Main antihemorrhagic medicines

1. Antifibrinolytics
   • Tranexamic acid (TXA), epsilon-aminocaproic acid
   • Prevent clot breakdown by inhibiting plasmin activity
   • Common uses: trauma bleeding, postpartum hemorrhage, perioperative bleeding, menorrhagia
   • Bailey & Love notes TXA reduces mortality in trauma bleeding and should be given early (ideally within 1 hour, not after 3 hours) (Bailey & Love, p. 377).
2. Vitamin K (phytomenadione)
   • Restores synthesis of vitamin K dependent clotting factors (II, VII, IX, X)
   • Used in vitamin K deficiency and warfarin associated coagulopathy (often with PCC/FFP if major bleed)
3. Clotting factor replacement / procoagulants
   • PCC (prothrombin complex concentrate), FFP, fibrinogen concentrate, cryoprecipitate, specific factor concentrates (eg, VIII, IX)
   • Used in major hemorrhage, inherited factor deficiencies, anticoagulant reversal, intracranial hemorrhage protocols
   • Stroke ICH guideline sections discuss these as key hemostatic strategies (guideline text, p. 16).
4. Platelet therapy
   • Platelet transfusion (when thrombocytopenia or platelet dysfunction contributes to bleeding)
5. Topical/local hemostatics
   • Thrombin, fibrin sealants, oxidized cellulose, gelatin sponges
   • Useful in surgical or procedural bleeding control

Commonly asked “antihemorrhagic drug” in prescriptions

• drug name
• adult dose
• typical indication
• major contraindications (eg, thrombosis risk, DIC context, renal dosing).