Aspirin injection dose
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aspirin injection dose IV lysine acetylsalicylate clinical use
Aspirin Injection (Intravenous/Injectable Form)
Standard aspirin (acetylsalicylic acid) is not available as an injectable in the conventional sense. The injectable form is lysine acetylsalicylate (also called D,L-lysine acetylsalicylate), a water-soluble salt of aspirin used when IV or IM administration is needed.
Formulations Available
| Product | Content per vial |
|---|---|
| Aspegic (Sanofi) | 900 mg lysine acetylsalicylate (= ~500 mg aspirin) |
| Aspirin IV (Bayer, BAY81-8781) | 1,000 mg lysine acetylsalicylate glycine (= ~500 mg aspirin) |
Note: 900 mg lysine acetylsalicylate is roughly equivalent to 500 mg of aspirin (acetylsalicylic acid).
Doses by Indication
Adults
| Indication | Dose | Route |
|---|---|---|
| Acute pain / fever | 500-1000 mg IV/IM | Single dose; may repeat every 4-6 hours; max 3-4 g/day |
| Acute Coronary Syndrome (antiplatelet) | 250-500 mg IV | Single loading bolus over ~30 seconds |
| Kawasaki disease (acute phase, if oral not tolerated) | 80-100 mg/kg/day IV | Divided doses |
Children (>6 months)
| Indication | Dose |
|---|---|
| Loading (intra-procedural / Kawasaki) | 10 mg/kg/dose IV; max 500 mg/dose |
| Maintenance | 3 mg/kg/dose IV once daily |
Administration
- IV bolus: Reconstitute powder with supplied water for injection; administer over ~30 seconds (for ACS loading dose) or slow infusion over 15-30 minutes (for analgesia/anti-inflammatory).
- IM: Inject into large muscle (less preferred due to local irritation).
Key Advantages Over Oral Aspirin
- Faster onset (immediate bioavailability)
- Useful when oral/nasogastric access is not possible (vomiting, pre-operative, unconscious patient)
- Less inter-patient variability in antiplatelet effect
- Shorter half-life (~17 minutes IV vs. oral)
Contraindications / Warnings
- Reye's syndrome risk - do NOT use in children/adolescents with febrile viral illness
- Peptic ulcer disease, active GI bleeding
- Severe G6PD deficiency (risk of haemolysis)
- Third trimester of pregnancy (premature closure of ductus arteriosus)
- Hypersensitivity to NSAIDs/aspirin
Important note: Availability of injectable aspirin (lysine acetylsalicylate) varies by country. It is approved and available in Europe (France, Germany, etc.) and used in some specialized pediatric/cardiac centers (e.g., for Kawasaki disease). It is not FDA-approved in the United States as a standalone IV product for routine use. Always confirm local formulary availability and consult prescribing guidelines for your region.
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