What's wrong with the liver.
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Liver Function Test Analysis - Mrs. Chanda Kalro (67F, collected 03-Jul-2026)
The Key Liver Findings
Two liver enzymes are significantly abnormal:
| Parameter | Result | Reference Range | Status |
|---|---|---|---|
| Alkaline Phosphatase (ALP) | 136 U/L | 35-105 U/L | HIGH |
| GGT (Gamma Glutamyl Transferase) | 338.50 U/L | 10-54 U/L | VERY HIGH |
| Bilirubin - Total | 0.61 mg/dL | 0.1-1.0 | Normal |
| Bilirubin - Direct | 0.32 mg/dL | 0.0-0.4 | Normal |
| SGOT (AST) | 15.70 U/L | 0.1-31 | Normal |
| SGPT (ALT) | 22.40 U/L | ≤34 U/L | Normal |
| Total Protein | 7.18 g/dL | 6.4-8.3 | Normal |
| Albumin | 4.41 g/dL | 3.2-4.6 | Normal |
What This Pattern Means
The most striking finding is GGT at 338.50 U/L - that is more than 6 times the upper limit of normal (54 U/L). This is a significant elevation. ALP is also elevated but mildly (about 30% above the upper limit).
Crucially, SGOT and SGPT are completely normal. This is important because:
- Normal ALT/AST = liver cells are NOT being actively destroyed (no hepatitis, no acute liver damage)
- Elevated GGT + elevated ALP with normal transaminases = cholestatic (bile duct) pattern, not a hepatocellular (liver cell) pattern
The most common causes of this specific pattern (high GGT + high ALP, normal transaminases) in a 67-year-old woman:
- Biliary obstruction or cholestasis - blocked bile ducts (gallstones, strictures)
- Non-alcoholic fatty liver disease (NAFLD/MASLD) - very likely given her elevated cholesterol (LDL 196.74, Total Cholesterol 267)
- Alcohol use - GGT is a sensitive marker for alcohol-related liver disease
- Medications - certain drugs raise GGT (statins, antiepileptics, etc.)
- Subclinical hypothyroidism - Her TSH is elevated at 5.38 uIU/mL (above the normal 0.3-4.5), which can independently elevate liver enzymes and worsen lipid profiles
The Bigger Picture - Connecting the Dots
Several findings in this report are related:
- TSH 5.38 (HIGH) - subclinical hypothyroidism - this alone can raise GGT, ALP, and cholesterol
- Total Cholesterol 267, LDL 196.74 (HIGH) - dyslipidemia, commonly worsened by hypothyroidism
- Elevated GGT + ALP - may partly be driven by hypothyroidism and/or fatty liver from dyslipidemia
- Calcium 10.80 mg/dL (slightly HIGH, normal up to 10.2) - this also needs evaluation
What She Should Do
- See a doctor promptly - a GGT of 338 needs to be investigated
- Ultrasound of the abdomen - to check for fatty liver, gallstones, bile duct dilation
- Get thyroid treatment evaluated - her TSH is above normal (subclinical hypothyroidism), which her doctor may recommend treating; this could also help normalize the cholesterol and potentially the liver enzymes
- Follow up on lipids - LDL of 196 is in the "Very High" category and significantly increases cardiovascular risk
- Repeat LFT in 4-6 weeks after addressing contributing causes
Important disclaimer: This is an interpretation of lab values for informational purposes only. Please share these results with a qualified doctor (physician or gastroenterologist) who can correlate them with symptoms, history, medications, and examination findings before any diagnosis or treatment.
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