I have taken 75 gms of glucose at 7:50am lab people gave me 75mg of glucose after first blood test and told me don't eat anything for 2 hrs then we will take another sample. But I am having epigastric pain can I take ppi
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can you take PPI proton pump inhibitor during OGTT oral glucose tolerance test fasting period
Here is a clear answer to your situation:
Your Situation: OGTT in Progress
You have had your fasting blood draw and consumed the 75g glucose load at 7:50 AM. You are now waiting for the 2-hour post-load blood sample (due around 9:50 AM). You are experiencing epigastric pain and want to know if you can take a PPI (like omeprazole or pantoprazole).
Can You Take a PPI During the OGTT Wait?
The short answer: PPIs are unlikely to affect your OGTT result, but you should still inform or ask your lab technician or doctor before taking anything.
Here is the reasoning:
What research says about PPIs and blood glucose:
A published cross-sectional study specifically looked at PPI use and OGTT results in patients undergoing a 75g OGTT. It found no significant association between PPI use and fasting or 2-hour post-load glucose levels - meaning PPIs did not meaningfully alter OGTT results. (International Journal of Medical Sciences study on PPIs and OGTT)
Why it matters to still ask:
- Standard OGTT instructions say do not eat, drink (except water), or take medications during the test window, unless specifically cleared by your doctor.
- Most guidelines (HealthLink BC, Cleveland Clinic, MedlinePlus) recommend telling your doctor about all medications and following their specific instructions.
- Some drugs can affect glucose metabolism - but PPIs (omeprazole, pantoprazole, rabeprazole) are not among the known interfering drugs for OGTT.
Practical Advice
- Call or walk up to the lab technician / phlebotomist right now and tell them you have epigastric pain. Ask if you can take a PPI - they may clear it immediately.
- If you cannot reach anyone, taking a single dose of a standard PPI (e.g., pantoprazole 40mg or omeprazole 20mg) is very unlikely to falsify your glucose result based on current evidence.
- Do not eat or drink anything other than water - this is more important for the test accuracy than the PPI question.
- Avoid antacids with large amounts of sugar or glucose in them (like some liquid antacid suspensions) - plain PPIs are fine.
Important Note
The epigastric pain itself may be related to the glucose load - some people feel nausea, bloating, or stomach discomfort after drinking the glucose solution. This typically eases on its own within 30-60 minutes. If the pain is severe, worsening, or associated with vomiting, inform the lab staff immediately, as vomiting can invalidate the test.
This is general medical information, not a substitute for advice from your treating doctor or the lab staff present with you. Please inform them before taking any medication during the test.
I took 1 hrs sample at home and it is 177 what does that mean
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OGTT 75g 1 hour glucose 177 mg/dL interpretation normal range diagnostic criteria
Here is what your 1-hour reading of 177 mg/dL means:
1-Hour OGTT Result: 177 mg/dL
For a Standard (Non-Pregnancy) Diabetes Screening OGTT:
The 1-hour value is not used for diagnosis in a standard non-pregnant OGTT. Per MedlinePlus / ADA guidelines, the reference cutoffs for the 75g OGTT are:
| Timepoint | Normal | Prediabetes | Diabetes |
|---|---|---|---|
| Fasting | < 100 mg/dL | 100-125 mg/dL | ≥ 126 mg/dL |
| 1 hour | < 200 mg/dL | (not used for diagnosis) | ≥ 200 mg/dL |
| 2 hours | < 140 mg/dL | 140-199 mg/dL | ≥ 200 mg/dL |
Your 1-hour value of 177 mg/dL is below the 200 mg/dL cutoff - so it is within the acceptable range at the 1-hour mark for a non-pregnant diabetes test. The diagnosis depends almost entirely on your 2-hour value.
If This is a Pregnancy (GDM) Test:
If you are pregnant and this is a gestational diabetes screen, the thresholds are stricter. Per IADPSG/ADA criteria:
| Timepoint | GDM Cutoff |
|---|---|
| Fasting | ≥ 92 mg/dL |
| 1 hour | ≥ 180 mg/dL |
| 2 hours | ≥ 153 mg/dL |
Your 1-hour value of 177 mg/dL is below the 180 mg/dL GDM cutoff as well - so it would still be considered normal at this timepoint for GDM screening too.
Bottom Line
- At 1 hour, 177 mg/dL is acceptable under both standard and pregnancy OGTT criteria.
- Your glucose is rising as expected after the load - a reading of 177 at 1 hour is normal physiology.
- The 2-hour value is the one that matters most. Wait for your 2-hour sample (around 9:50 AM) - if it comes back below 140 mg/dL, everything is normal. If it is 140-199, that indicates prediabetes/impaired glucose tolerance, and ≥200 would indicate diabetes.
- Do not eat, exercise, or smoke until that 2-hour sample is taken.
Your 1-hour result of 177 is not alarming. Focus on completing the 2-hour draw properly.
So what are recomme ded 2 hrs values for non pregnant women
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