IO access provides rapid access to the medullary venous circulation when IV access cannot be obtained promptly in a critically ill patient. It should be performed by trained clinicians, using the device protocol and local resuscitation guidance.
Avoid a site with fracture, infection/burn overlying it, prior IO attempt in the same bone within 24-48 hours, prosthetic joint nearby, or impaired venous drainage of that limb.
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Indication and preparation
- Use when immediate vascular access is needed and IV access is delayed or unsuccessful.
- Use gloves, antiseptic skin preparation, correct needle length, extension tubing, saline flush, and securement.
- If the patient is conscious, give local anesthetic where feasible.
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Identify landmarks
- For the proximal tibia in adults: locate the tibial tuberosity, then select the flat medial surface about 2 cm medial and 1-2 cm below it.
- In small children: use the flat anteromedial proximal tibia, avoiding the growth plate.
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Insert needle
- Clean the skin and allow antiseptic to dry.
- Stabilize the limb.
- Insert the IO needle at 90 degrees to the bone surface.
- Advance using the manual or powered device until there is a distinct loss of resistance as the needle enters the medullary cavity.
- Stop advancing, remove the stylet, and attach extension tubing.
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Confirm placement
- The needle should stand firmly without support.
- Attempt marrow aspiration, but failure to aspirate does not by itself mean failure.
- Flush with saline while observing for swelling, leakage, or resistance.
- Check that fluid infuses freely and there is no soft-tissue infiltration. The NCBI procedural review describes confirmation by stability and unobstructed flush.
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Use and secure
- Secure the line and label it clearly as IO.
- Give resuscitation drugs, fluids, blood products, and laboratory samples as indicated. Pressure infusion is often required for adequate flow.
- In an awake patient, medullary flushing and infusion can be very painful. Give appropriate analgesia according to local protocol.
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Remove promptly
- Establish conventional IV or central access as soon as practical.
- IO access is temporary, generally removed within 24 hours.
- After removal, apply pressure and dress the site.
Recent reviews underscore that IO is a rapid rescue route, not a replacement for obtaining IV access when feasible. A 2025 systematic review in adults is available via
PMID 39742938, and pediatric fracture complications are reviewed in
PMID 39675228.