You are answering a USMLE-style medical question. Question: A 46-year-old man presents with worsening pain in multiple joints for the past 2 weeks. He says the pain is most severe in the proximal parts of his fingers and his wrists, but it has now spread to his elbows, and, occasionally, his knees. He says the joint involvement is symmetric. He also complains of morning joint stiffness that improves with activity and reports feeling fatigued during the day. He started taking ibuprofen 2 months ago for the pain which initially subsided, but, over the last few weeks, it has worsened despite the medication. He was diagnosed with type 2 diabetes mellitus 1 year ago and has had difficulty controlling his blood glucose levels. The patient denies any smoking history, alcohol, or recreational drug use. A review of systems is significant for a weight loss of 3.0 kg (6.6 lb) over the last 3 months despite no change in diet or activity level. Which of the following is the most likely 1st-line medication in this patient? Options: A) Infliximab B) Anakinra C) Methotrexate D) High-dose prednisone for 60 days Reply with ONLY the letter of the correct answer (A, B, C, or D). No explanation.