Question 1: Clinical Case Presentation - Cardiorenal Risk in Hypertension A 62-year-old male patient with a history of essential hypertension, type 2 diabetes mellitus, and microalbuminuria is admitted to the general medicine ward. His vital signs and laboratory parameters are: BP 152/94 mmHg and Serum Creatinine 1.1 mg/dL. He is currently managed on Amlodipine 5 mg once daily. The clinical team asks for your clinical pharmacy consultation on whether adding an ACE inhibitor provides better renal and cardiovascular outcomes than increasing the Amlodipine dose to 10 mg. 1. PICO Formulation: Formulate a structured PICO question to systematically search the evidence for this clinical query. 2. Study Design Selection: Identify the primary study design best suited to address this clinical scenario and justify your selection. 3. Information Search Strategy: List the primary biomedical databases and EBM repositories you would utilize to retrieve relevant literature. 4. Evidence Synthesis: Summarize the current clinical evidence comparing dual ACEi + CCB therapy versus high-dose CB monotherapy regarding diabetic nephropathy and blood pressure control. 5. Clinical Recommendation & Monitoring: Provide an evidence-based recommendation for this patient, including dosage, therapeutic goals, and laboratory How to get the answers