1. Leprosy pathogenesis 2. Bone involvement in leprosy- pathogenesis 3

1. Leprosy pathogenesis 2. Bone involvement in leprosy- pathogenesis 3. Disabilities and deformities in leprosy 4. HIV skin manifestations 5. LGV-C/F, complications, Mx In 10 marks format for 3rd yr dermatology post graduate theory examination

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All five topics have been comprehensively covered above. Here is a quick orientation to what's been written:

What's Covered - Structure at a Glance

#	Topic	Key Sections
1	Leprosy Pathogenesis	Organism biology, entry, CMI spectrum (TT→LL), Th1 vs Th2, Virchow cells, PGL-1, Lepra reactions (Type 1 RR, Type 2 ENL, Lucio)
2	Bone Involvement in Leprosy	Specific (direct): periostitis, dactylitis, nasal bone, facies leonina. Secondary (neuropathic): Charcot joints, osteomyelitis, pathological fracture. X-ray findings tabulated
3	Disabilities & Deformities	WHO grades 0/1/2. Nerve-by-nerve breakdown: ulnar (claw hand), median (ape thumb), peroneal (foot drop), posterior tibial (plantar ulcer), facial (lagophthalmos), trigeminal (blind cornea). Eye, face, genital deformities. POD strategies
4	HIV Skin Manifestations	8 categories: viral (HSV, VZV, Molluscum, HPV, OHL), bacterial (Bacillary angiomatosis, syphilis, staph), fungal (candida, tinea, cryptococcus, penicilliosis), parasitic (Norwegian scabies), inflammatory (seborrheic, psoriasis, eosinophilic folliculitis, PPE), neoplastic (Kaposi sarcoma, NHL), drug reactions, IRIS
5	LGV	Etiology (L1-L3 serovars), 3 stages, Groove sign, anorectal LGV in MSM, acute + chronic complications, diagnosis (NAAT gold standard, MIF, CFT), treatment (Doxycycline 100mg BD x 21 days), bubo management (aspiration, not I&D), partner treatment, special populations

Each answer is written for a 10-mark PG theory examination - comprehensive headings, pathophysiology, classification tables, clinical pearls, and management points included throughout.

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