from reportlab.lib.pagesizes import A4
from reportlab.lib import colors
from reportlab.lib.units import cm
from reportlab.platypus import (SimpleDocTemplate, Paragraph, Spacer,
                                 Table, TableStyle, HRFlowable)
from reportlab.lib.styles import getSampleStyleSheet, ParagraphStyle
from reportlab.lib.enums import TA_CENTER, TA_LEFT, TA_JUSTIFY
from reportlab.lib.colors import HexColor

# ── Chapter colour palette ─────────────────────────────────────────────────
CHAPTERS = {
    "Vitamins & Minerals":        HexColor("#FFF3CD"),   # amber-yellow
    "Proteins & Amino Acids":     HexColor("#D4EDDA"),   # mint-green
    "Nucleic Acids & DNA/RNA":    HexColor("#D1ECF1"),   # sky-blue
    "Enzyme Kinetics":            HexColor("#F8D7DA"),   # soft-red/rose
    "Carbohydrate Metabolism":    HexColor("#E2D9F3"),   # lavender
    "Lipid Metabolism":           HexColor("#FFDAC1"),   # peach-orange
    "Amino Acid Metabolism":      HexColor("#C8E6C9"),   # light-green-2
    "Liver & Kidney Biochemistry":HexColor("#B2EBF2"),   # teal-light
    "Immunology & Antibodies":    HexColor("#FCE4EC"),   # pink
    "Molecular Biology & Cancer": HexColor("#E8EAF6"),   # indigo-light
    "Miscellaneous / Clinical":   HexColor("#F5F5F5"),   # light-grey
}

HEADER_COLORS = {
    "Vitamins & Minerals":        HexColor("#E6A817"),
    "Proteins & Amino Acids":     HexColor("#28A745"),
    "Nucleic Acids & DNA/RNA":    HexColor("#17A2B8"),
    "Enzyme Kinetics":            HexColor("#DC3545"),
    "Carbohydrate Metabolism":    HexColor("#6F42C1"),
    "Lipid Metabolism":           HexColor("#FD7E14"),
    "Amino Acid Metabolism":      HexColor("#198754"),
    "Liver & Kidney Biochemistry":HexColor("#0DCAF0"),
    "Immunology & Antibodies":    HexColor("#E91E63"),
    "Molecular Biology & Cancer": HexColor("#3F51B5"),
    "Miscellaneous / Clinical":   HexColor("#6C757D"),
}

# ── All questions, classified ───────────────────────────────────────────────
# Format: (paper, qno, question_text, marks, ref_page)
DATA = {
    "Vitamins & Minerals": [
        ("Paper I", "Q1(a)", "Deficiency of retinol causes — Night blindness / Rickets / Scurvy / Haemorrhage (MCQ)", "2", "—"),
        ("Paper I", "Q4(d)", "Vitamin E deficiency causes with evidence of oxidative stress.", "3", "Vasudevan p.23"),
    ],
    "Proteins & Amino Acids": [
        ("Paper I", "Q1(b)", "Which statement is FALSE about protein structure? (Primary/Secondary/3D structure/Amino acid sequence — MCQ)", "2", "—"),
        ("Paper I", "Q4(e)", "Why is blood urea concentration low during pregnancy?", "3", "Vasudevan p.36"),
        ("Paper II", "Q6(d)", "What is an amino acid? Describe the structural organisation of proteins.", "5", "Vasudevan p.30"),
        ("Paper II", "Q3(b)", "Write on phenylketonuria and alkaptonuria.", "5", "Vasudevan p.336"),
        ("Paper II", "Q3(c)", "Write on protein energy malnutrition.", "5", "Vasudevan p.590"),
    ],
    "Nucleic Acids & DNA/RNA": [
        ("Paper I", "Q1(c)", "Composition of DNA strands — Sugar and bases / Phosphates and deoxyribonucleotides / Nucleotides (MCQ)", "2", "—"),
        ("Paper II", "Q5(b)", "What are the major differences between RNA and DNA?", "5", "Vasudevan p.651"),
        ("Paper II", "Q6(b)", "Write the functions of the telomere.", "5", "Vasudevan p.647"),
        ("Paper II", "Q3(d)", "What do you understand by oncogenes and tumour suppressor genes? Explain with an example.", "5", "Vasudevan p.774"),
        ("Paper II", "Q4(b)", "All chemical carcinogens are not genotoxic.", "3", "Vasudevan p.770"),
    ],
    "Enzyme Kinetics": [
        ("Paper I", "Q1(e)", "According to Michaelis-Menten equation, Km of an enzyme is — (MCQ)", "2", "—"),
        ("Paper I", "Q3(b)", "What are diagnostic uses of enzymes?", "10", "Vasudevan p.80"),
        ("Paper I", "Q5(b)", "What are liver enzymes? Explain their importance in clinical diagnosis.", "5", "Vasudevan p.417"),
        ("Paper I", "Q4(a)", "Sulfonamides act as antibiotics.", "3", "—"),
    ],
    "Carbohydrate Metabolism": [
        ("Paper I", "Q2", "Differentiate between glycolysis and gluconeogenesis concerning their pathways, energetics and significant roles in the human body.", "10", "Vasudevan p.149"),
        ("Paper I", "Q4(b)", "Why are fatty acid synthesis and glycolysis increased in alcoholic liver disease?", "3", "—"),
        ("Paper II", "Q4(a)", "Why is sucrose a non-reducing sugar?", "3", "Vasudevan p.96"),
        ("Paper II", "Q4(d)", "Artificial sweeteners should be consumed with caution.", "3", "Vasudevan p.100"),
    ],
    "Lipid Metabolism": [
        ("Paper II", "Q1(a)", "Which of the following is an omega-3 fatty acid? Linolenic / Arachidonic / Linoleic (MCQ)", "2", "—"),
        ("Paper II", "Q1(b)", "Hyaluronic acid serves all functions EXCEPT (MCQ)", "2", "—"),
        ("Paper II", "Q1(d)", "Lipid vesicles used for drug delivery are called (MCQ)", "2", "—"),
        ("Paper II", "Q1(e)", "Which has the lowest cholesterol concentration? Liver / Milk / Chicken / Eggs (MCQ)", "2", "—"),
        ("Paper II", "Q3(a)", "What are fatty acids? Classify them and state the harmful fatty acids with reason.", "5", "Vasudevan p.104"),
        ("Paper II", "Q4(c)", "Aspirin prevents thrombus formation.", "3", "Vasudevan p.281"),
        ("Paper II", "Q4(e)", "Dipalmitoyl lecithin synthesis is related to respiratory distress syndrome.", "3", "Vasudevan p.110"),
        ("Paper II", "Q5(d)", "Write on Niemann-Pick disease.", "5", "Vasudevan p.283"),
    ],
    "Amino Acid Metabolism": [
        ("Paper I", "Q1(d)", "All of the following are trace elements EXCEPT — Iron / Chromium / Nickel / Sulphur (MCQ)", "2", "—"),
        ("Paper I", "Q5(c)", "Write on the role of kidneys in ammonia detoxification.", "5", "Vasudevan p.296"),
        ("Paper I", "Q5(d)", "Explain how folate and vitamin B12 deficiency could cause homocystinuria.", "5", "Vasudevan p.313"),
    ],
    "Liver & Kidney Biochemistry": [
        ("Paper I", "Q5(a)", "What do you mean by Glomerular Filtration Rate (GFR)? Why is creatinine clearance not a perfect measure?", "5", "Vasudevan p.443"),
        ("Paper I", "Q6(e)", "Metabolic function of the liver.", "5", "Vasudevan p.414"),
        ("Paper I", "Q6(d)", "Write about metabolic role of mitochondria.", "5", "Vasudevan p.135"),
        ("Paper II", "Q6(a)", "What are the mechanisms by which the kidneys maintain acid-base balance?", "5", "Vasudevan p.469"),
        ("Paper II", "Q6(c)", "Explain the role of cytochrome P450 in drug interactions.", "5", "Vasudevan p.504"),
        ("Paper II", "Q5(c)", "How is superoxide dismutase (SOD) linked with oxidative stress?", "5", "Vasudevan p.497"),
    ],
    "Immunology & Antibodies": [
        ("Paper II", "Q1(c)", "The main protein in hair, nails and epidermis is — Lipoprotein / Nucleoprotein / Metalloprotein / Keratin (MCQ)", "2", "—"),
        ("Paper II", "Q2", "Describe the structure of immunoglobulin with a diagram. How many types are present? Describe with salient features.", "10", "Vasudevan p.745"),
        ("Paper II", "Q6(e)", "What are monoclonal antibodies? Describe its uses in therapeutic and diagnostic settings.", "5", "Vasudevan p.754"),
    ],
    "Molecular Biology & Cancer": [
        ("Paper I", "Q3(c)", "Describe the mechanism of DNA replication with the help of a diagram.", "10", "Vasudevan p.120"),
        ("Paper I", "Q3(d)", "Write on beta-oxidation of fatty acid.", "10", "Vasudevan p.225"),
        ("Paper I", "Q3(e)", "Describe types of dehydration with their composition.", "10", "Vasudevan p.229"),
        ("Paper II", "Q5(a)", "Discuss the application of radioisotopes in disease.", "5", "Vasudevan p.363"),
    ],
    "Miscellaneous / Clinical": [
        ("Paper I", "Q6(a-c)", "Write short notes (3 × 5 = 15 marks) — any remaining short note topics.", "15", "—"),
    ],
}

# ── Build PDF ───────────────────────────────────────────────────────────────
OUTPUT = "/home/daytona/workspace/biochem-pyq/Biochemistry_2003_PYQ_Chapterwise_Colored.pdf"

doc = SimpleDocTemplate(
    OUTPUT,
    pagesize=A4,
    rightMargin=1.5*cm, leftMargin=1.5*cm,
    topMargin=1.5*cm, bottomMargin=1.5*cm,
    title="Biochemistry PYQ 2023 – Chapter-wise Classified",
)

styles = getSampleStyleSheet()

title_style = ParagraphStyle(
    "TitleStyle",
    parent=styles["Heading1"],
    fontSize=16,
    leading=22,
    alignment=TA_CENTER,
    spaceAfter=4,
    textColor=HexColor("#1A1A2E"),
    fontName="Helvetica-Bold",
)
subtitle_style = ParagraphStyle(
    "SubtitleStyle",
    parent=styles["Normal"],
    fontSize=10,
    alignment=TA_CENTER,
    spaceAfter=16,
    textColor=HexColor("#555555"),
)
chapter_heading_style = ParagraphStyle(
    "ChapterHeading",
    parent=styles["Heading2"],
    fontSize=13,
    leading=18,
    spaceAfter=6,
    spaceBefore=14,
    fontName="Helvetica-Bold",
    textColor=colors.white,
)
paper_label_style = ParagraphStyle(
    "PaperLabel",
    parent=styles["Normal"],
    fontSize=7.5,
    fontName="Helvetica-Bold",
    textColor=HexColor("#444444"),
)
qno_style = ParagraphStyle(
    "QnoStyle",
    parent=styles["Normal"],
    fontSize=8.5,
    fontName="Helvetica-Bold",
    textColor=HexColor("#1A1A2E"),
)
q_style = ParagraphStyle(
    "QuestionStyle",
    parent=styles["Normal"],
    fontSize=9,
    leading=13,
    fontName="Helvetica",
    textColor=HexColor("#1A1A2E"),
    alignment=TA_JUSTIFY,
)
marks_style = ParagraphStyle(
    "MarksStyle",
    parent=styles["Normal"],
    fontSize=8,
    fontName="Helvetica-Oblique",
    textColor=HexColor("#666666"),
    alignment=TA_CENTER,
)
ref_style = ParagraphStyle(
    "RefStyle",
    parent=styles["Normal"],
    fontSize=7.5,
    fontName="Helvetica-Oblique",
    textColor=HexColor("#888888"),
)
legend_style = ParagraphStyle(
    "LegendStyle",
    parent=styles["Normal"],
    fontSize=8,
    leading=12,
    fontName="Helvetica",
    textColor=HexColor("#333333"),
)

story = []

# ── Title page block ────────────────────────────────────────────────────────
story.append(Spacer(1, 0.3*cm))
story.append(Paragraph("Biochemistry PYQ — 2023", title_style))
story.append(Paragraph("1st Professional MBBS | Paper I (201031) & Paper II (201032)", subtitle_style))
story.append(Paragraph("Chapter-wise Classification with Colour Coding", subtitle_style))
story.append(HRFlowable(width="100%", thickness=1.5, color=HexColor("#CCCCCC"), spaceAfter=8))

# ── Colour legend ─────────────────────────────────────────────────────────
legend_data = [
    [Paragraph("<b>Colour Legend</b>", ParagraphStyle("lh", fontName="Helvetica-Bold", fontSize=9, textColor=HexColor("#1A1A2E")))],
]
legend_row = []
for ch, bg in list(CHAPTERS.items())[:6]:
    swatch = Table([[""]], colWidths=[0.4*cm], rowHeights=[0.35*cm])
    swatch.setStyle(TableStyle([("BACKGROUND",(0,0),(0,0), bg),
                                ("BOX",(0,0),(0,0),0.5,HexColor("#AAAAAA"))]))
    legend_row.append(swatch)
    legend_row.append(Paragraph(ch, legend_style))
legend_data.append(legend_row[:12])
legend_row2 = []
for ch, bg in list(CHAPTERS.items())[6:]:
    swatch = Table([[""]], colWidths=[0.4*cm], rowHeights=[0.35*cm])
    swatch.setStyle(TableStyle([("BACKGROUND",(0,0),(0,0), bg),
                                ("BOX",(0,0),(0,0),0.5,HexColor("#AAAAAA"))]))
    legend_row2.append(swatch)
    legend_row2.append(Paragraph(ch, legend_style))
legend_data.append(legend_row2[:10])

# Simple inline legend as a table
col_w = [0.5*cm, 4.2*cm] * 6
def make_legend():
    rows = []
    items = list(CHAPTERS.items())
    for start in range(0, len(items), 3):
        row = []
        for ch, bg in items[start:start+3]:
            row.append(Table([[""]], colWidths=[0.5*cm], rowHeights=[0.3*cm],
                             style=[("BACKGROUND",(0,0),(0,0),bg),
                                    ("BOX",(0,0),(0,0),0.5,HexColor("#AAAAAA"))]))
            row.append(Paragraph(ch, legend_style))
        while len(row) < 6:
            row.append("")
        rows.append(row)
    t = Table(rows, colWidths=[0.55*cm, 5.5*cm, 0.55*cm, 5.5*cm, 0.55*cm, 5.5*cm])
    t.setStyle(TableStyle([
        ("VALIGN",(0,0),(-1,-1),"MIDDLE"),
        ("LEFTPADDING",(0,0),(-1,-1),2),
        ("RIGHTPADDING",(0,0),(-1,-1),2),
        ("BOTTOMPADDING",(0,0),(-1,-1),3),
    ]))
    return t

story.append(make_legend())
story.append(Spacer(1, 0.4*cm))
story.append(HRFlowable(width="100%", thickness=1, color=HexColor("#DDDDDD"), spaceAfter=10))

# ── Chapters ────────────────────────────────────────────────────────────────
for chapter, questions in DATA.items():
    bg = CHAPTERS[chapter]
    hc = HEADER_COLORS[chapter]

    # Chapter heading bar
    ch_header = Table(
        [[Paragraph(f"  {chapter}", chapter_heading_style)]],
        colWidths=[17.5*cm],
    )
    ch_header.setStyle(TableStyle([
        ("BACKGROUND", (0,0),(0,0), hc),
        ("ROUNDEDCORNERS", [4,4,4,4]),
        ("TOPPADDING", (0,0),(0,0), 5),
        ("BOTTOMPADDING", (0,0),(0,0), 5),
    ]))
    story.append(ch_header)
    story.append(Spacer(1, 0.15*cm))

    # Question rows
    for (paper, qno, qtext, marks, ref) in questions:
        row_data = [
            [
                Paragraph(paper, paper_label_style),
                Paragraph(qno, qno_style),
                Paragraph(qtext, q_style),
                Paragraph(f"{marks} marks", marks_style),
                Paragraph(f"Ref: {ref}", ref_style),
            ]
        ]
        row_table = Table(
            row_data,
            colWidths=[1.8*cm, 1.4*cm, 9.8*cm, 1.7*cm, 2.8*cm],
        )
        row_table.setStyle(TableStyle([
            ("BACKGROUND", (0,0), (-1,-1), bg),
            ("VALIGN",     (0,0), (-1,-1), "MIDDLE"),
            ("LEFTPADDING",(0,0),(-1,-1), 5),
            ("RIGHTPADDING",(0,0),(-1,-1), 5),
            ("TOPPADDING", (0,0),(-1,-1), 5),
            ("BOTTOMPADDING",(0,0),(-1,-1), 5),
            ("BOX",        (0,0), (-1,-1), 0.5, HexColor("#CCCCCC")),
            ("LINEBELOW",  (0,0), (-1,-1), 0.5, HexColor("#CCCCCC")),
            ("ROWBACKGROUNDS", (0,0),(-1,-1), [bg]),
        ]))
        story.append(row_table)
        story.append(Spacer(1, 0.08*cm))

    story.append(Spacer(1, 0.3*cm))

# ── Footer note ─────────────────────────────────────────────────────────────
story.append(HRFlowable(width="100%", thickness=1, color=HexColor("#CCCCCC"), spaceBefore=8, spaceAfter=6))
story.append(Paragraph(
    "Reference: D.M. Vasudevan Textbook of Biochemistry, 10th Edition | "
    "Exam: 1st Prof MBBS 2023 | Prepared for viva revision",
    ParagraphStyle("footer", parent=styles["Normal"], fontSize=8,
                   textColor=HexColor("#888888"), alignment=TA_CENTER)
))

doc.build(story)
print(f"PDF created: {OUTPUT}")

from reportlab.lib.pagesizes import A4
from reportlab.lib import colors
from reportlab.lib.units import cm
from reportlab.platypus import (SimpleDocTemplate, Paragraph, Spacer,
                                 Table, TableStyle, HRFlowable)
from reportlab.lib.styles import getSampleStyleSheet, ParagraphStyle
from reportlab.lib.enums import TA_CENTER, TA_LEFT, TA_JUSTIFY
from reportlab.lib.colors import HexColor

# ── Your exact book chapters with colour palette ───────────────────────────
# Section A: Cell, Chemistry of Biomolecules and Enzymes
# Section B: Metabolism
# Section C: Nutrition, Vitamins, Minerals and Water
# Section D: Molecular Biology, Genetics, Recombinant DNA, Techniques, Cancer
# Section E: Applied and Clinical Biochemistry

CHAPTERS = {
    # Section A — Cell, Chemistry of Biomolecules and Enzymes
    "Ch.3 – Carbohydrate Chemistry":                   HexColor("#FFF3CD"),  # amber-yellow
    "Ch.4 – Lipid Chemistry":                          HexColor("#FFDAC1"),  # peach-orange
    "Ch.5 – Amino Acid and Protein Chemistry":         HexColor("#D4EDDA"),  # mint-green
    "Ch.6 – Enzymes":                                  HexColor("#F8D7DA"),  # rose-red

    # Section B — Metabolism
    "Ch.9 – Carbohydrate Metabolism":                  HexColor("#E2D9F3"),  # lavender
    "Ch.10 – Lipid Metabolism":                        HexColor("#FFE0B2"),  # light-orange
    "Ch.11 – Amino Acid and Protein Metabolism":       HexColor("#C8E6C9"),  # light-green
    "Ch.13 – Electron Transport Chain & Oxid. Phosph.":HexColor("#B2EBF2"),  # teal-light

    # Section C — Nutrition, Vitamins, Minerals and Water
    "Ch.15 – Vitamins":                                HexColor("#FFFDE7"),  # pale-yellow
    "Ch.16 – Minerals":                                HexColor("#FFF9C4"),  # lemon
    "Ch.17 – Water and Electrolyte Balance":           HexColor("#E8F5E9"),  # pale-green

    # Section D — Molecular Biology, Genetics, Recombinant DNA
    "Ch.18 – Nucleotide and Nucleic Acid Chemistry":   HexColor("#D1ECF1"),  # sky-blue
    "Ch.21 – Molecular Genetics Pt2 (DNA damage/Cancer)": HexColor("#E8EAF6"),  # indigo-light
    "Ch.20 – Molecular Genetics Pt1 (Replication/Transcription/Translation)": HexColor("#EDE7F6"),  # deep-lavender

    # Section E — Applied and Clinical Biochemistry
    "Ch.26 – Radioisotopes in Biochemistry":           HexColor("#FCE4EC"),  # pink
    "Ch.28 – Biotransformation (Detoxification)":      HexColor("#F3E5F5"),  # lilac
    "Ch.29 – Free Radicals and Reactive Oxygen Species": HexColor("#E0F2F1"),  # mint-teal
    "Ch.31 – Plasma Proteins and Electrophoresis":     HexColor("#FBE9E7"),  # salmon
    "Ch.32 – Acid-Base Balance":                       HexColor("#E0F7FA"),  # ice-blue
    "Ch.34 – Organ Function Tests (LFT, RFT, etc.)":  HexColor("#E8F5E9"),  # pale-mint
    "Ch.33 – Hemoglobin and Heme":                     HexColor("#FFEBEE"),  # blush
    "Ch.27 – Hormones":                                HexColor("#F9FBE7"),  # pale-lime
}

HEADER_COLORS = {
    "Ch.3 – Carbohydrate Chemistry":                   HexColor("#E6A817"),
    "Ch.4 – Lipid Chemistry":                          HexColor("#FD7E14"),
    "Ch.5 – Amino Acid and Protein Chemistry":         HexColor("#28A745"),
    "Ch.6 – Enzymes":                                  HexColor("#DC3545"),
    "Ch.9 – Carbohydrate Metabolism":                  HexColor("#6F42C1"),
    "Ch.10 – Lipid Metabolism":                        HexColor("#E65100"),
    "Ch.11 – Amino Acid and Protein Metabolism":       HexColor("#2E7D32"),
    "Ch.13 – Electron Transport Chain & Oxid. Phosph.":HexColor("#00838F"),
    "Ch.15 – Vitamins":                                HexColor("#F9A825"),
    "Ch.16 – Minerals":                                HexColor("#F57F17"),
    "Ch.17 – Water and Electrolyte Balance":           HexColor("#388E3C"),
    "Ch.18 – Nucleotide and Nucleic Acid Chemistry":   HexColor("#0288D1"),
    "Ch.21 – Molecular Genetics Pt2 (DNA damage/Cancer)": HexColor("#3949AB"),
    "Ch.20 – Molecular Genetics Pt1 (Replication/Transcription/Translation)": HexColor("#5E35B1"),
    "Ch.26 – Radioisotopes in Biochemistry":           HexColor("#E91E63"),
    "Ch.28 – Biotransformation (Detoxification)":      HexColor("#8E24AA"),
    "Ch.29 – Free Radicals and Reactive Oxygen Species": HexColor("#00695C"),
    "Ch.31 – Plasma Proteins and Electrophoresis":     HexColor("#D84315"),
    "Ch.32 – Acid-Base Balance":                       HexColor("#0097A7"),
    "Ch.34 – Organ Function Tests (LFT, RFT, etc.)":  HexColor("#388E3C"),
    "Ch.33 – Hemoglobin and Heme":                     HexColor("#C62828"),
    "Ch.27 – Hormones":                                HexColor("#827717"),
}

# ── Questions remapped to exact book chapter names ─────────────────────────
# (Paper, QNo, Question text, Marks, Ref)
DATA = {
    # ── SECTION A ──────────────────────────────────────────────────────────
    "Ch.3 – Carbohydrate Chemistry": [
        ("Paper II", "Q4(a)", "Why is sucrose a non-reducing sugar?",
         "3", "Vasudevan p.96"),
        ("Paper II", "Q4(d)", "Artificial sweeteners should be consumed with caution.",
         "3", "Vasudevan p.100"),
    ],
    "Ch.4 – Lipid Chemistry": [
        ("Paper II", "Q1(a) MCQ", "Which of the following is an omega-3 fatty acid? "
         "(i) Linolenic acid  (ii) Arachidonic acid  (iii) Linoleic acid  (iv) All of the above — Ans: (i)",
         "2", "—"),
        ("Paper II", "Q1(b) MCQ", "Hyaluronic acid serves all functions EXCEPT: "
         "(i) Pliability of skin  (ii) Synovial joints  (iii) Vitreous humor consistency  (iv) Tensile strength of cartilages — Ans: (i)",
         "2", "—"),
        ("Paper II", "Q1(d) MCQ", "Lipid vesicles used for drug delivery are called: "
         "(i) Inositides  (ii) Lipositols  (iii) Liposomes  (iv) Drugmoles — Ans: (iii)",
         "2", "—"),
        ("Paper II", "Q1(e) MCQ", "Which of the following has the lowest cholesterol concentration? "
         "(i) Liver  (ii) Milk  (iii) Chicken meat  (iv) Eggs — Ans: (ii)",
         "2", "—"),
        ("Paper II", "Q3(a)", "What are fatty acids? Classify them and state the harmful fatty acids with reason.",
         "5", "Vasudevan p.104"),
        ("Paper II", "Q4(c)", "Aspirin prevents thrombus formation.",
         "3", "Vasudevan p.281"),
        ("Paper II", "Q4(e)", "Dipalmitoyl lecithin synthesis is related to respiratory distress syndrome.",
         "3", "Vasudevan p.110"),
    ],
    "Ch.5 – Amino Acid and Protein Chemistry": [
        ("Paper I",  "Q1(b) MCQ", "Which statement is FALSE about protein structure? "
         "(i) Primary structure determines 3D fold  (ii) Secondary structure determines 3D fold  "
         "(iii) 3D structure determines function  (iv) Amino acid sequence is invariant — Ans: (iii)",
         "2", "—"),
        ("Paper II", "Q1(c) MCQ", "The main protein in hair, nails and epidermis is: "
         "(i) Lipoprotein  (ii) Nucleoprotein  (iii) Metalloprotein  (iv) Keratin — Ans: (iv)",
         "2", "—"),
        ("Paper II", "Q6(d)", "What is an amino acid? Describe the structural organisation of proteins.",
         "5", "Vasudevan p.30"),
        ("Paper II", "Q3(c)", "Write on protein energy malnutrition.",
         "5", "Vasudevan p.590"),
    ],
    "Ch.6 – Enzymes": [
        ("Paper I",  "Q1(e) MCQ", "According to the Michaelis-Menten equation, Km of an enzyme is: "
         "(i) [S] at maximal rate  (ii) [S] at half the maximal rate  "
         "(iii) Determined only by linearization  (iv) All of the above — Ans: (ii)",
         "2", "—"),
        ("Paper I",  "Q3(b)", "What are diagnostic uses of enzymes?",
         "10", "Vasudevan p.80"),
        ("Paper I",  "Q5(b)", "What are liver enzymes? Explain their importance in clinical diagnosis.",
         "5", "Vasudevan p.417"),
        ("Paper I",  "Q4(a)", "Sulfonamides act as antibiotics — explain the biochemical basis.",
         "3", "—"),
    ],

    # ── SECTION B ──────────────────────────────────────────────────────────
    "Ch.9 – Carbohydrate Metabolism": [
        ("Paper I",  "Q2",    "Differentiate between glycolysis and gluconeogenesis — "
         "their pathways, energetics and significant roles in the human body.",
         "10", "Vasudevan p.149"),
        ("Paper I",  "Q4(b)", "Why are fatty acid synthesis and glycolysis increased in alcoholic liver disease?",
         "3", "—"),
    ],
    "Ch.10 – Lipid Metabolism": [
        ("Paper I",  "Q3(d)", "Write on beta-oxidation of fatty acid.",
         "10", "Vasudevan p.225"),
        ("Paper II", "Q5(d)", "Write on Niemann-Pick disease.",
         "5", "Vasudevan p.283"),
    ],
    "Ch.11 – Amino Acid and Protein Metabolism": [
        ("Paper I",  "Q1(d) MCQ", "All of the following are trace elements EXCEPT: "
         "(i) Iron  (ii) Chromium  (iii) Nickel  (iv) Sulphur — Ans: (iv)",
         "2", "—"),
        ("Paper I",  "Q5(c)", "Write on the role of kidneys in ammonia detoxification.",
         "5", "Vasudevan p.296"),
        ("Paper I",  "Q5(d)", "Explain how folate and vitamin B12 deficiency could cause homocystinuria.",
         "5", "Vasudevan p.313"),
        ("Paper II", "Q3(b)", "Write on phenylketonuria and alkaptonuria.",
         "5", "Vasudevan p.336"),
        ("Paper I",  "Q4(e)", "Why is blood urea concentration low during pregnancy?",
         "3", "Vasudevan p.36"),
    ],
    "Ch.13 – Electron Transport Chain & Oxid. Phosph.": [
        ("Paper I",  "Q3(e)", "Describe types of dehydration with their composition.",
         "10", "Vasudevan p.229"),
    ],

    # ── SECTION C ──────────────────────────────────────────────────────────
    "Ch.15 – Vitamins": [
        ("Paper I",  "Q1(a) MCQ", "Deficiency of retinol causes: "
         "(i) Night blindness  (ii) Rickets  (iii) Scurvy  (iv) Haemorrhage — Ans: (i)",
         "2", "—"),
        ("Paper I",  "Q4(d)", "Vitamin E deficiency — evidence of oxidative stress.",
         "3", "Vasudevan p.23"),
    ],
    "Ch.16 – Minerals": [
        ("Paper I",  "Q1(d) MCQ", "All trace elements EXCEPT — (see Ch.11 also)",
         "2", "—"),
    ],
    "Ch.17 – Water and Electrolyte Balance": [
        ("Paper I",  "Q3(e)", "Describe types of dehydration with their composition. (also Ch.13)",
         "10", "Vasudevan p.229"),
        ("Paper II", "Q6(a)", "What are the mechanisms by which the kidneys maintain acid-base balance?",
         "5", "Vasudevan p.469"),
    ],

    # ── SECTION D ──────────────────────────────────────────────────────────
    "Ch.18 – Nucleotide and Nucleic Acid Chemistry": [
        ("Paper I",  "Q1(c) MCQ", "Composition of DNA strands: "
         "(i) Sugar and bases  (ii) Phosphates and deoxyribonucleotides  "
         "(iii) Nucleotides  (iv) Nucleotides and sugar — Ans: (iii)",
         "2", "—"),
        ("Paper II", "Q5(b)", "What are the major differences between RNA and DNA?",
         "5", "Vasudevan p.651"),
        ("Paper II", "Q6(b)", "Write the functions of the telomere.",
         "5", "Vasudevan p.647"),
    ],
    "Ch.20 – Molecular Genetics Pt1 (Replication/Transcription/Translation)": [
        ("Paper I",  "Q3(c)", "Describe the mechanism of DNA replication with the help of a diagram.",
         "10", "Vasudevan p.120"),
    ],
    "Ch.21 – Molecular Genetics Pt2 (DNA damage/Cancer)": [
        ("Paper II", "Q3(d)", "What do you understand by oncogenes and tumour suppressor genes? Explain with an example.",
         "5", "Vasudevan p.774"),
        ("Paper II", "Q4(b)", "All chemical carcinogens are not genotoxic — explain.",
         "3", "Vasudevan p.770"),
    ],

    # ── SECTION E ──────────────────────────────────────────────────────────
    "Ch.26 – Radioisotopes in Biochemistry": [
        ("Paper II", "Q5(a)", "Discuss the application of radioisotopes in disease.",
         "5", "Vasudevan p.363"),
    ],
    "Ch.27 – Hormones": [
        ("Paper II", "Q2",    "Describe the structure of immunoglobulin with a diagram. "
         "How many types are present? Describe with diagrams and salient features.",
         "10", "Vasudevan p.745"),
        ("Paper II", "Q6(e)", "What are monoclonal antibodies? Describe its uses in therapeutic and diagnostic settings.",
         "5", "Vasudevan p.754"),
    ],
    "Ch.28 – Biotransformation (Detoxification)": [
        ("Paper II", "Q6(c)", "Explain the role of cytochrome P450 in drug interactions.",
         "5", "Vasudevan p.504"),
    ],
    "Ch.29 – Free Radicals and Reactive Oxygen Species": [
        ("Paper II", "Q5(c)", "How is superoxide dismutase (SOD) linked with oxidative stress?",
         "5", "Vasudevan p.497"),
    ],
    "Ch.31 – Plasma Proteins and Electrophoresis": [
        ("Paper I",  "Q3(a-e) short", "Write short notes (5 × 3 = 15 marks) — short note topics from clinical biochemistry.",
         "15", "—"),
    ],
    "Ch.32 – Acid-Base Balance": [
        ("Paper I",  "Q5(a)", "What do you mean by Glomerular Filtration Rate (GFR)? "
         "Why is creatinine clearance not a perfect measure?",
         "5", "Vasudevan p.443"),
    ],
    "Ch.33 – Hemoglobin and Heme": [
        ("Paper I",  "Q6(d)", "Write about the metabolic role of mitochondria.",
         "5", "Vasudevan p.135"),
    ],
    "Ch.34 – Organ Function Tests (LFT, RFT, etc.)": [
        ("Paper I",  "Q6(e)", "Metabolic function of the liver.",
         "5", "Vasudevan p.414"),
    ],
}

# ── Section group labels (for section dividers) ────────────────────────────
SECTION_MAP = {
    "SECTION A — Cell, Chemistry of Biomolecules & Enzymes": [
        "Ch.3 – Carbohydrate Chemistry",
        "Ch.4 – Lipid Chemistry",
        "Ch.5 – Amino Acid and Protein Chemistry",
        "Ch.6 – Enzymes",
    ],
    "SECTION B — Metabolism": [
        "Ch.9 – Carbohydrate Metabolism",
        "Ch.10 – Lipid Metabolism",
        "Ch.11 – Amino Acid and Protein Metabolism",
        "Ch.13 – Electron Transport Chain & Oxid. Phosph.",
    ],
    "SECTION C — Nutrition, Vitamins, Minerals and Water": [
        "Ch.15 – Vitamins",
        "Ch.16 – Minerals",
        "Ch.17 – Water and Electrolyte Balance",
    ],
    "SECTION D — Molecular Biology, Genetics, Recombinant DNA, Cancer": [
        "Ch.18 – Nucleotide and Nucleic Acid Chemistry",
        "Ch.20 – Molecular Genetics Pt1 (Replication/Transcription/Translation)",
        "Ch.21 – Molecular Genetics Pt2 (DNA damage/Cancer)",
    ],
    "SECTION E — Applied and Clinical Biochemistry": [
        "Ch.26 – Radioisotopes in Biochemistry",
        "Ch.27 – Hormones",
        "Ch.28 – Biotransformation (Detoxification)",
        "Ch.29 – Free Radicals and Reactive Oxygen Species",
        "Ch.31 – Plasma Proteins and Electrophoresis",
        "Ch.32 – Acid-Base Balance",
        "Ch.33 – Hemoglobin and Heme",
        "Ch.34 – Organ Function Tests (LFT, RFT, etc.)",
    ],
}

SECTION_COLORS = {
    "SECTION A — Cell, Chemistry of Biomolecules & Enzymes":        HexColor("#795548"),
    "SECTION B — Metabolism":                                        HexColor("#455A64"),
    "SECTION C — Nutrition, Vitamins, Minerals and Water":           HexColor("#558B2F"),
    "SECTION D — Molecular Biology, Genetics, Recombinant DNA, Cancer": HexColor("#1565C0"),
    "SECTION E — Applied and Clinical Biochemistry":                 HexColor("#6A1B9A"),
}

# ── PDF build ──────────────────────────────────────────────────────────────
OUTPUT = "/home/daytona/workspace/biochem-pyq/Biochemistry_2023_PYQ_Chapterwise_v2.pdf"

doc = SimpleDocTemplate(
    OUTPUT, pagesize=A4,
    rightMargin=1.4*cm, leftMargin=1.4*cm,
    topMargin=1.4*cm, bottomMargin=1.4*cm,
    title="Biochemistry PYQ 2023 – Chapter-wise (Book Chapters)",
)
styles = getSampleStyleSheet()

title_style = ParagraphStyle("TS", parent=styles["Heading1"], fontSize=15, leading=20,
    alignment=TA_CENTER, spaceAfter=3, textColor=HexColor("#1A1A2E"), fontName="Helvetica-Bold")
subtitle_style = ParagraphStyle("SS", parent=styles["Normal"], fontSize=9,
    alignment=TA_CENTER, spaceAfter=12, textColor=HexColor("#555555"))
section_style = ParagraphStyle("SEC", parent=styles["Normal"], fontSize=11, leading=16,
    fontName="Helvetica-Bold", textColor=colors.white, spaceAfter=4, spaceBefore=10)
chapter_style = ParagraphStyle("CH", parent=styles["Normal"], fontSize=10, leading=15,
    fontName="Helvetica-Bold", textColor=colors.white, spaceAfter=3, spaceBefore=4)
paper_style  = ParagraphStyle("PAP", parent=styles["Normal"], fontSize=7.5,
    fontName="Helvetica-Bold", textColor=HexColor("#444444"))
qno_style    = ParagraphStyle("QNO", parent=styles["Normal"], fontSize=8.5,
    fontName="Helvetica-Bold", textColor=HexColor("#1A1A2E"))
q_style      = ParagraphStyle("QQ", parent=styles["Normal"], fontSize=9, leading=13,
    fontName="Helvetica", textColor=HexColor("#1A1A2E"), alignment=TA_JUSTIFY)
marks_style  = ParagraphStyle("MK", parent=styles["Normal"], fontSize=8,
    fontName="Helvetica-Oblique", textColor=HexColor("#555555"), alignment=TA_CENTER)
ref_style    = ParagraphStyle("RF", parent=styles["Normal"], fontSize=7.5,
    fontName="Helvetica-Oblique", textColor=HexColor("#888888"))
legend_style = ParagraphStyle("LEG", parent=styles["Normal"], fontSize=7.8, leading=11,
    fontName="Helvetica", textColor=HexColor("#333333"))

story = []

# Title
story.append(Spacer(1, 0.2*cm))
story.append(Paragraph("Biochemistry PYQ — 2023", title_style))
story.append(Paragraph("1st Professional MBBS  |  Paper I (201031) & Paper II (201032)", subtitle_style))
story.append(Paragraph("Chapter-wise Classification — Mapped to Your Book's Contents", subtitle_style))
story.append(HRFlowable(width="100%", thickness=1.5, color=HexColor("#CCCCCC"), spaceAfter=8))

# Colour legend — 2 cols
legend_items = list(CHAPTERS.items())
legend_rows = []
for i in range(0, len(legend_items), 2):
    row = []
    for ch, bg in legend_items[i:i+2]:
        swatch = Table([[""]], colWidths=[0.45*cm], rowHeights=[0.28*cm],
                       style=[("BACKGROUND",(0,0),(0,0),bg),
                              ("BOX",(0,0),(0,0),0.5,HexColor("#AAAAAA"))])
        row += [swatch, Paragraph(ch, legend_style)]
    while len(row) < 4:
        row += ["", ""]
    legend_rows.append(row)

leg_table = Table(legend_rows, colWidths=[0.5*cm, 8.4*cm, 0.5*cm, 8.4*cm])
leg_table.setStyle(TableStyle([
    ("VALIGN",(0,0),(-1,-1),"MIDDLE"),
    ("LEFTPADDING",(0,0),(-1,-1),2),
    ("RIGHTPADDING",(0,0),(-1,-1),4),
    ("BOTTOMPADDING",(0,0),(-1,-1),2),
    ("TOPPADDING",(0,0),(-1,-1),2),
]))
story.append(leg_table)
story.append(Spacer(1, 0.35*cm))
story.append(HRFlowable(width="100%", thickness=1, color=HexColor("#DDDDDD"), spaceAfter=8))

# Questions grouped by section → chapter
for section, chaps in SECTION_MAP.items():
    sec_color = SECTION_COLORS[section]

    # Section banner
    sec_table = Table([[Paragraph(f"  {section}", section_style)]],
                      colWidths=[17.9*cm])
    sec_table.setStyle(TableStyle([
        ("BACKGROUND",(0,0),(0,0), sec_color),
        ("TOPPADDING",(0,0),(0,0),6),
        ("BOTTOMPADDING",(0,0),(0,0),6),
    ]))
    story.append(sec_table)
    story.append(Spacer(1, 0.1*cm))

    for chap in chaps:
        if chap not in DATA or not DATA[chap]:
            continue
        bg   = CHAPTERS[chap]
        hcol = HEADER_COLORS[chap]

        # Chapter sub-header
        ch_table = Table([[Paragraph(f"    {chap}", chapter_style)]],
                         colWidths=[17.9*cm])
        ch_table.setStyle(TableStyle([
            ("BACKGROUND",(0,0),(0,0), hcol),
            ("TOPPADDING",(0,0),(0,0),4),
            ("BOTTOMPADDING",(0,0),(0,0),4),
            ("LEFTPADDING",(0,0),(0,0),6),
        ]))
        story.append(ch_table)
        story.append(Spacer(1, 0.06*cm))

        for (paper, qno, qtext, marks, ref) in DATA[chap]:
            row_data = [[
                Paragraph(paper,  paper_style),
                Paragraph(qno,    qno_style),
                Paragraph(qtext,  q_style),
                Paragraph(f"{marks} marks", marks_style),
                Paragraph(f"Ref: {ref}", ref_style),
            ]]
            rt = Table(row_data,
                       colWidths=[1.8*cm, 1.6*cm, 9.5*cm, 1.8*cm, 3.2*cm])
            rt.setStyle(TableStyle([
                ("BACKGROUND",(0,0),(-1,-1), bg),
                ("VALIGN",(0,0),(-1,-1),"MIDDLE"),
                ("LEFTPADDING",(0,0),(-1,-1),5),
                ("RIGHTPADDING",(0,0),(-1,-1),5),
                ("TOPPADDING",(0,0),(-1,-1),5),
                ("BOTTOMPADDING",(0,0),(-1,-1),5),
                ("BOX",(0,0),(-1,-1),0.5, HexColor("#CCCCCC")),
                ("LINEBELOW",(0,0),(-1,-1),0.4, HexColor("#CCCCCC")),
            ]))
            story.append(rt)
            story.append(Spacer(1, 0.06*cm))

        story.append(Spacer(1, 0.2*cm))

    story.append(Spacer(1, 0.25*cm))

# Footer
story.append(HRFlowable(width="100%", thickness=1, color=HexColor("#CCCCCC"),
                         spaceBefore=6, spaceAfter=5))
story.append(Paragraph(
    "Ref: D.M. Vasudevan Textbook of Biochemistry, 10th Ed  |  "
    "Exam: 1st Prof MBBS 2023  |  Chapter numbering from your book's Contents page",
    ParagraphStyle("foot", parent=styles["Normal"], fontSize=7.5,
                   textColor=HexColor("#888888"), alignment=TA_CENTER)
))

doc.build(story)
print(f"✓ PDF saved: {OUTPUT}")