St depression and t wave inversion diagram

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ST depression T wave inversion ECG diagram labeled

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Here are the key diagrams for ST depression and T wave inversion, sourced from authoritative medical textbooks and clinical resources:

ST Depression vs ST Elevation - Basic Morphology

ST elevation vs ST depression waveform comparison
The ST segment sits between the end of the QRS complex and the beginning of the T wave. In ST depression, the segment drops below the isoelectric (baseline) line rather than staying flat or rising above it.

ECG Abnormalities in UA/NSTEMI (T-wave Inversion + ST Depression)

UA/NSTEMI ECG diagram showing T-wave inversion and ST depression
This diagram (from Frameworks for Internal Medicine, based on Lilly's Pathophysiology of Heart Disease) shows the two hallmark ECG findings of UA/NSTEMI:
  • T-wave inversion - the T wave flips below the baseline
  • ST depression - the ST segment sags below the isoelectric line
  • Both are transient and may normalize over weeks

Ischemia Patterns - Endocardial vs Epicardial

ECG signs of ischemia and injury by myocardial layer
From Morgan and Mikhail's Clinical Anesthesiology. This diagram correlates the myocardial layer affected with the ECG pattern:
PatternLayer AffectedECG Finding
Endocardial ischemiaSubendocardiumT-wave inversion (T flips down)
Epicardial ischemiaFull thicknessDeep T-wave inversion (inverted in overlying lead)
Endocardial injurySubendocardiumST depression
Epicardial injuryTransmuralST elevation

Causes by Lead Location

ST depression and T wave inversion differential by lead
This reference chart (The ECG Educator) maps the causes of ST depression and T-wave inversion by the leads in which they appear:
LeadsCause
I, aVL, V4-6LVH with strain
V1-3RVH or Posterior STEMI (mirror image)
V2-3Ischemia (T-wave inversion)
Any lead with upright QRSIschemia (ST depression)
V4-6Digitalis effect
V1-2RBBB
I, V4-5LBBB
Precordial leadsSubarachnoid hemorrhage / CVA
Any leadWPW with pre-excitation

Key Clinical Points (Harrison's & Frameworks for IM)

  • T-wave inversion - reflects nontransmural, intramyocardial ischemia. Diagnostic criterion: ≥0.1 mV inversion in 2 contiguous leads with prominent R wave or R/S ratio >1
  • ST depression - reflects patchy subendocardial ischemia. Diagnostic criterion: new horizontal or downsloping ST depression ≥0.05 mV in 2 contiguous leads
  • Downsloping and horizontal ST depressions are more specific for ischemia than upsloping depression
  • In the context of ACS without ST elevation, these findings indicate NSTEMI or unstable angina - troponin elevation distinguishes the two
For a thorough video walkthrough of these ECG changes in the clinical context of NSTEMI:
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