You are answering a USMLE-style medical question. Question: A 42-year-old man comes to the physician because of progressive fatigue and shortness of breath for 1 month. He has been unable to practice with his recreational soccer team and has had to rest frequently when walking to work. His only medication is ibuprofen for joint pain. Physical examination shows tanned skin. There is tenderness to palpation and stiffness of the metacarpophalangeal joints of both hands. Pulmonary examination shows coarse crackles in both lung fields. The liver is palpated 4 cm below the right costal margin. Human leukocyte antigen (HLA) testing is most likely to be positive for which of the following? Options: A) HLA-DR3 B) HLA-DR4 C) HLA-B8 D) HLA-A3 Reply with ONLY the letter of the correct answer (A, B, C, or D). No explanation.