I now have comprehensive information from Bailey & Love's and Sabiston's Surgery textbooks. Let me compile the complete, detailed answer.
Surgery for Colorectal Carcinoma (CRC)
Surgery remains the primary curative treatment for colorectal carcinoma. The choice of operation depends on the tumour location (colon vs. rectum), the level within the rectum (upper/middle/lower third), tumour stage, and patient fitness.
Overview Comparison Table
| Feature | Right Hemicolectomy | Left Hemicolectomy | Sigmoid Colectomy | High Anterior Resection (HAR) | Low Anterior Resection (LAR) | Abdominoperineal Excision (APE) | Hartmann's Procedure | Pelvic Exenteration |
|---|
| Tumour location | Caecum, ascending, hepatic flexure, proximal transverse colon | Descending colon, splenic flexure | Sigmoid colon | Upper rectum (>12 cm from anal verge) | Middle/lower rectum (5-12 cm) | Low rectum/anus (distal 3rd, <5 cm from verge) | Sigmoid/upper rectum (unfit/frail patients) | Locally advanced rectum invading adjacent organs |
| Structures removed | Terminal ileum (10-15 cm), caecum, ascending colon, hepatic flexure, proximal transverse colon, associated mesocolon, ileocolic and right colic lymph nodes | Descending colon, splenic flexure, part of transverse colon, associated mesocolon, left colic LNs | Sigmoid colon, mesosigmoid, sigmoid vessels, LNs | Upper rectum (≥3 cm below tumour), mesorectum (partial TME), sigmoid colon, superior rectal vessels, LNs | Upper + middle + lower rectum (complete TME), mesorectum en bloc, sigmoid colon, pelvic LNs | Sigmoid colon, entire rectum, mesorectum, anus, anal sphincters, levator ani, ischiorectal fat, perineal skin, pelvic LNs | Sigmoid colon + rectum (stump closed), no anastomosis | All APE structures PLUS bladder ± prostate (male), or uterus ± posterior vaginal wall (female) |
| Anastomosis | Ileocolic (ileum to transverse colon) | Colorectal or colo-colic | Colorectal | Colorectal | Colorectal (stapled, low) | None - end colostomy | None - end colostomy (rectal stump closed) | Colostomy ± ileal conduit (if bladder removed) |
| Stoma | Usually none | Usually none | Usually none | Usually none | Defunctioning loop ileostomy often used | Permanent end-colostomy (left iliac fossa) | Permanent end-colostomy | Permanent colostomy ± urostomy |
| Anal sphincter preserved? | Yes | Yes | Yes | Yes | Yes | No | Yes | No (if APE component) |
| TME performed? | No | No | No | Partial (proximal TME) | Complete TME | Complete TME + extralevator excision | No | Complete |
| Key vessels ligated | Ileocolic artery, right colic artery, right branch of middle colic artery | Left colic artery, inferior mesenteric artery | Inferior mesenteric artery or sigmoid vessels | Superior rectal artery, IMA (high ligation) | IMA at origin or just distal (high ligation) | IMA, middle rectal vessels, pudendal branches | IMA | IMA + internal iliac vessels |
1. Right Hemicolectomy
Indication: Tumours of the caecum, ascending colon, hepatic flexure, and proximal transverse colon.
Steps:
- Incision - Midline laparotomy or right-sided laparoscopic ports
- Exploration - Assess liver, peritoneum for metastases
- Mobilisation - Divide peritoneal reflection lateral to ascending colon (white line of Toldt), reflect medially
- Ureter and duodenum identification - Protected during dissection (right ureter, second part of duodenum)
- Vascular ligation - High ligation of ileocolic artery, right colic artery, and right branch of middle colic artery at their origins (CME principle)
- Mesocolon division - En bloc with draining lymph nodes (complete mesocolic excision, CME)
- Bowel transection - Terminal ileum (10-15 cm proximal) and mid-transverse colon
- Anastomosis - Ileocolic anastomosis (hand-sewn or stapled)
Structures removed: Terminal ileum, caecum, ascending colon, hepatic flexure, proximal transverse colon, mesocolon, ileocolic and right colic lymph nodes.
2. Left Hemicolectomy
Indication: Tumours of the descending colon and splenic flexure.
Steps:
- Incision - Midline or laparoscopic approach
- Splenic flexure mobilisation - Divide gastrocolic and splenocolic ligaments
- Left ureter identification and protection
- Vascular ligation - Inferior mesenteric artery (IMA) or left colic artery ligation
- Mesocolon division (CME)
- Bowel transection - Proximal transverse colon to upper sigmoid/rectosigmoid junction
- Anastomosis - Colo-rectal or colo-colic
3. Sigmoid Colectomy
Indication: Sigmoid colon tumours.
Steps:
- Mobilise sigmoid colon by dividing lateral peritoneal attachments
- Identify and protect left ureter (crosses iliac vessels)
- High ligation of IMA or sigmoid branches
- Divide sigmoid mesentery with lymph node clearance
- Bowel transection: proximal sigmoid to upper rectum
- Colorectal anastomosis (stapled or hand-sewn)
4. Anterior Resection (AR) - for Rectal Cancer
This is the sphincter-saving operation for rectal cancers. The key principle is Total Mesorectal Excision (TME).
TME: Sharp dissection in the embryological plane between the investing fascia of the rectum (fascia propria) and the presacral/parietal pelvic fascia, removing the rectum en bloc with its intact mesorectum. This reduces local recurrence from ~25% to ~6% and improves 5-year survival from ~60% to ~73%.
Surgical Steps (Open / Laparoscopic / Robotic):
- Midline incision (or laparoscopic port placement)
- Full laparotomy - Assess for synchronous lesions, metastases
- Sigmoid and descending colon mobilisation - Divide left peritoneal reflection, mobilise to midline; protect left ureter and gonadal vessels
- Splenic flexure mobilisation - To achieve tension-free anastomosis
- IMA ligation - High ligation at or just below aorta (preserving superior hypogastric plexus where possible)
- Posterior rectal dissection - In the TME plane: anterior to presacral fascia, posterior to fascia propria; preserve hypogastric nerves over sacral promontory
- Lateral rectal dissection - Divide lateral ligaments; preserve pelvic plexuses (S2, S3, S4 parasympathetics)
- Anterior rectal dissection - Anterior to Denonvilliers' fascia (between rectum and prostate/seminal vesicles in male; rectum and vagina in female)
- Distal rectal transection - With linear stapler:
- High AR: at least 3 cm below the tumour (upper rectum)
- Low AR: at the anorectal junction (middle/lower rectum - complete TME)
- Proximal colonic transection - With adequate proximal margin
- Stapled colorectal anastomosis - Circular stapler per anum (end-to-end or end-to-side)
- Covering loop ileostomy - Often formed for low anastomoses to protect the join
Structures Removed:
- Sigmoid colon and upper rectum (with tumour)
- Complete mesorectum (in LAR) with all contained lymph nodes
- Superior rectal and inferior mesenteric vessels
Fascial anatomy diagram (Sabiston's Surgery):
Fascial planes of the rectum: The TME dissection plane runs between the investing fascia of the rectum and the presacral fascia posteriorly, and anterior to Denonvilliers' fascia anteriorly.
LAR dissection diagram (Sabiston's Surgery):
Low anterior resection: The dotted line shows the dissection plane removing the rectum and mesorectum en bloc while preserving the bladder anteriorly.
5. Abdominoperineal Excision of the Rectum (APER / Miles' Operation)
Indication: Tumours of the lower third of the rectum (<5 cm from anal verge), tumours invading the external sphincter, poor preoperative sphincter tone.
Surgical Steps:
Abdominal Phase (open or laparoscopic):
- Midline laparotomy or laparoscopic access
- Identical dissection to anterior resection up to the level of the seminal vesicles (male) or cervix (female) - then stop, do NOT "cone down" onto the tumour
- IMA ligation, mobilisation of sigmoid colon
- Sigmoid divided proximally; proximal end brought out as end colostomy in left iliac fossa
- Dissection purposely stops before reaching pelvic floor (to avoid thin margins)
Perineal Phase:
- Patient repositioned (prone jack-knife or Lloyd-Davies lithotomy)
- Circumanal incision - Elliptical incision around anus (anus sutured closed prior to incision)
- Deepened into ischiorectal fossae bilaterally, extending toward levator muscle attachment at pelvic side wall
- Posterior dissection - Waldeyer's (rectosacral) fascia is incised posteriorly; coccyx may be removed to improve access
- Anterior dissection - Plane between rectum and prostate/membranous urethra (male - catheter palpated to protect urethra) or between rectum and posterior vaginal wall (female)
- Levator ani division - Pubococcygeus and puborectalis divided from pelvic side wall
- Specimen retrieved through perineal wound en bloc
- Perineal wound closed with drains to pelvis
Perineal dissection in APER: circumanal approach with division of levator ani muscles.
Structures Removed (APER):
- Sigmoid colon + entire rectum + mesorectum
- Anus + anal canal
- Internal AND external anal sphincters
- Levator ani muscles (pubococcygeus, puborectalis, iliococcygeus)
- Ischiorectal fat bilaterally
- Perineal skin (elliptical)
- All pelvic lymph nodes
- Optional: coccyx (if needed for access/margins)
- In females with anterior tumour: posterior vaginal wall
Result: Permanent end-colostomy in left iliac fossa. No anal reconstruction.
6. Hartmann's Procedure
Indication: Frail or elderly patients with poor sphincter tone/anastomotic risk; emergency cases (obstruction, perforation).
Steps:
Same as anterior resection abdominal phase, but:
- Rectal stump is stapled closed (Hartmann's pouch)
- Proximal colon is brought out as a permanent end-colostomy
- No anastomosis is made
- Reversal is possible later, but often not undertaken
7. Pelvic Exenteration
Indication: Locally advanced rectal cancer with direct invasion of adjacent organs; locally recurrent rectal cancer.
| Type | Structures Removed |
|---|
| Posterior exenteration | Rectum + posterior vagina/uterus |
| Total exenteration | Rectum + bladder + prostate (male) OR rectum + uterus + bladder (female) |
| Extended | Above + sacrum, pelvic side wall muscles |
- Requires colostomy + ileal conduit (urinary diversion if bladder removed)
- Perineal defect reconstructed with rectus abdominis or gluteal flap
Key Structures Preserved (Nerves at Risk)
| Nerve | Origin | Function | At Risk During |
|---|
| Hypogastric plexus (sympathetic) | L1-L3 (preaortic) | Ejaculation, bladder neck closure | IMA high ligation, sacral promontory dissection |
| Pelvic plexus (parasympathetic) | S2, S3, S4 (nervi erigentes) | Erection, bladder voiding | Lateral rectal dissection |
| Pudendal nerve | S2-S4 | Anal sphincter tone, perineal sensation | Perineal phase of APER |
| Left ureter | Retroperitoneal | Urine drainage | Left colon / sigmoid mobilisation |
| Membranous urethra | - | Urinary continence | Anterior dissection in APER (male) |
Comparison: LAR vs. APER
| Feature | Low Anterior Resection (LAR) | Abdominoperineal Excision (APER) |
|---|
| Tumour level | Middle/upper rectum | Lower rectum / invades sphincter |
| Anal sphincters | Preserved | Excised |
| Stoma | Temporary covering ileostomy | Permanent end-colostomy |
| TME type | Complete | Complete + extralevator (cylindrical) |
| Approach | Abdominal only | Abdominal + perineal |
| Anastomosis | Yes (stapled) | No |
| Local recurrence risk | Low (with TME) | Low (with extralevator excision) |
| Positive CRM risk | Lower | Higher if standard (reduced with extralevator APER) |
Sources
- Bailey and Love's Short Practice of Surgery, 28th Edition, Chapter 79 (pp. 1434-1436)
- Sabiston Textbook of Surgery, 21st Edition, Chapter 96 (pp. 2137-2139)
- Fischer's Mastery of Surgery, 8th Edition, Chapter 145 (Mesorectal Anterior Excision)
- Yamada's Textbook of Gastroenterology, 7th Edition (Surgical treatment for rectal cancer)