Basic to Advanced", {
    x: 0.5, y: 1.65, w: 9, h: 0.6,
    fontSize: 20, italic: true, color: C_NAVY, fontFace: FONT, align: "center",
  });
  // Divider
  s.addShape(pres.ShapeType.rect, { x: 2, y: 2.4, w: 6, h: 0.04, fill: { color: C_NAVY }, line: { color: C_NAVY } });
  // Source note
  s.addText("Reference: Kanski's Clinical Ophthalmology 10th Ed. | Ryan's Retina 6th Ed.", {
    x: 0.5, y: 2.55, w: 9, h: 0.45,
    fontSize: 14, color: "666666", fontFace: FONT, align: "center", italic: true,
  });
  // Topic overview
  const topics = [
    "Anatomy & Choroidal Layers",
    "Pathogenesis & Classification",
    "Clinical Features & Investigations",
    "Specific Entities (Infectious & Non-infectious)",
    "Treatment Flowcharts",
    "Recent Advances & Clinical Trials (2022-2026)",
  ];
  const tArr = topics.map((t, i) => ({
    text: (i + 1) + ".  " + t,
    options: { breakLine: i < topics.length - 1, fontSize: 14, color: C_TEXT, fontFace: FONT }
  }));
  s.addText(tArr, { x: 1.8, y: 3.1, w: 6.4, h: 2.1, valign: "top" });
}

// ─────────────────────────────────────────────────────────────────────────────
// SLIDE 2 – ANATOMY OF THE CHOROID
// ─────────────────────────────────────────────────────────────────────────────
{
  const s = pres.addSlide();
  applyBg(s);
  addHeading(s, "Anatomy of the Choroid");
  addBullets(s, [
    "Choroid: highly vascular layer between retina (RPE) and sclera; 0.1–0.2 mm thick posteriorly",
    "Layers (inner to outer): Bruch's membrane → Choriocapillaris → Sattler's layer (medium vessels) → Haller's layer (large vessels) → Suprachoroid",
    "Blood supply: short posterior ciliary arteries (PCA); drainage via vortex veins",
    "Choriocapillaris: fenestrated lobular units — primary target in many choroiditides",
    "Provides 65–85% of outer retinal blood supply; rich in lymphocytes, melanocytes, mast cells",
    "Choroidal stroma: loose connective tissue; supports immune surveillance via resident macrophages",
  ]);
}

// ─────────────────────────────────────────────────────────────────────────────
// SLIDE 3 – DEFINITION & SCOPE
// ─────────────────────────────────────────────────────────────────────────────
{
  const s = pres.addSlide();
  applyBg(s);
  addHeading(s, "Choroiditis – Definition & Scope");
  addBullets(s, [
    "Choroiditis: inflammation of the choroid; may involve RPE, retina, and vitreous",
    "Posterior uveitis: broader term — inflammation behind the lens; choroiditis is a sub-category",
    "Incidence: ~4–6 per 100,000/year for all posterior uveitis; leading cause of visual morbidity in working-age adults",
    "Classification: Infectious vs. Non-infectious; Focal, multifocal, diffuse; Granulomatous vs. Non-granulomatous",
    "ICG-based (Kanski): Primary choriocapillaritis (1A/1B) vs. Primary stromal choroiditis (2A) vs. Secondary stromal (2B)",
    "Key message: choroid is an immune-active tissue — most choroiditides represent immune-mediated processes",
  ]);
}

// ─────────────────────────────────────────────────────────────────────────────
// SLIDE 4 – ETIOLOGY (WHY DOES IT HAPPEN?)
// ─────────────────────────────────────────────────────────────────────────────
{
  const s = pres.addSlide();
  applyBg(s);
  addHeading(s, "Etiology – Why Does It Happen?");
  addBullets(s, [
    "Infectious: bacteria (TB, syphilis, Lyme), viruses (CMV, EBV, VZV), fungi (Candida, Aspergillus, Cryptococcus, PCP), parasites (Toxoplasma, Toxocara)",
    "Autoimmune / idiopathic: MEWDS, APMPPE, multifocal choroiditis (MFC), PIC, serpiginous, birdshot",
    "HLA associations: HLA-A29 (birdshot), HLA-DR4/DRw53 (VKH), HLA-B51 (Behcet)",
    "Systemic disease: Sarcoidosis, VKH, Sympathetic ophthalmia, Behcet disease",
    "Iatrogenic / vaccine-triggered: post-vaccination choroiditis (COVID-19, influenza vaccines reported)",
    "Masquerade: lymphoma, metastases must be excluded in atypical presentations",
  ]);
}

// ─────────────────────────────────────────────────────────────────────────────
// SLIDE 5 – PATHOGENESIS FLOWCHART
// ─────────────────────────────────────────────────────────────────────────────
{
  const s = pres.addSlide();
  applyBg(s);
  addHeading(s, "Pathogenesis – How Does It Happen?");

  // Two parallel pathways: Infectious and Autoimmune
  // Left pathway: Infectious
  const lx = 0.5, rx = 5.5, bw = 3.8, bh = 0.48, gap = 0.2;

  // Column headers
  s.addText("INFECTIOUS PATHWAY", {
    x: lx, y: 0.82, w: bw, h: 0.35,
    fontSize: 12, bold: true, color: C_NAVY, fontFace: FONT, align: "center",
  });
  s.addText("IMMUNE-MEDIATED PATHWAY", {
    x: rx, y: 0.82, w: bw, h: 0.35,
    fontSize: 12, bold: true, color: C_NAVY, fontFace: FONT, align: "center",
  });

  // Infectious column boxes
  const lBoxes = [
    "Pathogen enters (hematogenous\nor direct spread)",
    "Antigenic stimulation of\nchoroidal macrophages/DCs",
    "Th1/Th17 cell activation\n+ cytokine storm (TNF-α, IL-17)",
    "Choriocapillaris endothelial\ndamage & occlusion",
    "RPE disruption → subretinal\nfluid / photoreceptor loss",
  ];
  const rBoxes = [
    "Molecular mimicry or\nautoantigen exposure",
    "T-cell mediated attack on\nchoroidal melanocytes / stroma",
    "B-cell activation &\nautoantibody formation",
    "Granuloma formation or\ndiffuse inflammatory infiltrate",
    "Choriocapillaris dropout\n→ ischaemic atrophy",
  ];

  let ly = 1.2, ry = 1.2;
  for (let i = 0; i < lBoxes.length; i++) {
    addFcBox(s, lBoxes[i], lx, ly, bw, bh, i === 0 ? "D6EAF8" : C_ACCENT, C_NAVY, 11);
    addFcBox(s, rBoxes[i], rx, ry, bw, bh, i === 0 ? "D5F5E3" : "E8F8E8", "1A5C2A", 11);
    if (i < lBoxes.length - 1) {
      const mid = ly + bh + gap / 2;
      addFcArrow(s, lx + bw / 2 - 0.02, ly + bh, ly + bh + gap);
      addFcArrow(s, rx + bw / 2 - 0.02, ry + bh, ry + bh + gap);
    }
    ly += bh + gap;
    ry += bh + gap;
  }

  // Convergence note
  s.addText("Both pathways → Choriocapillaritis → Outer retinal ischaemia → Visual loss", {
    x: 0.5, y: 5.1, w: 9, h: 0.4,
    fontSize: 12, bold: true, color: C_NAVY, fontFace: FONT, align: "center",
    fill: { color: "FFF3CD" },
  });
}

// ─────────────────────────────────────────────────────────────────────────────
// SLIDE 6 – CLASSIFICATION TABLE
// ─────────────────────────────────────────────────────────────────────────────
{
  const s = pres.addSlide();
  applyBg(s);
  addHeading(s, "ICG-Based Classification of Choroiditis (Kanski)");

  const rows = [
    [
      { text: "Category", options: { bold: true, color: "FFFFFF", fill: C_NAVY, align: "center" } },
      { text: "Type", options: { bold: true, color: "FFFFFF", fill: C_NAVY, align: "center" } },
      { text: "Examples", options: { bold: true, color: "FFFFFF", fill: C_NAVY, align: "center" } },
    ],
    [
      { text: "1A", options: { bold: true, color: C_NAVY, fill: "D6EAF8", align: "center" } },
      { text: "Primary choriocapillaritis (unknown trigger)", options: { color: C_TEXT } },
      { text: "MEWDS, APMPPE, Serpiginous, MFC, PIC", options: { color: C_TEXT } },
    ],
    [
      { text: "1B", options: { bold: true, color: C_NAVY, fill: "D6EAF8", align: "center" } },
      { text: "Secondary choriocapillaritis (pathogen-triggered)", options: { color: C_TEXT } },
      { text: "TB-related serpiginous, Acute syphilitic PPPC", options: { color: C_TEXT } },
    ],
    [
      { text: "2A", options: { bold: true, color: "1A5C2A", fill: "D5F5E3", align: "center" } },
      { text: "Primary stromal choroiditis (stroma as target)", options: { color: C_TEXT } },
      { text: "Birdshot (HLA-A29), VKH, Sympathetic ophthalmia", options: { color: C_TEXT } },
    ],
    [
      { text: "2B", options: { bold: true, color: "1A5C2A", fill: "D5F5E3", align: "center" } },
      { text: "Secondary stromal choroiditis", options: { color: C_TEXT } },
      { text: "Sarcoidosis, Tubercular, Syphilitic chorioretinitis", options: { color: C_TEXT } },
    ],
  ];

  s.addTable(rows, {
    x: 0.4, y: 0.88, w: 9.2, h: 4.5,
    rowH: 0.75,
    fontSize: 14, fontFace: FONT,
    colW: [0.7, 3.3, 5.2],
    border: { pt: 1, color: C_NAVY },
  });
}

// ─────────────────────────────────────────────────────────────────────────────
// SLIDE 7 – WHAT HAPPENS: CLINICAL FEATURES
// ─────────────────────────────────────────────────────────────────────────────
{
  const s = pres.addSlide();
  applyBg(s);
  addHeading(s, "What Happens – Clinical Presentation");
  addBullets(s, [
    "Symptoms: blurred vision, photopsia, floaters, scotomata, metamorphopsia, photophobia",
    "Anterior segment: may have AC cells/flare, keratic precipitates (granulomatous = large 'mutton fat' KPs)",
    "Vitreous: vitritis (cells & haze) — severity varies; absent in PIC, mild in MEWDS",
    "Fundus: white/yellow lesions at level of RPE/inner choroid; may be focal, multifocal or diffuse",
    "Complications: choroidal neovascularisation (MNV), cystoid macular oedema, subretinal fibrosis, disc oedema",
    "Systemic clues: skin/hair changes (VKH), lymphadenopathy (sarcoid), genital ulcers (Behcet), HIV status",
  ]);
}

// ─────────────────────────────────────────────────────────────────────────────
// SLIDE 8 – INVESTIGATIONS
// ─────────────────────────────────────────────────────────────────────────────
{
  const s = pres.addSlide();
  applyBg(s);
  addHeading(s, "Investigations");
  addBullets(s, [
    "Multimodal imaging: FFA (early hypo → late hyperfluorescence), ICGA (hypofluorescent lesions), FAF (hyper/hypo-AF borders), OCT (sub-RPE material, outer retinal disruption), OCTA (choriocapillaris flow void)",
    "B-scan ultrasound: choroidal thickening, posterior scleritis; EDI-OCT measures subfoveal choroidal thickness",
    "Serological: FTA-ABS/VDRL (syphilis), TB (Mantoux/IGRA), ANA, ACE, ANCA, HLA-A29, HLA-B51",
    "Aqueous/vitreous PCR: for viral (HSV, VZV, CMV), fungal, and TB in ambiguous cases; Goldmann-Witmer coefficient",
    "Systemic workup: CXR/CT chest (sarcoid), HIV, CECT where malignancy suspected",
    "Visual fields: enlargement of blind spot common in MEWDS/PIC; central scotomas in macular disease",
  ]);
}

// ─────────────────────────────────────────────────────────────────────────────
// SLIDE 9 – MEWDS (with image)
// ─────────────────────────────────────────────────────────────────────────────
{
  const s = pres.addSlide();
  applyBg(s);
  addHeading(s, "MEWDS – Multiple Evanescent White Dot Syndrome");
  addBulletsWithImage(s, [
    "Young adult women; unilateral; acute onset; often post-viral",
    "Tiny (100–300 µm) grey-white dots at posterior pole sparing fovea (which shows orange granularity)",
    "Subtle vitritis (50%); optic disc oedema occasionally",
    "Investigations: FA (early hypofluorescence, late hyperfluorescence), ICGA (hypofluorescent dots), FAF (hyperAF dots), OCT (outer retinal disruption)",
    "Self-limiting over weeks; recurrence in ~10% — suspect MFC if recurrent",
    "No specific treatment required; monitor for MNV",
  ], img(0), "Fig: Serpiginous early lesion (Kanski 10th Ed.)");
}

// ─────────────────────────────────────────────────────────────────────────────
// SLIDE 10 – APMPPE
// ─────────────────────────────────────────────────────────────────────────────
{
  const s = pres.addSlide();
  applyBg(s);
  addHeading(s, "APMPPE – Acute Posterior Multifocal Placoid Pigment Epitheliopathy");
  addBullets(s, [
    "Young adults, bilateral (asymmetric), often follows flu-like illness or vaccination",
    "Cream-coloured placoid lesions at RPE level in posterior pole; resolve in weeks leaving RPE mottling",
    "FA: classic 'early block, late stain' pattern (early hypofluorescence, late hyperfluorescence)",
    "OCTA: choriocapillaris flow deficits — key pathology is choriocapillaris ischaemia",
    "CNS vasculitis reported (headache, CSF pleocytosis) — exclude cerebral involvement",
    "Prognosis generally good; 20% have visual sequelae; recurrence uncommon",
  ]);
}

// ─────────────────────────────────────────────────────────────────────────────
// SLIDE 11 – SERPIGINOUS CHOROIDOPATHY (with image)
// ─────────────────────────────────────────────────────────────────────────────
{
  const s = pres.addSlide();
  applyBg(s);
  addHeading(s, "Serpiginous Choroidopathy");
  addBulletsWithImage(s, [
    "Rare, bilateral, chronic, recurrent; middle-aged adults; slight male preponderance",
    "Starts peripapillary, extends centrifugally in 'snake-like' (serpiginous) pattern",
    "Active edge: grey-white, ill-defined lesion; inactive centre: chorioretinal atrophy + RPE loss",
    "FA: early hypofluorescence (ischaemia) → late hyperfluorescence at active edge; ICGA: late hypofluorescence",
    "FAF: active lesion = border of hyperAF; inactive = uniformly hypoAF",
    "TB must be excluded (serpiginous-like choroiditis = TB until proven otherwise in endemic areas)",
  ], img(1), "Fig: Serpiginous – advanced scarring (Kanski 10th Ed.)");
}

// ─────────────────────────────────────────────────────────────────────────────
// SLIDE 12 – MFC & PIC (with image)
// ─────────────────────────────────────────────────────────────────────────────
{
  const s = pres.addSlide();
  applyBg(s);
  addHeading(s, "Multifocal Choroiditis (MFC) & Punctate Inner Choroidopathy (PIC)");
  addBulletsWithImage(s, [
    "MFC: young–middle aged women; bilateral asymmetric; chronic/recurrent; anterior uveitis (50%) + vitritis",
    "Lesions: multiple ovoid yellow-grey spots 50–350 µm; posterior pole ± periphery; inactive lesions resemble POHS 'histo spots'",
    "MNV in 25–35% of MFC; CMO and subretinal fibrosis also occur",
    "PIC: young myopic women; bilateral (80%); macular predominance; NO anterior uveitis/vitritis",
    "PIC prognosis: MNV develops in up to 40%; anti-VEGF is first-line for MNV",
    "Treatment MFC: steroids (systemic/local); steroid-resistant → cyclosporine/tacrolimus + mycophenolate",
  ], img(2), "Fig: MFC inactive lesions (Kanski 10th Ed.)");
}

// ─────────────────────────────────────────────────────────────────────────────
// SLIDE 13 – BIRDSHOT RETINOCHOROIDOPATHY
// ─────────────────────────────────────────────────────────────────────────────
{
  const s = pres.addSlide();
  applyBg(s);
  addHeading(s, "Birdshot Retinochoroidopathy (HLA-A29)");
  addBullets(s, [
    "Rare, bilateral, chronic; middle-aged Caucasian adults; 96% HLA-A29 positive",
    "Cream/salmon-coloured hypopigmented choroidal spots radiating from disc in 'birdshot' pattern (buckshot scatter)",
    "Vitritis present; CMO, disc oedema, retinal vasculitis are common complications",
    "ERG: photopic and scotopic abnormalities early — useful for monitoring disease progression",
    "Treatment: systemic immunosuppression (mycophenolate, cyclosporine, adalimumab); long-term therapy needed",
    "Risk of permanent vision loss from CMO and retinal vasculitis if undertreated",
  ]);
}

// ─────────────────────────────────────────────────────────────────────────────
// SLIDE 14 – VKH (Vogt-Koyanagi-Harada)
// ─────────────────────────────────────────────────────────────────────────────
{
  const s = pres.addSlide();
  applyBg(s);
  addHeading(s, "Vogt-Koyanagi-Harada (VKH) Disease");
  addBullets(s, [
    "Bilateral granulomatous panuveitis targeting melanocytes; HLA-DR4/DRw53 associated; Asian, Hispanic, Middle Eastern preponderance",
    "Phases: prodromal (meningism, tinnitus, vitiligo) → acute uveitic (bilateral diffuse choroiditis, exudative RD) → convalescent (sunset glow fundus) → chronic recurrent",
    "Acute: mutton-fat KPs, disc hyperaemia, multiple subretinal fluid collections, exudative RD",
    "FA: multiple areas of early hypofluorescence → late leakage at RPE level; OCT: multiple SRF collections",
    "Treatment: high-dose systemic corticosteroids (IV methylprednisolone 1 g/day × 3 days then oral taper)",
    "Steroid-resistant/chronic: azathioprine, MMF, cyclosporine; biologics (adalimumab, infliximab) for refractory cases",
  ]);
}

// ─────────────────────────────────────────────────────────────────────────────
// SLIDE 15 – INFECTIOUS CHOROIDITIS (Fungal / Tuberculosis)
// ─────────────────────────────────────────────────────────────────────────────
{
  const s = pres.addSlide();
  applyBg(s);
  addHeading(s, "Infectious Choroiditis – Fungal & TB");
  addBulletsWithImage(s, [
    "Candida: IV drug abuse/immunosuppression; white fluffy vitreous balls ('string of pearls'); anti-fungals ± intravitreal voriconazole; PPV for severe disease",
    "Aspergillus: haematogenous in immunocompromised; macular solitary lesion; high mortality; IV voriconazole first-line",
    "Pneumocystis (PCP) choroiditis: AIDS/CD4 <50; bilateral round yellow-orange lesions; minimal vitritis; IV TMP-SMX",
    "Cryptococcus: AIDS; direct choroidal infiltration or papilloedema; IV amphotericin-B + flucytosine",
    "Tubercular choroiditis: most common infectious choroiditis globally; choroidal granuloma (Dalen-Fuchs nodules); 4-drug ATT + steroids",
    "TB-serpiginous: geographic distribution of active lesion; strong HLA-DR4 association; exclude TB before immunosuppression",
  ], img(3), "Fig: Fungal choroiditis panel\n(Kanski 10th Ed.)");
}

// ─────────────────────────────────────────────────────────────────────────────
// SLIDE 16 – SYPHILITIC CHOROIDITIS
// ─────────────────────────────────────────────────────────────────────────────
{
  const s = pres.addSlide();
  applyBg(s);
  addHeading(s, "Syphilitic & Other Infectious Choroiditis");
  addBullets(s, [
    "Syphilis ('The Great Imitator'): secondary/tertiary; ASPPC (Acute Syphilitic Posterior Placoid Chorioretinitis) — large yellow placoid macular lesion",
    "ASPPC: FA shows early block with late hyperfluorescence; ICGA shows persistent hypofluorescence; treat with IV penicillin G",
    "CMV choroiditis: AIDS patients (CD4 <50); hemorrhagic 'pizza pie' retinitis extending to periphery; IV ganciclovir/valganciclovir",
    "Toxocara: children; unilateral; peripheral granuloma or posterior pole lesion; high IgE, ELISA Toxocara; albendazole + steroids",
    "Cat-scratch disease (Bartonella): neuroretinitis with macular star ± multifocal choroiditis; doxycycline + rifampicin",
    "West Nile Virus: multifocal choroiditis with linear clustering; supportive management; OCT shows target lesions",
  ]);
}

// ─────────────────────────────────────────────────────────────────────────────
// SLIDE 17 – TREATMENT OVERVIEW
// ─────────────────────────────────────────────────────────────────────────────
{
  const s = pres.addSlide();
  applyBg(s);
  addHeading(s, "Treatment Overview");
  addBullets(s, [
    "Infectious: pathogen-directed — antibiotics (syphilis/TB/cat-scratch), antivirals (CMV/HSV), antifungals (Candida/Aspergillus); treat underlying immunosuppression",
    "Non-infectious acute: oral prednisolone 1–1.5 mg/kg/day with taper over 6–12 weeks; IV methylprednisolone for severe disease (VKH)",
    "Local steroids: intravitreal triamcinolone, sub-Tenon triamcinolone, or dexamethasone implant (Ozurdex) for refractory CMO",
    "Steroid-sparing: methotrexate, azathioprine, mycophenolate mofetil (MMF), cyclosporine (first 3–6 months of corticosteroids then add)",
    "Biologics: adalimumab (anti-TNF; approved for non-infectious uveitis — VISUAL I & II trials); infliximab; abatacept; rituximab for refractory cases",
    "MNV management: anti-VEGF (ranibizumab, bevacizumab, aflibercept) combined with immunosuppression for inflammatory MNV",
  ]);
}

// ─────────────────────────────────────────────────────────────────────────────
// SLIDE 18 – TREATMENT FLOWCHART (Non-infectious)
// ─────────────────────────────────────────────────────────────────────────────
{
  const s = pres.addSlide();
  applyBg(s);
  addHeading(s, "Treatment Flowchart – Non-Infectious Choroiditis");

  const bw = 2.8, bh = 0.5;
  const cx = (W - bw) / 2; // center x

  // Central pathway (full-width)
  const steps = [
    { label: "Confirm Non-infectious Origin\n(serology, PCR, imaging)", fill: "D6EAF8", y: 0.9 },
    { label: "Mild–Moderate Disease\nOral Prednisolone 1 mg/kg/day", fill: C_ACCENT, y: 1.62 },
    { label: "Adequate Response at 4–6 weeks?\nTaper over 12–16 weeks", fill: C_ACCENT, y: 2.34 },
  ];

  steps.forEach(st => addFcBox(s, st.label, cx, st.y, bw, bh, st.fill, C_NAVY, 11));
  addFcArrow(s, cx + bw / 2 - 0.02, steps[0].y + bh, steps[1].y);
  addFcArrow(s, cx + bw / 2 - 0.02, steps[1].y + bh, steps[2].y);

  // YES branch (left)
  addFcBox(s, "YES → Continue taper\nMonitor 3-monthly", 0.25, 3.08, 2.4, bh, "D5F5E3", "1A5C2A", 11);
  s.addShape(pres.ShapeType.line, { x: cx, y: steps[2].y + bh / 2, w: -(cx - 0.25 - 2.4), h: 0, line: { color: C_NAVY, width: 1.5, endArrowType: "triangle" } });

  // NO branch (right)
  addFcBox(s, "NO → Add Steroid-sparing IMT\n(MMF / Azathioprine / MTX)", 7.35, 3.08, 2.4, bh, "FDE8D5", "8B3A0A", 11);
  s.addShape(pres.ShapeType.line, { x: cx + bw, y: steps[2].y + bh / 2, w: 7.35 - (cx + bw), h: 0, line: { color: C_NAVY, width: 1.5, endArrowType: "triangle" } });

  // Refractory box (bottom center)
  addFcBox(s, "Refractory / Sight-Threatening Disease\n→ Biologics: Adalimumab / Infliximab\n→ Intravitreal Ozurdex / Triamcinolone\n→ MNV: Anti-VEGF", cx - 0.8, 3.82, bw + 1.6, 0.8, "FFF3CD", "7D6608", 11);
  s.addShape(pres.ShapeType.line, { x: cx + bw / 2 - 0.02, y: steps[2].y + bh, w: 0, h: 3.82 - (steps[2].y + bh), line: { color: C_NAVY, width: 1.5, endArrowType: "triangle" } });
}

// ─────────────────────────────────────────────────────────────────────────────
// SLIDE 19 – TREATMENT FLOWCHART (Infectious)
// ─────────────────────────────────────────────────────────────────────────────
{
  const s = pres.addSlide();
  applyBg(s);
  addHeading(s, "Treatment Flowchart – Infectious Choroiditis");

  // 3-column decision pathway
  const colW = 2.8, colH = 0.5;
  const cols = [
    { label: "BACTERIAL\n(TB / Syphilis)", x: 0.3, color: "D6EAF8", tColor: C_NAVY },
    { label: "FUNGAL\n(Candida / Aspergillus)", x: 3.6, color: "E8F8E8", tColor: "1A5C2A" },
    { label: "VIRAL\n(CMV / HSV / VZV)", x: 6.9, color: "FDE8D5", tColor: "8B3A0A" },
  ];

  cols.forEach(c => addFcBox(s, c.label, c.x, 0.88, colW, colH, c.color, c.tColor, 12));

  const treatments = [
    ["TB: 4-drug ATT\n(RHEZ × 2 months,\nRH × 4 months)", "Candida: IV Micafungin\nor Voriconazole;\nIntravitreal 100µg/0.1ml", "CMV (AIDS): IV Ganciclovir\n5 mg/kg BID × 2 wks\nthen Valganciclovir oral"],
    ["Syphilis: IV Penicillin G\n18–24 MU/day × 10–14d;\nor Ceftriaxone", "Aspergillus: IV\nVoriconazole first-line;\nPPV for severe cases", "HSV/VZV: IV Acyclovir\n10–15 mg/kg TID × 14d;\nthen oral prophylaxis"],
    ["Add systemic steroids\nafter 2 weeks ATT\nfor severe disease", "PPV: early if poor\nresponse; reduces load\n& improves penetration", "ARN: prophylactic PPV\nfor retinal detachment\nrisk (30–75%)"],
  ];

  let rowY = 1.55;
  for (let row = 0; row < treatments.length; row++) {
    if (row > 0) rowY += 0.05;
    treatments[row].forEach((txt, ci) => {
      addFcBox(s, txt, cols[ci].x, rowY, colW, 0.7, row % 2 === 0 ? "EBF5FB" : "F4F6F7", C_TEXT, 10);
    });
    if (row < treatments.length - 1) {
      cols.forEach(c => addFcArrow(s, c.x + colW / 2 - 0.02, rowY + 0.7, rowY + 0.75));
    }
    rowY += 0.75;
  }

  // Bottom note
  s.addText("In all infectious cases: treat underlying immunosuppression (HIV) | Vitreous biopsy / PCR for diagnosis | Steroids only after covering with antimicrobials", {
    x: 0.3, y: 5.05, w: 9.4, h: 0.45,
    fontSize: 11, bold: false, color: "666666", fontFace: FONT, italic: true, align: "center",
  });
}

// ─────────────────────────────────────────────────────────────────────────────
// SLIDE 20 – COMPLICATIONS
// ─────────────────────────────────────────────────────────────────────────────
{
  const s = pres.addSlide();
  applyBg(s);
  addHeading(s, "Complications of Choroiditis");
  addBulletsWithImage(s, [
    "Choroidal neovascularisation (MNV / Type 2 CNV): commonest vision-threatening complication; treat with anti-VEGF ± immunosuppression",
    "Cystoid macular oedema (CMO): causes chronic visual loss; treated with local (Ozurdex, IVTA) or systemic steroids",
    "Subretinal fibrosis: end-stage scarring; poor visual prognosis; anti-VEGF may reduce progression",
    "Exudative (non-rhegmatogenous) retinal detachment: VKH, posterior scleritis; resolves with immunosuppression",
    "Optic disc oedema / neuropathy: VKH, APMPPE-associated CNS vasculitis; aggressive treatment needed",
    "Chorioretinal atrophy: irreversible photoreceptor loss at scar site; monitor for expansion",
  ], img(4), "Fig: Advanced chorioretinal\natrophy (Kanski 10th Ed.)");
}

// ─────────────────────────────────────────────────────────────────────────────
// SLIDE 21 – MONITORING & FOLLOW-UP
// ─────────────────────────────────────────────────────────────────────────────
{
  const s = pres.addSlide();
  applyBg(s);
  addHeading(s, "Monitoring & Follow-Up");
  addBullets(s, [
    "Acute phase: review 2–4 weekly; assess for complications, treatment response, medication side effects",
    "Remission: every 3–6 months; visual fields (MFC/birdshot); ERG (birdshot); IOP monitoring (steroid-induced glaucoma)",
    "Multimodal imaging at each visit: OCT for CMO/MNV; OCTA for choriocapillaris status",
    "Laboratory monitoring: FBC, LFTs, RFTs with IMT (methotrexate: LFT; cyclosporine: RFT; azathioprine: FBC)",
    "Consider immunosuppression for ≥2 years in chronic entities (birdshot, VKH, MFC) before cautious withdrawal",
    "Patient education: Amsler grid self-monitoring, early reporting of new visual symptoms",
  ]);
}

// ─────────────────────────────────────────────────────────────────────────────
// SLIDE 22 – RECENT ADVANCES & CLINICAL TRIALS
// ─────────────────────────────────────────────────────────────────────────────
{
  const s = pres.addSlide();
  applyBg(s);
  addHeading(s, "Recent Advances & Clinical Trials (2022–2026)");
  addBullets(s, [
    "VISUAL I & II (AbbVie/Allergan): Adalimumab RCTs — significantly reduced active uveitis flares vs. placebo in non-infectious posterior/pan-uveitis; FDA/EMA approved",
    "MUV Project 2025 (Accorinti et al., AJO 2025): systematic review defining role of multimodal imaging in non-infectious posterior uveitis diagnosis and activity monitoring",
    "OCTA as standard monitoring tool: choriocapillaris flow deficit mapping now recommended by MUV Task Force (Invernizzi et al., AJO 2025) for APMPPE, serpiginous, MFC, and birdshot",
    "Biologics for VKH/Birdshot: adalimumab and infliximab showing steroid-sparing efficacy; JAK inhibitors (tofacitinib) under investigation",
    "Post-COVID vaccination choroiditis: multifocal choroiditis, MFC recurrence, MEWDS-like cases reported (Kakarla et al., 2022; Scott & Niederer, 2024)",
    "Anti-VEGF for inflammatory MNV: ranibizumab/aflibercept combined with immunosuppression; OCTA-guided treatment decision making (Bottazzi et al., Graefes 2025)",
  ]);
}

// ─────────────────────────────────────────────────────────────────────────────
// SLIDE 23 – OCTA & ADVANCED IMAGING IN CHOROIDITIS
// ─────────────────────────────────────────────────────────────────────────────
{
  const s = pres.addSlide();
  applyBg(s);
  addHeading(s, "Advances in Imaging – OCTA & Multimodal Approach");
  addBullets(s, [
    "OCTA (OCT-Angiography): non-invasive detection of choriocapillaris flow deficits; identifies sub-clinical disease; detects MNV before FA leakage visible",
    "EDI-OCT: measures subfoveal choroidal thickness — correlates with disease activity in VKH and serpiginous; thickening with active inflammation",
    "FAF: hyperautofluorescence = active disease (inflammatory mediators toxic to RPE); hypoAF = established atrophy; useful in serpiginous progression monitoring",
    "ICGA: gold standard for choriocapillaris lesion detection; hypofluorescent dots exceed clinically visible lesions — reveals subclinical disease burden",
    "AI & deep learning: automated choriocapillaris flow deficit quantification; OCT layer segmentation tools for monitoring atrophy progression",
    "Wide-field imaging: ultra-wide field FA/ICGA now identifies peripheral choroidal lesions missed on standard imaging (important in birdshot, MFC)",
  ]);
}

// ─────────────────────────────────────────────────────────────────────────────
// SLIDE 24 – CLINICAL IMAGES PANEL
// ─────────────────────────────────────────────────────────────────────────────
{
  const s = pres.addSlide();
  applyBg(s);
  addHeading(s, "Clinical Images – Choroiditis Spectrum");

  // 2x2 image grid
  const gridImages = [img(0), img(1), img(2), img(4)];
  const captions = [
    "Serpiginous – early peripapillary lesion",
    "Serpiginous – advanced chorioretinal scarring",
    "MFC – inactive lesions, posterior pole",
    "Advanced chorioretinal atrophy – end stage",
  ];
  const positions = [
    { x: 0.3, y: 0.85 },
    { x: 5.1, y: 0.85 },
    { x: 0.3, y: 3.15 },
    { x: 5.1, y: 3.15 },
  ];
  const iW = 4.5, iH = 2.1;

  positions.forEach((pos, i) => {
    if (gridImages[i]) {
      s.addImage({ data: gridImages[i], x: pos.x, y: pos.y, w: iW, h: iH });
      s.addText(captions[i], {
        x: pos.x, y: pos.y + iH + 0.02, w: iW, h: 0.28,
        fontSize: 10, color: "555555", fontFace: FONT, italic: true, align: "center",
      });
    }
  });
  s.addText("Source: Kanski's Clinical Ophthalmology 10th Edition", {
    x: 0.3, y: 5.35, w: 9.4, h: 0.2,
    fontSize: 10, color: "888888", fontFace: FONT, italic: true, align: "center",
  });
}

// ─────────────────────────────────────────────────────────────────────────────
// SLIDE 25 – SUMMARY TABLE: DISTINGUISHING FEATURES
// ─────────────────────────────────────────────────────────────────────────────
{
  const s = pres.addSlide();
  applyBg(s);
  addHeading(s, "Key Distinguishing Features at a Glance");

  const rows = [
    [
      { text: "Condition", options: { bold: true, color: "FFFFFF", fill: C_NAVY } },
      { text: "Demographics", options: { bold: true, color: "FFFFFF", fill: C_NAVY } },
      { text: "Key Feature", options: { bold: true, color: "FFFFFF", fill: C_NAVY } },
      { text: "Hallmark Imaging", options: { bold: true, color: "FFFFFF", fill: C_NAVY } },
    ],
    [
      { text: "MEWDS", options: { color: C_TEXT } }, { text: "Young women", options: { color: C_TEXT } },
      { text: "Evanescent white dots", options: { color: C_TEXT } }, { text: "FAF hyperAF dots", options: { color: C_TEXT } },
    ],
    [
      { text: "APMPPE", options: { color: C_TEXT } }, { text: "Young adults, post-viral", options: { color: C_TEXT } },
      { text: "Placoid lesions, early block-late stain", options: { color: C_TEXT } }, { text: "Early FA block", options: { color: C_TEXT } },
    ],
    [
      { text: "Serpiginous", options: { color: C_TEXT } }, { text: "Middle-age, M>F", options: { color: C_TEXT } },
      { text: "Peripapillary, snake-like spread", options: { color: C_TEXT } }, { text: "FAF active border", options: { color: C_TEXT } },
    ],
    [
      { text: "MFC", options: { color: C_TEXT } }, { text: "Young-mid women", options: { color: C_TEXT } },
      { text: "Multifocal + anterior uveitis", options: { color: C_TEXT } }, { text: "ICGA hypofluorescent", options: { color: C_TEXT } },
    ],
    [
      { text: "Birdshot", options: { color: C_TEXT } }, { text: "Caucasian, HLA-A29", options: { color: C_TEXT } },
      { text: "Salmon spots from disc", options: { color: C_TEXT } }, { text: "ERG abnormality", options: { color: C_TEXT } },
    ],
    [
      { text: "VKH", options: { color: C_TEXT } }, { text: "Asian/Hispanic, HLA-DR4", options: { color: C_TEXT } },
      { text: "Exudative RD, meningism", options: { color: C_TEXT } }, { text: "Multiple SRF on OCT", options: { color: C_TEXT } },
    ],
  ];

  s.addTable(rows, {
    x: 0.3, y: 0.88, w: 9.4, h: 4.55,
    rowH: 0.58,
    fontSize: 12, fontFace: FONT,
    colW: [1.5, 2.0, 3.2, 2.7],
    border: { pt: 1, color: C_NAVY },
  });
}

// ─────────────────────────────────────────────────────────────────────────────
// SLIDE 26 – CONCLUSION
// ─────────────────────────────────────────────────────────────────────────────
{
  const s = pres.addSlide();
  applyBg(s);
  // top bar
  s.addShape(pres.ShapeType.rect, { x: 0, y: 0, w: W, h: 0.2, fill: { color: C_NAVY }, line: { color: C_NAVY } });
  // bottom bar
  s.addShape(pres.ShapeType.rect, { x: 0, y: 5.4, w: W, h: 0.22, fill: { color: C_NAVY }, line: { color: C_NAVY } });
  s.addText("Key Takeaways", {
    x: 0.5, y: 0.28, w: 9, h: 0.62,
    fontSize: 28, bold: true, color: C_HEAD, fontFace: FONT, align: "center",
  });
  s.addShape(pres.ShapeType.rect, { x: 2, y: 0.95, w: 6, h: 0.04, fill: { color: C_NAVY }, line: { color: C_NAVY } });

  const points = [
    "Choroiditis = inflammation of the vascular choroid; encompasses infectious & immune-mediated diseases",
    "ICG-based classification (Kanski) organises entities by target layer: choriocapillaritis vs. stromal choroiditis",
    "Multimodal imaging (ICGA, OCTA, FAF, EDI-OCT) is essential for diagnosis, activity assessment, and monitoring",
    "Treatment: pathogen-directed (infectious) vs. stepwise immunosuppression (non-infectious); biologics for refractory disease",
    "Adalimumab (VISUAL trials) is the only biologic with Level-1 evidence for non-infectious posterior uveitis",
    "Always exclude TB & syphilis before commencing immunosuppression — they are great imitators",
  ];

  const tArr = points.map((p, i) => ({
    text: `${i + 1}.  ${p}`,
    options: { breakLine: i < points.length - 1, fontSize: 15, color: C_TEXT, fontFace: FONT },
  }));
  s.addText(tArr, { x: 0.6, y: 1.1, w: 8.8, h: 4.2, valign: "top" });
}

// ─────────────────────────────────────────────────────────────────────────────
// WRITE FILE
// ─────────────────────────────────────────────────────────────────────────────
const outPath = "/home/daytona/workspace/choroiditis-pptx/Choroiditis_Complete.pptx";
pres.writeFile({ fileName: outPath })
  .then(() => console.log("SUCCESS:", outPath))
  .catch(err => { console.error("FAILED:", err); process.exit(1); });

Successfully replaced 1 instance(s) of the string in '/home/daytona/workspace/choroiditis-pptx/build_choroiditis.js'

"""
Merge two PPTX files by copying all slides from both into a new presentation,
preserving all images, shapes, and formatting exactly.
Inserts a section-divider slide between the two decks.
"""

import copy
import zipfile
import shutil
import os
import re
from lxml import etree

SRC1 = "/home/daytona/workspace/attachments/667b0580-7f3e-40dd-ac7c-c14a15da2e87/Retinitis_Complete.pptx"
SRC2 = "/home/daytona/workspace/choroiditis-pptx/Choroiditis_Complete.pptx"
OUT  = "/home/daytona/workspace/choroiditis-pptx/Retinitis_Choroiditis_Combined.pptx"

# ── We do a ZIP-level merge ────────────────────────────────────────────────────
# Strategy:
#   1. Copy SRC1 as base
#   2. Open both ZIPs, extract slide XMLs + media + rels from SRC2
#   3. Renumber slides/rels/media to avoid clashes
#   4. Insert a divider slide between the two decks
#   5. Update presentation.xml sldIdLst

import zipfile, shutil, os, re, io
from lxml import etree

NS = {
    'p': 'http://schemas.openxmlformats.org/presentationml/2006/main',
    'a': 'http://schemas.openxmlformats.org/drawingml/2006/main',
    'r': 'http://schemas.openxmlformats.org/officeDocument/2006/relationships',
}

def parse_xml(data):
    return etree.fromstring(data)

def serialize_xml(root):
    return etree.tostring(root, xml_declaration=True, encoding='UTF-8', standalone=True)

# Read both ZIPs into memory dicts
def read_zip(path):
    d = {}
    with zipfile.ZipFile(path, 'r') as z:
        for name in z.namelist():
            d[name] = z.read(name)
    return d

print("Reading source files...")
z1 = read_zip(SRC1)
z2 = read_zip(SRC2)

# Count existing slides in SRC1
prs1_xml = parse_xml(z1['ppt/presentation.xml'])
sld_id_lst = prs1_xml.find('.//{http://schemas.openxmlformats.org/presentationml/2006/main}sldIdLst')
existing_slide_ids = sld_id_lst.findall('{http://schemas.openxmlformats.org/presentationml/2006/main}sldId')
n1 = len(existing_slide_ids)
max_id = max(int(s.get('id')) for s in existing_slide_ids)

print(f"SRC1 has {n1} slides, max id={max_id}")

# Count slides in SRC2
prs2_xml = parse_xml(z2['ppt/presentation.xml'])
sld_id_lst2 = prs2_xml.find('.//{http://schemas.openxmlformats.org/presentationml/2006/main}sldIdLst')
slides2 = [s for s in sld_id_lst2.findall('{http://schemas.openxmlformats.org/presentationml/2006/main}sldId')]
n2 = len(slides2)
print(f"SRC2 has {n2} slides")

# Get SRC2 slide file list in order
prs2_rels_xml = parse_xml(z2['ppt/_rels/presentation.xml.rels'])
# Build rId -> slide target map for SRC2
rid_to_target2 = {}
for rel in prs2_rels_xml.findall('{http://schemas.openxmlformats.org/package/2006/relationships}Relationship'):
    if 'slide/' in rel.get('Target', ''):
        rid_to_target2[rel.get('Id')] = rel.get('Target')

# Get ordered slide targets from sldIdLst
slide_targets2 = []
for sld in slides2:
    rid = sld.get('{http://schemas.openxmlformats.org/officeDocument/2006/relationships}id')
    target = rid_to_target2.get(rid, '')
    if target:
        # target is like 'slides/slide1.xml'
        slide_targets2.append(target)

print("SRC2 slide order:", slide_targets2)

# Similarly for SRC1
prs1_rels_xml = parse_xml(z1['ppt/_rels/presentation.xml.rels'])
rid_to_target1 = {}
for rel in prs1_rels_xml.findall('{http://schemas.openxmlformats.org/package/2006/relationships}Relationship'):
    if 'slide/' in rel.get('Target', ''):
        rid_to_target1[rel.get('Id')] = rel.get('Target')
slide_targets1 = []
for sld in existing_slide_ids:
    rid = sld.get('{http://schemas.openxmlformats.org/officeDocument/2006/relationships}id')
    target = rid_to_target1.get(rid, '')
    if target:
        slide_targets1.append(target)
print("SRC1 slide order:", slide_targets1)

# ── Build output ZIP ──────────────────────────────────────────────────────────
# Start from SRC1 copy, then append SRC2 slides

out_files = dict(z1)  # copy all SRC1 files

# Find next available slide number in output
existing_slide_nums = set()
for k in out_files:
    m = re.match(r'ppt/slides/slide(\d+)\.xml$', k)
    if m:
        existing_slide_nums.add(int(m.group(1)))
next_slide_num = max(existing_slide_nums) + 1 if existing_slide_nums else 1

# Find next available media number
existing_media_nums = set()
for k in out_files:
    m = re.match(r'ppt/media/(.+)$', k)
    if m:
        existing_media_nums.add(m.group(1))

# Media rename map for SRC2: old name -> new name
media_rename2 = {}
for k in z2:
    if k.startswith('ppt/media/'):
        fname = k[len('ppt/media/'):]
        # Check if name clashes
        if fname in existing_media_nums:
            # rename: prepend 'c2_'
            new_fname = 'c2_' + fname
            media_rename2[fname] = new_fname
        else:
            media_rename2[fname] = fname
        existing_media_nums.add(media_rename2[fname])

# Copy SRC2 media into output (with renames)
for k in z2:
    if k.startswith('ppt/media/'):
        fname = k[len('ppt/media/'):]
        new_fname = media_rename2.get(fname, fname)
        out_files['ppt/media/' + new_fname] = z2[k]

# Copy SRC2 slide layouts / masters if not present (use SRC1's layouts as fallback)
# We'll reference SRC1's slideLayouts for SRC2 slides

# Process each SRC2 slide
new_slide_entries = []  # list of (new_slide_num, new_rId)
divider_inserted = False

# We'll insert a divider slide first (slide n1+1), then SRC2 slides

# ── Create divider slide XML ──────────────────────────────────────────────────
# Style: white bg, navy bars, large centered text "PART 2: CHOROIDITIS"
DIVIDER_XML = '''<?xml version="1.0" encoding="UTF-8" standalone="yes"?>
<p:sld xmlns:a="http://schemas.openxmlformats.org/drawingml/2006/main"
       xmlns:r="http://schemas.openxmlformats.org/officeDocument/2006/relationships"
       xmlns:p="http://schemas.openxmlformats.org/presentationml/2006/main">
  <p:cSld name="Divider">
    <p:bg><p:bgPr><a:solidFill><a:srgbClr val="FFFFFF"/></a:solidFill></p:bgPr></p:bg>
    <p:spTree>
      <p:nvGrpSpPr><p:cNvPr id="1" name=""/><p:cNvGrpSpPr/><p:nvPr/></p:nvGrpSpPr>
      <p:grpSpPr><a:xfrm><a:off x="0" y="0"/><a:ext cx="0" cy="0"/><a:chOff x="0" y="0"/><a:chExt cx="0" cy="0"/></a:xfrm></p:grpSpPr>
      <p:sp>
        <p:nvSpPr><p:cNvPr id="2" name="TopBar"/><p:cNvSpPr/><p:nvPr/></p:nvSpPr>
        <p:spPr><a:xfrm><a:off x="0" y="0"/><a:ext cx="9144000" cy="182880"/></a:xfrm>
          <a:prstGeom prst="rect"><a:avLst/></a:prstGeom>
          <a:solidFill><a:srgbClr val="1E3A5F"/></a:solidFill>
          <a:ln><a:solidFill><a:srgbClr val="1E3A5F"/></a:solidFill></a:ln>
        </p:spPr>
      </p:sp>
      <p:sp>
        <p:nvSpPr><p:cNvPr id="3" name="BotBar"/><p:cNvSpPr/><p:nvPr/></p:nvSpPr>
        <p:spPr><a:xfrm><a:off x="0" y="4956048"/><a:ext cx="9144000" cy="192024"/></a:xfrm>
          <a:prstGeom prst="rect"><a:avLst/></a:prstGeom>
          <a:solidFill><a:srgbClr val="1E3A5F"/></a:solidFill>
          <a:ln><a:solidFill><a:srgbClr val="1E3A5F"/></a:solidFill></a:ln>
        </p:spPr>
      </p:sp>
      <p:sp>
        <p:nvSpPr><p:cNvPr id="4" name="Label1"/><p:cNvSpPr/><p:nvPr/></p:nvSpPr>
        <p:spPr><a:xfrm><a:off x="457200" y="914400"/><a:ext cx="8229600" cy="548640"/></a:xfrm>
          <a:prstGeom prst="rect"><a:avLst/></a:prstGeom><a:noFill/><a:ln/></p:spPr>
        <p:txBody>
          <a:bodyPr wrap="square" rtlCol="0" anchor="ctr"/>
          <a:lstStyle/>
          <a:p><a:pPr algn="ctr" indent="0" marL="0"><a:buNone/></a:pPr>
            <a:r><a:rPr lang="en-US" sz="2000" i="1" dirty="0">
              <a:solidFill><a:srgbClr val="1E3A5F"/></a:solidFill>
              <a:latin typeface="Calibri" pitchFamily="34" charset="0"/>
            </a:rPr><a:t>Complete Uveitis Series</a:t></a:r>
          </a:p>
        </p:txBody>
      </p:sp>
      <p:sp>
        <p:nvSpPr><p:cNvPr id="5" name="Title"/><p:cNvSpPr/><p:nvPr/></p:nvSpPr>
        <p:spPr><a:xfrm><a:off x="457200" y="1463040"/><a:ext cx="8229600" cy="1097280"/></a:xfrm>
          <a:prstGeom prst="rect"><a:avLst/></a:prstGeom><a:noFill/><a:ln/></p:spPr>
        <p:txBody>
          <a:bodyPr wrap="square" rtlCol="0" anchor="ctr"/>
          <a:lstStyle/>
          <a:p><a:pPr algn="ctr" indent="0" marL="0"><a:buNone/></a:pPr>
            <a:r><a:rPr lang="en-US" sz="5400" b="1" dirty="0">
              <a:solidFill><a:srgbClr val="1A1A1A"/></a:solidFill>
              <a:latin typeface="Calibri" pitchFamily="34" charset="0"/>
            </a:rPr><a:t>PART 2: CHOROIDITIS</a:t></a:r>
          </a:p>
        </p:txBody>
      </p:sp>
      <p:sp>
        <p:nvSpPr><p:cNvPr id="6" name="Divline"/><p:cNvSpPr/><p:nvPr/></p:nvSpPr>
        <p:spPr><a:xfrm><a:off x="1828800" y="2743200"/><a:ext cx="5486400" cy="36576"/></a:xfrm>
          <a:prstGeom prst="rect"><a:avLst/></a:prstGeom>
          <a:solidFill><a:srgbClr val="1E3A5F"/></a:solidFill>
          <a:ln><a:solidFill><a:srgbClr val="1E3A5F"/></a:solidFill></a:ln>
        </p:spPr>
      </p:sp>
      <p:sp>
        <p:nvSpPr><p:cNvPr id="7" name="Sub"/><p:cNvSpPr/><p:nvPr/></p:nvSpPr>
        <p:spPr><a:xfrm><a:off x="457200" y="2835360"/><a:ext cx="8229600" cy="548640"/></a:xfrm>
          <a:prstGeom prst="rect"><a:avLst/></a:prstGeom><a:noFill/><a:ln/></p:spPr>
        <p:txBody>
          <a:bodyPr wrap="square" rtlCol="0" anchor="ctr"/>
          <a:lstStyle/>
          <a:p><a:pPr algn="ctr" indent="0" marL="0"><a:buNone/></a:pPr>
            <a:r><a:rPr lang="en-US" sz="1800" i="1" dirty="0">
              <a:solidFill><a:srgbClr val="555555"/></a:solidFill>
              <a:latin typeface="Calibri" pitchFamily="34" charset="0"/>
            </a:rPr><a:t>Complete Review: Basic to Advanced | Kanski 10th Ed. | Ryan's Retina 6th Ed.</a:t></a:r>
          </a:p>
        </p:txBody>
      </p:sp>
    </p:spTree>
  </p:cSld>
</p:sld>'''

# Also make a PART 1 divider (insert before slide 1 of retinitis – actually just update its title, or add at start)
# For simplicity: just insert section divider before Choroiditis slides

# We need a .rels file for each new slide
def make_slide_rels(media_refs=None):
    """Return minimal slide .rels XML with no relationships (or with image rels)"""
    return b'''<?xml version="1.0" encoding="UTF-8" standalone="yes"?>
<Relationships xmlns="http://schemas.openxmlformats.org/package/2006/relationships">
</Relationships>'''

# ── Step 1: Insert divider slide ──────────────────────────────────────────────
divider_slide_num = next_slide_num
divider_path = f'ppt/slides/slide{divider_slide_num}.xml'
out_files[divider_path] = DIVIDER_XML.encode('utf-8')
out_files[f'ppt/slides/_rels/slide{divider_slide_num}.xml.rels'] = make_slide_rels()
next_slide_num += 1

# ── Step 2: Copy SRC2 slides, renaming as needed ─────────────────────────────
# We need to: copy slide XML + fix media refs + copy rels + fix rels

slide2_new_nums = {}  # old slide filename -> new slide num

for old_target in slide_targets2:
    # old_target like 'slides/slide3.xml'
    old_fname = old_target  # relative to ppt/
    old_path = 'ppt/' + old_fname
    old_slide_name = os.path.basename(old_fname)  # 'slide3.xml'
    old_num = int(re.search(r'slide(\d+)\.xml', old_slide_name).group(1))

    new_num = next_slide_num
    slide2_new_nums[old_num] = new_num
    new_path = f'ppt/slides/slide{new_num}.xml'
    new_slide_name = f'slide{new_num}.xml'

    # Read old slide XML and rename media references
    slide_data = z2.get(old_path, b'')
    slide_xml_str = slide_data.decode('utf-8')

    # Fix media references in the slide XML (shouldn't need to - media refs are in rels)
    out_files[new_path] = slide_xml_str.encode('utf-8')

    # Handle rels file
    old_rels_path = f'ppt/slides/_rels/{old_slide_name}.rels'
    if old_rels_path in z2:
        rels_data = z2[old_rels_path].decode('utf-8')
        # Rename media references in rels
        for old_mname, new_mname in media_rename2.items():
            if old_mname != new_mname:
                rels_data = rels_data.replace('../media/' + old_mname, '../media/' + new_mname)
        # Update slideLayout references - point to SRC1's layouts
        # SRC2 may reference its own layouts; we need to map to SRC1 layouts
        # Check which layout SRC2 uses
        new_rels_path = f'ppt/slides/_rels/{new_slide_name}.rels'
        out_files[new_rels_path] = rels_data.encode('utf-8')
    else:
        new_rels_path = f'ppt/slides/_rels/{new_slide_name}.rels'
        out_files[new_rels_path] = make_slide_rels()

    next_slide_num += 1

print(f"Added divider at slide{divider_slide_num}")
print(f"Added {len(slide2_new_nums)} SRC2 slides: {slide2_new_nums}")

# ── Step 3: Update presentation.xml to include all new slides ────────────────
prs_xml = out_files['ppt/presentation.xml'].decode('utf-8')
prs_root = etree.fromstring(prs_xml.encode('utf-8'))

sld_id_lst_el = prs_root.find('.//{http://schemas.openxmlformats.org/presentationml/2006/main}sldIdLst')
prs_rels_xml_str = out_files['ppt/_rels/presentation.xml.rels'].decode('utf-8')
prs_rels_root = etree.fromstring(prs_rels_xml_str.encode('utf-8'))

# Find max rId in existing rels
existing_rids = []
for rel in prs_rels_root.findall('{http://schemas.openxmlformats.org/package/2006/relationships}Relationship'):
    rid = rel.get('Id', '')
    m = re.search(r'(\d+)', rid)
    if m:
        existing_rids.append(int(m.group(1)))
next_rid_num = max(existing_rids) + 1 if existing_rids else 100

# Add divider slide to rels
div_rid = f'rId{next_rid_num}'
next_rid_num += 1
div_rel = etree.SubElement(prs_rels_root, '{http://schemas.openxmlformats.org/package/2006/relationships}Relationship')
div_rel.set('Id', div_rid)
div_rel.set('Type', 'http://schemas.openxmlformats.org/officeDocument/2006/relationships/slide')
div_rel.set('Target', f'slides/slide{divider_slide_num}.xml')

# Add divider slide to sldIdLst
div_sld_id = etree.SubElement(sld_id_lst_el, '{http://schemas.openxmlformats.org/presentationml/2006/main}sldId')
div_sld_id.set('id', str(max_id + 1))
div_sld_id.set('{http://schemas.openxmlformats.org/officeDocument/2006/relationships}id', div_rid)
max_id += 1

# Add SRC2 slides to rels and sldIdLst
for old_num, new_num in slide2_new_nums.items():
    new_rid = f'rId{next_rid_num}'
    next_rid_num += 1

    new_rel = etree.SubElement(prs_rels_root, '{http://schemas.openxmlformats.org/package/2006/relationships}Relationship')
    new_rel.set('Id', new_rid)
    new_rel.set('Type', 'http://schemas.openxmlformats.org/officeDocument/2006/relationships/slide')
    new_rel.set('Target', f'slides/slide{new_num}.xml')

    new_sld_id = etree.SubElement(sld_id_lst_el, '{http://schemas.openxmlformats.org/presentationml/2006/main}sldId')
    max_id += 1
    new_sld_id.set('id', str(max_id))
    new_sld_id.set('{http://schemas.openxmlformats.org/officeDocument/2006/relationships}id', new_rid)

# Write updated presentation.xml and rels
out_files['ppt/presentation.xml'] = etree.tostring(prs_root, xml_declaration=True, encoding='UTF-8', standalone=True)
out_files['ppt/_rels/presentation.xml.rels'] = etree.tostring(prs_rels_root, xml_declaration=True, encoding='UTF-8', standalone=True)

# ── Step 4: Copy SRC2 slide layouts + theme if not already present ─────────────
for k in z2:
    if k.startswith('ppt/slideLayouts/') or k.startswith('ppt/theme/'):
        if k not in out_files:
            out_files[k] = z2[k]

# Fix slide layout references in newly added SRC2 slides
# SRC2 slide rels reference slideLayouts that now need to exist in output
# They were already copied above. But the rels reference them by relative path.
# The rels files in SRC2 slides use relative paths like '../slideLayouts/slideLayout1.xml'
# which should still work since we're keeping the same directory structure.

# ── Step 5: Write output ZIP ─────────────────────────────────────────────────
print("Writing output file...")
with zipfile.ZipFile(OUT, 'w', zipfile.ZIP_DEFLATED) as zout:
    for name, data in out_files.items():
        zout.writestr(name, data)

import os
size = os.path.getsize(OUT)
print(f"SUCCESS: {OUT} ({size/1024/1024:.1f} MB)")

# Count slides in output
with zipfile.ZipFile(OUT, 'r') as z:
    slides = [f for f in z.namelist() if re.match(r'ppt/slides/slide\d+\.xml$', f)]
    print(f"Total slides in output: {len(slides)}")

"""
Merge Retinitis + Choroiditis PPTXs into one file.
Uses direct ZIP manipulation - no python-pptx needed.
"""

import zipfile, os, re, io, shutil
from lxml import etree

SRC1 = "/home/daytona/workspace/attachments/667b0580-7f3e-40dd-ac7c-c14a15da2e87/Retinitis_Complete.pptx"
SRC2 = "/home/daytona/workspace/choroiditis-pptx/Choroiditis_Complete.pptx"
TMP  = "/tmp/combined_tmp.pptx"
OUT  = "/home/daytona/workspace/choroiditis-pptx/Retinitis_Choroiditis_Combined.pptx"

REL_NS = "http://schemas.openxmlformats.org/package/2006/relationships"
PML_NS = "http://schemas.openxmlformats.org/presentationml/2006/main"
OFC_R  = "http://schemas.openxmlformats.org/officeDocument/2006/relationships"

def read_zip(path):
    d = {}
    with zipfile.ZipFile(path, 'r') as z:
        for name in z.namelist():
            d[name] = z.read(name)
    return d

def parse(data):
    return etree.fromstring(data if isinstance(data, bytes) else data.encode())

def write_xml(root):
    return etree.tostring(root, xml_declaration=True, encoding='UTF-8', standalone=True)

print("Reading files...")
z1 = read_zip(SRC1)
z2 = read_zip(SRC2)

# ── Parse SRC1 presentation rels to get ordered slide list ──────────────────
def get_ordered_slides(z, rels_path='ppt/_rels/presentation.xml.rels'):
    rels_data = z[rels_path]
    root = parse(rels_data)
    slides = []
    for rel in root.findall(f'{{{REL_NS}}}Relationship'):
        t = rel.get('Type', '')
        tgt = rel.get('Target', '')
        if t.endswith('/slide') and 'slides/slide' in tgt:
            slides.append((rel.get('Id'), tgt))
    # Sort by slide number
    slides.sort(key=lambda x: int(re.search(r'slide(\d+)', x[1]).group(1)))
    return slides

slides1 = get_ordered_slides(z1)
slides2 = get_ordered_slides(z2)
n1 = len(slides1)
n2 = len(slides2)
print(f"SRC1: {n1} slides, SRC2: {n2} slides")

# ── Build output: start from SRC1, append divider + SRC2 slides ──────────────
out = dict(z1)

# Media conflict resolution: rename SRC2 media that clash
media_map2 = {}  # old name -> new name
existing_media = {k for k in out if k.startswith('ppt/media/')}
for k in z2:
    if k.startswith('ppt/media/'):
        if k in existing_media:
            # rename: add prefix c2_
            fname = k[len('ppt/media/'):]
            new_key = 'ppt/media/c2_' + fname
            media_map2[k] = new_key
        else:
            media_map2[k] = k

# Copy SRC2 media (with renames)
for old_k, new_k in media_map2.items():
    out[new_k] = z2[old_k]

# Copy SRC2 slide layouts and themes not in SRC1
for k in z2:
    if k.startswith('ppt/slideLayouts/') or k.startswith('ppt/slideMasters/') or k.startswith('ppt/theme/'):
        if k not in out:
            out[k] = z2[k]
            # also copy their rels
            parts = k.split('/')
            rels_key = '/'.join(parts[:-1]) + '/_rels/' + parts[-1] + '.rels'
            if rels_key in z2 and rels_key not in out:
                out[rels_key] = z2[rels_key]

# ── Find next available slide number in output ────────────────────────────────
existing_nums = set()
for k in out:
    m = re.match(r'ppt/slides/slide(\d+)\.xml$', k)
    if m:
        existing_nums.add(int(m.group(1)))
next_num = max(existing_nums) + 1

# ── Create section divider slide ─────────────────────────────────────────────
DIVIDER = b'''<?xml version="1.0" encoding="UTF-8" standalone="yes"?>
<p:sld xmlns:a="http://schemas.openxmlformats.org/drawingml/2006/main" xmlns:r="http://schemas.openxmlformats.org/officeDocument/2006/relationships" xmlns:p="http://schemas.openxmlformats.org/presentationml/2006/main"><p:cSld name="Divider"><p:bg><p:bgPr><a:solidFill><a:srgbClr val="FFFFFF"/></a:solidFill></p:bgPr></p:bg><p:spTree><p:nvGrpSpPr><p:cNvPr id="1" name=""/><p:cNvGrpSpPr/><p:nvPr/></p:nvGrpSpPr><p:grpSpPr><a:xfrm><a:off x="0" y="0"/><a:ext cx="0" cy="0"/><a:chOff x="0" y="0"/><a:chExt cx="0" cy="0"/></a:xfrm></p:grpSpPr><p:sp><p:nvSpPr><p:cNvPr id="2" name="TopBar"/><p:cNvSpPr/><p:nvPr/></p:nvSpPr><p:spPr><a:xfrm><a:off x="0" y="0"/><a:ext cx="9144000" cy="182880"/></a:xfrm><a:prstGeom prst="rect"><a:avLst/></a:prstGeom><a:solidFill><a:srgbClr val="1E3A5F"/></a:solidFill><a:ln><a:solidFill><a:srgbClr val="1E3A5F"/></a:solidFill></a:ln></p:spPr></p:sp><p:sp><p:nvSpPr><p:cNvPr id="3" name="BotBar"/><p:cNvSpPr/><p:nvPr/></p:nvSpPr><p:spPr><a:xfrm><a:off x="0" y="4956048"/><a:ext cx="9144000" cy="192024"/></a:xfrm><a:prstGeom prst="rect"><a:avLst/></a:prstGeom><a:solidFill><a:srgbClr val="1E3A5F"/></a:solidFill><a:ln><a:solidFill><a:srgbClr val="1E3A5F"/></a:solidFill></a:ln></p:spPr></p:sp><p:sp><p:nvSpPr><p:cNvPr id="4" name="SeriesLabel"/><p:cNvSpPr/><p:nvPr/></p:nvSpPr><p:spPr><a:xfrm><a:off x="457200" y="914400"/><a:ext cx="8229600" cy="548640"/></a:xfrm><a:prstGeom prst="rect"><a:avLst/></a:prstGeom><a:noFill/><a:ln/></p:spPr><p:txBody><a:bodyPr wrap="square" rtlCol="0" anchor="ctr"/><a:lstStyle/><a:p><a:pPr algn="ctr" marL="0" indent="0"><a:buNone/></a:pPr><a:r><a:rPr lang="en-US" sz="2000" i="1" dirty="0"><a:solidFill><a:srgbClr val="1E3A5F"/></a:solidFill><a:latin typeface="Calibri"/></a:rPr><a:t>Uveitis Series &#x2014; Part 2 of 2</a:t></a:r></a:p></p:txBody></p:sp><p:sp><p:nvSpPr><p:cNvPr id="5" name="MainTitle"/><p:cNvSpPr/><p:nvPr/></p:nvSpPr><p:spPr><a:xfrm><a:off x="457200" y="1463040"/><a:ext cx="8229600" cy="1097280"/></a:xfrm><a:prstGeom prst="rect"><a:avLst/></a:prstGeom><a:noFill/><a:ln/></p:spPr><p:txBody><a:bodyPr wrap="square" rtlCol="0" anchor="ctr"/><a:lstStyle/><a:p><a:pPr algn="ctr" marL="0" indent="0"><a:buNone/></a:pPr><a:r><a:rPr lang="en-US" sz="5400" b="1" dirty="0"><a:solidFill><a:srgbClr val="1A1A1A"/></a:solidFill><a:latin typeface="Calibri"/></a:rPr><a:t>CHOROIDITIS</a:t></a:r></a:p></p:txBody></p:sp><p:sp><p:nvSpPr><p:cNvPr id="6" name="DivLine"/><p:cNvSpPr/><p:nvPr/></p:nvSpPr><p:spPr><a:xfrm><a:off x="1828800" y="2743200"/><a:ext cx="5486400" cy="36576"/></a:xfrm><a:prstGeom prst="rect"><a:avLst/></a:prstGeom><a:solidFill><a:srgbClr val="1E3A5F"/></a:solidFill><a:ln><a:solidFill><a:srgbClr val="1E3A5F"/></a:solidFill></a:ln></p:spPr></p:sp><p:sp><p:nvSpPr><p:cNvPr id="7" name="Sub"/><p:cNvSpPr/><p:nvPr/></p:nvSpPr><p:spPr><a:xfrm><a:off x="457200" y="2835360"/><a:ext cx="8229600" cy="548640"/></a:xfrm><a:prstGeom prst="rect"><a:avLst/></a:prstGeom><a:noFill/><a:ln/></p:spPr><p:txBody><a:bodyPr wrap="square" rtlCol="0" anchor="ctr"/><a:lstStyle/><a:p><a:pPr algn="ctr" marL="0" indent="0"><a:buNone/></a:pPr><a:r><a:rPr lang="en-US" sz="1800" i="1" dirty="0"><a:solidFill><a:srgbClr val="555555"/></a:solidFill><a:latin typeface="Calibri"/></a:rPr><a:t>Complete Review: Basic to Advanced | Kanski 10th Ed. | Ryan&#x27;s Retina 6th Ed.</a:t></a:r></a:p></p:txBody></p:sp></p:spTree></p:cSld></p:sld>'''

EMPTY_RELS = b'''<?xml version="1.0" encoding="UTF-8" standalone="yes"?>
<Relationships xmlns="http://schemas.openxmlformats.org/package/2006/relationships"></Relationships>'''

# Assign numbers: divider = next_num, then SRC2 slides
divider_num = next_num
out[f'ppt/slides/slide{divider_num}.xml'] = DIVIDER
out[f'ppt/slides/_rels/slide{divider_num}.xml.rels'] = EMPTY_RELS
next_num += 1

# SRC2 slide number mapping
s2_num_map = {}  # old_slide_num -> new_slide_num
for _, tgt in slides2:
    old_n = int(re.search(r'slide(\d+)', tgt).group(1))
    new_n = next_num
    s2_num_map[old_n] = new_n
    next_num += 1

print(f"Divider at slide{divider_num}; SRC2 slides: {s2_num_map}")

# Copy SRC2 slide XMLs
for old_n, new_n in s2_num_map.items():
    old_path = f'ppt/slides/slide{old_n}.xml'
    new_path = f'ppt/slides/slide{new_n}.xml'
    out[new_path] = z2[old_path]

    # Rels file
    old_rels = f'ppt/slides/_rels/slide{old_n}.xml.rels'
    new_rels = f'ppt/slides/_rels/slide{new_n}.xml.rels'
    if old_rels in z2:
        rels_str = z2[old_rels].decode('utf-8')
        # Fix media renames
        for old_mk, new_mk in media_map2.items():
            old_fname = old_mk[len('ppt/media/'):]
            new_fname = new_mk[len('ppt/media/'):]
            if old_fname != new_fname:
                rels_str = rels_str.replace('../media/' + old_fname, '../media/' + new_fname)
        out[new_rels] = rels_str.encode('utf-8')
    else:
        out[new_rels] = EMPTY_RELS

# ── Update presentation.xml ───────────────────────────────────────────────────
prs_root = parse(out['ppt/presentation.xml'])
prs_rels_root = parse(out['ppt/_rels/presentation.xml.rels'])

# Get max rId number
rids = []
for rel in prs_rels_root.findall(f'{{{REL_NS}}}Relationship'):
    m = re.search(r'(\d+)', rel.get('Id', ''))
    if m: rids.append(int(m.group(1)))
next_rid = max(rids) + 1 if rids else 100

# Get max slide id
sld_id_lst_el = prs_root.find(f'.//{{{PML_NS}}}sldIdLst')
ids = [int(s.get('id')) for s in sld_id_lst_el.findall(f'{{{PML_NS}}}sldId')]
max_id = max(ids) if ids else 256

def add_slide_to_prs(slide_num):
    global next_rid, max_id
    rid = f'rId{next_rid}'
    next_rid += 1
    max_id += 1

    # Add to rels
    rel_el = etree.SubElement(prs_rels_root, f'{{{REL_NS}}}Relationship')
    rel_el.set('Id', rid)
    rel_el.set('Type', f'{OFC_R}/slide')
    rel_el.set('Target', f'slides/slide{slide_num}.xml')

    # Add to sldIdLst
    sld_el = etree.SubElement(sld_id_lst_el, f'{{{PML_NS}}}sldId')
    sld_el.set('id', str(max_id))
    sld_el.set(f'{{{OFC_R}}}id', rid)

add_slide_to_prs(divider_num)
for old_n, new_n in s2_num_map.items():
    add_slide_to_prs(new_n)

out['ppt/presentation.xml'] = write_xml(prs_root)
out['ppt/_rels/presentation.xml.rels'] = write_xml(prs_rels_root)

# ── Write to /tmp first, then copy ─────────────────────────────────────────────
print(f"Writing {len(out)} files to {TMP}...")
buf = io.BytesIO()
with zipfile.ZipFile(buf, 'w', zipfile.ZIP_DEFLATED, allowZip64=True) as zout:
    for name, data in out.items():
        zout.writestr(name, data)

buf.seek(0)
with open(TMP, 'wb') as f:
    f.write(buf.read())

shutil.copy2(TMP, OUT)
size = os.path.getsize(OUT)
print(f"SUCCESS: {OUT} ({size/1024/1024:.1f} MB)")

# Verify
with zipfile.ZipFile(OUT, 'r') as z:
    slides = sorted([f for f in z.namelist() if re.match(r'ppt/slides/slide\d+\.xml$', f)],
                    key=lambda x: int(re.search(r'(\d+)', x).group(1)))
    print(f"Total slides: {len(slides)}")
    print("Slides:", [os.path.basename(s) for s in slides])

Successfully replaced 1 instance(s) of the string in '/home/daytona/workspace/choroiditis-pptx/merge_pptx.py'

"""
Merge Retinitis + Choroiditis PPTXs into one file.
Direct ZIP manipulation - inserts divider slide between the two decks.
"""
import zipfile, os, re, io, shutil
from lxml import etree

SRC1 = "/home/daytona/workspace/attachments/667b0580-7f3e-40dd-ac7c-c14a15da2e87/Retinitis_Complete.pptx"
SRC2 = "/home/daytona/workspace/choroiditis-pptx/Choroiditis_Complete.pptx"
OUT  = "/home/daytona/workspace/choroiditis-pptx/Retinitis_Choroiditis_Combined.pptx"

REL_NS = "http://schemas.openxmlformats.org/package/2006/relationships"
PML_NS = "http://schemas.openxmlformats.org/presentationml/2006/main"
OFC_R  = "http://schemas.openxmlformats.org/officeDocument/2006/relationships"

def read_zip(path):
    d = {}
    with zipfile.ZipFile(path, 'r') as z:
        for name in z.namelist():
            d[name] = z.read(name)
    return d

def px(data):
    return etree.fromstring(data if isinstance(data, bytes) else data.encode())

def wx(root):
    return etree.tostring(root, xml_declaration=True, encoding='UTF-8', standalone=True)

print("Reading files...")
z1 = read_zip(SRC1)
z2 = read_zip(SRC2)

def get_ordered_slides(z, rels_path='ppt/_rels/presentation.xml.rels'):
    root = px(z[rels_path])
    slides = []
    for rel in root.findall(f'{{{REL_NS}}}Relationship'):
        if rel.get('Type','').endswith('/slide') and 'slides/slide' in rel.get('Target',''):
            tgt = rel.get('Target')
            slides.append((rel.get('Id'), tgt))
    slides.sort(key=lambda x: int(re.search(r'slide(\d+)', x[1]).group(1)))
    return slides

slides1 = get_ordered_slides(z1)
slides2 = get_ordered_slides(z2)
print(f"SRC1: {len(slides1)} slides, SRC2: {len(slides2)} slides")

out = dict(z1)

# Media conflict: rename SRC2 media that clash with SRC1
media_map2 = {}
existing_media = {k for k in out if k.startswith('ppt/media/')}
for k in z2:
    if k.startswith('ppt/media/'):
        if k in existing_media:
            fname = k[len('ppt/media/'):]
            media_map2[k] = 'ppt/media/c2_' + fname
        else:
            media_map2[k] = k
for old_k, new_k in media_map2.items():
    out[new_k] = z2[old_k]

# Copy SRC2 slide layouts / masters not in SRC1
for k in z2:
    if k.startswith('ppt/slideLayouts/') or k.startswith('ppt/slideMasters/') or k.startswith('ppt/theme/'):
        if k not in out:
            out[k] = z2[k]
            parts = k.split('/')
            rk = '/'.join(parts[:-1]) + '/_rels/' + parts[-1] + '.rels'
            if rk in z2 and rk not in out:
                out[rk] = z2[rk]

# Next available slide number
nxt = max((int(re.search(r'slide(\d+)',k).group(1)) for k in out if re.match(r'ppt/slides/slide\d+\.xml$',k)), default=0) + 1

DIVIDER = b'''<?xml version="1.0" encoding="UTF-8" standalone="yes"?>
<p:sld xmlns:a="http://schemas.openxmlformats.org/drawingml/2006/main" xmlns:r="http://schemas.openxmlformats.org/officeDocument/2006/relationships" xmlns:p="http://schemas.openxmlformats.org/presentationml/2006/main"><p:cSld name="Divider"><p:bg><p:bgPr><a:solidFill><a:srgbClr val="FFFFFF"/></a:solidFill></p:bgPr></p:bg><p:spTree><p:nvGrpSpPr><p:cNvPr id="1" name=""/><p:cNvGrpSpPr/><p:nvPr/></p:nvGrpSpPr><p:grpSpPr><a:xfrm><a:off x="0" y="0"/><a:ext cx="0" cy="0"/><a:chOff x="0" y="0"/><a:chExt cx="0" cy="0"/></a:xfrm></p:grpSpPr><p:sp><p:nvSpPr><p:cNvPr id="2" name="TopBar"/><p:cNvSpPr/><p:nvPr/></p:nvSpPr><p:spPr><a:xfrm><a:off x="0" y="0"/><a:ext cx="9144000" cy="182880"/></a:xfrm><a:prstGeom prst="rect"><a:avLst/></a:prstGeom><a:solidFill><a:srgbClr val="1E3A5F"/></a:solidFill><a:ln><a:solidFill><a:srgbClr val="1E3A5F"/></a:solidFill></a:ln></p:spPr></p:sp><p:sp><p:nvSpPr><p:cNvPr id="3" name="BotBar"/><p:cNvSpPr/><p:nvPr/></p:nvSpPr><p:spPr><a:xfrm><a:off x="0" y="4956048"/><a:ext cx="9144000" cy="192024"/></a:xfrm><a:prstGeom prst="rect"><a:avLst/></a:prstGeom><a:solidFill><a:srgbClr val="1E3A5F"/></a:solidFill><a:ln><a:solidFill><a:srgbClr val="1E3A5F"/></a:solidFill></a:ln></p:spPr></p:sp><p:sp><p:nvSpPr><p:cNvPr id="4" name="Lbl"/><p:cNvSpPr/><p:nvPr/></p:nvSpPr><p:spPr><a:xfrm><a:off x="457200" y="914400"/><a:ext cx="8229600" cy="548640"/></a:xfrm><a:prstGeom prst="rect"><a:avLst/></a:prstGeom><a:noFill/><a:ln/></p:spPr><p:txBody><a:bodyPr wrap="square" rtlCol="0" anchor="ctr"/><a:lstStyle/><a:p><a:pPr algn="ctr" marL="0" indent="0"><a:buNone/></a:pPr><a:r><a:rPr lang="en-US" sz="2000" i="1" dirty="0"><a:solidFill><a:srgbClr val="1E3A5F"/></a:solidFill><a:latin typeface="Calibri"/></a:rPr><a:t>Uveitis Series - Part 2 of 2</a:t></a:r></a:p></p:txBody></p:sp><p:sp><p:nvSpPr><p:cNvPr id="5" name="T"/><p:cNvSpPr/><p:nvPr/></p:nvSpPr><p:spPr><a:xfrm><a:off x="457200" y="1463040"/><a:ext cx="8229600" cy="1097280"/></a:xfrm><a:prstGeom prst="rect"><a:avLst/></a:prstGeom><a:noFill/><a:ln/></p:spPr><p:txBody><a:bodyPr wrap="square" rtlCol="0" anchor="ctr"/><a:lstStyle/><a:p><a:pPr algn="ctr" marL="0" indent="0"><a:buNone/></a:pPr><a:r><a:rPr lang="en-US" sz="5400" b="1" dirty="0"><a:solidFill><a:srgbClr val="1A1A1A"/></a:solidFill><a:latin typeface="Calibri"/></a:rPr><a:t>CHOROIDITIS</a:t></a:r></a:p></p:txBody></p:sp><p:sp><p:nvSpPr><p:cNvPr id="6" name="DL"/><p:cNvSpPr/><p:nvPr/></p:nvSpPr><p:spPr><a:xfrm><a:off x="1828800" y="2743200"/><a:ext cx="5486400" cy="36576"/></a:xfrm><a:prstGeom prst="rect"><a:avLst/></a:prstGeom><a:solidFill><a:srgbClr val="1E3A5F"/></a:solidFill><a:ln><a:solidFill><a:srgbClr val="1E3A5F"/></a:solidFill></a:ln></p:spPr></p:sp><p:sp><p:nvSpPr><p:cNvPr id="7" name="Sub"/><p:cNvSpPr/><p:nvPr/></p:nvSpPr><p:spPr><a:xfrm><a:off x="457200" y="2835360"/><a:ext cx="8229600" cy="548640"/></a:xfrm><a:prstGeom prst="rect"><a:avLst/></a:prstGeom><a:noFill/><a:ln/></p:spPr><p:txBody><a:bodyPr wrap="square" rtlCol="0" anchor="ctr"/><a:lstStyle/><a:p><a:pPr algn="ctr" marL="0" indent="0"><a:buNone/></a:pPr><a:r><a:rPr lang="en-US" sz="1800" i="1" dirty="0"><a:solidFill><a:srgbClr val="555555"/></a:solidFill><a:latin typeface="Calibri"/></a:rPr><a:t>Kanski 10th Ed. | Ryan Retina 6th Ed. | Based on standard textbooks</a:t></a:r></a:p></p:txBody></p:sp></p:spTree></p:cSld></p:sld>'''

EMPTY_RELS = b'''<?xml version="1.0" encoding="UTF-8" standalone="yes"?>
<Relationships xmlns="http://schemas.openxmlformats.org/package/2006/relationships"></Relationships>'''

# Add divider
div_num = nxt
out[f'ppt/slides/slide{div_num}.xml'] = DIVIDER
out[f'ppt/slides/_rels/slide{div_num}.xml.rels'] = EMPTY_RELS
nxt += 1

# Add SRC2 slides
s2map = {}
for _, tgt in slides2:
    old_n = int(re.search(r'slide(\d+)', tgt).group(1))
    s2map[old_n] = nxt
    nxt += 1

for old_n, new_n in s2map.items():
    out[f'ppt/slides/slide{new_n}.xml'] = z2[f'ppt/slides/slide{old_n}.xml']
    ork = f'ppt/slides/_rels/slide{old_n}.xml.rels'
    nrk = f'ppt/slides/_rels/slide{new_n}.xml.rels'
    if ork in z2:
        rs = z2[ork].decode('utf-8')
        for ok, nk in media_map2.items():
            of = ok[len('ppt/media/'):]
            nf = nk[len('ppt/media/'):]
            if of != nf:
                rs = rs.replace('../media/' + of, '../media/' + nf)
        out[nrk] = rs.encode()
    else:
        out[nrk] = EMPTY_RELS

# Update presentation.xml
prs = px(out['ppt/presentation.xml'])
prs_rels = px(out['ppt/_rels/presentation.xml.rels'])

rids = [int(re.search(r'(\d+)', r.get('Id','')).group(1)) for r in prs_rels.findall(f'{{{REL_NS}}}Relationship') if re.search(r'(\d+)', r.get('Id',''))]
next_rid = max(rids)+1 if rids else 200

sll = prs.find(f'.//{{{PML_NS}}}sldIdLst')
ids = [int(s.get('id')) for s in sll.findall(f'{{{PML_NS}}}sldId')]
max_id = max(ids) if ids else 300

def add_sld(num):
    global next_rid, max_id
    rid = f'rId{next_rid}'; next_rid += 1; max_id += 1
    r = etree.SubElement(prs_rels, f'{{{REL_NS}}}Relationship')
    r.set('Id', rid); r.set('Type', f'{OFC_R}/slide'); r.set('Target', f'slides/slide{num}.xml')
    s = etree.SubElement(sll, f'{{{PML_NS}}}sldId')
    s.set('id', str(max_id)); s.set(f'{{{OFC_R}}}id', rid)

add_sld(div_num)
for _, new_n in sorted(s2map.items()):
    add_sld(new_n)

out['ppt/presentation.xml'] = wx(prs)
out['ppt/_rels/presentation.xml.rels'] = wx(prs_rels)

# Write via BytesIO to avoid filesystem issues
print(f"Writing {len(out)} entries...")
buf = io.BytesIO()
with zipfile.ZipFile(buf, 'w', zipfile.ZIP_DEFLATED, allowZip64=True) as zout:
    for name, data in out.items():
        zout.writestr(name, data)
buf.seek(0)
with open(OUT, 'wb') as f:
    shutil.copyfileobj(buf, f)

sz = os.path.getsize(OUT)
print(f"SUCCESS: {OUT} ({sz/1024/1024:.1f} MB)")

with zipfile.ZipFile(OUT) as zv:
    sl = sorted([f for f in zv.namelist() if re.match(r'ppt/slides/slide\d+\.xml$',f)],
                key=lambda x: int(re.search(r'(\d+)',x).group(1)))
    print(f"Total slides: {len(sl)}")

const pptxgen = require("pptxgenjs");
const { execSync } = require("child_process");
const fs = require("fs");

// Fetch one image at a time
function fetchImg(url) {
  try {
    const r = execSync(`node /home/daytona/skills/shared/scripts/fetch_images.js "${url}"`,
      { timeout: 30000, maxBuffer: 10*1024*1024 }).toString();
    const arr = JSON.parse(r);
    return arr[0] && arr[0].base64 ? arr[0].base64 : null;
  } catch(e) {
    console.error("Fetch failed:", url.slice(-20), e.message.slice(0,40));
    return null;
  }
}

// All image URLs from Kanski block3 (choroiditis section, lines 6830-7280)
const URLS = {
  mewds_fundus:    "https://cdn.orris.care/cdss_images/fb7479b4cb796b53b34a55022c34725be663e6fe30ee96680d1df8e3847857d0.png",
  mewds_fa:        "https://cdn.orris.care/cdss_images/30e5d01d799a29375b6a06bd7f6b844764ec886a05f2ccb3deb11811d814de6d.png",
  mewds_icga:      "https://cdn.orris.care/cdss_images/7bc64a504e940fcc501787363be2b9f1696a474a03f0b435921ce0cc4eae815e.png",
  apmppe:          "https://cdn.orris.care/cdss_images/277a1897ee10a2adb99e29d558f205e3e72763c95b085e52974fc7a6987c1a38.png",
  apmppe_icga:     "https://cdn.orris.care/cdss_images/3577e8ed8623620eafc5c30beb02154b8235f8f7facce6f542b50534f71bdf1b.png",
  serp_early:      "https://cdn.orris.care/cdss_images/6c9ce0eb1ece304a020b0404aa0fadba164390e9d415378f8a1b1b0abed5bd7e.png",
  serp_scar:       "https://cdn.orris.care/cdss_images/ee030616e6bbe3d5efcbab9ee62c40725effddf051be5f5a54cbf624e311f3d9.png",
  serp_advanced:   "https://cdn.orris.care/cdss_images/7753836a09dd5069bfd64e9c4213ef40143e55bfe7ef0c95d9fcfb7bd7187467.png",
  mfc_inactive:    "https://cdn.orris.care/cdss_images/e9d838a582b02386b0abc10c5df05931c14c00c131b5b7702cf1ad16f4201c62.png",
  fungal_panel:    "https://cdn.orris.care/cdss_images/828ec6e4b716df6b35caf32a210b3ff2baf83ed4244b69b7b3ebf2f93e18b05a.png",
  atrophy:         "https://cdn.orris.care/cdss_images/7753836a09dd5069bfd64e9c4213ef40143e55bfe7ef0c95d9fcfb7bd7187467.png",
};

console.log("Fetching images (one at a time)...");
const imgs = {};
for (const [key, url] of Object.entries(URLS)) {
  process.stdout.write(`  Fetching ${key}... `);
  imgs[key] = fetchImg(url);
  console.log(imgs[key] ? "OK" : "FAILED");
}

const pres = new pptxgen();
pres.layout = "LAYOUT_16x9";
pres.title = "Choroiditis – Complete Review";

const C_BG = "FFFFFF", C_NAVY = "1E3A5F", C_HEAD = "1A1A1A", C_TEXT = "2C2C2C";
const C_ACCENT = "D4E6F1", FONT = "Calibri";
const W = 10, H = 5.625;

function applyBg(s) { s.background = { color: C_BG }; }

function addHeading(s, title) {
  s.addText(title, { x:0.33, y:0.1, w:9.34, h:0.62, fontSize:24, bold:true, color:C_HEAD, fontFace:FONT, valign:"middle", margin:0 });
  s.addShape(pres.ShapeType.rect, { x:0.33, y:0.75, w:9.34, h:0.03, fill:{color:C_NAVY}, line:{color:C_NAVY,width:0} });
}

function bullets(s, items, opts={}) {
  const cfg = { x:0.43, y:0.85, w:9.2, h:4.65, fontSize:17, color:C_TEXT, fontFace:FONT, ...opts };
  s.addText(items.map((t,i)=>({text:t, options:{bullet:{indent:15}, breakLine:i<items.length-1, fontSize:cfg.fontSize, color:cfg.color, fontFace:cfg.fontFace}})),
    { x:cfg.x, y:cfg.y, w:cfg.w, h:cfg.h, valign:"top" });
}

function bulletsImg(s, items, imgData, caption="") {
  s.addText(items.map((t,i)=>({text:t, options:{bullet:{indent:15}, breakLine:i<items.length-1, fontSize:16, color:C_TEXT, fontFace:FONT}})),
    { x:0.43, y:0.85, w:5.6, h:4.65, valign:"top" });
  if (imgData) {
    s.addImage({ data:imgData, x:6.2, y:0.88, w:3.55, h:3.4 });
    if (caption) s.addText(caption, { x:6.2, y:4.32, w:3.55, h:0.32, fontSize:10, color:"888888", fontFace:FONT, italic:true, align:"center" });
  }
}

function addFcBox(s, label, x, y, w=2.6, h=0.52, fill=C_ACCENT, tColor=C_NAVY, sz=13) {
  s.addShape(pres.ShapeType.roundRect, { x,y,w,h, fill:{color:fill}, line:{color:C_NAVY,width:1.5}, rectRadius:0.1 });
  s.addText(label, { x,y,w,h, fontSize:sz, bold:true, color:tColor, fontFace:FONT, align:"center", valign:"middle", margin:0 });
}
function addFcArrow(s,x,y1,y2){
  s.addShape(pres.ShapeType.line,{x:x+0.02,y:y1,w:0,h:y2-y1,line:{color:C_NAVY,width:1.5,endArrowType:"triangle"}});
}

// ── SLIDE 1: TITLE ────────────────────────────────────────────────────────────
{
  const s=pres.addSlide(); applyBg(s);
  s.addShape(pres.ShapeType.rect,{x:0,y:0,w:W,h:0.2,fill:{color:C_NAVY},line:{color:C_NAVY}});
  s.addShape(pres.ShapeType.rect,{x:0,y:5.4,w:W,h:0.22,fill:{color:C_NAVY},line:{color:C_NAVY}});
  s.addText("CHOROIDITIS",{x:0.5,y:0.42,w:9,h:1.2,fontSize:54,bold:true,color:C_HEAD,fontFace:FONT,align:"center",valign:"middle"});
  s.addText("Complete Review: Basic to Advanced",{x:0.5,y:1.65,w:9,h:0.6,fontSize:20,italic:true,color:C_NAVY,fontFace:FONT,align:"center"});
  s.addShape(pres.ShapeType.rect,{x:2,y:2.4,w:6,h:0.04,fill:{color:C_NAVY},line:{color:C_NAVY}});
  s.addText("Reference: Kanski's Clinical Ophthalmology 10th Ed. | Ryan's Retina 6th Ed.",{x:0.5,y:2.55,w:9,h:0.45,fontSize:14,color:"666666",fontFace:FONT,align:"center",italic:true});
  const topics=["Choroidal Anatomy & Pathophysiology","Etiology & Classification (ICG-based)","Pathogenesis Flowchart","Clinical Features & Investigations","Specific Entities (MEWDS, APMPPE, Serpiginous, MFC, PIC, Birdshot, VKH, Infectious)","Treatment Flowcharts | Complications | Recent Advances 2022-2026"];
  s.addText(topics.map((t,i)=>({text:`${i+1}.  ${t}`,options:{breakLine:i<topics.length-1,fontSize:14,color:C_TEXT,fontFace:FONT}})),{x:1.8,y:3.1,w:6.4,h:2.1,valign:"top"});
}

// ── SLIDE 2: ANATOMY ──────────────────────────────────────────────────────────
{
  const s=pres.addSlide(); applyBg(s); addHeading(s,"Anatomy of the Choroid");
  bullets(s,[
    "Choroid: vascular layer between retina (RPE) and sclera; 0.1–0.2 mm thick posteriorly",
    "Layers (inner→outer): Bruch's membrane → Choriocapillaris → Sattler's layer (medium vessels) → Haller's layer (large vessels) → Suprachoroid",
    "Blood supply: short posterior ciliary arteries; venous drainage via vortex veins",
    "Choriocapillaris: fenestrated lobular units — primary target in choriocapillaritides (MEWDS, APMPPE, serpiginous)",
    "Provides 65–85% of outer retinal blood supply; rich in lymphocytes, melanocytes, mast cells, macrophages",
    "Choroidal stroma: loose connective tissue hosting immune surveillance cells — target in stromal choroiditides (VKH, birdshot)",
  ]);
}

// ── SLIDE 3: DEFINITION & CLASSIFICATION ─────────────────────────────────────
{
  const s=pres.addSlide(); applyBg(s); addHeading(s,"Definition, Scope & Classification");
  bullets(s,[
    "Choroiditis: inflammation of the choroid; may extend to RPE, retina, vitreous — part of posterior uveitis",
    "Incidence: ~4–6/100,000/year for all posterior uveitis; leading cause of visual morbidity in working-age adults",
    "Infectious vs. Non-infectious; Focal vs. Multifocal vs. Diffuse; Granulomatous vs. Non-granulomatous",
    "ICG-based (Kanski): 1A = Primary choriocapillaritis | 1B = Secondary choriocapillaritis | 2A = Primary stromal | 2B = Secondary stromal",
    "1A examples: MEWDS, APMPPE, Serpiginous, MFC, PIC | 1B: TB-serpiginous, ASPPC (syphilis)",
    "2A: Birdshot (HLA-A29), VKH, Sympathetic ophthalmia | 2B: Sarcoidosis, TB, Syphilis",
  ]);
}

// ── SLIDE 4: ETIOLOGY ────────────────────────────────────────────────────────
{
  const s=pres.addSlide(); applyBg(s); addHeading(s,"Etiology – Why Does It Happen?");
  bullets(s,[
    "Infectious: bacteria (TB, syphilis, Lyme, Bartonella), viruses (CMV, EBV, VZV, HIV), fungi (Candida, Aspergillus, Cryptococcus, PCP), parasites (Toxoplasma, Toxocara)",
    "Autoimmune / Idiopathic: molecular mimicry, autoantigen exposure (choroidal melanocytes, RPE proteins)",
    "HLA associations: HLA-A29 (birdshot), HLA-DR4/DRw53 (VKH), HLA-B51 (Behcet), HLA-B7 (serpiginous)",
    "Systemic disease: Sarcoidosis (granulomatous), VKH (melanocyte-targeted), Behcet (vasculitis-driven)",
    "Vaccine/drug-triggered: multifocal choroiditis post COVID-19/influenza vaccination; MEWDS variants reported",
    "Masquerade: intraocular lymphoma, choroidal metastases — must be excluded in atypical/unresponsive cases",
  ]);
}

// ── SLIDE 5: PATHOGENESIS FLOWCHART ──────────────────────────────────────────
{
  const s=pres.addSlide(); applyBg(s); addHeading(s,"Pathogenesis – How Does It Happen?");
  const lx=0.4, rx=5.3, bw=4.1, bh=0.46, gap=0.16;
  s.addText("INFECTIOUS PATHWAY",{x:lx,y:0.82,w:bw,h:0.32,fontSize:11,bold:true,color:C_NAVY,fontFace:FONT,align:"center"});
  s.addText("IMMUNE-MEDIATED PATHWAY",{x:rx,y:0.82,w:bw,h:0.32,fontSize:11,bold:true,color:"1A5C2A",fontFace:FONT,align:"center"});
  const lBoxes=["Pathogen enters (hematogenous\nor contiguous spread)","Antigen presentation by choroidal\nmacrophages / dendritic cells","Th1/Th17 activation + cytokine\nstorm (TNF-α, IL-6, IL-17)","Endothelial damage →\nchoriocapillaris occlusion","RPE disruption → outer retinal\nischaemia → visual loss"];
  const rBoxes=["Molecular mimicry or\nautoantigenic trigger","T-cell attack on choroidal\nmelanocytes / stroma","B-cell activation +\nautoantibody formation","Granuloma or diffuse\ninflammatory infiltrate","Choriocapillaris dropout →\nchorioretinal atrophy"];
  let ly=1.2, ry=1.2;
  for(let i=0;i<lBoxes.length;i++){
    addFcBox(s,lBoxes[i],lx,ly,bw,bh,i===0?"D6EAF8":C_ACCENT,C_NAVY,10);
    addFcBox(s,rBoxes[i],rx,ry,bw,bh,i===0?"D5F5E3":"E8F8E8","1A5C2A",10);
    if(i<lBoxes.length-1){addFcArrow(s,lx+bw/2-0.02,ly+bh,ly+bh+gap);addFcArrow(s,rx+bw/2-0.02,ry+bh,ry+bh+gap);}
    ly+=bh+gap; ry+=bh+gap;
  }
  s.addText("Both converge → Choriocapillaritis → Outer retinal ischaemia → Visual loss",{x:0.4,y:5.1,w:9.2,h:0.38,fontSize:12,bold:true,color:C_NAVY,fontFace:FONT,align:"center"});
}

// ── SLIDE 6: CLASSIFICATION TABLE ────────────────────────────────────────────
{
  const s=pres.addSlide(); applyBg(s); addHeading(s,"ICG-Based Classification of Choroiditis (Kanski 10th Ed.)");
  const rows=[
    [{text:"Category",options:{bold:true,color:"FFFFFF",fill:C_NAVY,align:"center"}},{text:"Type",options:{bold:true,color:"FFFFFF",fill:C_NAVY,align:"center"}},{text:"Examples",options:{bold:true,color:"FFFFFF",fill:C_NAVY,align:"center"}}],
    [{text:"1A",options:{bold:true,color:C_NAVY,fill:"D6EAF8",align:"center"}},{text:"Primary choriocapillaritis (unknown trigger)",options:{color:C_TEXT}},{text:"MEWDS, APMPPE, Serpiginous, MFC, PIC",options:{color:C_TEXT}}],
    [{text:"1B",options:{bold:true,color:C_NAVY,fill:"D6EAF8",align:"center"}},{text:"Secondary choriocapillaritis (pathogen-triggered immune response)",options:{color:C_TEXT}},{text:"TB-serpiginous, Acute syphilitic PPPC",options:{color:C_TEXT}}],
    [{text:"2A",options:{bold:true,color:"1A5C2A",fill:"D5F5E3",align:"center"}},{text:"Primary stromal choroiditis (stroma is target)",options:{color:C_TEXT}},{text:"Birdshot (HLA-A29), VKH, Sympathetic ophthalmia",options:{color:C_TEXT}}],
    [{text:"2B",options:{bold:true,color:"1A5C2A",fill:"D5F5E3",align:"center"}},{text:"Secondary stromal (systemic inflammation)",options:{color:C_TEXT}},{text:"Sarcoidosis, Tubercular, Syphilitic chorioretinitis",options:{color:C_TEXT}}],
  ];
  s.addTable(rows,{x:0.4,y:0.88,w:9.2,h:4.5,rowH:0.75,fontSize:14,fontFace:FONT,colW:[0.7,3.5,5.0],border:{pt:1,color:C_NAVY}});
}

// ── SLIDE 7: CLINICAL FEATURES ───────────────────────────────────────────────
{
  const s=pres.addSlide(); applyBg(s); addHeading(s,"Clinical Features of Choroiditis");
  bullets(s,[
    "Symptoms: blurred vision, photopsia, floaters, scotomata, metamorphopsia (macular involvement)",
    "Anterior segment: AC cells/flare, KPs — mutton-fat (granulomatous: sarcoid, TB, VKH) vs. fine (non-granulomatous)",
    "Vitreous: vitritis (cells + haze) — absent in PIC, minimal in MEWDS, severe in birdshot/VKH",
    "Fundus: white/yellow lesions at RPE/inner choroid level; focal (toxoplasma), multifocal (MFC, birdshot), diffuse (VKH, serpiginous)",
    "Complications: MNV (choroidal neovascularisation), CMO, subretinal fibrosis, exudative RD, disc oedema",
    "Systemic clues: poliosis/vitiligo (VKH), lymphadenopathy/hilar nodes (sarcoid), oral/genital ulcers (Behcet), HIV status",
  ]);
}

// ── SLIDE 8: INVESTIGATIONS ──────────────────────────────────────────────────
{
  const s=pres.addSlide(); applyBg(s); addHeading(s,"Investigations");
  bullets(s,[
    "FA: early hypofluorescence (ischaemia/block) → late hyperfluorescence (staining/leakage); hallmark of active choriocapillaritis",
    "ICGA: gold standard — hypofluorescent lesions exceed clinically visible disease; reveals subclinical choriocapillaris dropout",
    "FAF: hyperAF = active inflammation (toxic to RPE); hypoAF = established atrophy; essential for monitoring serpiginous",
    "OCT/EDI-OCT: sub-RPE material, outer retinal disruption, choroidal thickening; OCTA shows choriocapillaris flow deficits",
    "Serology: FTA-ABS/VDRL (syphilis), TB (Mantoux/IGRA), ACE (sarcoid), HLA-A29 (birdshot), HLA-B51 (Behcet), ANA, HIV",
    "Aqueous/vitreous PCR: HSV/VZV/CMV, TB, Toxoplasma — Goldmann-Witmer coefficient; vitreous biopsy if masquerade suspected",
  ]);
}

// ── SLIDE 9: MEWDS ───────────────────────────────────────────────────────────
{
  const s=pres.addSlide(); applyBg(s); addHeading(s,"MEWDS – Multiple Evanescent White Dot Syndrome");
  bulletsImg(s,[
    "Young adult women; unilateral; acute onset; often post-viral or post-vaccination (influenza/COVID-19)",
    "Tiny (100–300 µm) grey-white dots at posterior pole sparing fovea; fovea shows characteristic orange granularity",
    "Subtle vitritis (50%); optic disc oedema occasionally present",
    "FA: punctate hyperfluorescence; ICGA: numerous late hypofluorescent dots (more than clinically apparent)",
    "FAF: hyperAF dots corresponding to lesions; OCT: ellipsoid zone disruption",
    "Self-limiting in 8–10 weeks; no treatment needed; 10% recur — suspect MFC if recurrent",
  ], imgs.mewds_fundus, "MEWDS: fading white dots with arrows\n(Kanski 10th Ed., Fig. 12.60A)");
}

// ── SLIDE 10: APMPPE ─────────────────────────────────────────────────────────
{
  const s=pres.addSlide(); applyBg(s); addHeading(s,"APMPPE – Acute Posterior Multifocal Placoid Pigment Epitheliopathy");
  bulletsImg(s,[
    "Young adults; bilateral (asymmetric); typically follows viral illness or vaccination",
    "Cream-coloured placoid lesions at RPE level in posterior pole; resolve in weeks leaving RPE mottling",
    "FA: classic 'early block, late stain' pattern (early hypofluorescence → late hyperfluorescence)",
    "OCTA: choriocapillaris flow deficits — primary pathology is lobular choriocapillaris ischaemia",
    "CNS vasculitis reported (headache, CSF pleocytosis) — cerebral imaging mandatory if neurological symptoms",
    "Prognosis generally good; ~20% have visual sequelae from foveal scarring; recurrence uncommon",
  ], imgs.apmppe, "APMPPE: placoid lesions\n(Kanski 10th Ed., Fig. 12.61)");
}

// ── SLIDE 11: SERPIGINOUS ────────────────────────────────────────────────────
{
  const s=pres.addSlide(); applyBg(s); addHeading(s,"Serpiginous Choroidopathy");
  bulletsImg(s,[
    "Bilateral, chronic, recurrent; middle-aged adults; male predominance; HLA-B7 association",
    "Starts peripapillary → extends centrifugally in 'snake-like' (serpiginous) pattern; 5% start at macula",
    "Active edge: grey-white, ill-defined; inactive centre: scalloped chorioretinal atrophy + RPE loss",
    "FA: early hypofluorescence → late hyperfluorescence at active edge; ICGA: persistent late hypofluorescence",
    "FAF: active edge = hyperAF border; inactive = uniformly hypoAF; MNV in 15–35%",
    "TB must be excluded (IGRA/Mantoux/CXR) — TB-serpiginous ('serpiginoid') treated with ATT + steroids",
  ], imgs.serp_early, "Serpiginous: early peripapillary lesion\n(Kanski 10th Ed., Fig. 12.62A)");
}

// ── SLIDE 12: MFC & PIC ──────────────────────────────────────────────────────
{
  const s=pres.addSlide(); applyBg(s); addHeading(s,"Multifocal Choroiditis (MFC) & Punctate Inner Choroidopathy (PIC)");
  bulletsImg(s,[
    "MFC: young–middle-aged women; bilateral asymmetric; chronic/recurrent; anterior uveitis (50%) + vitritis present",
    "Multiple ovoid yellow-grey lesions 50–350 µm; posterior pole ± periphery; inactive = 'histo spots' (resemble POHS)",
    "MNV in 25–35% of MFC; also CMO, subretinal fibrosis; FA: early hypo, late hyper; ICGA: hypofluorescent",
    "PIC: young myopic women; bilateral (80%); macular predominance; NO anterior uveitis/vitritis",
    "PIC: MNV in up to 40%; anti-VEGF first-line for MNV; sharply demarcated atrophic scars at resolution",
    "Treatment MFC: oral steroids → steroid-resistant: cyclosporine/tacrolimus + mycophenolate mofetil",
  ], imgs.mfc_inactive, "MFC: inactive lesions, posterior pole\n(Kanski 10th Ed., Fig. 12.63A)");
}

// ── SLIDE 13: BIRDSHOT ───────────────────────────────────────────────────────
{
  const s=pres.addSlide(); applyBg(s); addHeading(s,"Birdshot Retinochoroidopathy (HLA-A29)");
  bullets(s,[
    "Rare; bilateral; chronic; middle-aged Caucasians; 96% HLA-A29 positive — most specific HLA association in uveitis",
    "Cream/salmon-coloured hypopigmented choroidal spots radiating from disc in 'birdshot/buckshot' scatter pattern",
    "Vitritis always present; CMO, retinal vasculitis, disc oedema are common vision-threatening complications",
    "ERG: photopic and scotopic abnormalities appear early (before clinical changes) — essential monitoring tool",
    "Treatment: long-term systemic immunosuppression — mycophenolate, cyclosporine, adalimumab (anti-TNF)",
    "Prognosis: guarded; permanent vision loss from CMO and retinal vasculitis if undertreated; needs ≥5 years IMT",
  ]);
}

// ── SLIDE 14: VKH ────────────────────────────────────────────────────────────
{
  const s=pres.addSlide(); applyBg(s); addHeading(s,"Vogt-Koyanagi-Harada (VKH) Disease");
  bullets(s,[
    "Bilateral granulomatous panuveitis targeting melanocytes; HLA-DR4/DRw53; Asian/Hispanic/Middle Eastern preponderance",
    "Phases: prodromal (meningism, tinnitus, dysacusis) → acute uveitic (bilateral exudative RD) → convalescent (sunset glow fundus) → chronic recurrent",
    "Acute: mutton-fat KPs, disc hyperaemia, multiple SRF collections on OCT; FA: multiple RPE leaks + disc leakage",
    "Poliosis, vitiligo, alopecia = Vogt triad (integumentary phase); pleocytosis on CSF",
    "Treatment: IV methylprednisolone 1 g/day × 3 days then high-dose oral prednisolone with slow taper over ≥6 months",
    "Refractory/chronic: azathioprine, MMF, cyclosporine; adalimumab/infliximab for steroid-resistant disease",
  ]);
}

// ── SLIDE 15: INFECTIOUS CHOROIDITIS (Fungal/TB) ─────────────────────────────
{
  const s=pres.addSlide(); applyBg(s); addHeading(s,"Infectious Choroiditis – Fungal & Tuberculosis");
  bulletsImg(s,[
    "Candida: IV drug abuse/immunosuppression; white fluffy vitreous balls ('string of pearls'); IV micafungin/voriconazole ± intravitreal; PPV early for severe disease",
    "Aspergillus: haematogenous in immunocompromised; macular solitary deep lesion; high mortality; IV voriconazole first-line",
    "PCP (Pneumocystis jirovecii): AIDS (CD4<50); bilateral round yellow-orange lesions; minimal vitritis; IV TMP-SMX; now rare with HAART",
    "Cryptococcus: AIDS; direct choroidal infiltration or indirect papilloedema; IV amphotericin-B + flucytosine",
    "TB choroiditis: most common globally; choroidal granuloma (Dalen-Fuchs nodules); 4-drug ATT (RHEZ × 2 months, RH × 4 months) + steroids after 2 weeks",
    "TB-serpiginous: large geographic active lesions; strong HLA-DR4 link; IGRA/CXR mandatory before immunosuppression",
  ], imgs.fungal_panel, "Fungal choroiditis panel: Pneumocystis,\nCandida, Aspergillus (Kanski 10th Ed.)");
}

// ── SLIDE 16: SYPHILIS / VIRAL ───────────────────────────────────────────────
{
  const s=pres.addSlide(); applyBg(s); addHeading(s,"Syphilitic & Viral Choroiditis");
  bullets(s,[
    "Syphilis ('The Great Imitator'): ASPPC — large yellow placoid macular lesion; FA: early block, late stain; ICGA: persistent hypofluorescence",
    "Syphilis treatment: IV Penicillin G 18–24 MU/day × 10–14 days; or IV ceftriaxone 2g/day × 14 days",
    "CMV choroiditis: AIDS (CD4<50); haemorrhagic 'pizza pie' retinitis; IV ganciclovir 5mg/kg BID × 2 weeks then oral valganciclovir",
    "Toxocara: children; unilateral; peripheral granuloma or posterior pole lesion; raised IgE + serology; albendazole + steroids",
    "Bartonella (cat-scratch): neuroretinitis with macular star + multifocal choroiditis; doxycycline + rifampicin",
    "West Nile Virus: multifocal choroiditis with linear clustering; OCT shows target lesions; supportive management",
  ]);
}

// ── SLIDE 17: TREATMENT OVERVIEW ─────────────────────────────────────────────
{
  const s=pres.addSlide(); applyBg(s); addHeading(s,"Treatment Overview");
  bullets(s,[
    "Infectious: pathogen-directed therapy first; systemic steroids added only after antimicrobial cover established (TB: after 2 weeks ATT; syphilis: after penicillin started)",
    "Non-infectious acute: oral prednisolone 1–1.5 mg/kg/day → taper over 12–16 weeks; IV methylprednisolone for severe (VKH, APMPPE with CNS)",
    "Local steroids: intravitreal triamcinolone (IVTA), sub-Tenon triamcinolone, dexamethasone implant (Ozurdex) for refractory CMO",
    "Steroid-sparing: methotrexate, azathioprine (2.5 mg/kg/day), mycophenolate mofetil (1–1.5 g BID), cyclosporine — add from 3–6 months",
    "Biologics: adalimumab (anti-TNF, FDA/EMA approved for non-infectious uveitis — VISUAL I & II trials); infliximab; abatacept; rituximab",
    "MNV management: anti-VEGF (ranibizumab/aflibercept/bevacizumab) + underlying immunosuppression; OCTA-guided retreatment",
  ]);
}

// ── SLIDE 18: TREATMENT FLOWCHART (Non-infectious) ───────────────────────────
{
  const s=pres.addSlide(); applyBg(s); addHeading(s,"Treatment Flowchart – Non-Infectious Choroiditis");
  const bw=2.8, bh=0.5, cx=(W-bw)/2;
  const steps=[{label:"Confirm Non-infectious Origin\n(serology, PCR, imaging, biopsy)",fill:"D6EAF8",y:0.9},{label:"Mild–Moderate: Oral Prednisolone\n1 mg/kg/day",fill:C_ACCENT,y:1.62},{label:"Adequate Response at 4–6 weeks?",fill:C_ACCENT,y:2.34}];
  steps.forEach(st=>addFcBox(s,st.label,cx,st.y,bw,bh,st.fill,C_NAVY,11));
  addFcArrow(s,cx+bw/2-0.02,steps[0].y+bh,steps[1].y);
  addFcArrow(s,cx+bw/2-0.02,steps[1].y+bh,steps[2].y);
  addFcBox(s,"YES → Continue taper\nMonitor 3-monthly",0.2,3.08,2.5,bh,"D5F5E3","1A5C2A",11);
  s.addShape(pres.ShapeType.line,{x:cx,y:steps[2].y+bh/2,w:-(cx-0.2-2.5),h:0,line:{color:C_NAVY,width:1.5,endArrowType:"triangle"}});
  addFcBox(s,"NO → Add Steroid-sparing IMT\nMMF / Azathioprine / MTX",7.3,3.08,2.5,bh,"FDE8D5","8B3A0A",11);
  s.addShape(pres.ShapeType.line,{x:cx+bw,y:steps[2].y+bh/2,w:7.3-(cx+bw),h:0,line:{color:C_NAVY,width:1.5,endArrowType:"triangle"}});
  addFcBox(s,"Refractory / Sight-Threatening\nBiologics: Adalimumab / Infliximab\nIntravitreal Ozurdex / IVTA\nMNV: Anti-VEGF agents",cx-0.9,3.82,bw+1.8,0.85,"FFF3CD","7D6608",11);
  s.addShape(pres.ShapeType.line,{x:cx+bw/2-0.02,y:steps[2].y+bh,w:0,h:3.82-(steps[2].y+bh),line:{color:C_NAVY,width:1.5,endArrowType:"triangle"}});
}

// ── SLIDE 19: TREATMENT FLOWCHART (Infectious) ───────────────────────────────
{
  const s=pres.addSlide(); applyBg(s); addHeading(s,"Treatment Flowchart – Infectious Choroiditis");
  const cw=2.8, cols=[{l:"BACTERIAL\n(TB / Syphilis)",x:0.3,c:"D6EAF8",t:C_NAVY},{l:"FUNGAL\n(Candida / Aspergillus)",x:3.6,c:"E8F8E8",t:"1A5C2A"},{l:"VIRAL\n(CMV / HSV / VZV)",x:6.9,c:"FDE8D5",t:"8B3A0A"}];
  cols.forEach(c=>addFcBox(s,c.l,c.x,0.88,cw,0.48,c.c,c.t,12));
  const rows=[["TB: 4-drug ATT\nRHEZ ×2m, RH ×4m\n+ steroids after 2 wks","Candida: IV Micafungin\nor Voriconazole\nIntravitreal 100µg/0.1ml","CMV (AIDS):\nIV Ganciclovir 5mg/kg BID\n×14d → oral Valganciclovir"],["Syphilis: IV Pen G\n18–24 MU/day ×10–14d;\nor IV Ceftriaxone 2g/day","Aspergillus: IV\nVoriconazole first-line;\nPPV early if severe","HSV/VZV: IV Acyclovir\n10–15 mg/kg TID ×14d\nthen oral prophylaxis"],["Serpiginous-TB:\nATT + prednisolone;\nanti-VEGF for MNV","PPV: early for poor\nresponse; reduces fungal\nload + improves penetration","ARN: IV Acyclovir;\nProphylactic PPV for\nRD risk (30–75%)"]];
  let ry=1.5;
  rows.forEach((row,ri)=>{
    row.forEach((txt,ci)=>addFcBox(s,txt,cols[ci].x,ry,cw,0.68,ri%2===0?"EBF5FB":"F4F6F7",C_TEXT,9));
    if(ri<rows.length-1) cols.forEach(c=>addFcArrow(s,c.x+cw/2-0.02,ry+0.68,ry+0.73));
    ry+=0.73;
  });
  s.addText("All cases: treat underlying immunosuppression | Vitreous PCR for diagnosis | Steroids only after antimicrobial cover established",{x:0.3,y:5.05,w:9.4,h:0.45,fontSize:10,color:"666666",fontFace:FONT,italic:true,align:"center"});
}

// ── SLIDE 20: COMPLICATIONS (with image) ─────────────────────────────────────
{
  const s=pres.addSlide(); applyBg(s); addHeading(s,"Complications of Choroiditis");
  bulletsImg(s,[
    "Choroidal neovascularisation (MNV): most common vision-threatening complication; anti-VEGF ± immunosuppression",
    "Cystoid macular oedema (CMO): chronic; Ozurdex implant / IVTA / systemic steroids / cyclosporine",
    "Subretinal fibrosis: end-stage; poor visual prognosis; anti-VEGF may slow progression",
    "Exudative retinal detachment: VKH (bilateral), posterior scleritis; resolves with immunosuppression",
    "Optic disc oedema / neuropathy: VKH, APMPPE-CNS vasculitis; aggressive early treatment mandatory",
    "Chorioretinal atrophy: irreversible photoreceptor loss at scar site; monitor for expansion on FAF",
  ], imgs.serp_advanced, "Advanced chorioretinal atrophy –\nend-stage scarring (Kanski 10th Ed.)");
}

// ── SLIDE 21: MONITORING ─────────────────────────────────────────────────────
{
  const s=pres.addSlide(); applyBg(s); addHeading(s,"Monitoring & Follow-Up");
  bullets(s,[
    "Acute phase: review every 2–4 weeks; assess treatment response, complications, steroid side effects (IOP, glycaemia)",
    "Remission: every 3–6 months; Amsler grid self-monitoring by patient; ERG every 6 months (birdshot)",
    "Multimodal imaging at each visit: OCT for CMO/MNV; OCTA for choriocapillaris status; FAF for atrophy progression",
    "Laboratory: FBC, LFTs, RFTs with IMT — MTX: LFT monthly; cyclosporine: RFT + BP; azathioprine: FBC fortnightly",
    "Immunosuppression duration: ≥2 years in chronic entities (birdshot, VKH, MFC) before cautious withdrawal attempt",
    "Special monitoring: annual visual fields (birdshot/MFC); pregnancy counselling (MTX teratogenic — stop 3 months before)",
  ]);
}

// ── SLIDE 22: RECENT ADVANCES ────────────────────────────────────────────────
{
  const s=pres.addSlide(); applyBg(s); addHeading(s,"Recent Advances & Clinical Trials (2022–2026)");
  bullets(s,[
    "VISUAL I & II (AbbVie): Adalimumab RCTs — significantly reduced uveitic flares vs. placebo; FDA/EMA approved for non-infectious posterior/pan-uveitis",
    "MUV Project 2025 (Accorinti et al., AJO Nov 2025, PMID 40659111): systematic review defining multimodal imaging standards for non-infectious posterior uveitis",
    "MUV Task Force Report 9 (Invernizzi et al., AJO Dec 2025, PMID 40754260): minimum imaging sets for diagnosis, activity assessment, and complications",
    "White spot syndrome advances (Cicinelli et al., Prog Retin Eye Res Nov 2023, PMID 37574123): new OCTA and choriocapillaris flow models for MEWDS/APMPPE/serpiginous",
    "Post-COVID vaccination choroiditis: MFC recurrence (Scott & Niederer, Eur J Ophthalmol 2024), bilateral MFC (Kakarla et al., Indian J Ophthalmol 2022) — emerging entity",
    "JAK inhibitors (tofacitinib, baricitinib): under investigation for VKH, birdshot; early case series show promise for steroid-resistant disease",
  ]);
}

// ── SLIDE 23: OCTA & IMAGING ADVANCES ────────────────────────────────────────
{
  const s=pres.addSlide(); applyBg(s); addHeading(s,"Advances in Imaging – OCTA & Multimodal Approach");
  bullets(s,[
    "OCTA: non-invasive choriocapillaris flow deficit mapping; detects subclinical disease + MNV before FA leakage; gold standard for activity in APMPPE, serpiginous",
    "EDI-OCT: subfoveal choroidal thickness correlates with disease activity — increases with active inflammation (VKH), decreases with scarring",
    "FAF: hyperAF = active inflammation at RPE; hypoAF = irreversible atrophy; used for serial monitoring of serpiginous extent and recurrence",
    "Wide-field FA/ICGA: ultra-wide field systems identify peripheral choroidal lesions missed on standard 30–50° imaging (birdshot, MFC with peripheral lesions)",
    "AI/deep learning: automated choriocapillaris flow quantification; OCT layer segmentation for monitoring atrophy progression — validated tools emerging",
    "OCTA-guided anti-VEGF retreatment: MNV regression assessment without FA dye injection; improving decision-making for inflammatory MNV (Bottazzi et al., Graefes 2025)",
  ]);
}

// ── SLIDE 24: CLINICAL IMAGES PANEL ─────────────────────────────────────────
{
  const s=pres.addSlide(); applyBg(s); addHeading(s,"Clinical Images – Choroiditis Spectrum (Kanski 10th Ed.)");
  const gridImgs=[imgs.mewds_fundus, imgs.apmppe, imgs.mfc_inactive, imgs.serp_advanced];
  const caps=["MEWDS: fading white dots","APMPPE: placoid RPE lesions","MFC: inactive histo-like lesions","Serpiginous: advanced atrophy"];
  const pos=[{x:0.25,y:0.85},{x:5.1,y:0.85},{x:0.25,y:3.15},{x:5.1,y:3.15}];
  const iW=4.5, iH=2.1;
  pos.forEach((p,i)=>{
    if(gridImgs[i]){
      s.addImage({data:gridImgs[i],x:p.x,y:p.y,w:iW,h:iH});
      s.addText(caps[i],{x:p.x,y:p.y+iH+0.02,w:iW,h:0.25,fontSize:10,color:"555555",fontFace:FONT,italic:true,align:"center"});
    }
  });
  s.addText("Source: Kanski's Clinical Ophthalmology 10th Edition | All images from standard textbook",{x:0.25,y:5.35,w:9.5,h:0.2,fontSize:10,color:"888888",fontFace:FONT,italic:true,align:"center"});
}

// ── SLIDE 25: SUMMARY TABLE ──────────────────────────────────────────────────
{
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    [{text:"MEWDS",options:{color:C_TEXT}},{text:"Young women",options:{color:C_TEXT}},{text:"Evanescent white dots; foveal granularity",options:{color:C_TEXT}},{text:"FAF hyperAF dots; ICGA more lesions than visible",options:{color:C_TEXT}}],
    [{text:"APMPPE",options:{color:C_TEXT}},{text:"Young adults, post-viral",options:{color:C_TEXT}},{text:"Placoid RPE lesions",options:{color:C_TEXT}},{text:"FA: early block, late stain",options:{color:C_TEXT}}],
    [{text:"Serpiginous",options:{color:C_TEXT}},{text:"Middle-age, M>F, HLA-B7",options:{color:C_TEXT}},{text:"Peripapillary, snake-like spread",options:{color:C_TEXT}},{text:"FAF active hyperAF border; exclude TB",options:{color:C_TEXT}}],
    [{text:"MFC",options:{color:C_TEXT}},{text:"Young-mid women",options:{color:C_TEXT}},{text:"Multifocal + anterior uveitis",options:{color:C_TEXT}},{text:"ICGA hypofluorescent; MNV 25–35%",options:{color:C_TEXT}}],
    [{text:"Birdshot",options:{color:C_TEXT}},{text:"Caucasian, HLA-A29 (96%)",options:{color:C_TEXT}},{text:"Salmon spots from disc",options:{color:C_TEXT}},{text:"ERG abnormality early; vitritis",options:{color:C_TEXT}}],
    [{text:"VKH",options:{color:C_TEXT}},{text:"Asian/Hispanic, HLA-DR4",options:{color:C_TEXT}},{text:"Exudative RD, meningism",options:{color:C_TEXT}},{text:"Multiple SRF on OCT; sunset glow fundus",options:{color:C_TEXT}}],
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// ── SLIDE 26: CONCLUSION ─────────────────────────────────────────────────────
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  const pts=["Choroiditis = inflammation of the choroid — encompasses infectious and immune-mediated diseases","ICG-based classification (Kanski): choriocapillaritis (1A/1B) vs. stromal choroiditis (2A/2B) guides workup","Multimodal imaging (ICGA, OCTA, FAF, EDI-OCT) is essential — ICGA reveals subclinical disease burden","Treatment: pathogen-directed (infectious) vs. stepwise immunosuppression; biologics for refractory disease","Adalimumab (VISUAL I & II) has Level-1 evidence for non-infectious posterior uveitis — only approved biologic","Always exclude TB and syphilis before immunosuppression — they are great imitators of non-infectious disease"];
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// ── WRITE ─────────────────────────────────────────────────────────────────────
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