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Prepare poster for poster presention in up pathcon 2026, use the headings introductuon, material and metjods/case report, resukts, conckusion, discussion , references, use the format provided

analyse_media
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Reading File
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Browsing Directory

~/

Searching PubMed

cutaneous squamous cell carcinoma AND verrucous epidermal nevus

Searching the Web

cutaneous squamous cell carcinoma arising in verrucous epidermal nevus review

Finding Sources
Finding Sources
Reading File
Browsing Directory

~/attachments/58afe95e-8136-4658-9150-93e210dfad91/

Running Command

python -c "from pptx import Presentation; p=Presentation('/tmp/workspace/attachments/58afe95e-8136-4658-9150-93e210dfad91/UPPATHCON_EPoster.pptx'); print('slides',len(p.slides),'size',p.slide_width,p.slide_height);\nfor i,s in enumerate(p.slides,1):\n print('SLIDE',i);\n for sh in s.shapes:\n t=sh.text if getattr(sh,'has_text_frame',False) else ''; print(sh.shape_type,sh.name,round(sh.left/914400,2),round(sh.top/914400,2),round(sh.width/914400,2),round(sh.height/914400,2),repr(t[:200]))"

Running Command

python -c "from pptx import Presentation; p=Presentation('/tmp/workspace/attachments/58afe95e-8136-4658-9150-93e210dfad91/UPPATHCON_EPoster.pptx'); print('slides',len(p.slides),'size inches',p.slide_width/914400,p.slide_height/914400); [(print('SLIDE',i+1),[(print(sh.shape_type,sh.name,round(sh.left/914400,2),round(sh.top/914400,2),round(sh.width/914400,2),round(sh.height/914400,2),repr(sh.text[:160] if getattr(sh,\"has_text_frame\",False) else \"\"))) for sh in s.shapes]) for i,s in enumerate(p.slides)]"

Reading Article

PMID: 24403890

Reading Article

PMID: 8884151

Finding Sources
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Running Command

mkdir -p "/tmp/workspace/uppathcon-2026-poster/output" && printf 'created\n'

Searching Images

well differentiated cutaneous squamous cell carcinoma histopathology keratin pearls H&E microscopy

Running Command

python - <<'PY' from pptx import Presentation from pptx.util import Inches, Pt from pptx.enum.text import PP_ALIGN, MSO_ANCHOR from pptx.enum.shapes import MSO_SHAPE from pptx.dml.color import RGBColor from pptx.enum.dml import MSO_THEME_COLOR from pptx.enum.text import MSO_AUTO_SIZE from pathlib import Path src=Path('/tmp/workspace/attachments/58afe95e-8136-4658-9150-93e210dfad91/UPPATHCON_EPoster.pptx') out=Path('/tmp/workspace/uppathcon-2026-poster/output/UPPATHCON_2026_EPoster_Microinvasive_SCC.pptx') prs=Presentation(str(src)); slide=prs.slides[0] # Colors NAVY=RGBColor(18,48,91); BLUE=RGBColor(34,97,150); TEAL=RGBColor(19,117,125); GOLD=RGBColor(211,160,37); GREY=RGBColor(70,77,87); WHITE=RGBColor(255,255,255); LIGHT=RGBColor(242,247,250); PALE=RGBColor(232,242,245); RED=RGBColor(157,45,44) # map existing text texts=[sh for sh in slide.shapes if getattr(sh,'has_text_frame',False)] # Template shape texts by original for sh in texts: old=sh.text.strip() if old=='TITLE OF POSTER': sh.text='MICROINVASIVE WELL-DIFFERENTIATED CUTANEOUS SQUAMOUS\nCELL CARCINOMA ARISING IN A VERRUCOUS EPIDERMAL NEVUS' tf=sh.text_frame; tf.clear(); p=tf.paragraphs[0]; p.text='MICROINVASIVE WELL-DIFFERENTIATED CUTANEOUS SQUAMOUS'; p.font.name='Arial';p.font.size=Pt(18);p.font.bold=True;p.font.color.rgb=WHITE;p.alignment=PP_ALIGN.CENTER p=tf.add_paragraph();p.text='CELL CARCINOMA ARISING IN A VERRUCOUS EPIDERMAL NEVUS';p.font.name='Arial';p.font.size=Pt(18);p.font.bold=True;p.font.color.rgb=WHITE;p.alignment=PP_ALIGN.CENTER elif old=='Authors and affiliation': sh.text='Department of Pathology, King George’s Medical University, Lucknow, Uttar Pradesh, India' p=sh.text_frame.paragraphs[0]; p.font.name='Arial';p.font.size=Pt(10.5);p.font.color.rgb=WHITE;p.alignment=PP_ALIGN.CENTER elif old=='Click to add content': sh.text='' elif old.startswith('UP PATHCON 2026'): # Leave footer but make bold/legible p=sh.text_frame.paragraphs[0];p.font.name='Arial';p.font.size=Pt(8);p.font.bold=True;p.font.color.rgb=NAVY # Remove blank title placeholders? retain def textbox(x,y,w,h,text,size=11,color=GREY,bold=False,align=PP_ALIGN.LEFT,margin=0.03,fill=None, line=None): if fill is not None: box=slide.shapes.add_shape(MSO_SHAPE.ROUNDED_RECTANGLE, Inches(x),Inches(y),Inches(w),Inches(h)) box.fill.solid();box.fill.fore_color.rgb=fill box.line.color.rgb=line if line else fill tf=box.text_frame else: box=slide.shapes.add_textbox(Inches(x),Inches(y),Inches(w),Inches(h)); tf=box.text_frame tf.clear(); tf.word_wrap=True; tf.margin_left=Inches(margin);tf.margin_right=Inches(margin);tf.margin_top=Inches(margin);tf.margin_bottom=Inches(margin) p=tf.paragraphs[0]; p.text=text;p.font.name='Arial';p.font.size=Pt(size);p.font.bold=bold;p.font.color.rgb=color;p.alignment=align;p.space_after=Pt(0) tf.vertical_anchor=MSO_ANCHOR.TOP return box def heading(x,y,w,text): textbox(x,y,w,0.28,text.upper(),12,WHITE,True,PP_ALIGN.LEFT,0.07,fill=NAVY,line=NAVY) def bullets(x,y,w,h,items,size=9.1): box=slide.shapes.add_textbox(Inches(x), Inches(y), Inches(w), Inches(h));tf=box.text_frame;tf.clear();tf.word_wrap=True tf.margin_left=Inches(0.06);tf.margin_right=Inches(0.03);tf.margin_top=Inches(0.03);tf.margin_bottom=Inches(0.02) for j,(lead,body) in enumerate(items): p=tf.paragraphs[0] if j==0 else tf.add_paragraph() p.text=''; p.level=0; p.font.name='Arial';p.font.size=Pt(size);p.font.color.rgb=GREY;p.space_after=Pt(3) p.text='• ' r=p.add_run();r.text=lead;r.font.bold=True;r.font.name='Arial';r.font.size=Pt(size);r.font.color.rgb=NAVY r=p.add_run();r.text=body;r.font.name='Arial';r.font.size=Pt(size);r.font.color.rgb=GREY return box # Column 1 heading(.38,1.70,3.85,'Introduction') textbox(.43,2.05,3.75,.61,'Verrucous epidermal nevus is a benign keratinocytic hamartoma. Malignant transformation is uncommon, but cutaneous squamous cell carcinoma (cSCC) has been reported.',9.2) textbox(.43,2.70,3.75,.35,'Objective: To document histomorphology of microinvasive well-differentiated cSCC developing in a verrucous epidermal nevus.',9.2,NAVY,True,fill=PALE,line=TEAL) heading(.38,3.15,3.85,'Material and Methods / Case Report') bullets(.43,3.50,3.75,2.12,[ ('Patient: ','63-year-old man.'), ('Site/specimen: ','Edge biopsy from left infra-axillary skin lesion.'), ('Clinical context: ','HCV-positive status recorded on requisition. No additional clinical history was available.'), ('Gross: ','Single grey-brown soft-tissue fragment, 2.0 × 1.2 × 0.7 cm, with attached skin; entirely embedded.'), ('Method: ','Routine formalin-fixed, paraffin-embedded sections stained with hematoxylin and eosin (H&E).') ],8.85) textbox(.43,5.72,3.75,.40,'Ethics: Identifying details have been removed. This educational case report is based on archived diagnostic material.',7.7,TEAL,False,fill=LIGHT,line=TEAL) # Column 2 heading(4.74,1.70,3.85,'Results') textbox(4.79,2.05,3.75,.35,'HISTOPATHOLOGIC FINDINGS',10,NAVY,True,PP_ALIGN.CENTER,fill=PALE,line=TEAL) bullets(4.79,2.44,3.75,2.15,[ ('Architecture: ','Marked papillomatosis and diffuse squamous epithelial proliferation with broad, downward elongated, anastomosing rete ridges.'), ('Cytology: ','Large polygonal cells with nuclear enlargement, prominent nucleoli, brisk basal mitoses and focal atypical mitoses.'), ('Differentiation: ','Orderly maturation largely retained; keratinizing squamous cells present in centers of epithelial islands.'), ('Stroma: ','Dense lymphocytic infiltrate with focal interface obscuration; neutrophilic infiltration into epithelial islands.') ],8.45) textbox(4.79,4.73,3.75,.28,'FEATURE SUPPORTING MICROINVASION',9.2,WHITE,True,PP_ALIGN.CENTER,fill=RED,line=RED) textbox(4.87,5.07,3.57,.64,'Occasional small epithelial nests in immediate subepithelial stroma showed poor basement-membrane delineation and mature squamous cells without a basal-cell layer.',8.8,GREY,False,PP_ALIGN.CENTER,fill=LIGHT,line=RED) textbox(4.79,5.81,3.75,.47,'FINAL DIAGNOSIS: Microinvasive well-differentiated squamous cell carcinoma arising in a verrucous epidermal nevus.',9.0,NAVY,True,PP_ALIGN.CENTER,fill=PALE,line=TEAL) textbox(4.79,6.38,3.75,.56,'Teaching point: Careful assessment of the epithelial-stromal interface is required in verrucous lesions, particularly when cytologic atypia or irregular small nests are present.',8.2,TEAL,False,PP_ALIGN.CENTER,fill=LIGHT,line=TEAL) # Column 3 heading(9.10,1.70,3.85,'Discussion') bullets(9.15,2.06,3.75,1.63,[ ('Rare event: ','cSCC arising in a verrucous epidermal nevus is rare, described chiefly in isolated case reports.'), ('Diagnostic issue: ','Verrucous architecture can conceal invasion. In this case, the diagnosis rests on atypia with focal subepithelial nests and loss of a definable basal layer.'), ('Practical implication: ','New nodularity, ulceration, rapid growth or bleeding in a longstanding verrucous nevus warrants prompt biopsy and thorough sampling.') ],8.55) heading(9.10,3.82,3.85,'Conclusion') textbox(9.15,4.17,3.75,.72,'Microinvasive well-differentiated cSCC may arise in a verrucous epidermal nevus. Correlation of architectural pattern, cytologic atypia and the epithelial-stromal interface is necessary to avoid underdiagnosis.',9.0,NAVY,True,PP_ALIGN.CENTER,fill=PALE,line=TEAL) heading(9.10,5.02,3.85,'References') refs=[ '1. Ichikawa T, Saiki M, Kaneko M, Saida T. Squamous cell carcinoma arising in a verrucous epidermal nevus. Dermatology. 1996;193:135-138. doi:10.1159/000246229.', '2. Hassan R, Khaled M, Al S et al. Fatal metastatic cutaneous squamous cell carcinoma evolving from a localized verrucous epidermal nevus. Case Rep Dermatol. 2013;5:278-283. doi:10.1159/000355605.', '3. Kumar V, Abbas AK, Aster JC. Robbins & Kumar Basic Pathology. 10th ed. Elsevier; 2017. Chapter: Tumors of the Skin.' ] box=slide.shapes.add_textbox(Inches(9.15), Inches(5.36), Inches(3.75), Inches(1.18));tf=box.text_frame;tf.clear();tf.word_wrap=True;tf.margin_left=Inches(.03);tf.margin_right=Inches(.02);tf.margin_top=Inches(.02) for i,rtext in enumerate(refs): p=tf.paragraphs[0] if i==0 else tf.add_paragraph();p.text=rtext;p.font.name='Arial';p.font.size=Pt(7.4);p.font.color.rgb=GREY;p.space_after=Pt(3) textbox(9.15,6.62,3.75,.32,'Corresponding author: [Insert name and email]',7.7,TEAL,False,PP_ALIGN.CENTER) # Ensure footer in correct location because template's one is outside slide at y7.57 footer=textbox(.22,7.22,12.89,.18,'UP PATHCON 2026 | E-POSTER',7.6,NAVY,True,PP_ALIGN.CENTER) # Core properties prs.core_properties.title='Microinvasive Well-Differentiated Cutaneous Squamous Cell Carcinoma Arising in a Verrucous Epidermal Nevus' prs.core_properties.subject='UPPathCon 2026 e-poster case report' prs.core_properties.author='Department of Pathology, King George’s Medical University' prs.save(str(out)) print(out) PY

Running Command

python - <<'PY' from pptx import Presentation from pathlib import Path p=Path('/tmp/workspace/uppathcon-2026-poster/output/UPPATHCON_2026_EPoster_Microinvasive_SCC.pptx') prs=Presentation(str(p)); s=prs.slides[0] print('exists',p.exists(),'bytes',p.stat().st_size,'slides',len(prs.slides)) print('size',prs.slide_width/914400,prs.slide_height/914400) for sh in s.shapes: if getattr(sh,'has_text_frame',False) and sh.text.strip(): if sh.top+sh.height > prs.slide_height: print('OUT_OF_BOUNDS',sh.name,sh.top/914400,sh.height/914400) print(round(sh.left/914400,2),round(sh.top/914400,2),repr(sh.text[:85].replace('\n',' | '))) PY

Running Command

python - <<'PY' from pptx import Presentation from pathlib import Path p=Path('/tmp/workspace/uppathcon-2026-poster/output/UPPATHCON_2026_EPoster_Microinvasive_SCC.pptx') prs=Presentation(str(p)); s=prs.slides[0] # Remove the original footer placeholder outside slide bounds for sh in list(s.shapes): if getattr(sh,'has_text_frame',False) and sh.text.strip()=='UP PATHCON 2026 | E-POSTER' and sh.top/914400 > 7.4: sp=sh._element; sp.getparent().remove(sp) prs.save(str(p)) # Reopen validation q=Presentation(str(p)); slide=q.slides[0] oob=[] for sh in slide.shapes: if sh.top+sh.height > q.slide_height: oob.append(sh.name) print('final_exists',p.exists(),'size_bytes',p.stat().st_size,'slides',len(q.slides),'shapes',len(slide.shapes),'out_of_bounds',oob) print('required headings', [h for h in ['INTRODUCTION','MATERIAL AND METHODS / CASE REPORT','RESULTS','DISCUSSION','CONCLUSION','REFERENCES'] if any(getattr(sh,'has_text_frame',False) and sh.text.strip()==h for sh in slide.shapes)]) PY

Prepared the UPPathCon 2026 e-poster using the supplied template and case details. It includes the requested headings: Introduction, Material and Methods/Case Report, Results, Discussion, Conclusion, and References.

UPPATHCON 2026 EPoster Microinvasive SCC

Presentation · PPTX

Before submission, replace the placeholder corresponding-author name and email if required.

Create a speaker script for presenting this poster

Reading File

Speaker Script for Poster Presentation

Good morning respected chairpersons, judges, and delegates.
I am presenting our case report titled “Microinvasive Well-Differentiated Cutaneous Squamous Cell Carcinoma Arising in a Verrucous Epidermal Nevus.”
Verrucous epidermal nevus is a benign keratinocytic hamartoma, typically presenting as a longstanding verrucous plaque. Although it is usually benign, malignant transformation is rare. Cutaneous squamous cell carcinoma developing in such a lesion has only been described sporadically in the literature.
The purpose of this presentation is to highlight the histomorphological clues that suggest early microinvasion within a verrucous epidermal lesion.
Our patient was a 63-year-old man with a lesion over the left infra-axillary skin. An edge biopsy was received in the Department of Pathology. The requisition form also documented HCV positivity. However, no further relevant clinical history was available for correlation.
Grossly, the specimen consisted of a single grey-brown soft-tissue piece measuring 2.0 by 1.2 by 0.7 centimetres, with attached skin. The specimen was entirely submitted for histopathological examination.
On microscopy, the lesion showed marked papillomatosis and diffuse proliferation of squamous epithelium. There were broad, downward elongated, and anastomosing rete ridges, consistent with a verrucous epidermal nevus.
However, several concerning cytological features were identified. The squamous cells were large and polygonal, with nuclear enlargement, prominent nucleoli, brisk mitotic activity in the lower epidermis, and occasional atypical mitoses. Although much of the lesion retained an orderly maturation pattern, keratinizing squamous cells were seen in the centers of epithelial islands.
The stroma showed a dense lymphocytic inflammatory infiltrate with focal obscuration of the epithelial-stromal interface. Neutrophils were also noted within epithelial islands.
The key diagnostic finding was the presence of occasional small epithelial nests in the immediate subepithelial zone. These nests showed poor delineation of the basement membrane and consisted of mature squamous cells lacking an identifiable basal-cell layer. In the background of cytological atypia, these features supported microinvasion.
Therefore, the final diagnosis was microinvasive well-differentiated squamous cell carcinoma arising in a verrucous epidermal nevus.
This case is important because the verrucous architecture of an epidermal nevus can obscure early invasive carcinoma. In a longstanding verrucous lesion, the development of nodularity, ulceration, rapid growth, bleeding, or suspicious histological atypia should prompt adequate biopsy and careful assessment of the epithelial-stromal interface.
To conclude, malignant transformation in verrucous epidermal nevus is rare but possible. Recognition of subtle invasion requires correlation of architectural abnormalities, cytological atypia, and the status of the basement membrane and stromal interface.
Thank you. I welcome any questions.

Possible closing line if asked about management

“Since this was an edge biopsy showing microinvasive squamous cell carcinoma, complete clinical evaluation and definitive complete excision with margin assessment would be required for further management.”

Create a speaker script for presenting this poster and give a catcht ttile for the poster

Reading File

Recommended Catchy Title

Beneath the Verrucous Surface: Microinvasive Squamous Cell Carcinoma Arising in an Epidermal Nevus
Scientific subtitle, if desired:
A rare histopathological pitfall in a longstanding verrucous lesion

Speaker Script, approximately 3 minutes

Good morning respected chairpersons, judges, and delegates.
I am presenting our case titled, “Beneath the Verrucous Surface: Microinvasive Squamous Cell Carcinoma Arising in an Epidermal Nevus.”
Verrucous epidermal nevus is a benign keratinocytic hamartoma, usually recognized by its longstanding verrucous or papillomatous appearance. Malignant transformation is uncommon. However, squamous cell carcinoma may rarely arise within these lesions, and its recognition can be difficult because the verrucous architecture may mask early invasion.
The aim of our case was to identify the histomorphological features of microinvasive well-differentiated cutaneous squamous cell carcinoma arising in a verrucous epidermal nevus.
Our patient was a 63-year-old male. An edge biopsy was received from a lesion involving the left infra-axillary skin. The tissue was processed routinely and examined on hematoxylin and eosin-stained sections.
Grossly, the specimen was a grey-brown soft-tissue fragment measuring 2 by 1.2 by 0.7 centimetres, with attached skin. The specimen was entirely embedded.
On microscopy, the lesion showed marked papillomatosis and diffuse squamous epithelial proliferation. There were broad, downward elongated and anastomosing rete ridges, producing a verrucous pattern.
However, careful examination revealed concerning features. The squamous epithelial cells were large and polygonal, with nuclear enlargement, prominent nucleoli, brisk mitotic activity in the basal region, and occasional atypical mitoses. Although overall maturation was relatively maintained, keratinization was present within the centers of larger epithelial islands.
The dermal stroma showed dense lymphocytic inflammation, with focal obscuration of the epithelial-stromal interface. Neutrophilic infiltration into epithelial islands was also seen.
The most important finding was the presence of occasional small epithelial nests in the immediate subepithelial stroma. These nests had poorly defined basement-membrane boundaries and were composed of mature squamous cells without a clear basal-cell layer. In conjunction with cytological atypia, these features supported the diagnosis of microinvasion.
Therefore, the final diagnosis was microinvasive well-differentiated squamous cell carcinoma arising in a verrucous epidermal nevus.
The key learning point from this case is that a verrucous lesion should not be dismissed as benign solely on the basis of its architecture. In a lesion showing atypia, brisk mitoses, irregular epithelial nests, or disturbance at the epithelial-stromal interface, careful and extensive evaluation is needed to exclude early invasive squamous cell carcinoma.
To conclude, malignant transformation in verrucous epidermal nevus is rare but diagnostically significant. Recognition of subtle stromal invasion can prevent underdiagnosis and guide appropriate further clinical management.
Thank you.

Beneath thr verrucous veil

Beneath the Verrucous Veil: Microinvasive Squamous Cell Carcinoma Arising in an Epidermal Nevus
This is a strong, memorable title. It keeps the diagnostic surprise while remaining appropriate for a pathology conference poster.

Give the poster text here, include a heading of ihc for p16 wich was negetive

Reading File

Beneath the Verrucous Veil: Microinvasive Squamous Cell Carcinoma Arising in a Verrucous Epidermal Nevus

[Author names]
Department of Pathology, King George’s Medical University, Lucknow, Uttar Pradesh, India
Corresponding author: [Name and email]

INTRODUCTION

Verrucous epidermal nevus is a benign keratinocytic hamartoma characterized by hyperkeratotic and papillomatous epidermal proliferation. Malignant transformation is rare; however, squamous cell carcinoma (SCC) may occasionally arise within a longstanding verrucous epidermal nevus.
Recognition of early invasion can be challenging because the verrucous architecture and broad rete ridges may mask subtle epithelial-stromal invasion.
Aim: To highlight the histomorphological features of microinvasive well-differentiated SCC arising in a verrucous epidermal nevus.

MATERIAL AND METHODS / CASE REPORT

A 63-year-old male underwent an edge biopsy from a lesion involving the left infra-axillary skin. The requisition form recorded HCV positivity. Further relevant clinical history was not available.

Gross Examination

A single grey-brown soft-tissue piece measuring 2.0 × 1.2 × 0.7 cm was received with attached skin measuring 2.0 × 1.2 × 0.5 cm. The specimen was entirely submitted.

Histopathology

Routine formalin-fixed, paraffin-embedded sections were examined following hematoxylin and eosin staining.

RESULTS

Histological sections showed:
  • Marked papillomatosis with diffuse proliferation of squamous epithelium.
  • Broad, downward elongated and anastomosing rete ridges, producing a verrucous architecture.
  • Large polygonal squamous cells with nuclear enlargement and prominent nucleoli.
  • Brisk mitotic activity in the lower epidermis with occasional atypical mitoses.
  • Overall maturation pattern largely retained, with keratinizing squamous cells within the centers of larger epithelial islands.
  • Dense lymphocytic inflammatory infiltrate in the intervening dermis, focally obscuring the epithelial-stromal interface.
  • Focal neutrophilic infiltration within epithelial islands.
  • Occasional small epithelial nests in the immediate subepithelial zone, showing poor basement-membrane delineation and loss of an identifiable basal-cell layer.
These features were consistent with microinvasion in a background of verrucous epidermal nevus.

IMMUNOHISTOCHEMISTRY

p16 immunohistochemistry was negative in the lesional squamous epithelium.
The absence of block-type p16 expression does not support an HPV-associated pattern in this lesion. However, p16 negativity alone does not definitively exclude HPV infection.

DIAGNOSIS

Microinvasive well-differentiated squamous cell carcinoma arising in a verrucous epidermal nevus.

DISCUSSION

Verrucous epidermal nevi are generally benign lesions, but rare malignant transformation has been documented, including the development of SCC.
In the present case, the principal diagnostic challenge was distinguishing exaggerated verrucous epidermal hyperplasia from early invasive SCC. Features favoring carcinoma included cytological atypia, prominent nucleoli, atypical mitoses, focal loss of basal-layer organization, poor basement-membrane delineation, and small subepithelial epithelial nests.
A new nodule, ulceration, bleeding, rapid enlargement, or alteration in a longstanding verrucous lesion should prompt adequate biopsy and detailed histological examination.

CONCLUSION

  • SCC arising in a verrucous epidermal nevus is rare but should be considered when atypia is present.
  • Verrucous architecture may obscure subtle early invasion.
  • Thorough evaluation of the epithelial-stromal interface is essential.
  • The presence of small subepithelial epithelial nests, poor basement-membrane definition, and loss of the basal-cell layer supports microinvasion.
  • In this case, p16 was negative, with no block-type p16 expression identified.

REFERENCES

  1. Ichikawa T, Saiki M, Kaneko M, Saida T. Squamous cell carcinoma arising in a verrucous epidermal nevus. Dermatology. 1996;193:135-138. doi:10.1159/000246229.
  2. Hassan R, Khaled M, Al S, et al. Fatal metastatic cutaneous squamous cell carcinoma evolving from a localized verrucous epidermal nevus. Case Rep Dermatol. 2013;5:278-283. doi:10.1159/000355605.
  3. Kumar V, Abbas AK, Aster JC. Robbins & Kumar Basic Pathology. 10th ed. Elsevier; 2017. Chapter: Tumors of the Skin.

Verucus epidermal nevus in simpke lznguage

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Verucus epidermal nevus in simpke lznguage

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Finding Sources
Searching PubMed

epidermal nevus

Searching the Web

epidermal nevus patient information overview

Verrucous epidermal nevus is a non-cancerous, long-standing skin growth caused by extra growth of the outer layer of skin.
In simple words:
  • It usually appears at birth or during childhood.
  • It looks like a rough, thick, dark, warty, or raised patch of skin.
  • It may occur in a line or follow a particular pattern on the body.
  • It is caused by a small change in skin cells during early development. It is usually not inherited and does not spread from person to person.
  • Most cases are harmless, but the patch often remains throughout life.
  • Very rarely, a cancer such as squamous cell carcinoma can develop in it.
Simple poster line:
“Verrucous epidermal nevus is a benign, long-standing, rough and warty overgrowth of the outer skin layer.”
For your case, you can add:
“Although usually harmless, any new ulceration, bleeding, rapid increase in size, or nodule in a longstanding verrucous epidermal nevus should be biopsied to rule out malignant change.”

Verucus epidermal nevus in simpke lznguage

Reading File
Verrucous epidermal nevus is a harmless, long-standing patch of thick and rough skin.
It often looks like a dark, raised, warty patch and usually starts in childhood. It happens because some skin cells grow more than normal. It is not contagious and usually does not cause serious problems.
Very simple poster line:
“Verrucous epidermal nevus is a benign, rough, warty overgrowth of the skin that is usually present from childhood.”

How many cases of scc in verrucus nevus worldwide

Reading File
Searching PubMed

"verrucous epidermal nevus" AND "squamous cell carcinoma"

Searching the Web

"squamous cell carcinoma" "verrucous epidermal nevus" how many cases reported

Finding Sources
Reading Article

PMID: 24403890

Reading Article

PMID: 28300931

Reading Web Page

https://pmc.ncbi.nlm.nih.gov/articles/PMC3884180

There is no official worldwide registry count for squamous cell carcinoma arising in verrucous epidermal nevus.
The best literature-based estimate is that about 12 cases had been reported in the literature in a review cited in 2016. Another report mentions 13 cases, reflecting differences in which cases and subtypes were included. Therefore, avoid claiming an exact current worldwide number.

Best line for your poster

“Squamous cell carcinoma arising in verrucous epidermal nevus is exceedingly rare, with only about 12-13 cases reported in the literature in earlier reviews.”
Or, more cautiously:
“Fewer than 15 cases of squamous cell carcinoma arising in verrucous epidermal nevus have been described in earlier published literature.”
The 2016 report states that a prior review had identified 12 reported cases of SCC arising in verrucous epidermal nevus, with a mean age of 53.4 years. See the 2016 case review.

Verrucous epidermal nevus is a benign, rough, warty overgrowth of the skin that is usually present from childhood. Histopathology wise its a benign keratinocytic hamartoma characterized by hyperkeratotic and papillomatous epidermal proliferation. Malignant transformation is rare; however, squamous cell carcinoma (SCC) may occasionally arise within a longstanding verrucous epidermal nevus. Squamous cell carcinoma arising in verrucous epidermal nevus is exceedingly rare, with only about 12-13 cases reported in the literature in earlier reviews refine this

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Verrucous epidermal nevus is a benign, rough, warty overgrowth of the skin that is usually present from childhood. Histopathology wise its a benign keratinocytic hamartoma characterized by hyperkeratotic and papillomatous epidermal proliferation. Malignant transformation is rare; however, squamous cell carcinoma (SCC) may occasionally arise within a longstanding verrucous epidermal nevus. Squamous cell carcinoma arising in verrucous epidermal nevus is exceedingly rare, with only about 12-13 cases reported in the literature in earlier reviews refine this

Reading File
Verrucous epidermal nevus is a benign, rough, warty overgrowth of the skin, usually present since childhood. Histologically, it is a benign keratinocytic hamartoma characterized by hyperkeratosis, papillomatosis, and epidermal hyperplasia. Although malignant transformation is rare, squamous cell carcinoma may occasionally develop in a longstanding lesion. SCC arising in a verrucous epidermal nevus is exceedingly uncommon, with earlier literature reviews documenting only approximately 12-13 reported cases worldwide.

Give the microscopy in a refined kanguage

Microscopy

Sections from the left infra-axillary skin lesion show marked papillomatosis and diffuse proliferation of squamous epithelium, forming broad, elongated, downward-growing, and anastomosing rete ridges. The proliferating squamous cells are large and polygonal, with enlarged nuclei, prominent nucleoli, and brisk mitotic activity in the lower epidermis, including occasional atypical mitoses.
Despite the cytological atypia, an overall orderly maturation pattern is largely maintained, with keratinizing squamous cells seen in the centers of larger epithelial islands. The intervening dermal stroma shows a dense lymphocytic inflammatory infiltrate, which focally obscures the epithelial-stromal interface. Focal neutrophilic infiltration within epithelial islands is also noted.
Importantly, occasional small epithelial nests are present in the immediate subepithelial stroma. These nests show poor delineation of the basement membrane and are composed of mature squamous cells lacking an identifiable basal-cell layer, findings suggestive of microinvasion.
p16 immunohistochemistry is negative in the lesional squamous epithelium.

Give the microscopy in a refined kanguage

Reading File

Microscopy

Sections show skin with marked papillomatosis and acanthosis. The epidermis exhibits a diffuse proliferation of squamous epithelium arranged in broad, elongated, downward-growing, and focally anastomosing rete ridges, imparting a verrucous architecture.
The squamous cells are large and polygonal, showing nuclear enlargement, vesicular chromatin, prominent nucleoli, and increased mitotic activity within the lower epidermal layers. Occasional atypical mitotic figures are identified. Despite these atypical features, maturation towards the surface is largely preserved, with focal keratinization and keratin pearl formation within larger epithelial islands.
The intervening dermal stroma shows a dense lymphocytic inflammatory infiltrate, focally obscuring the epithelial-stromal interface. Focal intraepithelial neutrophilic infiltrates are also present.
Of note, occasional small irregular nests of squamous epithelium are identified in the immediate subepithelial stroma. These nests show poor basement membrane delineation and lack a peripheral basal-cell layer, supporting early stromal invasion.
Immunohistochemistry: p16 is negative in the lesional squamous epithelium.
Overall features are consistent with microinvasive well-differentiated squamous cell carcinoma arising in a verrucous epidermal nevus.

Give in points

Microscopy

  • Sections show skin with marked papillomatosis and acanthosis.
  • The epidermis shows diffuse squamous epithelial proliferation arranged in broad, elongated, downward-growing, and focally anastomosing rete ridges, producing a verrucous architecture.
  • Squamous cells are large and polygonal with nuclear enlargement, vesicular chromatin, and prominent nucleoli.
  • Brisk mitotic activity is present in the lower epidermis, with occasional atypical mitotic figures.
  • Epidermal maturation is largely retained, with focal keratinization and keratin pearl formation within larger epithelial islands.
  • The intervening dermis shows a dense lymphocytic inflammatory infiltrate, focally obscuring the epithelial-stromal interface.
  • Focal intraepithelial neutrophilic infiltration is also seen.
  • Occasional small, irregular squamous epithelial nests are present in the immediate subepithelial stroma.
  • These nests show poor basement membrane delineation and lack a well-defined peripheral basal-cell layer, supporting early stromal invasion.
  • p16 immunohistochemistry is negative in the lesional squamous epithelium.
Diagnosis: Microinvasive well-differentiated squamous cell carcinoma arising in a verrucous epidermal nevus.

Give a catchy concluding line to place at the end of the poster

“Beneath a benign verrucous surface may lie a subtle invasion - vigilance at the epithelial-stromal interface is the key.”

More catchy lines

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Here are some catchy concluding lines for the poster:
  1. “Not every verrucous lesion is innocent: look beyond the surface for invasion.”
  2. “When a benign nevus changes its pattern, pathology must look deeper.”
  3. “A warty surface can conceal an invasive truth.”
  4. “Beneath the verrucous veil, subtle invasion may be hiding.”
  5. “In longstanding verrucous lesions, the epithelial-stromal interface tells the real story.”
  6. “Verrucous does not always mean benign: vigilance can uncover microinvasion.”
  7. “The diagnosis lies not only in the surface architecture, but in what lies beneath it.”
  8. “Small invasive nests beneath a verrucous lesion can make a major diagnostic difference.”
  9. “Look beyond papillomatosis: early invasion may be subtle, but significant.”
  10. “A careful search beneath the verrucous surface prevents overlooking early carcinoma.”
Best choice for your poster:
“Not every verrucous lesion is innocent: look beyond the surface for invasion.”

More catchy lines

Reading File
  1. “Behind the warty façade, a carcinoma may quietly emerge.”
  2. “The surface may be verrucous, but the answer lies at the base.”
  3. “From hamartoma to carcinoma: never overlook the interface.”
  4. “A benign-looking surface can hide a malignant step below.”
  5. “When rete ridges deepen, look carefully for invasion.”
  6. “In verrucous lesions, the smallest nests may carry the greatest significance.”
  7. “What appears benign above may be invasive below.”
  8. “Do not let a verrucous pattern veil microinvasion.”
  9. “The real clue lies beneath the papillomatous surface.”
  10. “Verrucous architecture may distract, but invasion defines the diagnosis.”
  11. “From a harmless-looking nevus to hidden carcinoma: histology reveals the truth.”
  12. “Beyond the ridges lies the diagnosis: search for stromal invasion.”
  13. “A closer look beneath the veil can change the diagnosis.”
  14. “Every verrucous lesion deserves a look below the surface.”
Most catchy and poster-appropriate:
“The surface may be verrucous, but the answer lies at the base.”
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