Abolish FX 120 tablets
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Here is a comprehensive overview of Abolish-FX 120 Tablets:
Abolish-FX 120 Tablets
Composition
- Fexofenadine 120 mg (second-generation, non-sedating H1 antihistamine)
- Manufactured in India; brand equivalent to Allegra 120 mg
Mechanism of Action
Fexofenadine selectively blocks peripheral histamine H1 receptors, preventing histamine — the chemical mediator released during allergic reactions — from binding to target tissues. This reduces allergy symptoms (itching, sneezing, rhinorrhoea, urticaria).
Key points:
- Does not easily cross the blood-brain barrier → minimal sedation ("non-drowsy formula")
- Does not inhibit histamine release; it blocks the receptor response
- Also inhibits antigen-induced bronchospasm
- Minimal hepatic metabolism → low risk of drug-drug interactions via CYP450 enzymes
- Lippincott Illustrated Reviews: Pharmacology
Indications / Uses
- Allergic rhinitis (hay fever) — sneezing, runny nose, itchy/watery eyes
- Urticaria (hives) — chronic idiopathic or allergic
- Atopic dermatitis / eczema
- Allergic conjunctivitis
- Reactions to insect bites and stings
- Mild food allergy symptoms (itching, hives, swelling)
Dosage
| Patient | Dose |
|---|---|
| 6 months – <2 years | 15–30 mg twice daily |
| 2–11 years | 30 mg twice daily |
| ≥12 years / Adults | 60 mg twice daily OR 120–180 mg once daily |
- Abolish-FX 120 mg is typically taken once daily in adults
- Can be taken with or without food
- Do not take antacids within 2 hours of the dose (reduces absorption)
- Harriet Lane Handbook, 23rd ed.
Side Effects
Common:
- Headache
- Nausea, dyspepsia
- Dizziness
- Drowsiness / fatigue (mild, less than first-generation antihistamines)
- Dry mouth
- Dysmenorrhoea
Important: Fexofenadine has not been implicated in causing cardiac arrhythmias (unlike its predecessor terfenadine), even when used with CYP450-metabolized drugs like ketoconazole or erythromycin.
Drug Interactions
- Antacids (aluminium/magnesium-containing): reduce fexofenadine absorption — avoid within 2 hours
- Grapefruit juice: inhibits OATP1A2 transporter → decreases fexofenadine blood levels → reduced effect
- OATP transporter substrates (e.g., statins, valsartan): shared transporter competition
- Lippincott Illustrated Reviews: Pharmacology
Renal Impairment
Dose reduction is required:
- Child 6 mo–<2 yr: 15 mg once daily
- Child 6–11 yr: 30 mg once daily
- ≥12 yr/adult: 60 mg once daily
- Harriet Lane Handbook, 23rd ed.
Contraindications / Precautions
- Avoid in known hypersensitivity to fexofenadine
- Use with caution in severe renal impairment
- Fexofenadine is safe in pregnancy (Category C — consult prescriber)
- Not the drug of choice for bronchial asthma (histamine is only one of several mediators in asthma)
- Epinephrine remains the drug of choice for systemic anaphylaxis
Key Advantage Over First-Generation Antihistamines
Fexofenadine is a second-generation antihistamine with peripheral selectivity. It does not cross the blood-brain barrier significantly, so it does not cause the sedation, cognitive impairment, or anticholinergic effects (dry mouth, urinary retention, blurred vision) associated with diphenhydramine or chlorpheniramine.
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