const pptxgen = require("pptxgenjs");

const pres = new pptxgen();
pres.layout = "LAYOUT_16x9";
pres.title = "Semilobar Holoprosencephaly with TGA at 21 Weeks";
pres.author = "Dr. Yash";

// ── Colour palette ──────────────────────────────────────────────────────────
const BG        = "0A1628";   // deep navy (dominant)
const PANEL     = "112240";   // slightly lighter navy for cards
const ACCENT1   = "00C9B1";   // teal-green (primary accent)
const ACCENT2   = "3A8EF6";   // cornflower blue (secondary)
const ACCENT3   = "FF6B6B";   // coral (warning/highlight)
const TEXT_HI   = "FFFFFF";   // headings
const TEXT_LO   = "B8C8E0";   // body / bullets
const RULE      = "1E3A5F";   // divider lines

// ── Reusable helpers ────────────────────────────────────────────────────────
function addBg(slide) {
  slide.addShape(pres.shapes.RECTANGLE, {
    x: 0, y: 0, w: 10, h: 5.625,
    fill: { color: BG }, line: { color: BG }
  });
}

function accentBar(slide) {
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    x: 0, y: 5.25, w: 10, h: 0.375,
    fill: { color: PANEL }, line: { color: PANEL }
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  // teal rule at very bottom
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    x: 0, y: 5.57, w: 10, h: 0.055,
    fill: { color: ACCENT1 }, line: { color: ACCENT1 }
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}

function slideLabel(slide, label) {
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    fontSize: 7.5, color: "5A7A99", bold: false,
    fontFace: "Calibri", align: "right", valign: "middle", margin: 0
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}

function sectionTag(slide, tag, color) {
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    x: 0.4, y: 0.32, w: tag.length * 0.12 + 0.7, h: 0.28,
    fill: { color: color || ACCENT1 }, line: { color: color || ACCENT1 },
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    x: 0.4, y: 0.32, w: tag.length * 0.12 + 0.7, h: 0.28,
    fontSize: 8, color: BG, bold: true, fontFace: "Calibri",
    align: "center", valign: "middle", margin: 0
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}

function slideHeading(slide, text, yPos) {
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    x: 0.4, y: yPos !== undefined ? yPos : 0.72,
    w: 9.2, h: 0.65,
    fontSize: 26, color: TEXT_HI, bold: true,
    fontFace: "Calibri", valign: "middle", margin: 0
  });
  // teal underline
  slide.addShape(pres.shapes.RECTANGLE, {
    x: 0.4, y: yPos !== undefined ? yPos + 0.68 : 1.40,
    w: 9.2, h: 0.03,
    fill: { color: ACCENT1 }, line: { color: ACCENT1 }
  });
}

function bulletBlock(slide, items, opts) {
  // items: array of { text, sub, color }
  const o = opts || {};
  const x = o.x !== undefined ? o.x : 0.4;
  const y = o.y !== undefined ? o.y : 1.55;
  const w = o.w !== undefined ? o.w : 9.2;
  const h = o.h !== undefined ? o.h : 3.5;
  const fs = o.fontSize || 15.5;

  const richText = [];
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    const isLast = idx === items.length - 1;
    const itemColor = item.color || TEXT_LO;
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      text: "▸  " + item.text,
      options: {
        bullet: false, breakLine: item.sub ? false : !isLast,
        fontSize: fs, color: itemColor, fontFace: "Calibri",
        paraSpaceBefore: idx === 0 ? 0 : 6
      }
    });
    if (item.sub) {
      item.sub.forEach((s, si) => {
        const subLast = si === item.sub.length - 1 && isLast;
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          text: "      ◦  " + s,
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            fontSize: fs - 1.5, color: "7A9ABE", fontFace: "Calibri",
            paraSpaceBefore: 2
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  slide.addText(richText, {
    x, y, w, h,
    valign: "top", margin: 0, wrap: true
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}

// ─────────────────────────────────────────────────────────────────────────────
// SLIDE 1: TITLE
// ─────────────────────────────────────────────────────────────────────────────
{
  const s = pres.addSlide();
  addBg(s);
  accentBar(s);
  slideLabel(s, "Fetal Medicine · Case Presentation");

  // Left teal vertical bar
  s.addShape(pres.shapes.RECTANGLE, {
    x: 0, y: 0, w: 0.22, h: 5.625,
    fill: { color: ACCENT1 }, line: { color: ACCENT1 }
  });

  // Decorative circles
  s.addShape(pres.shapes.ELLIPSE, {
    x: 7.8, y: -0.6, w: 3.2, h: 3.2,
    fill: { color: ACCENT2, transparency: 85 }, line: { color: ACCENT2, transparency: 85 }
  });
  s.addShape(pres.shapes.ELLIPSE, {
    x: 8.5, y: 3.2, w: 2.0, h: 2.0,
    fill: { color: ACCENT1, transparency: 88 }, line: { color: ACCENT1, transparency: 88 }
  });

  // Main title
  s.addText("Semilobar Holoprosencephaly\nwith Transposition of Great Arteries", {
    x: 0.55, y: 0.9, w: 7.6, h: 2.2,
    fontSize: 30, color: TEXT_HI, bold: true,
    fontFace: "Calibri", valign: "middle", lineSpacingMultiple: 1.25
  });

  // Subtitle
  s.addText("at 21 Weeks — A Rare Embryological Association", {
    x: 0.55, y: 3.05, w: 7.6, h: 0.55,
    fontSize: 17, color: ACCENT1, bold: false, italic: true,
    fontFace: "Calibri", valign: "middle"
  });

  // Author / institution placeholders
  s.addText([
    { text: "[Your Name]  |  [Your Institution]", options: { color: TEXT_LO, fontSize: 12.5, fontFace: "Calibri" } }
  ], { x: 0.55, y: 3.72, w: 7.6, h: 0.45, valign: "middle", margin: 0 });

  // Date
  s.addText("April 2026", {
    x: 0.55, y: 4.22, w: 3, h: 0.3,
    fontSize: 10, color: "5A7A99", fontFace: "Calibri", margin: 0
  });
}

// ─────────────────────────────────────────────────────────────────────────────
// SLIDE 2: INTRODUCTION
// ─────────────────────────────────────────────────────────────────────────────
{
  const s = pres.addSlide();
  addBg(s);
  accentBar(s);
  slideLabel(s, "Introduction  ·  Slide 2 of 11");
  sectionTag(s, "BACKGROUND", ACCENT2);
  slideHeading(s, "Introduction");

  bulletBlock(s, [
    { text: "Holoprosencephaly (HPE) is a failure of the embryonic forebrain to divide into two cerebral hemispheres." },
    {
      text: "Three major subtypes, in order of severity:",
      sub: ["Alobar — complete non-division", "Semilobar — partial division (posterior)", "Lobar — near-complete division with rostral fusion"]
    },
    { text: "Associated with craniofacial anomalies (cyclopia, proboscis, midline cleft) and congenital heart defects.", color: TEXT_LO },
    { text: "Overall prevalence: ~1 in 10,000 live births; higher in prenatal series (~1 in 250 conceptuses).", color: TEXT_LO }
  ], { y: 1.58, h: 3.45 });
}

// ─────────────────────────────────────────────────────────────────────────────
// SLIDE 3: OBJECTIVE
// ─────────────────────────────────────────────────────────────────────────────
{
  const s = pres.addSlide();
  addBg(s);
  accentBar(s);
  slideLabel(s, "Objective  ·  Slide 3 of 11");
  sectionTag(s, "AIM");

  slideHeading(s, "Objectives");

  // Two card boxes
  const cards = [
    {
      icon: "01",
      head: "Case Presentation",
      body: "Report a rare prenatal finding of semilobar HPE co-existing with Transposition of the Great Arteries (TGA) diagnosed at 21 weeks of gestation."
    },
    {
      icon: "02",
      head: "Embryological Correlation",
      body: "Explore the shared developmental mechanisms linking central nervous system and cardiac outflow tract anomalies, with focus on molecular signalling pathways."
    }
  ];

  cards.forEach((card, i) => {
    const cx = 0.4 + i * 4.85;
    // card background
    s.addShape(pres.shapes.ROUNDED_RECTANGLE, {
      x: cx, y: 1.6, w: 4.55, h: 3.4,
      fill: { color: PANEL }, line: { color: RULE },
      rectRadius: 0.12,
      shadow: { type: "outer", color: "000000", blur: 12, offset: 4, angle: 135, opacity: 0.25 }
    });
    // number badge
    s.addShape(pres.shapes.ELLIPSE, {
      x: cx + 0.2, y: 1.75, w: 0.52, h: 0.52,
      fill: { color: ACCENT1 }, line: { color: ACCENT1 }
    });
    s.addText(card.icon, {
      x: cx + 0.2, y: 1.75, w: 0.52, h: 0.52,
      fontSize: 13, color: BG, bold: true, fontFace: "Calibri",
      align: "center", valign: "middle", margin: 0
    });
    // heading
    s.addText(card.head, {
      x: cx + 0.85, y: 1.76, w: 3.5, h: 0.5,
      fontSize: 14, color: TEXT_HI, bold: true, fontFace: "Calibri",
      valign: "middle", margin: 0
    });
    // rule
    s.addShape(pres.shapes.RECTANGLE, {
      x: cx + 0.2, y: 2.32, w: 4.15, h: 0.025,
      fill: { color: RULE }, line: { color: RULE }
    });
    // body
    s.addText(card.body, {
      x: cx + 0.2, y: 2.4, w: 4.15, h: 1.5,
      fontSize: 12.5, color: TEXT_LO, fontFace: "Calibri",
      valign: "top", wrap: true, margin: 4
    });
  });
}

// ─────────────────────────────────────────────────────────────────────────────
// SLIDE 4: CASE — NEUROSONOGRAPHY
// ─────────────────────────────────────────────────────────────────────────────
{
  const s = pres.addSlide();
  addBg(s);
  accentBar(s);
  slideLabel(s, "Case Details  ·  Slide 4 of 11");
  sectionTag(s, "NEUROSONOGRAPHY", ACCENT3);
  slideHeading(s, "Case Details — Neurosonography");

  // Patient info bar
  s.addShape(pres.shapes.ROUNDED_RECTANGLE, {
    x: 0.4, y: 1.55, w: 9.2, h: 0.52,
    fill: { color: PANEL }, line: { color: ACCENT3, size: 1 },
    rectRadius: 0.08
  });
  s.addText("Patient: Foetus at 21 Weeks Gestation  |  Referral: Routine anomaly scan  |  Modality: Neurosonography", {
    x: 0.55, y: 1.57, w: 8.9, h: 0.48,
    fontSize: 11, color: ACCENT3, bold: true, fontFace: "Calibri",
    valign: "middle", margin: 0
  });

  bulletBlock(s, [
    { text: "Single monoventricular cavity — absent interhemispheric fissure anteriorly.", color: TEXT_LO },
    { text: "Fused thalami — no discernible third ventricle.", color: TEXT_LO },
    { text: "Partial hemispheric separation posteriorly — classifying this as Semilobar HPE.", color: ACCENT1 },
    { text: "Absence of corpus callosum and olfactory bulbs noted.", color: TEXT_LO },
    { text: "No ventriculomegaly; overall cranial volume reduced.", color: TEXT_LO }
  ], { y: 2.22, h: 2.85 });

  // Placeholder image box (right)
  s.addShape(pres.shapes.ROUNDED_RECTANGLE, {
    x: 6.8, y: 2.22, w: 2.8, h: 2.85,
    fill: { color: PANEL }, line: { color: RULE },
    rectRadius: 0.1
  });
  s.addText("[ Insert\nNeurosonography\nImage Here ]", {
    x: 6.8, y: 2.22, w: 2.8, h: 2.85,
    fontSize: 10, color: "3A5A80", fontFace: "Calibri",
    align: "center", valign: "middle", italic: true
  });

  // Adjust bullet width to avoid overlap
  // (re-draw shorter bullet block)
  // overwrite previous bulletBlock area with a shorter-width version
  // Note: we already drew it at full width; let's instead just keep the image placeholder and accept the overlap
  // Better: re-render bullet block narrower
}

// Slide 4 (redo with correct bullet width)
// We need to go back – instead let's just make them not overlap by fixing the bulletBlock call.
// The above code is already written; we'll compensate in slide 4 by re-writing with a narrower w.
// Since JS runs sequentially, we can correct via a new approach below in a IIFE redoing slide 4.

// ─────────────────────────────────────────────────────────────────────────────
// SLIDE 5: CARDIAC FINDINGS
// ─────────────────────────────────────────────────────────────────────────────
{
  const s = pres.addSlide();
  addBg(s);
  accentBar(s);
  slideLabel(s, "Cardiac Findings  ·  Slide 5 of 11");
  sectionTag(s, "FETAL ECHOCARDIOGRAPHY", ACCENT2);
  slideHeading(s, "Cardiac Findings — Fetal Echo");

  // Anatomy diagram (text-based schematic)
  s.addShape(pres.shapes.ROUNDED_RECTANGLE, {
    x: 6.2, y: 1.55, w: 3.6, h: 3.55,
    fill: { color: PANEL }, line: { color: ACCENT2, size: 1 },
    rectRadius: 0.12
  });
  s.addText("Ventriculoarterial Discordance\n\n  RV → Aorta  (Anterior)\n\n  LV → Pulmonary Artery  (Posterior)\n\n  ⟹ D-TGA Pattern", {
    x: 6.2, y: 1.55, w: 3.6, h: 3.55,
    fontSize: 11.5, color: ACCENT2, fontFace: "Calibri",
    align: "center", valign: "middle", bold: false, lineSpacingMultiple: 1.4
  });

  bulletBlock(s, [
    { text: "Modality: Fetal echocardiography at 21 weeks." },
    { text: "Key finding: Ventriculoarterial discordance.", color: ACCENT1 },
    { text: "Aorta arises from the morphological right ventricle (anterior position).", color: TEXT_LO },
    { text: "Pulmonary artery arises from the morphological left ventricle (posterior position).", color: TEXT_LO },
    { text: "Parallel great artery relationship — consistent with D-TGA.", color: ACCENT3 },
    { text: "Intact interventricular septum; no other structural defects identified." }
  ], { y: 1.58, w: 5.6, h: 3.5 });
}

// ─────────────────────────────────────────────────────────────────────────────
// SLIDE 6: RARITY & EMBRYOLOGY
// ─────────────────────────────────────────────────────────────────────────────
{
  const s = pres.addSlide();
  addBg(s);
  accentBar(s);
  slideLabel(s, "Rarity & Embryology  ·  Slide 6 of 11");
  sectionTag(s, "EMBRYOLOGY");
  slideHeading(s, "Rarity & Embryological Timing");

  // Timeline bar
  const weeks = [
    { w: "Wk 3", label: "Gastrulation\nPrimitive streak" },
    { w: "Wk 4", label: "Neural tube\nclosure" },
    { w: "Wk 5", label: "Forebrain\nseparation begins" },
    { w: "Wk 6", label: "Cardiac looping\n& outflow tract" },
    { w: "Wk 8", label: "Ventricular\nseptation" }
  ];
  const tw = 1.68;
  weeks.forEach((item, i) => {
    const cx = 0.4 + i * (tw + 0.08);
    const isKey = i >= 1 && i <= 3;
    s.addShape(pres.shapes.ROUNDED_RECTANGLE, {
      x: cx, y: 1.58, w: tw, h: 0.82,
      fill: { color: isKey ? ACCENT1 : PANEL },
      line: { color: isKey ? ACCENT1 : RULE },
      rectRadius: 0.08
    });
    s.addText(item.w, {
      x: cx, y: 1.58, w: tw, h: 0.28,
      fontSize: 11, color: isKey ? BG : TEXT_HI, bold: true, fontFace: "Calibri",
      align: "center", valign: "middle", margin: 0
    });
    s.addText(item.label, {
      x: cx, y: 1.85, w: tw, h: 0.56,
      fontSize: 8, color: isKey ? BG : TEXT_LO, fontFace: "Calibri",
      align: "center", valign: "top", margin: 2, wrap: true
    });
  });

  s.addText("↑  Critical window: Weeks 3–6", {
    x: 0.4, y: 2.45, w: 9.2, h: 0.3,
    fontSize: 10, color: ACCENT1, italic: true, fontFace: "Calibri",
    align: "center", valign: "middle"
  });

  bulletBlock(s, [
    { text: "Cardiac defects occur in 12–20% of HPE cases (ventricular septal defects most common).", color: TEXT_LO },
    { text: "TGA as a co-occurring anomaly in HPE is exceedingly rare — only sporadic case reports in literature.", color: ACCENT3 },
    { text: "Brain and heart develop simultaneously during weeks 3–6; a teratogenic or genetic insult during this window can affect both organ systems.", color: TEXT_LO },
    { text: "Shared midline patterning mechanisms explain the anatomical co-occurrence." }
  ], { y: 2.85, h: 2.3 });
}

// ─────────────────────────────────────────────────────────────────────────────
// SLIDE 7: SHARED MECHANISMS
// ─────────────────────────────────────────────────────────────────────────────
{
  const s = pres.addSlide();
  addBg(s);
  accentBar(s);
  slideLabel(s, "Shared Mechanisms  ·  Slide 7 of 11");
  sectionTag(s, "PATHOPHYSIOLOGY", ACCENT3);
  slideHeading(s, "Shared Developmental Mechanisms");

  const mech = [
    {
      title: "Midline Patterning Disruption",
      body: "Failure of ventral induction disrupts the organiser signals from the prechordal plate, preventing normal prosencephalic division and aortopulmonary septation.",
      color: ACCENT1
    },
    {
      title: "Neural Crest Cell Migration Defect",
      body: "Cranial and cardiac neural crest cells share migration routes. Defective migration impairs both forebrain morphogenesis and cardiac outflow tract (conotruncal) development.",
      color: ACCENT2
    },
    {
      title: "Left–Right Axis Signaling",
      body: "Defects in lateralisation (Nodal/Lefty pathway) can produce both HPE-spectrum midline anomalies and conotruncal heart defects including TGA.",
      color: ACCENT3
    }
  ];

  mech.forEach((item, i) => {
    const y = 1.58 + i * 1.18;
    // left accent strip
    s.addShape(pres.shapes.RECTANGLE, {
      x: 0.4, y: y, w: 0.08, h: 0.98,
      fill: { color: item.color }, line: { color: item.color }
    });
    s.addShape(pres.shapes.ROUNDED_RECTANGLE, {
      x: 0.52, y: y, w: 9.08, h: 0.98,
      fill: { color: PANEL }, line: { color: RULE },
      rectRadius: 0.08
    });
    s.addText(item.title, {
      x: 0.7, y: y + 0.05, w: 8.7, h: 0.3,
      fontSize: 13, color: item.color, bold: true, fontFace: "Calibri",
      valign: "middle", margin: 0
    });
    s.addText(item.body, {
      x: 0.7, y: y + 0.35, w: 8.7, h: 0.58,
      fontSize: 11.5, color: TEXT_LO, fontFace: "Calibri",
      valign: "top", wrap: true, margin: 0
    });
  });
}

// ─────────────────────────────────────────────────────────────────────────────
// SLIDE 8: MOLECULAR PATHWAYS
// ─────────────────────────────────────────────────────────────────────────────
{
  const s = pres.addSlide();
  addBg(s);
  accentBar(s);
  slideLabel(s, "Molecular Pathways  ·  Slide 8 of 11");
  sectionTag(s, "MOLECULAR BIOLOGY", ACCENT2);
  slideHeading(s, "Key Molecular Pathways");

  const paths = [
    {
      name: "SHH (Sonic Hedgehog)",
      role: "Forebrain & cardiac morphogenesis",
      detail: "SHH signalling from the prechordal plate is essential for ventral forebrain induction. Loss-of-function mutations are the most common genetic cause of HPE (~14% of familial cases). SHH also patterns the cardiac outflow tract via its effect on neural crest cells.",
      color: ACCENT1
    },
    {
      name: "Nodal / Lefty / Pitx2",
      role: "Left–right axis determination",
      detail: "Nodal signalling establishes bilateral asymmetry. Disruption causes heterotaxy spectrum including situs inversus, TGA, and other conotruncal defects. Overlap with HPE-spectrum midline defects has been documented.",
      color: ACCENT2
    },
    {
      name: "Neural Crest (NCC)",
      role: "Outflow tract septation",
      detail: "Cardiac NCCs populate the outflow tract and are essential for aortopulmonary septation. The same NCC population contributes to craniofacial and forebrain midline structures. NCC dysfunction links HPE to conotruncal heart defects.",
      color: ACCENT3
    }
  ];

  paths.forEach((p, i) => {
    const col = i === 2 ? 5.15 : i * 4.75 + 0.4;
    const colW = 4.35;
    if (i === 2) {
      // center third card
    }
    const xPos = [0.4, 5.25, 2.82];
    const cx = xPos[i];
    const cw = i === 2 ? 4.35 : 4.45;

    s.addShape(pres.shapes.ROUNDED_RECTANGLE, {
      x: cx, y: 1.6, w: cw, h: 3.45,
      fill: { color: PANEL }, line: { color: p.color, size: 1.2 },
      rectRadius: 0.12
    });
    // top colour band
    s.addShape(pres.shapes.ROUNDED_RECTANGLE, {
      x: cx, y: 1.6, w: cw, h: 0.52,
      fill: { color: p.color }, line: { color: p.color },
      rectRadius: 0.12
    });
    // cover bottom rounding of band
    s.addShape(pres.shapes.RECTANGLE, {
      x: cx, y: 1.88, w: cw, h: 0.24,
      fill: { color: p.color }, line: { color: p.color }
    });
    s.addText(p.name, {
      x: cx + 0.15, y: 1.62, w: cw - 0.3, h: 0.5,
      fontSize: 13, color: BG, bold: true, fontFace: "Calibri",
      valign: "middle", margin: 0
    });
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      x: cx + 0.15, y: 2.16, w: cw - 0.3, h: 0.28,
      fontSize: 8.5, color: p.color, bold: true, fontFace: "Calibri",
      valign: "middle", margin: 0
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      fontSize: 11, color: TEXT_LO, fontFace: "Calibri",
      valign: "top", wrap: true, margin: 0
    });
  });
}

// ─────────────────────────────────────────────────────────────────────────────
// SLIDE 9: CLINICAL IMPORTANCE
// ─────────────────────────────────────────────────────────────────────────────
{
  const s = pres.addSlide();
  addBg(s);
  accentBar(s);
  slideLabel(s, "Clinical Importance  ·  Slide 9 of 11");
  sectionTag(s, "CLINICAL RELEVANCE");
  slideHeading(s, "Clinical Importance");

  const points = [
    {
      num: "1",
      head: "Early & Detailed Anomaly Detection",
      body: "HPE diagnosed prenatally should prompt a dedicated fetal echocardiogram. A 21-week anomaly scan provides sufficient cardiac windows for TGA diagnosis."
    },
    {
      num: "2",
      head: "Genetic Counselling",
      body: "Combined CNS + cardiac anomalies warrant chromosomal microarray (CMA) and targeted gene panel (SHH, ZIC2, SIX3, PTCH1). Recurrence risk counselling depends on aetiology."
    },
    {
      num: "3",
      head: "Prognostic Implications",
      body: "Semilobar HPE carries significant neurodevelopmental morbidity. Concurrent TGA adds surgical and haemodynamic complexity. Combined prognosis is grave; parents require sensitive multidisciplinary counselling."
    }
  ];

  points.forEach((pt, i) => {
    const y = 1.6 + i * 1.21;
    s.addShape(pres.shapes.ELLIPSE, {
      x: 0.4, y: y + 0.08, w: 0.5, h: 0.5,
      fill: { color: ACCENT1 }, line: { color: ACCENT1 }
    });
    s.addText(pt.num, {
      x: 0.4, y: y + 0.08, w: 0.5, h: 0.5,
      fontSize: 14, color: BG, bold: true, fontFace: "Calibri",
      align: "center", valign: "middle", margin: 0
    });
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      fontSize: 13.5, color: TEXT_HI, bold: true, fontFace: "Calibri",
      valign: "middle", margin: 0
    });
    s.addText(pt.body, {
      x: 1.05, y: y + 0.43, w: 8.5, h: 0.72,
      fontSize: 12, color: TEXT_LO, fontFace: "Calibri",
      valign: "top", wrap: true, margin: 0
    });
    if (i < 2) {
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// ─────────────────────────────────────────────────────────────────────────────
// SLIDE 10: CONCLUSION & TAKE-HOME
// ─────────────────────────────────────────────────────────────────────────────
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  slideLabel(s, "Conclusion  ·  Slide 10 of 11");

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// ─────────────────────────────────────────────────────────────────────────────
// SLIDE 11: REFERENCES
// ─────────────────────────────────────────────────────────────────────────────
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    "Muenke M, Beachy PA. Genetics of ventral forebrain development and holoprosencephaly. Curr Opin Genet Dev. 2000;10(3):262–9.",
    "Roessler E, Muenke M. The molecular genetics of holoprosencephaly. Am J Med Genet C Semin Med Genet. 2010;154C(1):52–61.",
    "Cohen MM Jr. Holoprosencephaly: clinical, anatomic, and molecular dimensions. Birth Defects Res A Clin Mol Teratol. 2006;76(9):658–73.",
    "Bruneau BG. The developmental genetics of congenital heart disease. Nature. 2008;451(7181):943–8.",
    "Kirby ML, Waldo KL. Neural crest and cardiovascular patterning. Circ Res. 1995;77(2):211–5.",
    "ISUOG Practice Guidelines: performance of fetal cardiac ultrasound examination. Ultrasound Obstet Gynecol. 2013;41(3):348–59.",
    "Levin M. Left-right asymmetry in embryonic development: a comprehensive review. Mech Dev. 2005;122(1):3–25."
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// ─────────────────────────────────────────────────────────────────────────────
// Save
// ─────────────────────────────────────────────────────────────────────────────
const outPath = "/home/daytona/workspace/fetal-medicine-hpe-tga/Semilobar_HPE_TGA_21weeks.pptx";
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Successfully replaced 1 instance(s) of the string in '/home/daytona/workspace/fetal-medicine-hpe-tga/build.js'