I now have enough information. The question "আকিল মারিওটলে অমরকী কী medication দেতে পরে" means "What medications are given for Amoebiasis (amoebic infection)?" with Bangladeshi branded names.
Here is a complete answer:
Medications for Amoebiasis - with Bangladesh Brand Names
Amoebiasis is caused by Entamoeba histolytica and treatment depends on whether it is intestinal (symptomatic/invasive) or asymptomatic luminal infection.
1. Metronidazole - Drug of Choice for Symptomatic/Invasive Amoebiasis
Mechanism: Nitroimidazole - reduced by anaerobic organisms to a toxic intermediate that damages DNA.
Dose: 400-800 mg three times daily for 5-10 days (adults)
Bangladesh Brand Names (from MedEx):
| Brand Name | Manufacturer | Form |
|---|
| Amodis | Square Pharmaceuticals | Tablet 400 mg / Suspension |
| Amotrex | ACI Limited | Tablet 200/400 mg / Suspension / IV |
| Amezol | Cosmic Pharma | Tablet 400 mg / Suspension |
| Metrogyl | Rephco Pharmaceuticals | Tablet 200/400 mg / Suspension |
| Metrogard | Guardian Healthcare | Tablet 400 mg |
| Metrol | Indo Bangla Pharmaceutical | Tablet / Suspension |
| Ormet | Belsen Pharmaceuticals | Tablet 400 mg |
Important: Alcohol must be avoided during treatment and for 2-3 days after (disulfiram-like reaction).
2. Tinidazole - Alternative to Metronidazole (better tolerated)
Dose: 2 g once daily for 3 days (intestinal); 2 g once daily for 5 days (liver abscess)
Common in Bangladesh as combination products with Diloxanide:
- Amibactin DS (Diloxanide Furoate 300 mg + Tinidazole 500 mg)
- Amibactin BD (Diloxanide Furoate 600 mg + Tinidazole 750 mg)
3. Diloxanide Furoate - Luminal Agent (to eradicate cysts after systemic treatment)
Used after metronidazole/tinidazole to clear intestinal cysts (40-60% of patients still carry cysts after metronidazole alone).
Dose: 500 mg three times daily for 10 days
Bangladesh Brand:
- Amibazol (Diloxanide Furoate alone)
- Dilomet DS (Diloxanide Furoate + Metronidazole combination)
Summary of Treatment Protocol
| Condition | First-line | Follow-up |
|---|
| Symptomatic intestinal amoebiasis | Metronidazole (Amodis/Amotrex) | + Diloxanide furoate (Amibazol) |
| Amoebic liver abscess | Metronidazole IV/oral (Amotrex IV) | + Diloxanide furoate |
| Asymptomatic cyst carrier | Diloxanide furoate alone | - |
Source: MedEx Bangladesh - Metronidazole brands | Basic Medical Biochemistry (Lieberman) | Sleisenger & Fordtran's GI Disease