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Anatomy of the Female Reproductive Tract
(Source: Sabiston Textbook of Surgery, 21st ed., Chapter 120; Berek & Novak's Gynecology)
Overview
The female reproductive tract is divided into:
- External genitalia (Vulva)
- Internal genitalia - Vagina, Cervix, Uterus, Fallopian Tubes, Ovaries
- Supporting structures - Ligaments, blood supply, nerve supply
1. External Female Reproductive Anatomy (Vulva)
The vulva comprises all external female genital structures:
Key structures:
- Mons pubis - fatty tissue overlying the pubic bone; its lower part is divided by the pudendal cleft into the labia majora
- Labia majora & labia minora - separated by the interlabial sulci; the labia minora fuses anteriorly to form the clitoral hood (prepuce) and posteriorly to form the vestibule
- Clitoral glans - erectile tissue, homologous to the male glans penis
- Vestibule - bounded by Hart's line; contains the vaginal introitus (outlined by the hymenal ring) and the urethral meatus
- Anterior boundary: frenulum of the clitoris
- Posterior boundary: posterior fourchette
- Contains the fossa navicularis (small depression at posterior vestibule)
- Bartholin's glands (greater vestibular glands) - lie at the 4 and 8 o'clock positions of the vaginal introitus; secrete mucus for lubrication
- Skene's glands (lesser vestibular / paraurethral glands) - drain along the lateral urethral meatus
2. Internal Female Reproductive Anatomy
FIGURE: Internal genitalia (anterior view). A = Symphysis pubis; B = Bladder; C = Corpus uteri; D = Round ligament; E = Fallopian tube; F = Ovary; G = Uteroovarian ligament; H = Broad ligament; J = Ovarian artery
FIGURE: Lateral sagittal view of female pelvic organs.
A. Vagina
- A flexible, expandable fibromuscular tube, flattened at rest; lies mostly horizontal in the upright female
- Layers (center to periphery):
- Mucosa - stratified squamous epithelium
- Lamina propria - collagen, elastic tissue, vascular and lymph supply
- Muscular layer
- Areolar connective tissue (with rich blood supply)
- Development: Lower portion from endoderm of the urogenital sinus; upper portion from the Müllerian (paramesonephric) ducts
- Blood supply: Vaginal artery (branch of internal iliac artery); anastomoses with uterine, internal pudendal, inferior vesical, and middle hemorrhoidal arteries
- Nerve supply: Autonomic - lumbosacral plexus (S2-S4), culminating in the pudendal nerve; most sensory innervation is in the distal vagina
B. Cervix
- The narrow, distal part of the uterus, visible and palpable at the upper end of the vaginal canal
- Round/donut-shaped; mostly fibrous tissue; average length ~3 cm
- Has a central canal called the os (external os opens into vagina; internal os opens into uterine cavity)
- Epithelial transition:
- Ectocervix (vaginal portion) - stratified squamous epithelium
- Endocervix (cervical canal) - columnar epithelium (mucus-secreting)
- The junction is the Squamocolumnar junction (Transformation zone) - the site where cervical intraepithelial neoplasia (CIN) arises
- Blood supply: Descending branch of the uterine artery at 3 o'clock and 9 o'clock; azygos arteries run anteriorly and posteriorly
- Nerve supply: Parasympathetic - lumbosacral plexus (S2-S4); majority of nerve endings in endocervical region
C. Uterus
- An intraperitoneal muscular organ posterior to the bladder and anterior to the rectum
- In the nonpregnant state, weighs 40-80 g; smaller in prepubertal/postmenopausal years
Three layers:
| Layer | Description |
|---|
| Serosa (perimetrium) | Outer thin layer; contiguous with the broad ligament and pelvic peritoneum |
| Myometrium | Middle, thick smooth muscle layer in three distinct sub-layers |
| Endometrium | Inner mucous epithelial lining; thickness varies with hormonal cycle |
Supporting ligaments:
- Broad ligaments - extend laterally from uterine corpus, continuous with pelvic peritoneum
- Round ligaments - originate at uterine cornua, pass through inguinal ring, terminate in labia majora (maintain anteversion)
- Cardinal (Mackenrodt's) ligaments - attach laterally to pelvic diaphragm, fuse with vagina at cervical level; primary support against prolapse
- Uterosacral ligaments - posterior cervix to 3rd sacral vertebra; arch around rectum; maintain anteflexion
Blood supply:
- Uterine arteries (branches of internal iliac arteries) - travel within the cardinal ligament, then up lateral aspect of uterine body
- Ovarian arteries (from abdominal aorta directly)
Nerve supply:
- Sympathetic: hypogastric and ovarian plexus
- Parasympathetic: lumbosacral plexus (S2-S4)
- Afferent pain fibers: travel with sympathetic nerves via lumbosacral plexus (T11-T12 - hence referred labor pain to lower abdomen)
D. Fallopian Tubes (Oviducts)
- Originate at the cornua of the uterus; extend laterally ~10-14 cm, coiling around the ipsilateral ovary
Four anatomic segments (medial to lateral):
| Segment | Description | Length |
|---|
| Interstitial (Intramural) | Traverses the uterine wall; surrounded by myometrium | 1-2 cm |
| Isthmus | Narrowest, most muscular segment; just lateral to uterine wall | ~4 cm |
| Ampulla | Widest; site of fertilization | 4-6 cm |
| Infundibulum | Funnel-shaped; ends in finger-like fimbriae that surround the ostia and capture the oocyte | - |
Layers of the tube:
- Mucosa - columnar ciliated, secretory, and peg cells (ratio varies by region)
- Lamina propria
- Muscular layer
- Adventitial layer
Blood supply: Tubal branches of uterine and ovarian arteries
E. Ovaries
- Paired gonadal organs producing oocytes and reproductive hormones (estrogen, progesterone)
- Lie in the ovarian fossa on the lateral pelvic sidewall, attached to the posterior broad ligament by the mesovarium
- Uteroovarian ligament connects the ovary medially to the uterine cornu
- Infundibulopelvic (suspensory) ligament carries the ovarian vessels superiorly
- Blood supply: Ovarian arteries (directly from abdominal aorta at L2 level); venous drainage - right ovarian vein drains to IVC, left ovarian vein drains to left renal vein
3. Developmental Notes (Clinically Important)
| Structure | Embryological Origin | Clinical Significance |
|---|
| Lower vagina | Urogenital sinus (endoderm) | Transverse vaginal septa |
| Upper vagina, cervix, uterus, fallopian tubes | Müllerian (paramesonephric) ducts | Uterine anomalies (bicornuate, septate, unicornuate uterus) if fusion fails |
| Ovaries | Genital ridge (mesoderm + primordial germ cells) | - |
Summary Table
| Structure | Normal Size | Key Feature |
|---|
| Vagina | ~8-10 cm (adult) | Rugae; H-shaped cross-section at rest |
| Cervix | ~3 cm length | Transformation zone - site of CIN |
| Uterus | 40-80 g (non-pregnant) | 3 layers; held by 4 ligaments |
| Fallopian tube | 10-14 cm | Ampulla = fertilization site |
| Ovary | ~3 x 2 x 1 cm | R. vein → IVC; L. vein → renal vein |
Sources: Sabiston Textbook of Surgery, 21st ed., Chapter 120 (Female Reproductive and Pelvic Anatomy); Berek & Novak's Gynecology, 16th ed.