ls -la /home/daytona/workspace/ 2>/dev/null || mkdir -p /home/daytona/workspace/

mkdir -p /home/daytona/workspace/ricin-ppt

~/ricin-ppt/build.js

const pptxgen = require("pptxgenjs");
const pres = new pptxgen();
pres.layout = "LAYOUT_16x9";
pres.title = "Ricin Poisoning - FMT Seminar";
pres.author = "MBBS Third Year";

// ─── COLOR PALETTE ────────────────────────────────────────────────────────────
// Deep forest green dominant, cream accent, red warning, gold highlight
const C = {
  darkGreen:  "1A3C2E",   // dominant dark bg
  midGreen:   "2D6A4F",   // section header bg
  lightGreen: "40916C",   // accent bars
  cream:      "F8F4E8",   // body text / card bg
  offWhite:   "FAFAFA",
  gold:       "D4A017",   // accent / highlight
  red:        "C0392B",   // warning / fatal
  charcoal:   "2C2C2C",   // dark text on light bg
  white:      "FFFFFF",
  mutedGray:  "B0B0B0",
};

// ─── HELPERS ──────────────────────────────────────────────────────────────────
function titleSlide(slide) {
  // full bg
  slide.addShape(pres.ShapeType.rect, { x: 0, y: 0, w: 10, h: 5.625, fill: { color: C.darkGreen } });
  // decorative left bar
  slide.addShape(pres.ShapeType.rect, { x: 0, y: 0, w: 0.35, h: 5.625, fill: { color: C.lightGreen } });
  // gold accent line
  slide.addShape(pres.ShapeType.rect, { x: 0.35, y: 2.55, w: 9.3, h: 0.06, fill: { color: C.gold } });
}

function sectionHeaderSlide(slide) {
  slide.addShape(pres.ShapeType.rect, { x: 0, y: 0, w: 10, h: 5.625, fill: { color: C.darkGreen } });
  slide.addShape(pres.ShapeType.rect, { x: 0, y: 0, w: 0.35, h: 5.625, fill: { color: C.lightGreen } });
  slide.addShape(pres.ShapeType.rect, { x: 0.35, y: 4.9, w: 9.3, h: 0.1, fill: { color: C.gold } });
}

function contentSlide(slide) {
  slide.addShape(pres.ShapeType.rect, { x: 0, y: 0, w: 10, h: 5.625, fill: { color: C.cream } });
  // top header band
  slide.addShape(pres.ShapeType.rect, { x: 0, y: 0, w: 10, h: 1.05, fill: { color: C.darkGreen } });
  // left accent bar
  slide.addShape(pres.ShapeType.rect, { x: 0, y: 0, w: 0.22, h: 5.625, fill: { color: C.lightGreen } });
  // gold bottom line
  slide.addShape(pres.ShapeType.rect, { x: 0.22, y: 5.45, w: 9.6, h: 0.06, fill: { color: C.gold } });
}

function slideTitle(slide, text) {
  slide.addText(text, {
    x: 0.45, y: 0.12, w: 9.3, h: 0.78,
    fontSize: 26, bold: true, color: C.white,
    fontFace: "Calibri", valign: "middle", margin: 0,
  });
}

function bullets(slide, items, opts = {}) {
  const defaults = {
    x: 0.55, y: 1.18, w: 9.1, h: 4.1,
    fontSize: 17, color: C.charcoal, fontFace: "Calibri",
    valign: "top", paraSpaceAfter: 4,
  };
  const merged = Object.assign({}, defaults, opts);
  slide.addText(items.map((item, i) => {
    const isLast = i === items.length - 1;
    if (typeof item === "string") {
      return { text: item, options: { bullet: { type: "bullet", indent: 15 }, breakLine: !isLast } };
    }
    // { text, sub, bold, color }
    return {
      text: item.text,
      options: {
        bullet: item.sub ? { type: "bullet", indent: item.sub ? 30 : 15 } : { type: "bullet", indent: 15 },
        bold: !!item.bold,
        color: item.color || C.charcoal,
        breakLine: !isLast,
        indentLevel: item.sub ? 1 : 0,
      },
    };
  }), merged);
}

// ═══════════════════════════════════════════════════════════════════════════════
// SLIDE 1 — TITLE
// ═══════════════════════════════════════════════════════════════════════════════
{
  const sl = pres.addSlide();
  titleSlide(sl);

  // Subtitle label top
  sl.addText("FMT SEMINAR • MBBS THIRD YEAR", {
    x: 0.55, y: 0.55, w: 9, h: 0.4,
    fontSize: 11, color: C.mutedGray, charSpacing: 3,
    fontFace: "Calibri", bold: false,
  });

  // Main title
  sl.addText("RICIN POISONING", {
    x: 0.55, y: 1.25, w: 9, h: 1.2,
    fontSize: 48, bold: true, color: C.white,
    fontFace: "Calibri", charSpacing: 2,
  });

  // Botanical subtitle
  sl.addText("Ricinus communis  |  Castor Plant Toxicology", {
    x: 0.55, y: 2.6, w: 9, h: 0.5,
    fontSize: 18, color: C.gold, fontFace: "Calibri", italic: true,
  });

  // Tags row
  const tags = ["Toxalbumin", "Phytotoxin", "Bioweapon Category B", "GIT Irritant"];
  tags.forEach((tag, i) => {
    sl.addShape(pres.ShapeType.roundRect, {
      x: 0.55 + i * 2.3, y: 3.3, w: 2.1, h: 0.38,
      fill: { color: C.midGreen }, line: { color: C.lightGreen, width: 1 },
      rectRadius: 0.08,
    });
    sl.addText(tag, {
      x: 0.55 + i * 2.3, y: 3.3, w: 2.1, h: 0.38,
      fontSize: 11, color: C.cream, fontFace: "Calibri",
      align: "center", valign: "middle", margin: 0,
    });
  });

  // Footer
  sl.addText("Forensic Medicine & Toxicology", {
    x: 0.55, y: 5.1, w: 9, h: 0.35,
    fontSize: 12, color: C.mutedGray, fontFace: "Calibri",
  });
}

// ═══════════════════════════════════════════════════════════════════════════════
// SLIDE 2 — OVERVIEW (TABLE OF CONTENTS)
// ═══════════════════════════════════════════════════════════════════════════════
{
  const sl = pres.addSlide();
  contentSlide(sl);
  slideTitle(sl, "Overview");

  const topics = [
    "01  Introduction",
    "02  Features of the Plant",
    "03  Toxic Principle",
    "04  Mechanism of Action",
    "05  Clinical Features",
    "06  Management",
    "07  Autopsy Findings",
    "08  Medicolegal Importance",
  ];

  // Two columns
  const col1 = topics.slice(0, 4);
  const col2 = topics.slice(4);

  const boxOpts = (x, y) => ({
    x, y, w: 4.35, h: 0.62,
    fill: { color: C.midGreen },
    line: { color: C.lightGreen, width: 1 },
    rectRadius: 0.07,
  });
  const textOpts = (x, y) => ({
    x, y, w: 4.35, h: 0.62,
    fontSize: 15, color: C.cream,
    fontFace: "Calibri", valign: "middle", margin: 8,
  });

  col1.forEach((t, i) => {
    sl.addShape(pres.ShapeType.roundRect, boxOpts(0.4, 1.22 + i * 0.74));
    sl.addText(t, textOpts(0.4, 1.22 + i * 0.74));
  });
  col2.forEach((t, i) => {
    sl.addShape(pres.ShapeType.roundRect, boxOpts(5.2, 1.22 + i * 0.74));
    sl.addText(t, textOpts(5.2, 1.22 + i * 0.74));
  });
}

// ═══════════════════════════════════════════════════════════════════════════════
// SLIDE 3 — SECTION: INTRODUCTION
// ═══════════════════════════════════════════════════════════════════════════════
{
  const sl = pres.addSlide();
  sectionHeaderSlide(sl);
  sl.addText("01", { x: 0.55, y: 0.7, w: 9, h: 1.2, fontSize: 96, color: C.lightGreen, fontFace: "Calibri", bold: true, transparency: 60 });
  sl.addText("Introduction", { x: 0.55, y: 1.5, w: 9, h: 1.2, fontSize: 44, bold: true, color: C.white, fontFace: "Calibri" });
  sl.addText("Ricinus communis  —  The Castor Plant", { x: 0.55, y: 2.8, w: 9, h: 0.5, fontSize: 18, color: C.gold, fontFace: "Calibri", italic: true });
}

// ═══════════════════════════════════════════════════════════════════════════════
// SLIDE 4 — INTRODUCTION
// ═══════════════════════════════════════════════════════════════════════════════
{
  const sl = pres.addSlide();
  contentSlide(sl);
  slideTitle(sl, "Introduction");

  // Info cards
  const cards = [
    { label: "Type", value: "Organic poisonous plant" },
    { label: "Botanical Name", value: "Ricinus communis" },
    { label: "Common Names", value: "Castor, Arandi, Arand" },
    { label: "Poison Class", value: "Gastrointestinal Irritant" },
  ];

  cards.forEach((card, i) => {
    const x = 0.4 + (i % 2) * 4.8;
    const y = 1.25 + Math.floor(i / 2) * 1.55;
    // card bg
    sl.addShape(pres.ShapeType.roundRect, { x, y, w: 4.5, h: 1.3, fill: { color: C.white }, line: { color: C.lightGreen, width: 1.5 }, rectRadius: 0.1 });
    // label bar
    sl.addShape(pres.ShapeType.roundRect, { x, y, w: 4.5, h: 0.42, fill: { color: C.midGreen }, line: { color: C.midGreen, width: 0 }, rectRadius: 0.1 });
    sl.addText(card.label, { x, y, w: 4.5, h: 0.42, fontSize: 13, bold: true, color: C.cream, fontFace: "Calibri", align: "center", valign: "middle", margin: 0 });
    sl.addText(card.value, { x, y: y + 0.45, w: 4.5, h: 0.8, fontSize: 16, color: C.charcoal, fontFace: "Calibri", align: "center", valign: "middle", margin: 4 });
  });
}

// ═══════════════════════════════════════════════════════════════════════════════
// SLIDE 5 — SECTION: FEATURES
// ═══════════════════════════════════════════════════════════════════════════════
{
  const sl = pres.addSlide();
  sectionHeaderSlide(sl);
  sl.addText("02", { x: 0.55, y: 0.7, w: 9, h: 1.2, fontSize: 96, color: C.lightGreen, fontFace: "Calibri", bold: true, transparency: 60 });
  sl.addText("Features of the Plant", { x: 0.55, y: 1.5, w: 9, h: 1.2, fontSize: 44, bold: true, color: C.white, fontFace: "Calibri" });
  sl.addText("Morphology of Ricinus communis", { x: 0.55, y: 2.8, w: 9, h: 0.5, fontSize: 18, color: C.gold, fontFace: "Calibri", italic: true });
}

// ═══════════════════════════════════════════════════════════════════════════════
// SLIDE 6 — FEATURES: PLANT & LEAVES
// ═══════════════════════════════════════════════════════════════════════════════
{
  const sl = pres.addSlide();
  contentSlide(sl);
  slideTitle(sl, "Features — Plant & Leaves");

  bullets(sl, [
    { text: "Plant", bold: true, color: C.midGreen },
    { text: "Tall plant, grows all over India — especially in wastelands", sub: true },
    { text: "" },
    { text: "Leaves", bold: true, color: C.midGreen },
    { text: "Lobate with toothed (serrated) margins", sub: true },
    { text: "" },
    { text: "Fruit", bold: true, color: C.midGreen },
    { text: "1.2 – 2.5 cm long, globular, three-lobed, softly spiny", sub: true },
    { text: "Blue-green or rose-red when immature", sub: true },
    { text: "Brown and bristly when ripe and dry", sub: true },
  ], { fontSize: 16 });
}

// ═══════════════════════════════════════════════════════════════════════════════
// SLIDE 7 — FEATURES: SEEDS
// ═══════════════════════════════════════════════════════════════════════════════
{
  const sl = pres.addSlide();
  contentSlide(sl);
  slideTitle(sl, "Features — Seeds");

  // Two boxes: large seeds & small seeds
  const boxData = [
    {
      label: "Large Seeds",
      color: C.darkGreen,
      points: [
        "Mottled, dark-brown in color",
        "Shiny hard seed cover (pericarp)",
        "Variable, smooth, flattened-oval shape",
      ],
    },
    {
      label: "Small Seeds",
      color: C.red,
      points: [
        "1–2 cm long, 0.8 cm broad",
        "Variable, smooth, flattened-oval shape",
        "Resembles croton seeds",
      ],
    },
  ];

  boxData.forEach((box, i) => {
    const x = 0.4 + i * 4.8;
    sl.addShape(pres.ShapeType.roundRect, { x, y: 1.2, w: 4.5, h: 3.9, fill: { color: C.white }, line: { color: box.color, width: 2 }, rectRadius: 0.12 });
    sl.addShape(pres.ShapeType.roundRect, { x, y: 1.2, w: 4.5, h: 0.55, fill: { color: box.color }, line: { color: box.color, width: 0 }, rectRadius: 0.12 });
    sl.addText(box.label, { x, y: 1.2, w: 4.5, h: 0.55, fontSize: 15, bold: true, color: C.white, fontFace: "Calibri", align: "center", valign: "middle", margin: 0 });
    const items = box.points.map((p, pi) => ({
      text: p,
      options: { bullet: { type: "bullet", indent: 15 }, breakLine: pi < box.points.length - 1, color: C.charcoal },
    }));
    sl.addText(items, { x: x + 0.15, y: 1.85, w: 4.2, h: 3.1, fontSize: 15, fontFace: "Calibri", valign: "top", color: C.charcoal, paraSpaceAfter: 6 });
  });
}

// ═══════════════════════════════════════════════════════════════════════════════
// SLIDE 8 — SECTION: TOXIC PRINCIPLE
// ═══════════════════════════════════════════════════════════════════════════════
{
  const sl = pres.addSlide();
  sectionHeaderSlide(sl);
  sl.addText("03", { x: 0.55, y: 0.7, w: 9, h: 1.2, fontSize: 96, color: C.lightGreen, fontFace: "Calibri", bold: true, transparency: 60 });
  sl.addText("Toxic Principle", { x: 0.55, y: 1.5, w: 9, h: 1.2, fontSize: 44, bold: true, color: C.white, fontFace: "Calibri" });
  sl.addText("Ricin — A Deadly Toxalbumin", { x: 0.55, y: 2.8, w: 9, h: 0.5, fontSize: 18, color: C.gold, fontFace: "Calibri", italic: true });
}

// ═══════════════════════════════════════════════════════════════════════════════
// SLIDE 9 — TOXIC PRINCIPLE
// ═══════════════════════════════════════════════════════════════════════════════
{
  const sl = pres.addSlide();
  contentSlide(sl);
  slideTitle(sl, "Toxic Principle");

  bullets(sl, [
    { text: "Entire plant is toxic — seeds are MOST toxic", bold: true, color: C.red },
    { text: "Active toxin: Ricin — a water-soluble glycoprotein (toxalbumin)", sub: true },
    { text: "Seeds also contain ricinoleic acid (purgative oil)", sub: true },
    { text: "" },
    { text: "Key facts about ricin forms:", bold: true, color: C.midGreen },
    { text: "Unbroken seeds — NON-poisonous when swallowed or cooked", sub: true },
    { text: "Castor oil — NON-poisonous", sub: true },
    { text: "Crushed seeds — POISONOUS", sub: true },
    { text: "Available as powder, mist, or pellet", sub: true },
    { text: "" },
    { text: "Toxalbumin (phytotoxin) properties:", bold: true, color: C.midGreen },
    { text: "Inhibits ribosomes → disrupts protein synthesis", sub: true },
    { text: "Antigenic in nature, agglutinates RBCs, causes hemolysis & cell destruction", sub: true },
    { text: "Similar in structure to toxins of cholera, tetanus, diphtheria, botulinum, pseudomonas", sub: true },
    { text: "Physiological properties similar to viperine snake venom", sub: true },
  ], { fontSize: 14.5 });
}

// ═══════════════════════════════════════════════════════════════════════════════
// SLIDE 10 — SECTION: MECHANISM OF ACTION
// ═══════════════════════════════════════════════════════════════════════════════
{
  const sl = pres.addSlide();
  sectionHeaderSlide(sl);
  sl.addText("04", { x: 0.55, y: 0.7, w: 9, h: 1.2, fontSize: 96, color: C.lightGreen, fontFace: "Calibri", bold: true, transparency: 60 });
  sl.addText("Mechanism of Action", { x: 0.55, y: 1.5, w: 9, h: 1.2, fontSize: 44, bold: true, color: C.white, fontFace: "Calibri" });
  sl.addText("How Ricin Kills Cells", { x: 0.55, y: 2.8, w: 9, h: 0.5, fontSize: 18, color: C.gold, fontFace: "Calibri", italic: true });
}

// ═══════════════════════════════════════════════════════════════════════════════
// SLIDE 11 — MECHANISM: STRUCTURE
// ═══════════════════════════════════════════════════════════════════════════════
{
  const sl = pres.addSlide();
  contentSlide(sl);
  slideTitle(sl, "Mechanism of Action — Structure of Ricin");

  // Structure box
  sl.addShape(pres.ShapeType.roundRect, { x: 0.4, y: 1.2, w: 9.2, h: 1.3, fill: { color: C.midGreen }, line: { color: C.lightGreen, width: 1.5 }, rectRadius: 0.12 });
  sl.addText([
    { text: "Ricin = Two Polypeptide Chains linked by a Disulfide Bond\n", options: { bold: true, color: C.gold, breakLine: true } },
    { text: "  Chain A  ", options: { bold: true, color: C.cream } },
    { text: "(Active / Toxic component)       ", options: { color: C.cream } },
    { text: "  Chain B  ", options: { bold: true, color: C.cream } },
    { text: "(Binding component)", options: { color: C.cream } },
  ], { x: 0.4, y: 1.2, w: 9.2, h: 1.3, fontSize: 15, fontFace: "Calibri", align: "center", valign: "middle", margin: 6 });

  // Steps
  const steps = [
    { num: "1", title: "Binding", desc: "Chain B binds galactose receptors on cell membrane (glycoproteins/glycolipids)" },
    { num: "2", title: "Cell Entry", desc: "Ricin enters via endocytosis → Endosomes → Golgi → Endoplasmic Reticulum" },
    { num: "3", title: "Translocation", desc: "Chain A separates in ER and moves into cytosol" },
    { num: "4", title: "Ribosome Damage", desc: "Chain A inactivates 28S rRNA of 60S ribosomal subunit" },
    { num: "5", title: "Cell Death", desc: "Irreversible inhibition of protein synthesis → cytotoxic cell death" },
  ];

  steps.forEach((step, i) => {
    const x = 0.4 + (i % 3) * 3.08;
    const y = i < 3 ? 2.68 : 4.0;
    const w = i >= 3 ? 4.5 : 2.85;
    const xx = i >= 3 ? 0.4 + (i - 3) * 4.8 : x;

    sl.addShape(pres.ShapeType.roundRect, { x: xx, y, w, h: 1.05, fill: { color: C.white }, line: { color: C.lightGreen, width: 1.2 }, rectRadius: 0.1 });
    sl.addShape(pres.ShapeType.ellipse, { x: xx + 0.07, y: y + 0.28, w: 0.48, h: 0.48, fill: { color: C.darkGreen }, line: { color: C.darkGreen, width: 0 } });
    sl.addText(step.num, { x: xx + 0.07, y: y + 0.28, w: 0.48, h: 0.48, fontSize: 13, bold: true, color: C.gold, fontFace: "Calibri", align: "center", valign: "middle", margin: 0 });
    sl.addText(step.title, { x: xx + 0.62, y: y + 0.06, w: w - 0.72, h: 0.38, fontSize: 13, bold: true, color: C.darkGreen, fontFace: "Calibri", valign: "middle", margin: 0 });
    sl.addText(step.desc, { x: xx + 0.62, y: y + 0.44, w: w - 0.72, h: 0.55, fontSize: 11, color: C.charcoal, fontFace: "Calibri", valign: "top", margin: 0 });
  });
}

// ═══════════════════════════════════════════════════════════════════════════════
// SLIDE 12 — SECTION: CLINICAL FEATURES
// ═══════════════════════════════════════════════════════════════════════════════
{
  const sl = pres.addSlide();
  sectionHeaderSlide(sl);
  sl.addText("05", { x: 0.55, y: 0.7, w: 9, h: 1.2, fontSize: 96, color: C.lightGreen, fontFace: "Calibri", bold: true, transparency: 60 });
  sl.addText("Clinical Features", { x: 0.55, y: 1.5, w: 9, h: 1.2, fontSize: 44, bold: true, color: C.white, fontFace: "Calibri" });
  sl.addText("Routes: Inhalation • Ingestion • Injection • Skin Contact", { x: 0.55, y: 2.8, w: 9, h: 0.5, fontSize: 17, color: C.gold, fontFace: "Calibri", italic: true });
}

// ═══════════════════════════════════════════════════════════════════════════════
// SLIDE 13 — CLINICAL: INHALATION / DUST
// ═══════════════════════════════════════════════════════════════════════════════
{
  const sl = pres.addSlide();
  contentSlide(sl);
  slideTitle(sl, "Clinical Features — Dust & Inhalation Exposure");

  // Two panels
  const panels = [
    {
      label: "Dust of Seeds",
      color: C.midGreen,
      items: ["Watering of the eyes (lacrimation)", "Conjunctivitis", "Sneezing", "Acute nasal inflammation", "Headache", "Pharyngitis", "Asthmatic bronchitis", "Dermatitis", "Gastric upset"],
    },
    {
      label: "Inhalation Exposure",
      color: C.red,
      items: ["Redness and pain in eyes and throat", "Dyspnea (difficulty breathing)", "Wheezing", "Respiratory distress", "Fever and cough", "Tightness in chest", "Sweating", "Pulmonary edema"],
    },
  ];

  panels.forEach((panel, i) => {
    const x = 0.4 + i * 4.8;
    sl.addShape(pres.ShapeType.roundRect, { x, y: 1.2, w: 4.45, h: 4.0, fill: { color: C.white }, line: { color: panel.color, width: 2 }, rectRadius: 0.12 });
    sl.addShape(pres.ShapeType.roundRect, { x, y: 1.2, w: 4.45, h: 0.5, fill: { color: panel.color }, line: { color: panel.color, width: 0 }, rectRadius: 0.12 });
    sl.addText(panel.label, { x, y: 1.2, w: 4.45, h: 0.5, fontSize: 14, bold: true, color: C.white, fontFace: "Calibri", align: "center", valign: "middle", margin: 0 });
    const items = panel.items.map((p, pi) => ({
      text: p,
      options: { bullet: { type: "bullet", indent: 12 }, breakLine: pi < panel.items.length - 1, color: C.charcoal },
    }));
    sl.addText(items, { x: x + 0.12, y: 1.8, w: 4.2, h: 3.3, fontSize: 13.5, fontFace: "Calibri", valign: "top", color: C.charcoal, paraSpaceAfter: 4 });
  });
}

// ═══════════════════════════════════════════════════════════════════════════════
// SLIDE 14 — CLINICAL: ORAL INGESTION
// ═══════════════════════════════════════════════════════════════════════════════
{
  const sl = pres.addSlide();
  contentSlide(sl);
  slideTitle(sl, "Clinical Features — Oral Ingestion (Crushed Seeds)");

  const left = [
    "Abdominal pain",
    "Vomiting & diarrhea (with/without blood)",
    "Hematemesis and melena",
    "Dehydration",
    "Circulatory collapse",
    "Muscular pain and cramps in limbs",
    "Convulsions",
  ];
  const right = [
    "Drowsiness and delirium",
    "Jaundice",
    "Hepatic failure",
    "Oliguria",
    "Uremia",
    "Multiorgan failure",
    "Cardiovascular collapse",
  ];

  const renderList = (items, x) => items.map((p, pi) => ({
    text: p,
    options: { bullet: { type: "bullet", indent: 12 }, breakLine: pi < items.length - 1, color: C.charcoal },
  }));

  sl.addShape(pres.ShapeType.roundRect, { x: 0.35, y: 1.15, w: 4.5, h: 4.0, fill: { color: C.white }, line: { color: C.midGreen, width: 1.5 }, rectRadius: 0.1 });
  sl.addShape(pres.ShapeType.roundRect, { x: 5.15, y: 1.15, w: 4.5, h: 4.0, fill: { color: C.white }, line: { color: C.midGreen, width: 1.5 }, rectRadius: 0.1 });
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// ═══════════════════════════════════════════════════════════════════════════════
// SLIDE 15 — CLINICAL: INJECTION
// ═══════════════════════════════════════════════════════════════════════════════
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    { text: "Pain, erythema (redness), induration", sub: true },
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    { text: "" },
    { text: "Systemic Effects:", bold: true, color: C.midGreen },
    { text: "Muscular pain", sub: true },
    { text: "Capillary leak syndrome", sub: true },
    { text: "Circulatory collapse", sub: true },
    { text: "Convulsions", sub: true },
    { text: "Multiorgan failure", sub: true },
    { text: "Respiratory failure", sub: true },
  ], { fontSize: 16 });
}

// ═══════════════════════════════════════════════════════════════════════════════
// SLIDE 16 — SECTION: MANAGEMENT
// ═══════════════════════════════════════════════════════════════════════════════
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// ═══════════════════════════════════════════════════════════════════════════════
// SLIDE 17 — MANAGEMENT
// ═══════════════════════════════════════════════════════════════════════════════
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  contentSlide(sl);
  slideTitle(sl, "Management");

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    { label: "IV Fluids & Correction", color: C.darkGreen, items: ["Glucose and saline administration", "Sodium bicarbonate 2–5 g every 8 hours by mouth", "Correction of electrolyte abnormalities"] },
    { label: "Supportive Care", color: C.lightGreen, items: ["Management of shock", "Treatment of convulsions", "Blood transfusion if needed"] },
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}

// ═══════════════════════════════════════════════════════════════════════════════
// SLIDE 18 — SECTION: AUTOPSY FINDINGS
// ═══════════════════════════════════════════════════════════════════════════════
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// ═══════════════════════════════════════════════════════════════════════════════
// SLIDE 19 — AUTOPSY FINDINGS
// ═══════════════════════════════════════════════════════════════════════════════
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  const sl = pres.addSlide();
  contentSlide(sl);
  slideTitle(sl, "Autopsy Findings");

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    { organ: "Gastrointestinal Tract", desc: "Mucosa is congested, softened and inflamed with occasional erosions and submucous hemorrhages. Fragments of seeds may be found in stomach and intestines." },
    { organ: "Heart", desc: "Dilation of the heart chambers with hemorrhages in the pleura." },
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  });
}

// ═══════════════════════════════════════════════════════════════════════════════
// SLIDE 20 — SECTION: MEDICOLEGAL IMPORTANCE
// ═══════════════════════════════════════════════════════════════════════════════
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  const sl = pres.addSlide();
  sectionHeaderSlide(sl);
  sl.addText("08", { x: 0.55, y: 0.7, w: 9, h: 1.2, fontSize: 96, color: C.lightGreen, fontFace: "Calibri", bold: true, transparency: 60 });
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// ═══════════════════════════════════════════════════════════════════════════════
// SLIDE 21 — MEDICOLEGAL IMPORTANCE
// ═══════════════════════════════════════════════════════════════════════════════
{
  const sl = pres.addSlide();
  contentSlide(sl);
  slideTitle(sl, "Medicolegal Importance");

  bullets(sl, [
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    { text: "Common in children while playing with seeds or exploring the plant", sub: true },
    { text: "" },
    { text: "Homicidal use", bold: true, color: C.red },
    { text: "Ricin has been used for deliberate homicide", sub: true },
    { text: "" },
    { text: "Criminal abortion", bold: true, color: C.red },
    { text: "Pulp of seeds used to procure illegal abortion", sub: true },
    { text: "" },
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    { text: "Causes anaphylactic-type reactions, dermatitis, rhinitis, asthma, conjunctivitis", sub: true },
    { text: "" },
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// ═══════════════════════════════════════════════════════════════════════════════
// SLIDE 22 — GEORGI MARKOV CASE (Historical)
// ═══════════════════════════════════════════════════════════════════════════════
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// ═══════════════════════════════════════════════════════════════════════════════
// SLIDE 23 — LABORATORY DIAGNOSIS
// ═══════════════════════════════════════════════════════════════════════════════
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  const sl = pres.addSlide();
  contentSlide(sl);
  slideTitle(sl, "Laboratory Diagnosis");

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    { text: "Liquid Chromatography-Mass Spectrometry (LC-MS)", bold: true, color: C.midGreen },
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    { text: "" },
    { text: "Immunoassays", bold: true, color: C.midGreen },
    { text: "Enzyme-linked immunosorbent assay (ELISA) and similar tests", sub: true },
    { text: "" },
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    { text: "Comprehensive untargeted urine drug screening is highly valuable", sub: true },
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// ═══════════════════════════════════════════════════════════════════════════════
// SLIDE 24 — SUMMARY SLIDE
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    ["Most Toxic Part", "Crushed seeds — unbroken seeds and castor oil are non-toxic"],
    ["Mechanism", "Ricin A chain inactivates 28S rRNA → inhibits protein synthesis → cell death"],
    ["Fatal Dose", "5–10 seeds or 1 mg/kg body weight; fatal period: 2 days"],
    ["Treatment", "No antidote — gastric lavage, activated charcoal, supportive care"],
    ["Bioweapon", "CDC Category B biological weapon; Markov assassination (1978)"],
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// ═══════════════════════════════════════════════════════════════════════════════
// SLIDE 25 — THANK YOU
// ═══════════════════════════════════════════════════════════════════════════════
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}

// ─── WRITE FILE ────────────────────────────────────────────────────────────────
pres.writeFile({ fileName: "/home/daytona/workspace/ricin-ppt/Ricin_Poisoning_FMT.pptx" })
  .then(() => console.log("SUCCESS: Presentation created."))
  .catch(err => { console.error("ERROR:", err); process.exit(1); });

cd /home/daytona/workspace/ricin-ppt && node build.js

ls -lh /home/daytona/workspace/ricin-ppt/Ricin_Poisoning_FMT.pptx

~/ricin-ppt/build2.js

const pptxgen = require("pptxgenjs");
const pres = new pptxgen();
pres.layout = "LAYOUT_16x9";
pres.title = "Ricin Poisoning - FMT Seminar";

// ─── LIGHT COLOR PALETTE ──────────────────────────────────────────────────────
const C = {
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  bgLight:    "F4F8FF",   // very light blue-white for slide bg
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  lightTeal:  "E0F7FA",   // very light teal
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  midGray:    "757575",
  white:      "FFFFFF",
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// ─── HELPER: draw plain rect (no roundRect) ───────────────────────────────────
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// ─── HELPER: slide background ─────────────────────────────────────────────────
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// ─── HELPER: header bar on content slides ────────────────────────────────────
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// ─── HELPER: bullet list ──────────────────────────────────────────────────────
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}

// ═══════════════════════════════════════════════════════════════════════════════
// SLIDE 1 — TITLE
// ═══════════════════════════════════════════════════════════════════════════════
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}

// ═══════════════════════════════════════════════════════════════════════════════
// SLIDE 2 — OVERVIEW
// ═══════════════════════════════════════════════════════════════════════════════
{
  const sl = pres.addSlide();
  lightBg(sl);
  addHeader(sl, "Overview");

  const topics = [
    "01  Introduction",
    "02  Features of the Plant",
    "03  Toxic Principle",
    "04  Mechanism of Action",
    "05  Clinical Features",
    "06  Management",
    "07  Autopsy Findings",
    "08  Medicolegal Importance",
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// ═══════════════════════════════════════════════════════════════════════════════
// SLIDE 3 — SECTION DIVIDER: INTRODUCTION
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  });
  sl.addText("Introduction", {
    x: 0.5, y: 1.6, w: 9, h: 1.3,
    fontSize: 46, bold: true, color: C.white, fontFace: "Calibri",
  });
  sl.addText("Ricinus communis — The Castor Plant", {
    x: 0.5, y: 3.1, w: 9, h: 0.6,
    fontSize: 20, color: C.lightBlue, fontFace: "Calibri", italic: true,
  });
}

// ═══════════════════════════════════════════════════════════════════════════════
// SLIDE 4 — INTRODUCTION
// ═══════════════════════════════════════════════════════════════════════════════
{
  const sl = pres.addSlide();
  lightBg(sl);
  addHeader(sl, "Introduction");

  const cards = [
    { label: "Type", value: "Organic Poisonous Plant", bg: C.lightBlue },
    { label: "Class", value: "Gastrointestinal Irritant", bg: C.lightTeal },
    { label: "Botanical Name", value: "Ricinus communis", bg: C.lightGreen },
    { label: "Common Names", value: "Castor / Arandi / Arand", bg: C.lightOrange },
  ];

  cards.forEach((card, i) => {
    const x = 0.35 + (i % 2) * 4.85;
    const y = 1.25 + Math.floor(i / 2) * 1.95;
    rect(sl, x, y, 4.55, 1.65, card.bg, C.accentBlue);
    sl.addText(card.label, {
      x: x + 0.15, y: y + 0.12, w: 4.25, h: 0.45,
      fontSize: 13, bold: true, color: C.headerBlue, fontFace: "Calibri",
    });
    sl.addText(card.value, {
      x: x + 0.15, y: y + 0.55, w: 4.25, h: 0.85,
      fontSize: 17, color: C.charcoal, fontFace: "Calibri", valign: "middle",
    });
  });
}

// ═══════════════════════════════════════════════════════════════════════════════
// SLIDE 5 — SECTION DIVIDER: FEATURES
// ═══════════════════════════════════════════════════════════════════════════════
{
  const sl = pres.addSlide();
  rect(sl, 0, 0, 10, 5.625, C.teal);
  rect(sl, 0, 4.8, 10, 0.12, "00ACC1");

  sl.addText("02", {
    x: 0.5, y: 0.3, w: 3, h: 2.2,
    fontSize: 130, bold: true, color: "00ACC1",
    fontFace: "Calibri", transparency: 50,
  });
  sl.addText("Features of the Plant", {
    x: 0.5, y: 1.6, w: 9, h: 1.3,
    fontSize: 40, bold: true, color: C.white, fontFace: "Calibri",
  });
  sl.addText("Morphology of Ricinus communis", {
    x: 0.5, y: 3.1, w: 9, h: 0.6,
    fontSize: 20, color: C.lightTeal, fontFace: "Calibri", italic: true,
  });
}

// ═══════════════════════════════════════════════════════════════════════════════
// SLIDE 6 — FEATURES: PLANT, LEAVES, FRUIT
// ═══════════════════════════════════════════════════════════════════════════════
{
  const sl = pres.addSlide();
  lightBg(sl);
  addHeader(sl, "Features — Plant, Leaves & Fruit");

  addBullets(sl, [
    { text: "Plant", bold: true, color: C.headerBlue },
    { text: "Tall plant — grows all over India, especially in wastelands", sub: true },
    "",
    { text: "Leaves", bold: true, color: C.headerBlue },
    { text: "Lobate with toothed (serrated) margins", sub: true },
    "",
    { text: "Fruit", bold: true, color: C.headerBlue },
    { text: "1.2 to 2.5 cm long, globular, three-lobed, softly spiny", sub: true },
    { text: "Blue-green or rose-red when immature", sub: true },
    { text: "Brown and bristly when ripe and dry", sub: true },
  ], 0.4, 1.15, 9.2, 4.3, 16);
}

// ═══════════════════════════════════════════════════════════════════════════════
// SLIDE 7 — FEATURES: SEEDS
// ═══════════════════════════════════════════════════════════════════════════════
{
  const sl = pres.addSlide();
  lightBg(sl);
  addHeader(sl, "Features — Seeds");

  // Large seeds box
  rect(sl, 0.35, 1.15, 4.55, 4.0, C.lightBlue, C.accentBlue);
  labelBox(sl, 0.35, 1.15, 4.55, 0.5, C.accentBlue, C.white, "Large Seeds", 14);
  addBullets(sl, [
    "Mottled, dark-brown in color",
    "Shiny hard seed cover (pericarp)",
    "Variable, smooth, flattened-oval shape",
  ], 0.55, 1.75, 4.15, 3.3, 15);

  // Small seeds box
  rect(sl, 5.1, 1.15, 4.55, 4.0, C.lightGreen, C.green);
  labelBox(sl, 5.1, 1.15, 4.55, 0.5, C.green, C.white, "Small Seeds", 14);
  addBullets(sl, [
    "1–2 cm long, 0.8 cm broad",
    "Variable, smooth, flattened-oval shape",
    "Resembles croton seeds",
  ], 5.3, 1.75, 4.15, 3.3, 15);
}

// ═══════════════════════════════════════════════════════════════════════════════
// SLIDE 8 — SECTION DIVIDER: TOXIC PRINCIPLE
// ═══════════════════════════════════════════════════════════════════════════════
{
  const sl = pres.addSlide();
  rect(sl, 0, 0, 10, 5.625, C.green);
  rect(sl, 0, 4.8, 10, 0.12, "43A047");

  sl.addText("03", {
    x: 0.5, y: 0.3, w: 3, h: 2.2,
    fontSize: 130, bold: true, color: "43A047",
    fontFace: "Calibri", transparency: 50,
  });
  sl.addText("Toxic Principle", {
    x: 0.5, y: 1.6, w: 9, h: 1.3,
    fontSize: 44, bold: true, color: C.white, fontFace: "Calibri",
  });
  sl.addText("Ricin — A Deadly Toxalbumin", {
    x: 0.5, y: 3.1, w: 9, h: 0.6,
    fontSize: 20, color: C.lightGreen, fontFace: "Calibri", italic: true,
  });
}

// ═══════════════════════════════════════════════════════════════════════════════
// SLIDE 9 — TOXIC PRINCIPLE
// ═══════════════════════════════════════════════════════════════════════════════
{
  const sl = pres.addSlide();
  lightBg(sl);
  addHeader(sl, "Toxic Principle");

  // Key warning box
  rect(sl, 0.35, 1.12, 9.3, 0.55, C.lightRed, C.red);
  sl.addText("Entire plant is toxic — SEEDS are most toxic (contain ricin, a water-soluble glycoprotein)", {
    x: 0.5, y: 1.12, w: 9.0, h: 0.55,
    fontSize: 14, bold: true, color: C.red, fontFace: "Calibri", valign: "middle",
  });

  addBullets(sl, [
    { text: "Ricin forms — which are poisonous?", bold: true, color: C.headerBlue },
    { text: "Unbroken seeds — NON-poisonous when swallowed or cooked", sub: true },
    { text: "Castor oil — NON-poisonous", sub: true },
    { text: "Crushed seeds — POISONOUS", sub: true },
    { text: "Can be in form of powder, mist or pellet", sub: true },
    "",
    { text: "Toxalbumin (Ricin) properties:", bold: true, color: C.headerBlue },
    { text: "Inhibits ribosomes → disrupts protein synthesis", sub: true },
    { text: "Antigenic — agglutinates RBCs, causes hemolysis & cell destruction", sub: true },
    { text: "Similar structure to toxins of cholera, tetanus, diphtheria, botulinum", sub: true },
    { text: "Similar properties to viperine snake venom", sub: true },
  ], 0.4, 1.78, 9.2, 3.7, 14.5);
}

// ═══════════════════════════════════════════════════════════════════════════════
// SLIDE 10 — SECTION DIVIDER: MECHANISM OF ACTION
// ═══════════════════════════════════════════════════════════════════════════════
{
  const sl = pres.addSlide();
  rect(sl, 0, 0, 10, 5.625, "4527A0");
  rect(sl, 0, 4.8, 10, 0.12, "7E57C2");

  sl.addText("04", {
    x: 0.5, y: 0.3, w: 3, h: 2.2,
    fontSize: 130, bold: true, color: "7E57C2",
    fontFace: "Calibri", transparency: 50,
  });
  sl.addText("Mechanism of Action", {
    x: 0.5, y: 1.6, w: 9, h: 1.3,
    fontSize: 40, bold: true, color: C.white, fontFace: "Calibri",
  });
  sl.addText("How Ricin Kills Cells", {
    x: 0.5, y: 3.1, w: 9, h: 0.6,
    fontSize: 20, color: "EDE7F6", fontFace: "Calibri", italic: true,
  });
}

// ═══════════════════════════════════════════════════════════════════════════════
// SLIDE 11 — MECHANISM: STRUCTURE
// ═══════════════════════════════════════════════════════════════════════════════
{
  const sl = pres.addSlide();
  lightBg(sl);
  addHeader(sl, "Mechanism of Action — Structure of Ricin");

  // Structure banner
  rect(sl, 0.35, 1.12, 9.3, 0.62, "EDE7F6", "7E57C2");
  sl.addText("Ricin = Chain A (Toxic) + Chain B (Binding)  linked by a Disulfide Bond", {
    x: 0.5, y: 1.12, w: 9.0, h: 0.62,
    fontSize: 15, bold: true, color: "4527A0", fontFace: "Calibri",
    align: "center", valign: "middle",
  });

  // 5 steps as numbered rows
  const steps = [
    { num: "1", title: "Binding", desc: "Chain B binds galactose receptors on cell membrane" },
    { num: "2", title: "Cell Entry", desc: "Endocytosis → Endosomes → Golgi → Endoplasmic Reticulum" },
    { num: "3", title: "Translocation", desc: "Chain A separates in ER and moves into cytosol" },
    { num: "4", title: "Ribosome Damage", desc: "Chain A inactivates 28S rRNA of 60S ribosomal subunit" },
    { num: "5", title: "Cell Death", desc: "Irreversible inhibition of protein synthesis → cytotoxic death" },
  ];

  const rowBg = ["EDE7F6", "E8EAF6", "E3F2FD", "E0F2F1", "FFEBEE"];
  const numColors = ["4527A0", "283593", "0277BD", "00695C", C.red];

  steps.forEach((step, i) => {
    const y = 1.85 + i * 0.72;
    rect(sl, 0.35, y, 9.3, 0.65, rowBg[i], rowBg[i]);
    // number circle (use rect as fallback)
    rect(sl, 0.38, y + 0.1, 0.44, 0.44, numColors[i], numColors[i]);
    sl.addText(step.num, {
      x: 0.38, y: y + 0.1, w: 0.44, h: 0.44,
      fontSize: 14, bold: true, color: C.white, fontFace: "Calibri",
      align: "center", valign: "middle",
    });
    sl.addText(step.title + ":", {
      x: 0.9, y: y + 0.08, w: 2.1, h: 0.5,
      fontSize: 14, bold: true, color: numColors[i], fontFace: "Calibri", valign: "middle",
    });
    sl.addText(step.desc, {
      x: 3.1, y: y + 0.08, w: 6.3, h: 0.5,
      fontSize: 13.5, color: C.charcoal, fontFace: "Calibri", valign: "middle",
    });
  });
}

// ═══════════════════════════════════════════════════════════════════════════════
// SLIDE 12 — SECTION DIVIDER: CLINICAL FEATURES
// ═══════════════════════════════════════════════════════════════════════════════
{
  const sl = pres.addSlide();
  rect(sl, 0, 0, 10, 5.625, C.orange);
  rect(sl, 0, 4.8, 10, 0.12, "FF8F00");

  sl.addText("05", {
    x: 0.5, y: 0.3, w: 3, h: 2.2,
    fontSize: 130, bold: true, color: "FF8F00",
    fontFace: "Calibri", transparency: 50,
  });
  sl.addText("Clinical Features", {
    x: 0.5, y: 1.6, w: 9, h: 1.3,
    fontSize: 44, bold: true, color: C.white, fontFace: "Calibri",
  });
  sl.addText("Routes: Inhalation  •  Ingestion  •  Injection  •  Skin Contact", {
    x: 0.5, y: 3.1, w: 9, h: 0.6,
    fontSize: 18, color: C.lightOrange, fontFace: "Calibri", italic: true,
  });
}

// ═══════════════════════════════════════════════════════════════════════════════
// SLIDE 13 — CLINICAL: DUST & INHALATION
// ═══════════════════════════════════════════════════════════════════════════════
{
  const sl = pres.addSlide();
  lightBg(sl);
  addHeader(sl, "Clinical Features — Dust & Inhalation");

  // Dust panel
  rect(sl, 0.35, 1.15, 4.55, 4.15, C.lightTeal, C.teal);
  labelBox(sl, 0.35, 1.15, 4.55, 0.5, C.teal, C.white, "Dust of Seeds", 14);
  addBullets(sl, [
    "Watering of the eyes (lacrimation)",
    "Conjunctivitis",
    "Sneezing",
    "Acute nasal inflammation",
    "Headache",
    "Pharyngitis",
    "Asthmatic bronchitis",
    "Dermatitis & gastric upset",
  ], 0.5, 1.72, 4.25, 3.5, 14);

  // Inhalation panel
  rect(sl, 5.1, 1.15, 4.55, 4.15, C.lightOrange, C.orange);
  labelBox(sl, 5.1, 1.15, 4.55, 0.5, C.orange, C.white, "Inhalation Exposure", 14);
  addBullets(sl, [
    "Redness and pain in eyes & throat",
    "Dyspnea (difficulty breathing)",
    "Wheezing",
    "Respiratory distress",
    "Fever and cough",
    "Tightness in chest",
    "Sweating",
    "Pulmonary edema",
  ], 5.25, 1.72, 4.25, 3.5, 14);
}

// ═══════════════════════════════════════════════════════════════════════════════
// SLIDE 14 — CLINICAL: ORAL INGESTION
// ═══════════════════════════════════════════════════════════════════════════════
{
  const sl = pres.addSlide();
  lightBg(sl);
  addHeader(sl, "Clinical Features — Oral Ingestion (Crushed Seeds)");

  rect(sl, 0.35, 1.15, 4.55, 3.7, C.lightBlue, C.accentBlue);
  addBullets(sl, [
    "Abdominal pain",
    "Vomiting & diarrhea (with/without blood)",
    "Hematemesis and melena",
    "Dehydration",
    "Circulatory collapse",
    "Muscular pain & cramps in limbs",
    "Convulsions",
  ], 0.5, 1.2, 4.25, 3.55, 14.5);

  rect(sl, 5.1, 1.15, 4.55, 3.7, C.lightRed, C.red);
  addBullets(sl, [
    "Drowsiness and delirium",
    "Jaundice",
    "Hepatic failure",
    "Oliguria",
    "Uremia",
    "Multiorgan failure",
    "Cardiovascular collapse",
  ], 5.25, 1.2, 4.25, 3.55, 14.5);

  // Fatal dose
  rect(sl, 0.35, 5.0, 9.3, 0.48, C.red, C.red);
  sl.addText("FATAL DOSE: 5–10 seeds  |  1 mg/kg body weight  |  Fatal Period: 2 days to a few days", {
    x: 0.4, y: 5.0, w: 9.2, h: 0.48,
    fontSize: 13, bold: true, color: C.white, fontFace: "Calibri",
    align: "center", valign: "middle",
  });
}

// ═══════════════════════════════════════════════════════════════════════════════
// SLIDE 15 — CLINICAL: INJECTION
// ═══════════════════════════════════════════════════════════════════════════════
{
  const sl = pres.addSlide();
  lightBg(sl);
  addHeader(sl, "Clinical Features — Injection Exposure");

  addBullets(sl, [
    { text: "Local Effects at Injection Site:", bold: true, color: C.headerBlue },
    { text: "Pain, erythema (redness), induration", sub: true },
    { text: "Localized necrosis at injection site", sub: true },
    "",
    { text: "Systemic Effects:", bold: true, color: C.red },
    { text: "Muscular pain", sub: true },
    { text: "Capillary leak syndrome", sub: true },
    { text: "Circulatory collapse", sub: true },
    { text: "Convulsions", sub: true },
    { text: "Multiorgan failure", sub: true },
    { text: "Respiratory failure", sub: true },
  ], 0.4, 1.15, 9.2, 4.3, 16);
}

// ═══════════════════════════════════════════════════════════════════════════════
// SLIDE 16 — SECTION DIVIDER: MANAGEMENT
// ═══════════════════════════════════════════════════════════════════════════════
{
  const sl = pres.addSlide();
  rect(sl, 0, 0, 10, 5.625, C.red);
  rect(sl, 0, 4.8, 10, 0.12, "EF5350");

  sl.addText("06", {
    x: 0.5, y: 0.3, w: 3, h: 2.2,
    fontSize: 130, bold: true, color: "EF5350",
    fontFace: "Calibri", transparency: 50,
  });
  sl.addText("Management", {
    x: 0.5, y: 1.6, w: 9, h: 1.3,
    fontSize: 46, bold: true, color: C.white, fontFace: "Calibri",
  });
  sl.addText("No Antidote — Treatment is Purely Supportive", {
    x: 0.5, y: 3.1, w: 9, h: 0.6,
    fontSize: 19, color: C.lightRed, fontFace: "Calibri", bold: true,
  });
}

// ═══════════════════════════════════════════════════════════════════════════════
// SLIDE 17 — MANAGEMENT
// ═══════════════════════════════════════════════════════════════════════════════
{
  const sl = pres.addSlide();
  lightBg(sl);
  addHeader(sl, "Management");

  // No antidote warning
  rect(sl, 0.35, 1.12, 9.3, 0.52, C.lightRed, C.red);
  sl.addText("NO SPECIFIC ANTIDOTE — Treatment is purely supportive", {
    x: 0.5, y: 1.12, w: 9.0, h: 0.52,
    fontSize: 14, bold: true, color: C.red, fontFace: "Calibri",
    align: "center", valign: "middle",
  });

  // 3 columns
  const cols = [
    { label: "Decontamination", bg: C.lightBlue, hdr: C.accentBlue, items: ["Gastric lavage", "Emetics and demulcents", "Activated charcoal"] },
    { label: "IV Fluids & Correction", bg: C.lightTeal, hdr: C.teal, items: ["Glucose and saline", "Sodium bicarbonate 2–5 g every 8 hours by mouth", "Correct electrolyte abnormalities"] },
    { label: "Supportive Care", bg: C.lightGreen, hdr: C.green, items: ["Management of shock", "Treatment of convulsions", "Blood transfusion if needed"] },
  ];

  cols.forEach((col, i) => {
    const x = 0.35 + i * 3.12;
    rect(sl, x, 1.75, 2.95, 3.65, col.bg, col.hdr);
    labelBox(sl, x, 1.75, 2.95, 0.5, col.hdr, C.white, col.label, 13);
    addBullets(sl, col.items, x + 0.12, 2.32, 2.7, 3.0, 13.5);
  });
}

// ═══════════════════════════════════════════════════════════════════════════════
// SLIDE 18 — SECTION DIVIDER: AUTOPSY FINDINGS
// ═══════════════════════════════════════════════════════════════════════════════
{
  const sl = pres.addSlide();
  rect(sl, 0, 0, 10, 5.625, "37474F");
  rect(sl, 0, 4.8, 10, 0.12, "78909C");

  sl.addText("07", {
    x: 0.5, y: 0.3, w: 3, h: 2.2,
    fontSize: 130, bold: true, color: "78909C",
    fontFace: "Calibri", transparency: 50,
  });
  sl.addText("Autopsy Findings", {
    x: 0.5, y: 1.6, w: 9, h: 1.3,
    fontSize: 44, bold: true, color: C.white, fontFace: "Calibri",
  });
  sl.addText("Post-mortem Changes in Ricin Poisoning", {
    x: 0.5, y: 3.1, w: 9, h: 0.6,
    fontSize: 19, color: "B0BEC5", fontFace: "Calibri", italic: true,
  });
}

// ═══════════════════════════════════════════════════════════════════════════════
// SLIDE 19 — AUTOPSY FINDINGS
// ═══════════════════════════════════════════════════════════════════════════════
{
  const sl = pres.addSlide();
  lightBg(sl);
  addHeader(sl, "Autopsy Findings");

  const findings = [
    {
      organ: "GIT",
      bg: C.lightRed, hdr: C.red,
      desc: "Congested, softened & inflamed mucosa with erosions and submucous hemorrhages. Fragments of seeds may be found in stomach and intestines.",
    },
    {
      organ: "Heart",
      bg: C.lightOrange, hdr: C.orange,
      desc: "Dilation of heart chambers with hemorrhages in the pleura.",
    },
    {
      organ: "Liver / Kidneys / Spleen / Lungs",
      bg: C.lightBlue, hdr: C.accentBlue,
      desc: "Edema and congestion — hallmark of multiorgan involvement.",
    },
  ];

  findings.forEach((f, i) => {
    const y = 1.15 + i * 1.42;
    rect(sl, 0.35, y, 9.3, 1.25, f.bg, f.hdr);
    labelBox(sl, 0.35, y, 2.2, 1.25, f.hdr, C.white, f.organ, 13);
    sl.addText(f.desc, {
      x: 2.65, y: y + 0.12, w: 6.85, h: 1.0,
      fontSize: 14, color: C.charcoal, fontFace: "Calibri", valign: "middle", wrap: true,
    });
  });
}

// ═══════════════════════════════════════════════════════════════════════════════
// SLIDE 20 — SECTION DIVIDER: MEDICOLEGAL
// ═══════════════════════════════════════════════════════════════════════════════
{
  const sl = pres.addSlide();
  rect(sl, 0, 0, 10, 5.625, "880E4F");
  rect(sl, 0, 4.8, 10, 0.12, "E91E63");

  sl.addText("08", {
    x: 0.5, y: 0.3, w: 3, h: 2.2,
    fontSize: 130, bold: true, color: "E91E63",
    fontFace: "Calibri", transparency: 50,
  });
  sl.addText("Medicolegal Importance", {
    x: 0.5, y: 1.6, w: 9, h: 1.3,
    fontSize: 38, bold: true, color: C.white, fontFace: "Calibri",
  });
  sl.addText("Forensic & Legal Significance of Ricin", {
    x: 0.5, y: 3.1, w: 9, h: 0.6,
    fontSize: 19, color: "FCE4EC", fontFace: "Calibri", italic: true,
  });
}

// ═══════════════════════════════════════════════════════════════════════════════
// SLIDE 21 — MEDICOLEGAL IMPORTANCE
// ═══════════════════════════════════════════════════════════════════════════════
{
  const sl = pres.addSlide();
  lightBg(sl);
  addHeader(sl, "Medicolegal Importance");

  addBullets(sl, [
    { text: "Accidental Poisoning", bold: true, color: C.headerBlue },
    { text: "Common in children while playing with seeds or exploring the plant", sub: true },
    "",
    { text: "Homicidal Use", bold: true, color: C.red },
    { text: "Ricin has been used for deliberate homicide (e.g. Georgi Markov, 1978)", sub: true },
    "",
    { text: "Criminal Abortion", bold: true, color: C.red },
    { text: "Seed pulp used to procure illegal abortion", sub: true },
    "",
    { text: "Hypersensitivity Reactions", bold: true, color: C.teal },
    { text: "Allergenic glycoprotein causes dermatitis, rhinitis, asthma, conjunctivitis", sub: true },
    "",
    { text: "Bioweapon — CDC Category B", bold: true, color: C.red },
    { text: "Easy availability + high toxicity = classified as Category B biological weapon", sub: true },
  ], 0.4, 1.15, 9.2, 4.3, 14.5);
}

// ═══════════════════════════════════════════════════════════════════════════════
// SLIDE 22 — GEORGI MARKOV CASE
// ═══════════════════════════════════════════════════════════════════════════════
{
  const sl = pres.addSlide();
  lightBg(sl);
  addHeader(sl, "Notable Case — Georgi Markov (1978)");

  rect(sl, 0.35, 1.15, 9.3, 3.7, "FCE4EC", "E91E63");

  sl.addText([
    { text: "Georgi Markov", options: { bold: true, color: C.red } },
    { text: " was a Bulgarian dissident and journalist.\n\n", options: { color: C.charcoal, breakLine: true } },
    { text: "In 1978 in London, he was attacked by a man with a specially rigged ", options: { color: C.charcoal } },
    { text: "umbrella", options: { bold: true, color: C.red } },
    { text: " that injected a tiny ", options: { color: C.charcoal } },
    { text: "ricin-laced pellet", options: { bold: true, color: C.red } },
    { text: " under the skin of his thigh.\n\n", options: { color: C.charcoal, breakLine: true } },
    { text: "He died 3 days later.", options: { bold: true, color: C.red } },
    { text: "\n\nThis remains one of the most famous cases of ricin used as an assassination weapon.", options: { color: C.charcoal, breakLine: true } },
    { text: "\n\nForensic significance: Demonstrates ricin's potential as a covert assassination tool — relevant for medicolegal practice.", options: { color: C.darkGray, italic: true } },
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// ═══════════════════════════════════════════════════════════════════════════════
// SLIDE 23 — LABORATORY DIAGNOSIS
// ═══════════════════════════════════════════════════════════════════════════════
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    { label: "Ricin-Antibody Conjugates", full: "In surviving patients", desc: "Detectable approximately 2 weeks after exposure", bg: C.lightOrange, hdr: C.orange },
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// ═══════════════════════════════════════════════════════════════════════════════
// SLIDE 24 — KEY TAKEAWAYS
// ═══════════════════════════════════════════════════════════════════════════════
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  addHeader(sl, "Key Takeaways");

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    ["Fatal Dose", "5–10 seeds or 1 mg/kg; fatal period: 2 days"],
    ["Treatment", "No antidote — gastric lavage, activated charcoal, supportive care"],
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// ═══════════════════════════════════════════════════════════════════════════════
// SLIDE 25 — THANK YOU
// ═══════════════════════════════════════════════════════════════════════════════
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  sl.addText("References: Reddy's Essentials of Forensic Medicine & Toxicology  |  Narayan Reddy  |  Modi's Medical Jurisprudence", {
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    fontSize: 10, color: C.midGray, fontFace: "Calibri", align: "center",
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// ─── WRITE ────────────────────────────────────────────────────────────────────
pres.writeFile({ fileName: "/home/daytona/workspace/ricin-ppt/Ricin_Poisoning_FMT_v2.pptx" })
  .then(() => console.log("SUCCESS"))
  .catch(err => { console.error(err); process.exit(1); });

cd /home/daytona/workspace/ricin-ppt && node build2.js

ls -lh /home/daytona/workspace/ricin-ppt/Ricin_Poisoning_FMT_v2.pptx

~/ricin-ppt/build3.js

const pptxgen = require("pptxgenjs");
const pres = new pptxgen();
pres.layout = "LAYOUT_16x9";
pres.title = "Ricin Poisoning - FMT Seminar";

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// ═══════════════════════════════════════════════════════════════════════════
// SLIDE 1 — TITLE
// ═══════════════════════════════════════════════════════════════════════════
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    fontSize:14, color:"37474F", fontFace:"Calibri", align:"center", valign:"middle"
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}

// ═══════════════════════════════════════════════════════════════════════════
// SLIDE 2 — INTRODUCTION
// ═══════════════════════════════════════════════════════════════════════════
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  hbar(sl, "1.  Introduction", BLUE);

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    { text:"Ricin is derived from an organic poisonous plant known as Ricinus communis.", bold:false },
    { text:"It belongs to the category of Gastrointestinal Irritants.", bold:false },
    "",
    { text:"Botanical Name:", bold:true, color:BLUE },
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    "",
    { text:"Common Names:", bold:true, color:BLUE },
    { text:"Castor, Arandi, Arand", sub:true },
    "",
    { text:"The plant is widely distributed across India and found in tropical regions worldwide.",bold:false },
    { text:"It is commonly found growing in wastelands, roadsides, and uncultivated lands.", bold:false },
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}

// ═══════════════════════════════════════════════════════════════════════════
// SLIDE 3 — FEATURES: PLANT & LEAVES & FRUIT
// ═══════════════════════════════════════════════════════════════════════════
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    { text:"Turns brown and bristly when ripe and dry.", sub:true },
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}

// ═══════════════════════════════════════════════════════════════════════════
// SLIDE 4 — FEATURES: SEEDS
// ═══════════════════════════════════════════════════════════════════════════
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    { text:"Seeds — General Properties:", bold:true, color:TEAL },
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    "",
    { text:"Large Seeds:", bold:true, color:BLUE },
    { text:"Mottled, dark-brown in colour.", sub:true },
    { text:"Covered with a shiny hard seed coat called Pericarp.", sub:true },
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    { text:"Small Seeds:", bold:true, color:GREEN },
    { text:"1 to 2 cm long and 0.8 cm broad in size.", sub:true },
    { text:"Variable, smooth, flattened-oval in shape.", sub:true },
    { text:"Closely resemble Croton seeds in appearance.", sub:true },
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// ═══════════════════════════════════════════════════════════════════════════
// SLIDE 5 — TOXIC PRINCIPLE (Part 1)
// ═══════════════════════════════════════════════════════════════════════════
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  hbar(sl, "3.  Toxic Principle", GREEN);

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    { text:"The entire plant is toxic, but the seeds are the most toxic part.", bold:true, color:RED },
    { text:"Seeds contain Ricin — a water-soluble glycoprotein (toxalbumin) present at the highest levels.", sub:true },
    { text:"Seeds also contain a powerful allergen.", sub:true },
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    "",
    { text:"Important Points Regarding Forms:", bold:true, color:GREEN },
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    { text:"Castor oil — Non-poisonous.", sub:true },
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// ═══════════════════════════════════════════════════════════════════════════
// SLIDE 6 — TOXIC PRINCIPLE (Part 2 — Toxalbumin)
// ═══════════════════════════════════════════════════════════════════════════
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    { text:"Toxalbumin (Phytotoxin) is a toxic protein found in plants such as Castor, Croton, and Rati (Abrus precatorius).", bold:false },
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    { text:"Antigenic in nature — capable of stimulating immune response.", sub:true },
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    { text:"Causes haemolysis (destruction of RBCs) and cell destruction.", sub:true },
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// ═══════════════════════════════════════════════════════════════════════════
// SLIDE 7 — MECHANISM OF ACTION (Structure)
// ═══════════════════════════════════════════════════════════════════════════
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// ═══════════════════════════════════════════════════════════════════════════
// SLIDE 8 — MECHANISM OF ACTION (Step-by-step)
// ═══════════════════════════════════════════════════════════════════════════
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    "",
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    "",
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// ═══════════════════════════════════════════════════════════════════════════
// SLIDE 9 — CLINICAL FEATURES: Routes & Dust
// ═══════════════════════════════════════════════════════════════════════════
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    { text:"Conjunctivitis (inflammation of the conjunctiva)", sub:true },
    { text:"Sneezing", sub:true },
    { text:"Acute nasal inflammation (Rhinitis)", sub:true },
    { text:"Headache", sub:true },
    { text:"Pharyngitis (throat inflammation)", sub:true },
    { text:"Asthmatic bronchitis", sub:true },
    { text:"Dermatitis (skin inflammation)", sub:true },
    { text:"Gastric upset", sub:true },
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// ═══════════════════════════════════════════════════════════════════════════
// SLIDE 10 — CLINICAL FEATURES: Inhalation
// ═══════════════════════════════════════════════════════════════════════════
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    { text:"Wheezing", bold:false },
    { text:"Respiratory distress", bold:false },
    { text:"Fever", bold:false },
    { text:"Cough", bold:false },
    { text:"Tightness in the chest", bold:false },
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// ═══════════════════════════════════════════════════════════════════════════
// SLIDE 11 — CLINICAL FEATURES: Oral Ingestion
// ═══════════════════════════════════════════════════════════════════════════
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    { text:"Dehydration", bold:false },
    { text:"Circulatory collapse", bold:false },
    { text:"Muscular pain and cramps in the limbs", bold:false },
    { text:"Convulsions", bold:false },
    { text:"Drowsiness", bold:false },
    { text:"Delirium", bold:false },
    { text:"Jaundice", bold:false },
    { text:"Haemolysis (destruction of red blood cells)", bold:false },
    { text:"Hepatic failure (liver failure)", bold:false },
    { text:"Oliguria (reduced urine output)", bold:false },
    { text:"Uraemia (accumulation of waste products in blood)", bold:false },
    { text:"Death may occur due to Multiorgan Failure or Cardiovascular Collapse.", bold:true, color:RED },
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// ═══════════════════════════════════════════════════════════════════════════
// SLIDE 12 — CLINICAL FEATURES: Injection + Fatal Dose
// ═══════════════════════════════════════════════════════════════════════════
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    { text:"Muscular pain.", sub:true },
    { text:"Capillary leak syndrome.", sub:true },
    { text:"Circulatory collapse.", sub:true },
    { text:"Convulsions.", sub:true },
    { text:"Multiorgan failure.", sub:true },
    { text:"Respiratory failure.", sub:true },
    "",
    { text:"Fatal Dose:", bold:true, color:RED },
    { text:"5 to 10 seeds.", sub:true },
    { text:"1 mg/kg body weight for Ricin.", sub:true },
    { text:"Fatal Period: 2 days to a few days.", sub:true },
  ], 0.4, 1.25, 9.2, 4.22, 17, BLACK);
}

// ═══════════════════════════════════════════════════════════════════════════
// SLIDE 13 — MANAGEMENT
// ═══════════════════════════════════════════════════════════════════════════
{
  const sl = pres.addSlide();
  bg(sl, GRAY);
  hbar(sl, "6.  Management", BLUE);

  // No antidote box
  sl.addShape(pres.ShapeType.rect, { x:0.4, y:1.2, w:9.2, h:0.58, fill:{color:LRED}, line:{color:RED,width:1.5} });
  sl.addText("IMPORTANT: There is no specific antidote available for Ricin poisoning.", {
    x:0.5, y:1.2, w:9.0, h:0.58,
    fontSize:15, bold:true, color:RED, fontFace:"Calibri", valign:"middle"
  });

  addBulletBox(sl, [
    { text:"In Case of Ingestion:", bold:true, color:BLUE },
    { text:"Gastric lavage (stomach wash).", sub:true },
    { text:"Administration of Emetics and Demulcents.", sub:true },
    { text:"Administration of Glucose and Saline intravenously.", sub:true },
    { text:"2 to 5 g of Sodium Bicarbonate given 8 hourly by mouth.", sub:true },
    { text:"Blood transfusion may be needed in some patients.", sub:true },
    { text:"Gastric lavage followed by administration of Activated Charcoal.", sub:true },
    "",
    { text:"Supportive Treatment:", bold:true, color:BLUE },
    { text:"Management of shock.", sub:true },
    { text:"Correction of electrolyte abnormalities.", sub:true },
    { text:"Treatment of convulsions.", sub:true },
  ], 0.4, 1.88, 9.2, 3.62, 16, BLACK);
}

// ═══════════════════════════════════════════════════════════════════════════
// SLIDE 14 — AUTOPSY FINDINGS
// ═══════════════════════════════════════════════════════════════════════════
{
  const sl = pres.addSlide();
  bg(sl, GRAY);
  hbar(sl, "7.  Autopsy Findings", "37474F");

  addBulletBox(sl, [
    { text:"Gastrointestinal Tract (GIT):", bold:true, color:"37474F" },
    { text:"The mucosa is congested, softened, and inflamed.", sub:true },
    { text:"Occasional erosions are present.", sub:true },
    { text:"Submucous haemorrhages are seen.", sub:true },
    { text:"Fragments of seeds may be found in the stomach and intestines.", sub:true },
    "",
    { text:"Heart:", bold:true, color:"37474F" },
    { text:"Dilation of the heart chambers is observed.", sub:true },
    { text:"Haemorrhages are present in the pleura.", sub:true },
    "",
    { text:"Other Organs — Liver, Kidneys, Spleen, and Lungs:", bold:true, color:"37474F" },
    { text:"Oedema (swelling) and congestion of all these organs are noted.", sub:true },
    { text:"This reflects multiorgan involvement as a result of systemic ricin toxicity.", sub:true },
  ], 0.4, 1.25, 9.2, 4.22, 17, BLACK);
}

// ═══════════════════════════════════════════════════════════════════════════
// SLIDE 15 — MEDICOLEGAL IMPORTANCE
// ═══════════════════════════════════════════════════════════════════════════
{
  const sl = pres.addSlide();
  bg(sl, GRAY);
  hbar(sl, "8.  Medicolegal Importance", "880E4F");

  addBulletBox(sl, [
    { text:"Accidental Poisoning:", bold:true, color:"880E4F" },
    { text:"Accidental poisoning may occur especially in children while playing or exploring the plant and its seeds.", sub:true },
    "",
    { text:"Homicidal Use:", bold:true, color:RED },
    { text:"Ricin has been used for homicidal purposes due to its extreme potency.", sub:true },
    "",
    { text:"Criminal Abortion:", bold:true, color:RED },
    { text:"Ricin has been used to procure criminal abortion.", sub:true },
    "",
    { text:"Anaphylactic Hypersensitivity:", bold:true, color:"880E4F" },
    { text:"Ricin can cause an anaphylactic type of hypersensitivity reaction in humans.", sub:true },
    { text:"The pulp of the seed contains an allergenic glycoprotein which may cause Dermatitis, Rhinitis, Asthma, and Conjunctivitis in allergic individuals.", sub:true },
  ], 0.4, 1.25, 9.2, 4.22, 16, BLACK);
}

// ═══════════════════════════════════════════════════════════════════════════
// SLIDE 16 — MEDICOLEGAL: Bioweapon + Markov Case
// ═══════════════════════════════════════════════════════════════════════════
{
  const sl = pres.addSlide();
  bg(sl, GRAY);
  hbar(sl, "8.  Medicolegal Importance — Bioweapon & Case", "880E4F");

  addBulletBox(sl, [
    { text:"Potential Bioweapon:", bold:true, color:RED },
    { text:"Because of its easy availability and extreme toxicity, Ricin has been classified by the Centre for Disease Control and Prevention (CDC) as a Category B Biological Weapon.", sub:true },
    { text:"Category B agents are the second highest priority agents and include those that are moderately easy to disseminate.", sub:true },
    "",
    { text:"Notable Historical Case — Georgi Markov (1978):", bold:true, color:"880E4F" },
    { text:"In 1978, Georgi Markov, a Bulgarian dissident and journalist, died after being attacked by a man wielding an umbrella.", sub:true },
    { text:"The umbrella was specially rigged to inject a ricin-laced pellet under the skin of Markov's thigh.", sub:true },
    { text:"He died three days after the attack.", sub:true },
    { text:"This case remains one of the most documented examples of ricin being used as a covert assassination weapon.", sub:true },
  ], 0.4, 1.25, 9.2, 4.22, 16, BLACK);
}

// ═══════════════════════════════════════════════════════════════════════════
// SLIDE 17 — LABORATORY DIAGNOSIS
// ═══════════════════════════════════════════════════════════════════════════
{
  const sl = pres.addSlide();
  bg(sl, GRAY);
  hbar(sl, "Laboratory Diagnosis", TEAL);

  addBulletBox(sl, [
    { text:"Liquid Chromatography-Mass Spectrometry (LC-MS):", bold:true, color:TEAL },
    { text:"The gold-standard confirmatory test for detection of Ricin.", sub:true },
    "",
    { text:"Immunoassays:", bold:true, color:TEAL },
    { text:"Enzyme-linked immunosorbent assay (ELISA) and similar immunological tests are used.", sub:true },
    "",
    { text:"Ricinine Detection:", bold:true, color:TEAL },
    { text:"Ricinine is an alkaloid present in the castor plant.", sub:true },
    { text:"It can be detected in both serum and urine samples.", sub:true },
    { text:"Comprehensive untargeted urine drug screening is highly valuable for diagnosis.", sub:true },
    "",
    { text:"Ricin-Antibody Conjugates:", bold:true, color:TEAL },
    { text:"Ricin-specific antibody conjugates can be detected in surviving patients approximately 2 weeks after exposure.", sub:true },
  ], 0.4, 1.25, 9.2, 4.22, 17, BLACK);
}

// ═══════════════════════════════════════════════════════════════════════════
// SLIDE 18 — SUMMARY / KEY POINTS
// ═══════════════════════════════════════════════════════════════════════════
{
  const sl = pres.addSlide();
  bg(sl, LBLUE);
  hbar(sl, "Key Points — Summary", BLUE);

  const rows = [
    ["Plant",          "Ricinus communis — GIT irritant; toxalbumin ricin is the main poison",     LBLUE,  BLUE],
    ["Toxic Part",     "Crushed seeds are toxic; unbroken seeds and castor oil are non-toxic",       LGREEN, GREEN],
    ["Mechanism",      "Chain A → damages 28S rRNA of 60S ribosome → inhibits protein synthesis → cell death", LPURP, PURPLE],
    ["Fatal Dose",     "5–10 seeds  |  1 mg/kg body weight  |  Fatal Period: 2 days",               LRED,   RED],
    ["Treatment",      "No antidote — gastric lavage, activated charcoal, supportive care",          LORNG,  ORANGE],
    ["Bioweapon",      "CDC Category B biological weapon; Georgi Markov assassination (1978)",       LRED,   RED],
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    sl.addShape(pres.ShapeType.rect, { x:0.35, y, w:1.95, h:0.62, fill:{color:r[3]}, line:{color:r[3],width:0} });
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    sl.addText(r[1], { x:2.4, y, w:7.1, h:0.62, fontSize:13.5, color:BLACK, fontFace:"Calibri", valign:"middle" });
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}

// ═══════════════════════════════════════════════════════════════════════════
// SLIDE 19 — THANK YOU
// ═══════════════════════════════════════════════════════════════════════════
{
  const sl = pres.addSlide();
  sl.addShape(pres.ShapeType.rect, { x:0, y:0, w:10, h:5.625, fill:{color:BLUE}, line:{color:BLUE,width:0} });
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  sl.addShape(pres.ShapeType.rect, { x:0, y:3.2, w:10, h:2.425, fill:{color:LBLUE}, line:{color:LBLUE,width:0} });

  sl.addText("THANK YOU", {
    x:0.5, y:0.55, w:9, h:1.5,
    fontSize:56, bold:true, color:WHITE, fontFace:"Calibri", align:"center"
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  sl.addText("Ricin Poisoning  |  Forensic Medicine & Toxicology", {
    x:0.5, y:2.05, w:9, h:0.6,
    fontSize:19, color:"BBDEFB", fontFace:"Calibri", italic:true, align:"center"
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  sl.addText("MBBS Third Year  •  FMT Seminar", {
    x:0.5, y:3.35, w:9, h:0.5,
    fontSize:16, color:"37474F", fontFace:"Calibri", align:"center"
  });
  sl.addText("References: Reddy's Essentials of Forensic Medicine & Toxicology  |  Narayan Reddy  |  Modi's Medical Jurisprudence & Toxicology", {
    x:0.5, y:5.1, w:9, h:0.35,
    fontSize:10, color:"757575", fontFace:"Calibri", align:"center"
  });
}

// ── WRITE FILE ────────────────────────────────────────────────────────────────
pres.writeFile({ fileName: "/home/daytona/workspace/ricin-ppt/Ricin_Poisoning_v3.pptx" })
  .then(() => console.log("SUCCESS"))
  .catch(err => { console.error(err); process.exit(1); });

cd /home/daytona/workspace/ricin-ppt && node build3.js

libreoffice --headless --convert-to pdf /home/daytona/workspace/ricin-ppt/Ricin_…

mkdir -p /home/daytona/workspace/ricin-ppt/out && libreoffice --headless --conve…

chmod 777 /home/daytona/workspace/ricin-ppt/out && libreoffice --headless --conv…

ls -la /home/daytona/workspace/ricin-ppt/ && cp /home/daytona/workspace/ricin-pp…

cp /tmp/ricin.pdf /home/daytona/workspace/ricin-ppt/Ricin_Poisoning_v3.pdf && ls…

~/ricin-ppt/build3.js

Successfully replaced 1 instance(s) of the string in '/home/daytona/workspace/ricin-ppt/build3.js'

~/ricin-ppt/build3.js

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~/ricin-ppt/build3.js

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~/ricin-ppt/build3.js

Successfully replaced 1 instance(s) of the string in '/home/daytona/workspace/ricin-ppt/build3.js'

cd /home/daytona/workspace/ricin-ppt && node build3.js

cp /home/daytona/workspace/ricin-ppt/Castor_Poisoning_v4.pptx /tmp/castor_v4.ppt…

Ricinus communis castor plant leaves fruit seeds high quality image site:wikimedia.org OR site:commons.wikimedia.org

node /home/daytona/skills/shared/scripts/fetch_images.js \ "https://c8.alamy.c…

# Convert all images to base64 strings for use in pptxgenjs node -e " const fs =…

~/ricin-ppt/build3.js

Successfully replaced 1 instance(s) of the string in '/home/daytona/workspace/ricin-ppt/build3.js'

~/ricin-ppt/build3.js

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~/ricin-ppt/build3.js

Successfully replaced 1 instance(s) of the string in '/home/daytona/workspace/ricin-ppt/build3.js'

cd /home/daytona/workspace/ricin-ppt && node build3.js 2>&1

cp /home/daytona/workspace/ricin-ppt/Castor_Poisoning_v5.pptx /tmp/castor_v5.ppt…

~/ricin-ppt/build_final.js

const pptxgen = require("pptxgenjs");
const IMGS = JSON.parse(require("fs").readFileSync("/tmp/castor_images.json","utf8"));
const pres = new pptxgen();
pres.layout = "LAYOUT_16x9";
pres.title = "Castor Poisoning";

// ── PALETTE ──────────────────────────────────────────────────────────────────
const BLUE   = "1565C0";
const LBLUE  = "E3F2FD";
const WHITE  = "FFFFFF";
const BLACK  = "1A1A1A";
const GRAY   = "F5F5F5";
const RED    = "B71C1C";
const LRED   = "FFEBEE";
const GREEN  = "1B5E20";
const TEAL   = "004D40";
const ORANGE = "E65100";
const PURPLE = "4A148C";

// ── HELPERS ──────────────────────────────────────────────────────────────────
function bg(sl, color) {
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function hbar(sl, title, barColor) {
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function makeBullets(items, fontSize, defaultColor) {
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function bullets(sl, items, x, y, w, h, fontSize, defaultColor) {
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}

function imgSlide(sl, imgKey, caption, captionColor) {
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}

// ═══════════════════════════════════════════════════════════════════════════
// SLIDE 1 — TITLE
// ═══════════════════════════════════════════════════════════════════════════
{
  const sl = pres.addSlide();
  bg(sl, LBLUE);
  sl.addShape(pres.ShapeType.rect, { x:0, y:0, w:10, h:3.05, fill:{color:BLUE}, line:{color:BLUE, width:0} });
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  sl.addText("CASTOR POISONING", {
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  sl.addText("Ricinus communis — Ricin Toxicology", {
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  // Divider line
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  // LEFT — Guided by
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    fontSize:17, bold:true, color:BLUE, fontFace:"Calibri"
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  sl.addText("Resp. Dr. R.K. Singh Sir", {
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    fontSize:17, bold:true, color:BLUE, fontFace:"Calibri"
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    fontSize:24, bold:true, color:BLACK, fontFace:"Calibri"
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  sl.addText("Roll No. 106", {
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    fontSize:17, color:"37474F", fontFace:"Calibri"
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}

// ═══════════════════════════════════════════════════════════════════════════
// SLIDE 2 — INTRODUCTION
// ═══════════════════════════════════════════════════════════════════════════
{
  const sl = pres.addSlide();
  bg(sl, GRAY);
  hbar(sl, "Introduction", BLUE);

  bullets(sl, [
    { text:"Ricin is derived from an organic poisonous plant known as Ricinus communis.", bold:false },
    { text:"It belongs to the category of Gastrointestinal Irritants.", bold:false },
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    { text:"Botanical Name:", bold:true, color:BLUE },
    { text:"Ricinus communis", sub:true, italic:true },
    "",
    { text:"Common Names:", bold:true, color:BLUE },
    { text:"Castor, Arandi, Arand", sub:true },
    "",
    { text:"The plant is widely distributed across India and found in tropical regions worldwide.", bold:false },
    { text:"It is commonly found growing in wastelands, roadsides, and uncultivated lands.", bold:false },
  ], 0.4, 1.25, 9.2, 4.2, 19, BLACK);
}

// ═══════════════════════════════════════════════════════════════════════════
// SLIDE 3 — FEATURES: PLANT (image)
// ═══════════════════════════════════════════════════════════════════════════
{
  const sl = pres.addSlide();
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  hbar(sl, "Features of the Plant", TEAL);

  bullets(sl, [
    { text:"General Appearance:", bold:true, color:TEAL },
    { text:"Tall plant that grows all over India.", sub:true },
    { text:"Especially found in wastelands and uncultivated areas.", sub:true },
    { text:"Also commonly seen along roadsides and open fields.", sub:true },
  ], 0.4, 1.25, 5.0, 4.2, 19, BLACK);

  imgSlide(sl, "plant", "Ricinus communis — Castor Plant", TEAL);
}

// ═══════════════════════════════════════════════════════════════════════════
// SLIDE 4 — LEAVES (image)
// ═══════════════════════════════════════════════════════════════════════════
{
  const sl = pres.addSlide();
  bg(sl, GRAY);
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  bullets(sl, [
    { text:"Shape:", bold:true, color:TEAL },
    { text:"Lobate (palm-shaped) with toothed (serrated) margins.", sub:true },
    { text:"Large, alternate leaves with long petioles.", sub:true },
    { text:"Green to reddish-purple in colour depending on variety.", sub:true },
  ], 0.4, 1.25, 5.0, 4.2, 19, BLACK);

  imgSlide(sl, "leaf", "Castor Leaf — Lobate with Serrated Margins", TEAL);
}

// ═══════════════════════════════════════════════════════════════════════════
// SLIDE 5 — FRUIT & SEEDS (image)
// ═══════════════════════════════════════════════════════════════════════════
{
  const sl = pres.addSlide();
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  hbar(sl, "Fruit & Seeds", TEAL);

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    { text:"Fruit:", bold:true, color:TEAL },
    { text:"1.2 to 2.5 cm long, globular, three-lobed, softly spiny.", sub:true },
    { text:"Blue-green or rose-red when immature.", sub:true },
    { text:"Brown and bristly when ripe and dry.", sub:true },
    "",
    { text:"Seeds — Two Sizes:", bold:true, color:BLUE },
    { text:"Large seeds: Mottled, dark-brown, with shiny hard pericarp.", sub:true },
    { text:"Small seeds: 1 to 2 cm long, 0.8 cm broad, resemble croton seeds.", sub:true },
    { text:"Both are smooth and flattened-oval in shape.", sub:true },
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  imgSlide(sl, "fruits_seeds_leaf", "Castor Fruit, Seeds & Leaf", BLUE);
}

// ═══════════════════════════════════════════════════════════════════════════
// SLIDE 6 — SEEDS CLOSE-UP (image)
// ═══════════════════════════════════════════════════════════════════════════
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  bg(sl, GRAY);
  hbar(sl, "Large & Small Seeds", TEAL);

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    { text:"Variable, smooth, flattened-oval in shape.", sub:true },
    "",
    { text:"Small Seeds:", bold:true, color:GREEN },
    { text:"1 to 2 cm long and 0.8 cm broad in size.", sub:true },
    { text:"Variable, smooth, flattened-oval in shape.", sub:true },
    { text:"Closely resemble Croton seeds in appearance.", sub:true },
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  imgSlide(sl, "seeds", "Castor Seeds — Large & Small Varieties", BLUE);
}

// ═══════════════════════════════════════════════════════════════════════════
// SLIDE 7 — TOXIC PRINCIPLE (Part 1)
// ═══════════════════════════════════════════════════════════════════════════
{
  const sl = pres.addSlide();
  bg(sl, GRAY);
  hbar(sl, "Toxic Principle", GREEN);

  // warning box
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  bullets(sl, [
    { text:"Seeds are rich in a purgative oil — pale-yellow with a faint odour and acrid taste.", bold:false },
    { text:"The oil extract of seeds contains an acid called Ricinoleic Acid.", sub:true },
    { text:"The leftover seed cake after oil extraction contains the toxalbumin Ricin.", sub:true },
    "",
    { text:"Important — Which forms are poisonous?", bold:true, color:GREEN },
    { text:"Unbroken seeds — Non-poisonous when swallowed or cooked.", sub:true },
    { text:"Castor oil — Non-poisonous.", sub:true },
    { text:"Crushed seeds — Poisonous.", sub:true },
    { text:"Ricin can exist in the form of powder, mist, or pellet.", sub:true },
  ], 0.4, 1.85, 9.2, 3.6, 18, BLACK);
}

// ═══════════════════════════════════════════════════════════════════════════
// SLIDE 8 — TOXIC PRINCIPLE (Part 2 — Toxalbumin)
// ═══════════════════════════════════════════════════════════════════════════
{
  const sl = pres.addSlide();
  bg(sl, GRAY);
  hbar(sl, "Toxalbumin (Ricin) — Properties", GREEN);

  bullets(sl, [
    { text:"Toxalbumin (Phytotoxin) is a toxic protein found in plants such as Castor, Croton, and Rati (Abrus precatorius).", bold:false },
    "",
    { text:"Properties:", bold:true, color:GREEN },
    { text:"Disables ribosomes and thereby inhibits protein synthesis.", sub:true },
    { text:"Antigenic in nature — capable of stimulating immune response.", sub:true },
    { text:"Agglutinates (clumps) red blood cells (RBCs).", sub:true },
    { text:"Causes haemolysis (destruction of RBCs) and cell destruction.", sub:true },
    "",
    { text:"Comparison with Other Toxins:", bold:true, color:GREEN },
    { text:"Similar in structure to toxins of Cholera, Tetanus, Diphtheria, Pseudomonas, and Botulinum.", sub:true },
    { text:"Physiological and toxic properties are also similar to those of Viperine snake venom.", sub:true },
  ], 0.4, 1.25, 9.2, 4.2, 18, BLACK);
}

// ═══════════════════════════════════════════════════════════════════════════
// SLIDE 9 — MECHANISM: STRUCTURE
// ═══════════════════════════════════════════════════════════════════════════
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  bg(sl, GRAY);
  hbar(sl, "Mechanism of Action — Structure of Ricin", PURPLE);

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  });

  bullets(sl, [
    { text:"In the Gastrointestinal Tract:", bold:true, color:PURPLE },
    { text:"Chain B binds to the surface of the cell (galactose-containing receptors on glycoproteins and glycolipids).", sub:true },
    { text:"Chain A enters into the cytoplasm of the cell.", sub:true },
    "",
    { text:"Effect of Chain A:", bold:true, color:PURPLE },
    { text:"Chain A acts on the 60S ribosomal subunit (specifically 28S rRNA) and disrupts protein synthesis.", sub:true },
    { text:"Ricin is antigenic in nature, agglutinates red blood cells, and causes haemolysis and cell destruction.", sub:true },
  ], 0.4, 1.9, 9.2, 3.6, 18, BLACK);
}

// ═══════════════════════════════════════════════════════════════════════════
// SLIDE 10 — MECHANISM: STEP BY STEP
// ═══════════════════════════════════════════════════════════════════════════
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  bg(sl, GRAY);
  hbar(sl, "Mechanism of Action — Step by Step", PURPLE);

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    { num:"1", title:"Binding",                color:"4527A0", desc:"Chain B binds to galactose receptors on cell membrane (glycoproteins & glycolipids)." },
    { num:"2", title:"Cell Entry",             color:"283593", desc:"Ricin enters via Endocytosis → Endosomes → Golgi Apparatus → Endoplasmic Reticulum." },
    { num:"3", title:"Translocation",          color:"0277BD", desc:"Inside the ER, Chain A separates and moves into the cytosol." },
    { num:"4", title:"Ribosome Damage",        color:RED,      desc:"Chain A inactivates 28S rRNA of the 60S ribosomal subunit → irreversible inhibition of protein synthesis." },
    { num:"5", title:"Cell Death",             color:RED,      desc:"Failure of protein synthesis → cell cannot survive → cytotoxic cell death." },
  ];

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}

// ═══════════════════════════════════════════════════════════════════════════
// SLIDE 11 — CLINICAL FEATURES: Routes & Dust
// ═══════════════════════════════════════════════════════════════════════════
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  bg(sl, GRAY);
  hbar(sl, "Clinical Features", ORANGE);

  bullets(sl, [
    { text:"Routes of Absorption:", bold:true, color:ORANGE },
    { text:"Ricin can be absorbed through Inhalation, Ingestion, Injection, and Skin Contact.", sub:true },
    "",
    { text:"Dust of Seeds:", bold:true, color:ORANGE },
    { text:"Watering of the eyes (Lacrimation)", sub:true },
    { text:"Conjunctivitis", sub:true },
    { text:"Sneezing, Acute nasal inflammation (Rhinitis)", sub:true },
    { text:"Headache", sub:true },
    { text:"Pharyngitis (throat inflammation)", sub:true },
    { text:"Asthmatic bronchitis", sub:true },
    { text:"Dermatitis (skin inflammation)", sub:true },
    { text:"Gastric upset", sub:true },
  ], 0.4, 1.25, 9.2, 4.2, 18, BLACK);
}

// ═══════════════════════════════════════════════════════════════════════════
// SLIDE 12 — INHALATION
// ═══════════════════════════════════════════════════════════════════════════
{
  const sl = pres.addSlide();
  bg(sl, GRAY);
  hbar(sl, "Inhalation Exposure", ORANGE);

  bullets(sl, [
    { text:"When ricin is inhaled, it produces the following clinical features:", bold:false },
    "",
    "Redness and pain in the eyes and throat",
    "Dyspnoea (difficulty in breathing)",
    "Wheezing",
    "Respiratory distress",
    "Fever",
    "Cough",
    "Tightness in the chest",
    "Sweating",
    "Pulmonary Oedema (fluid accumulation in the lungs)",
  ], 0.4, 1.25, 9.2, 4.2, 19, BLACK);
}

// ═══════════════════════════════════════════════════════════════════════════
// SLIDE 13 — ORAL INGESTION
// ═══════════════════════════════════════════════════════════════════════════
{
  const sl = pres.addSlide();
  bg(sl, GRAY);
  hbar(sl, "Oral Ingestion (Crushed Seeds)", RED);

  bullets(sl, [
    { text:"When crushed seeds are ingested, the following clinical features are produced:", bold:false },
    "",
    "Abdominal pain",
    "Vomiting and diarrhoea with or without blood (Haematemesis and Melaena)",
    "Dehydration",
    "Circulatory collapse",
    "Muscular pain and cramps in the limbs",
    "Convulsions",
    "Drowsiness and Delirium",
    "Jaundice",
    "Haemolysis (destruction of red blood cells)",
    "Hepatic failure (liver failure)",
    "Oliguria (reduced urine output)",
    "Uraemia (accumulation of waste products in blood)",
    { text:"Death may occur due to Multiorgan Failure or Cardiovascular Collapse.", bold:true, color:RED },
  ], 0.4, 1.25, 9.2, 4.22, 17, BLACK);
}

// ═══════════════════════════════════════════════════════════════════════════
// SLIDE 14 — INJECTION + FATAL DOSE
// ═══════════════════════════════════════════════════════════════════════════
{
  const sl = pres.addSlide();
  bg(sl, GRAY);
  hbar(sl, "Injection Exposure & Fatal Dose", RED);

  bullets(sl, [
    { text:"Injection Manifestations:", bold:true, color:RED },
    { text:"Pain at the injection site, erythema (redness), induration, or localised necrosis.", sub:true },
    { text:"Muscular pain.", sub:true },
    { text:"Capillary leak syndrome.", sub:true },
    { text:"Circulatory collapse.", sub:true },
    { text:"Convulsions.", sub:true },
    { text:"Multiorgan failure.", sub:true },
    { text:"Respiratory failure.", sub:true },
    "",
    { text:"Fatal Dose:", bold:true, color:RED },
    { text:"5 to 10 seeds.", sub:true },
    { text:"1 mg/kg body weight for Ricin.", sub:true },
    { text:"Fatal Period: 2 days to a few days.", sub:true },
  ], 0.4, 1.25, 9.2, 4.22, 18, BLACK);
}

// ═══════════════════════════════════════════════════════════════════════════
// SLIDE 15 — MANAGEMENT
// ═══════════════════════════════════════════════════════════════════════════
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  bg(sl, GRAY);
  hbar(sl, "Management", BLUE);

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    { text:"In Case of Ingestion:", bold:true, color:BLUE },
    { text:"Gastric lavage (stomach wash).", sub:true },
    { text:"Administration of Emetics and Demulcents.", sub:true },
    { text:"Administration of Glucose and Saline intravenously.", sub:true },
    { text:"2 to 5 g of Sodium Bicarbonate given 8 hourly by mouth.", sub:true },
    { text:"Blood transfusion may be needed in some patients.", sub:true },
    { text:"Gastric lavage followed by administration of Activated Charcoal.", sub:true },
    "",
    { text:"Supportive Treatment:", bold:true, color:BLUE },
    { text:"Management of shock.", sub:true },
    { text:"Correction of electrolyte abnormalities.", sub:true },
    { text:"Treatment of convulsions.", sub:true },
  ], 0.4, 1.82, 9.2, 3.65, 18, BLACK);
}

// ═══════════════════════════════════════════════════════════════════════════
// SLIDE 16 — AUTOPSY FINDINGS
// ═══════════════════════════════════════════════════════════════════════════
{
  const sl = pres.addSlide();
  bg(sl, GRAY);
  hbar(sl, "Autopsy Findings", "37474F");

  bullets(sl, [
    { text:"Gastrointestinal Tract:", bold:true, color:"37474F" },
    { text:"The mucosa is congested, softened, and inflamed.", sub:true },
    { text:"Occasional erosions and submucous haemorrhages are present.", sub:true },
    { text:"Fragments of seeds may be found in the stomach and intestines.", sub:true },
    "",
    { text:"Heart:", bold:true, color:"37474F" },
    { text:"Dilation of the heart chambers is observed.", sub:true },
    { text:"Haemorrhages are present in the pleura.", sub:true },
    "",
    { text:"Liver, Kidneys, Spleen, and Lungs:", bold:true, color:"37474F" },
    { text:"Oedema (swelling) and congestion of all these organs.", sub:true },
    { text:"Reflects multiorgan involvement as a result of systemic ricin toxicity.", sub:true },
  ], 0.4, 1.25, 9.2, 4.22, 18, BLACK);
}

// ═══════════════════════════════════════════════════════════════════════════
// SLIDE 17 — MEDICOLEGAL IMPORTANCE
// ═══════════════════════════════════════════════════════════════════════════
{
  const sl = pres.addSlide();
  bg(sl, GRAY);
  hbar(sl, "Medicolegal Importance", "880E4F");

  bullets(sl, [
    { text:"Accidental Poisoning:", bold:true, color:"880E4F" },
    { text:"Common in children while playing or exploring the plant and its seeds.", sub:true },
    "",
    { text:"Homicidal Use:", bold:true, color:RED },
    { text:"Ricin has been used for homicidal purposes due to its extreme potency.", sub:true },
    "",
    { text:"Criminal Abortion:", bold:true, color:RED },
    { text:"Seed pulp has been used to procure criminal abortion.", sub:true },
    "",
    { text:"Anaphylactic Hypersensitivity:", bold:true, color:"880E4F" },
    { text:"Can cause anaphylactic type of hypersensitivity reactions in humans.", sub:true },
    { text:"Allergenic glycoprotein causes Dermatitis, Rhinitis, Asthma, and Conjunctivitis.", sub:true },
    "",
    { text:"Bioweapon — CDC Category B:", bold:true, color:RED },
    { text:"Classified as a Category B Biological Weapon due to easy availability and high toxicity.", sub:true },
  ], 0.4, 1.25, 9.2, 4.22, 17, BLACK);
}

// ═══════════════════════════════════════════════════════════════════════════
// SLIDE 18 — GEORGI MARKOV CASE
// ═══════════════════════════════════════════════════════════════════════════
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  const sl = pres.addSlide();
  bg(sl, GRAY);
  hbar(sl, "Notable Case — Georgi Markov (1978)", "880E4F");

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  sl.addText([
    { text:"Georgi Markov", options:{ bold:true, color:RED } },
    { text:" was a Bulgarian dissident and journalist.\n\n", options:{ color:BLACK, breakLine:true } },
    { text:"In 1978 in London, he was attacked by a man with a specially rigged ", options:{ color:BLACK } },
    { text:"umbrella", options:{ bold:true, color:RED } },
    { text:" that injected a tiny ", options:{ color:BLACK } },
    { text:"ricin-laced pellet", options:{ bold:true, color:RED } },
    { text:" under the skin of his thigh.\n\n", options:{ color:BLACK, breakLine:true } },
    { text:"He died 3 days after the attack.\n\n", options:{ bold:true, color:RED, breakLine:true } },
    { text:"This case remains one of the most documented examples of ricin being used as a covert assassination weapon.\n\n", options:{ color:BLACK, breakLine:true } },
    { text:"Forensic significance: ", options:{ bold:true, color:"880E4F" } },
    { text:"Demonstrates ricin's potential as a covert assassination tool — highly relevant for medicolegal practice.", options:{ color:"37474F", italic:true } },
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}

// ═══════════════════════════════════════════════════════════════════════════
// SLIDE 19 — LABORATORY DIAGNOSIS
// ═══════════════════════════════════════════════════════════════════════════
{
  const sl = pres.addSlide();
  bg(sl, GRAY);
  hbar(sl, "Laboratory Diagnosis", TEAL);

  bullets(sl, [
    { text:"Liquid Chromatography-Mass Spectrometry (LC-MS):", bold:true, color:TEAL },
    { text:"Gold-standard confirmatory test for detection of Ricin.", sub:true },
    "",
    { text:"Immunoassays:", bold:true, color:TEAL },
    { text:"ELISA and similar immunological tests are used.", sub:true },
    "",
    { text:"Ricinine Detection:", bold:true, color:TEAL },
    { text:"Ricinine is an alkaloid present in the castor plant.", sub:true },
    { text:"Can be detected in both serum and urine samples.", sub:true },
    { text:"Comprehensive untargeted urine drug screening is highly valuable for diagnosis.", sub:true },
    "",
    { text:"Ricin-Antibody Conjugates:", bold:true, color:TEAL },
    { text:"Detectable in surviving patients approximately 2 weeks after exposure.", sub:true },
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// ═══════════════════════════════════════════════════════════════════════════
// SLIDE 20 — REFERENCES (no boxes, clean list)
// ═══════════════════════════════════════════════════════════════════════════
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  bg(sl, LBLUE);
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    { num:"1.", author:"Gautam Biswas", title:"Textbook of Forensic Medicine & Toxicology", pub:"Jaypee Brothers Medical Publishers" },
    { num:"2.", author:"K. S. Narayan Reddy", title:"The Essentials of Forensic Medicine & Toxicology", pub:"Jaypee Brothers Medical Publishers" },
    { num:"3.", author:"Rajesh Bardale", title:"Textbook of Forensic Medicine & Toxicology", pub:"Oxford University Press" },
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}

// ═══════════════════════════════════════════════════════════════════════════
// SLIDE 21 — THANK YOU
// ═══════════════════════════════════════════════════════════════════════════
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  sl.addShape(pres.ShapeType.rect, { x:0, y:0, w:10, h:3.1, fill:{color:BLUE}, line:{color:BLUE, width:0} });
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  sl.addText("THANK YOU", {
    x:0.5, y:0.55, w:9, h:1.6,
    fontSize:58, bold:true, color:WHITE, fontFace:"Calibri", align:"center"
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  sl.addText("Presented by: Komal Rathore  |  Roll No. 106", {
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}

// ── WRITE FILE ────────────────────────────────────────────────────────────────
pres.writeFile({ fileName: "/home/daytona/workspace/ricin-ppt/Castor_Poisoning_Final.pptx" })
  .then(() => console.log("SUCCESS"))
  .catch(err => { console.error(err); process.exit(1); });

cd /home/daytona/workspace/ricin-ppt && node build_final.js 2>&1

cp /home/daytona/workspace/ricin-ppt/Castor_Poisoning_Final.pptx /tmp/final.pptx…

Ricinus communis castor plant full plant photo wikimedia commons free use

castor plant leaf close up wikimedia commons

castor bean seeds only ricinus communis seeds wikimedia commons

node /home/daytona/skills/shared/scripts/fetch_images.js \ "https://upload.wik…

# Download each image separately with curl curl -L -s --max-time 20 "https://upl…

# Seeds image too small (1966 bytes = failed/blocked). Try alternate seeds URL c…

node -e " const fs = require('fs'); const out = { plant: 'image/jpeg;base64,' …

~/ricin-ppt/build_final.js

Successfully replaced 1 instance(s) of the string in '/home/daytona/workspace/ricin-ppt/build_final.js'

~/ricin-ppt/build_final.js

Successfully replaced 1 instance(s) of the string in '/home/daytona/workspace/ricin-ppt/build_final.js'

~/ricin-ppt/build_final.js

Successfully replaced 1 instance(s) of the string in '/home/daytona/workspace/ricin-ppt/build_final.js'

~/ricin-ppt/build_final.js

Successfully replaced 1 instance(s) of the string in '/home/daytona/workspace/ricin-ppt/build_final.js'

cd /home/daytona/workspace/ricin-ppt && node build_final.js 2>&1

cp /home/daytona/workspace/ricin-ppt/Castor_Poisoning_v6.pptx /tmp/v6.pptx && li…

~/ricin-ppt/build_v7.js

const pptxgen = require("pptxgenjs");
const IMGS = JSON.parse(require("fs").readFileSync("/tmp/castor_images_v2.json","utf8"));
const pres = new pptxgen();
pres.layout = "LAYOUT_16x9";
pres.title = "Castor Poisoning";

const BLUE   = "1565C0";
const LBLUE  = "E3F2FD";
const WHITE  = "FFFFFF";
const BLACK  = "1A1A1A";
const GRAY   = "F5F5F5";
const RED    = "B71C1C";
const LRED   = "FFEBEE";
const GREEN  = "1B5E20";
const TEAL   = "004D40";
const ORANGE = "E65100";
const PURPLE = "4A148C";

function bg(sl, color) {
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// Each item in array = {text, bold, color, sub, italic} OR ""
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function imgRight(sl, imgKey, caption, captionColor) {
  sl.addImage({ data: IMGS[imgKey], x:5.55, y:1.1, w:4.1, h:3.9, sizing:{type:"contain",w:4.1,h:3.9} });
  sl.addShape(pres.ShapeType.rect, { x:5.55, y:5.0, w:4.1, h:0.42, fill:{color: captionColor||TEAL}, line:{color: captionColor||TEAL, width:0} });
  sl.addText(caption, { x:5.55, y:5.0, w:4.1, h:0.42, fontSize:13, bold:true, color:WHITE, fontFace:"Calibri", align:"center", valign:"middle" });
}

// ═══════════════════════════════════════════════════════════════
// SLIDE 1 — TITLE
// ═══════════════════════════════════════════════════════════════
{
  const sl = pres.addSlide();
  bg(sl, LBLUE);
  sl.addShape(pres.ShapeType.rect, { x:0, y:0, w:10, h:3.05, fill:{color:BLUE}, line:{color:BLUE,width:0} });
  sl.addShape(pres.ShapeType.rect, { x:0, y:3.05, w:10, h:0.08, fill:{color:"42A5F5"}, line:{color:"42A5F5",width:0} });

  sl.addText("CASTOR POISONING", { x:0.5, y:0.18, w:9, h:1.55, fontSize:54, bold:true, color:WHITE, fontFace:"Calibri", align:"center" });
  sl.addText("Ricinus communis — Ricin Toxicology", { x:0.5, y:1.75, w:9, h:0.58, fontSize:20, color:"BBDEFB", fontFace:"Calibri", italic:true, align:"center" });
  sl.addText("Forensic Medicine & Toxicology", { x:0.5, y:2.45, w:9, h:0.4, fontSize:14, color:"BBDEFB", fontFace:"Calibri", align:"center" });

  sl.addShape(pres.ShapeType.rect, { x:0.5, y:3.22, w:9, h:0.04, fill:{color:"90CAF9"}, line:{color:"90CAF9",width:0} });

  sl.addText("Guided by:", { x:0.5, y:3.35, w:4.5, h:0.42, fontSize:17, bold:true, color:BLUE, fontFace:"Calibri" });
  sl.addText("Resp. Dr. R.K. Singh Sir", { x:0.5, y:3.75, w:4.5, h:0.45, fontSize:20, bold:true, color:BLACK, fontFace:"Calibri" });
  sl.addText("Head of Department\nForensic Medicine & Toxicology", { x:0.5, y:4.2, w:4.5, h:0.65, fontSize:16, color:"37474F", fontFace:"Calibri" });

  sl.addText("Presented by:", { x:5.4, y:3.35, w:4.2, h:0.42, fontSize:17, bold:true, color:BLUE, fontFace:"Calibri" });
  sl.addText("Komal Rathore", { x:5.4, y:3.75, w:4.2, h:0.45, fontSize:24, bold:true, color:BLACK, fontFace:"Calibri" });
  sl.addText("Roll No. 106", { x:5.4, y:4.2, w:4.2, h:0.4, fontSize:17, color:"37474F", fontFace:"Calibri" });
}

// ═══════════════════════════════════════════════════════════════
// SLIDE 2 — INTRODUCTION
// ═══════════════════════════════════════════════════════════════
{
  const sl = pres.addSlide();
  bg(sl, GRAY);
  hbar(sl, "Introduction", BLUE);
  addLines(sl, [
    { text:"Ricin is derived from an organic poisonous plant known as Ricinus communis." },
    { text:"It belongs to the category of Gastrointestinal Irritants." },
    "",
    { text:"Botanical Name:", bold:true, color:BLUE },
    { text:"Ricinus communis", sub:true, italic:true },
    "",
    { text:"Common Names:", bold:true, color:BLUE },
    { text:"Castor, Arandi, Arand", sub:true },
    "",
    { text:"The plant is widely distributed across India and found in tropical regions worldwide." },
    { text:"It is commonly found growing in wastelands, roadsides, and uncultivated lands." },
  ], 0.4, 1.12, 9.2, 4.3, 19);
}

// ═══════════════════════════════════════════════════════════════
// SLIDE 3 — FEATURES: PLANT (image right)
// ═══════════════════════════════════════════════════════════════
{
  const sl = pres.addSlide();
  bg(sl, GRAY);
  hbar(sl, "Features of the Plant", TEAL);
  addLines(sl, [
    { text:"General Appearance:", bold:true, color:TEAL },
    { text:"Tall plant that grows all over India.", sub:true },
    { text:"Especially found in wastelands and uncultivated areas.", sub:true },
    { text:"Also seen along roadsides and open fields.", sub:true },
  ], 0.4, 1.12, 5.0, 4.3, 19);
  imgRight(sl, "plant", "Ricinus communis — Castor Plant", TEAL);
}

// ═══════════════════════════════════════════════════════════════
// SLIDE 4 — LEAVES (image right)
// ═══════════════════════════════════════════════════════════════
{
  const sl = pres.addSlide();
  bg(sl, GRAY);
  hbar(sl, "Leaves", TEAL);
  addLines(sl, [
    { text:"Lobate (palm-shaped) with toothed (serrated) margins.", bold:false },
    { text:"Large, alternate leaves with long petioles.", bold:false },
    { text:"Green to reddish-purple in colour depending on variety.", bold:false },
  ], 0.4, 1.12, 5.0, 4.3, 19);
  imgRight(sl, "leaf", "Castor Leaf — Lobate with Serrated Margins", TEAL);
}

// ═══════════════════════════════════════════════════════════════
// SLIDE 5 — FRUIT (text only)
// ═══════════════════════════════════════════════════════════════
{
  const sl = pres.addSlide();
  bg(sl, GRAY);
  hbar(sl, "Fruit", TEAL);
  addLines(sl, [
    { text:"1.2 to 2.5 cm long." },
    { text:"Globular in shape, three-lobed." },
    { text:"Softly spiny on the outer surface." },
    { text:"Blue-green or rose-red in colour when immature." },
    { text:"Turns brown and bristly when ripe and dry." },
  ], 0.4, 1.12, 9.2, 4.3, 21);
}

// ═══════════════════════════════════════════════════════════════
// SLIDE 6 — SEEDS (image right, NO size text with image)
// ═══════════════════════════════════════════════════════════════
{
  const sl = pres.addSlide();
  bg(sl, GRAY);
  hbar(sl, "Seeds", TEAL);
  addLines(sl, [
    { text:"Large Seeds:", bold:true, color:BLUE },
    { text:"Mottled, dark-brown in colour.", sub:true },
    { text:"Shiny hard seed coat — called Pericarp.", sub:true },
    { text:"Smooth, flattened-oval in shape.", sub:true },
    "",
    { text:"Small Seeds:", bold:true, color:GREEN },
    { text:"Smooth, flattened-oval in shape.", sub:true },
    { text:"Closely resemble Croton seeds.", sub:true },
  ], 0.4, 1.12, 5.0, 4.3, 19);
  imgRight(sl, "seeds", "Castor Seeds", BLUE);
}

// ═══════════════════════════════════════════════════════════════
// SLIDE 7 — TOXIC PRINCIPLE (Part 1)
// ═══════════════════════════════════════════════════════════════
{
  const sl = pres.addSlide();
  bg(sl, GRAY);
  hbar(sl, "Toxic Principle", GREEN);

  sl.addShape(pres.ShapeType.rect, { x:0.35, y:1.08, w:9.3, h:0.52, fill:{color:LRED}, line:{color:RED,width:1.5} });
  sl.addText("Entire plant is toxic — Seeds are the most toxic part", {
    x:0.45, y:1.08, w:9.1, h:0.52, fontSize:15, bold:true, color:RED, fontFace:"Calibri", align:"center", valign:"middle"
  });

  addLines(sl, [
    { text:"Seeds contain Ricin — a water-soluble glycoprotein (toxalbumin)." },
    { text:"Seeds are rich in a purgative oil — pale-yellow, faint odour, acrid taste." },
    { text:"The oil extract contains Ricinoleic Acid.", sub:true },
    { text:"The leftover seed cake after oil extraction contains the toxalbumin Ricin.", sub:true },
  ], 0.4, 1.72, 9.2, 3.7, 19);
}

// ═══════════════════════════════════════════════════════════════
// SLIDE 8 — TOXIC PRINCIPLE (Part 2 — which forms are poisonous)
// ═══════════════════════════════════════════════════════════════
{
  const sl = pres.addSlide();
  bg(sl, GRAY);
  hbar(sl, "Toxic Principle — Poisonous Forms", GREEN);
  addLines(sl, [
    { text:"Which forms are poisonous?", bold:true, color:GREEN },
    { text:"Unbroken seeds — Non-poisonous when swallowed or cooked.", sub:true },
    { text:"Castor oil — Non-poisonous.", sub:true },
    { text:"Crushed seeds — Poisonous.", sub:true },
    { text:"Ricin can exist in the form of powder, mist, or pellet.", sub:true },
    "",
    { text:"Toxalbumin (Phytotoxin) Properties:", bold:true, color:GREEN },
    { text:"Disables ribosomes and inhibits protein synthesis.", sub:true },
    { text:"Antigenic in nature.", sub:true },
    { text:"Agglutinates (clumps) red blood cells.", sub:true },
    { text:"Causes haemolysis and cell destruction.", sub:true },
    { text:"Similar in structure to toxins of Cholera, Tetanus, Diphtheria, Pseudomonas, and Botulinum.", sub:true },
    { text:"Properties similar to Viperine snake venom.", sub:true },
  ], 0.4, 1.12, 9.2, 4.3, 18);
}

// ═══════════════════════════════════════════════════════════════
// SLIDE 9 — MECHANISM: STRUCTURE
// ═══════════════════════════════════════════════════════════════
{
  const sl = pres.addSlide();
  bg(sl, GRAY);
  hbar(sl, "Mechanism of Action — Structure of Ricin", PURPLE);

  sl.addShape(pres.ShapeType.rect, { x:0.35, y:1.08, w:9.3, h:0.58, fill:{color:"EDE7F6"}, line:{color:PURPLE,width:1.5} });
  sl.addText("Ricin = Chain A (Toxic / Active)  +  Chain B (Binding)  —  connected by a Disulfide Bond", {
    x:0.45, y:1.08, w:9.1, h:0.58, fontSize:17, bold:true, color:PURPLE, fontFace:"Calibri", align:"center", valign:"middle"
  });

  addLines(sl, [
    { text:"In the Gastrointestinal Tract:", bold:true, color:PURPLE },
    { text:"Chain B binds to galactose-containing receptors on cell membrane (glycoproteins and glycolipids).", sub:true },
    { text:"Chain A enters into the cytoplasm of the cell.", sub:true },
    "",
    { text:"Effect of Chain A:", bold:true, color:PURPLE },
    { text:"Acts on 60S ribosomal subunit (specifically 28S rRNA) and disrupts protein synthesis.", sub:true },
    { text:"Antigenic, agglutinates red blood cells, causes haemolysis and cell destruction.", sub:true },
  ], 0.4, 1.78, 9.2, 3.7, 19);
}

// ═══════════════════════════════════════════════════════════════
// SLIDE 10 — MECHANISM: STEP BY STEP
// ═══════════════════════════════════════════════════════════════
{
  const sl = pres.addSlide();
  bg(sl, GRAY);
  hbar(sl, "Mechanism of Action — Step by Step", PURPLE);

  const steps = [
    { num:"1", title:"Binding",         color:"4527A0", desc:"Chain B binds to galactose receptors on cell membrane." },
    { num:"2", title:"Cell Entry",      color:"283593", desc:"Endocytosis → Endosomes → Golgi Apparatus → Endoplasmic Reticulum." },
    { num:"3", title:"Translocation",   color:"0277BD", desc:"Chain A separates in the ER and moves into the cytosol." },
    { num:"4", title:"Ribosome Damage", color:RED,      desc:"Chain A inactivates 28S rRNA of 60S ribosomal subunit → irreversible inhibition of protein synthesis." },
    { num:"5", title:"Cell Death",      color:RED,      desc:"Failure of protein synthesis → cell cannot survive → cytotoxic cell death." },
  ];
  const rowBgs = ["EDE7F6","E8EAF6","E3F2FD","FFEBEE","FFEBEE"];
  steps.forEach((step, i) => {
    const y = 1.1 + i * 0.88;
    sl.addShape(pres.ShapeType.rect, { x:0.35, y, w:9.3, h:0.78, fill:{color:rowBgs[i]}, line:{color:rowBgs[i],width:0} });
    sl.addShape(pres.ShapeType.rect, { x:0.35, y, w:0.55, h:0.78, fill:{color:step.color}, line:{color:step.color,width:0} });
    sl.addText(step.num, { x:0.35, y, w:0.55, h:0.78, fontSize:18, bold:true, color:WHITE, fontFace:"Calibri", align:"center", valign:"middle" });
    sl.addText(step.title + ":", { x:0.96, y:y+0.12, w:2.1, h:0.55, fontSize:15, bold:true, color:step.color, fontFace:"Calibri", valign:"middle" });
    sl.addText(step.desc, { x:3.12, y:y+0.1, w:6.38, h:0.6, fontSize:14.5, color:BLACK, fontFace:"Calibri", valign:"middle", wrap:true });
  });
}

// ═══════════════════════════════════════════════════════════════
// SLIDE 11 — CLINICAL FEATURES: Routes & Dust
// ═══════════════════════════════════════════════════════════════
{
  const sl = pres.addSlide();
  bg(sl, GRAY);
  hbar(sl, "Clinical Features — Routes & Dust", ORANGE);
  addLines(sl, [
    { text:"Routes of Absorption:", bold:true, color:ORANGE },
    { text:"Inhalation", sub:true },
    { text:"Ingestion", sub:true },
    { text:"Injection", sub:true },
    { text:"Skin Contact", sub:true },
    "",
    { text:"Dust of Seeds:", bold:true, color:ORANGE },
    { text:"Watering of the eyes (Lacrimation)", sub:true },
    { text:"Conjunctivitis", sub:true },
    { text:"Sneezing", sub:true },
    { text:"Acute nasal inflammation (Rhinitis)", sub:true },
    { text:"Headache", sub:true },
  ], 0.4, 1.12, 9.2, 4.3, 18);
}

// ═══════════════════════════════════════════════════════════════
// SLIDE 12 — CLINICAL: DUST (continued)
// ═══════════════════════════════════════════════════════════════
{
  const sl = pres.addSlide();
  bg(sl, GRAY);
  hbar(sl, "Clinical Features — Dust (continued)", ORANGE);
  addLines(sl, [
    { text:"Dust of Seeds (continued):", bold:true, color:ORANGE },
    { text:"Pharyngitis (throat inflammation)", sub:true },
    { text:"Asthmatic bronchitis", sub:true },
    { text:"Dermatitis (skin inflammation)", sub:true },
    { text:"Gastric upset", sub:true },
  ], 0.4, 1.12, 9.2, 4.3, 20);
}

// ═══════════════════════════════════════════════════════════════
// SLIDE 13 — CLINICAL: INHALATION
// ═══════════════════════════════════════════════════════════════
{
  const sl = pres.addSlide();
  bg(sl, GRAY);
  hbar(sl, "Inhalation Exposure", ORANGE);
  addLines(sl, [
    { text:"Redness and pain in the eyes and throat" },
    { text:"Dyspnoea (difficulty in breathing)" },
    { text:"Wheezing" },
    { text:"Respiratory distress" },
    { text:"Fever" },
    { text:"Cough" },
    { text:"Tightness in the chest" },
    { text:"Sweating" },
    { text:"Pulmonary Oedema (fluid accumulation in the lungs)" },
  ], 0.4, 1.12, 9.2, 4.3, 19);
}

// ═══════════════════════════════════════════════════════════════
// SLIDE 14 — CLINICAL: ORAL INGESTION (Part 1)
// ═══════════════════════════════════════════════════════════════
{
  const sl = pres.addSlide();
  bg(sl, GRAY);
  hbar(sl, "Oral Ingestion — Crushed Seeds", RED);
  sl.addText("When crushed seeds are ingested, the following clinical features are produced:", {
    x:0.4, y:1.1, w:9.2, h:0.42, fontSize:17, color:BLACK, fontFace:"Calibri", italic:true
  });
  addLines(sl, [
    { text:"Abdominal pain" },
    { text:"Vomiting and diarrhoea with or without blood" },
    { text:"Haematemesis (vomiting blood) and Melaena (black stools)" },
    { text:"Dehydration" },
    { text:"Circulatory collapse" },
    { text:"Muscular pain and cramps in the limbs" },
    { text:"Convulsions" },
  ], 0.4, 1.58, 9.2, 3.9, 18);
}

// ═══════════════════════════════════════════════════════════════
// SLIDE 15 — CLINICAL: ORAL INGESTION (Part 2)
// ═══════════════════════════════════════════════════════════════
{
  const sl = pres.addSlide();
  bg(sl, GRAY);
  hbar(sl, "Oral Ingestion — continued", RED);
  addLines(sl, [
    { text:"Drowsiness and Delirium" },
    { text:"Jaundice" },
    { text:"Haemolysis (destruction of red blood cells)" },
    { text:"Hepatic failure (liver failure)" },
    { text:"Oliguria (reduced urine output)" },
    { text:"Uraemia (accumulation of waste products in blood)" },
    "",
    { text:"Death may occur due to Multiorgan Failure or Cardiovascular Collapse.", bold:true, color:RED },
  ], 0.4, 1.12, 9.2, 4.3, 19);
}

// ═══════════════════════════════════════════════════════════════
// SLIDE 16 — CLINICAL: INJECTION
// ═══════════════════════════════════════════════════════════════
{
  const sl = pres.addSlide();
  bg(sl, GRAY);
  hbar(sl, "Injection Exposure", RED);
  addLines(sl, [
    { text:"Pain at the injection site" },
    { text:"Erythema (redness) and induration" },
    { text:"Localised necrosis at injection site" },
    { text:"Muscular pain" },
    { text:"Capillary leak syndrome" },
    { text:"Circulatory collapse" },
    { text:"Convulsions" },
    { text:"Multiorgan failure" },
    { text:"Respiratory failure" },
  ], 0.4, 1.12, 9.2, 4.3, 19);
}

// ═══════════════════════════════════════════════════════════════
// SLIDE 17 — FATAL DOSE
// ═══════════════════════════════════════════════════════════════
{
  const sl = pres.addSlide();
  bg(sl, GRAY);
  hbar(sl, "Fatal Dose", RED);
  addLines(sl, [
    { text:"5 to 10 seeds.", bold:true, color:RED },
    { text:"1 mg per kg body weight for Ricin.", bold:true, color:RED },
    { text:"Fatal Period: 2 days to a few days.", bold:true, color:RED },
  ], 0.4, 1.12, 9.2, 4.3, 24);
}

// ═══════════════════════════════════════════════════════════════
// SLIDE 18 — MANAGEMENT (Part 1)
// ═══════════════════════════════════════════════════════════════
{
  const sl = pres.addSlide();
  bg(sl, GRAY);
  hbar(sl, "Management", BLUE);

  sl.addShape(pres.ShapeType.rect, { x:0.35, y:1.08, w:9.3, h:0.5, fill:{color:LRED}, line:{color:RED,width:1.5} });
  sl.addText("NO SPECIFIC ANTIDOTE AVAILABLE — Treatment is purely supportive", {
    x:0.45, y:1.08, w:9.1, h:0.5, fontSize:15, bold:true, color:RED, fontFace:"Calibri", align:"center", valign:"middle"
  });

  addLines(sl, [
    { text:"In Case of Ingestion:", bold:true, color:BLUE },
    { text:"Gastric lavage (stomach wash).", sub:true },
    { text:"Administration of Emetics and Demulcents.", sub:true },
    { text:"Administration of Glucose and Saline intravenously.", sub:true },
    { text:"2 to 5 g of Sodium Bicarbonate given 8 hourly by mouth.", sub:true },
    { text:"Blood transfusion may be needed in some patients.", sub:true },
    { text:"Gastric lavage followed by administration of Activated Charcoal.", sub:true },
  ], 0.4, 1.68, 9.2, 3.8, 18);
}

// ═══════════════════════════════════════════════════════════════
// SLIDE 19 — MANAGEMENT (Part 2)
// ═══════════════════════════════════════════════════════════════
{
  const sl = pres.addSlide();
  bg(sl, GRAY);
  hbar(sl, "Management — Supportive Treatment", BLUE);
  addLines(sl, [
    { text:"Supportive Treatment:", bold:true, color:BLUE },
    { text:"Management of shock.", sub:true },
    { text:"Correction of electrolyte abnormalities.", sub:true },
    { text:"Treatment of convulsions.", sub:true },
  ], 0.4, 1.12, 9.2, 4.3, 21);
}

// ═══════════════════════════════════════════════════════════════
// SLIDE 20 — AUTOPSY FINDINGS (Part 1)
// ═══════════════════════════════════════════════════════════════
{
  const sl = pres.addSlide();
  bg(sl, GRAY);
  hbar(sl, "Autopsy Findings", "37474F");
  addLines(sl, [
    { text:"Gastrointestinal Tract:", bold:true, color:"37474F" },
    { text:"The mucosa is congested, softened, and inflamed.", sub:true },
    { text:"Occasional erosions and submucous haemorrhages are present.", sub:true },
    { text:"Fragments of seeds may be found in the stomach and intestines.", sub:true },
    "",
    { text:"Heart:", bold:true, color:"37474F" },
    { text:"Dilation of the heart chambers is observed.", sub:true },
    { text:"Haemorrhages are present in the pleura.", sub:true },
  ], 0.4, 1.12, 9.2, 4.3, 19);
}

// ═══════════════════════════════════════════════════════════════
// SLIDE 21 — AUTOPSY FINDINGS (Part 2)
// ═══════════════════════════════════════════════════════════════
{
  const sl = pres.addSlide();
  bg(sl, GRAY);
  hbar(sl, "Autopsy Findings — continued", "37474F");
  addLines(sl, [
    { text:"Liver, Kidneys, Spleen, and Lungs:", bold:true, color:"37474F" },
    { text:"Oedema (swelling) and congestion of all these organs.", sub:true },
    { text:"Reflects multiorgan involvement as a result of systemic ricin toxicity.", sub:true },
  ], 0.4, 1.12, 9.2, 4.3, 21);
}

// ═══════════════════════════════════════════════════════════════
// SLIDE 22 — MEDICOLEGAL IMPORTANCE (Part 1)
// ═══════════════════════════════════════════════════════════════
{
  const sl = pres.addSlide();
  bg(sl, GRAY);
  hbar(sl, "Medicolegal Importance", "880E4F");
  addLines(sl, [
    { text:"Accidental Poisoning:", bold:true, color:"880E4F" },
    { text:"Common in children while playing or exploring the plant and its seeds.", sub:true },
    "",
    { text:"Homicidal Use:", bold:true, color:RED },
    { text:"Ricin has been used for homicidal purposes due to its extreme potency.", sub:true },
    "",
    { text:"Criminal Abortion:", bold:true, color:RED },
    { text:"Seed pulp has been used to procure criminal abortion.", sub:true },
    "",
    { text:"Anaphylactic Hypersensitivity:", bold:true, color:"880E4F" },
    { text:"Can cause anaphylactic type of hypersensitivity reactions in humans.", sub:true },
    { text:"Allergenic glycoprotein causes Dermatitis, Rhinitis, Asthma, and Conjunctivitis.", sub:true },
  ], 0.4, 1.12, 9.2, 4.3, 18);
}

// ═══════════════════════════════════════════════════════════════
// SLIDE 23 — MEDICOLEGAL: BIOWEAPON + MARKOV
// ═══════════════════════════════════════════════════════════════
{
  const sl = pres.addSlide();
  bg(sl, GRAY);
  hbar(sl, "Medicolegal — Bioweapon & Notable Case", "880E4F");
  addLines(sl, [
    { text:"Bioweapon — CDC Category B:", bold:true, color:RED },
    { text:"Classified as a Category B Biological Weapon due to easy availability and high toxicity.", sub:true },
    "",
    { text:"Notable Case — Georgi Markov (1978):", bold:true, color:"880E4F" },
    { text:"A Bulgarian dissident and journalist.", sub:true },
    { text:"Attacked in London with a specially rigged umbrella.", sub:true },
    { text:"The umbrella injected a ricin-laced pellet under the skin of his thigh.", sub:true },
    { text:"He died 3 days after the attack.", sub:true },
    { text:"One of the most documented cases of ricin used as an assassination weapon.", sub:true },
  ], 0.4, 1.12, 9.2, 4.3, 18);
}

// ═══════════════════════════════════════════════════════════════
// SLIDE 24 — LABORATORY DIAGNOSIS
// ═══════════════════════════════════════════════════════════════
{
  const sl = pres.addSlide();
  bg(sl, GRAY);
  hbar(sl, "Laboratory Diagnosis", TEAL);
  addLines(sl, [
    { text:"Liquid Chromatography-Mass Spectrometry (LC-MS):", bold:true, color:TEAL },
    { text:"Gold-standard confirmatory test for detection of Ricin.", sub:true },
    "",
    { text:"Immunoassays:", bold:true, color:TEAL },
    { text:"ELISA and similar immunological tests are used.", sub:true },
    "",
    { text:"Ricinine Detection:", bold:true, color:TEAL },
    { text:"Ricinine (an alkaloid) can be detected in serum and urine.", sub:true },
    { text:"Comprehensive untargeted urine drug screening is highly valuable.", sub:true },
    "",
    { text:"Ricin-Antibody Conjugates:", bold:true, color:TEAL },
    { text:"Detectable in surviving patients approximately 2 weeks after exposure.", sub:true },
  ], 0.4, 1.12, 9.2, 4.3, 18);
}

// ═══════════════════════════════════════════════════════════════
// SLIDE 25 — REFERENCES
// ═══════════════════════════════════════════════════════════════
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  bg(sl, LBLUE);
  sl.addShape(pres.ShapeType.rect, { x:0, y:0, w:10, h:1.2, fill:{color:BLUE}, line:{color:BLUE,width:0} });
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  sl.addText("REFERENCES", { x:0.5, y:0, w:9, h:1.2, fontSize:38, bold:true, color:WHITE, fontFace:"Calibri", align:"center", valign:"middle" });

  const refs = [
    { num:"1.", author:"Gautam Biswas", title:"Textbook of Forensic Medicine & Toxicology", pub:"Jaypee Brothers Medical Publishers" },
    { num:"2.", author:"K.S. Narayan Reddy", title:"The Essentials of Forensic Medicine & Toxicology", pub:"Jaypee Brothers Medical Publishers" },
    { num:"3.", author:"Rajesh Bardale", title:"Textbook of Forensic Medicine & Toxicology", pub:"Oxford University Press" },
  ];
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  });
}

// ═══════════════════════════════════════════════════════════════
// SLIDE 26 — THANK YOU (only)
// ═══════════════════════════════════════════════════════════════
{
  const sl = pres.addSlide();
  bg(sl, BLUE);
  sl.addText("THANK YOU", {
    x:0, y:1.5, w:10, h:2.6,
    fontSize:72, bold:true, color:WHITE, fontFace:"Calibri", align:"center", valign:"middle"
  });
}

// ── WRITE ────────────────────────────────────────────────────────
pres.writeFile({ fileName: "/home/daytona/workspace/ricin-ppt/Castor_Poisoning_v7.pptx" })
  .then(() => console.log("SUCCESS"))
  .catch(err => { console.error(err); process.exit(1); });

cd /home/daytona/workspace/ricin-ppt && node build_v7.js 2>&1

cp /home/daytona/workspace/ricin-ppt/Castor_Poisoning_v7.pptx /tmp/v7.pptx && li…

# Green castor leaf curl -L -s --max-time 25 "https://upload.wikimedia.org/wikip…

# Seeds PNG too small (blocked), try alternate curl -L -s --max-time 25 "https:/…

node -e " const fs = require('fs'); const out = { plant: 'image/jpeg;base6…

# /tmp gets cleared between sessions - re-download plant image curl -L -s --max-…

~/ricin-ppt/build_v8.js

const pptxgen = require("pptxgenjs");
const IMGS = JSON.parse(require("fs").readFileSync("/tmp/castor_imgs_final.json","utf8"));
const pres = new pptxgen();
pres.layout = "LAYOUT_16x9";
pres.title = "Castor Poisoning";

const BLUE   = "1565C0";
const LBLUE  = "E3F2FD";
const WHITE  = "FFFFFF";
const BLACK  = "1A1A1A";
const GRAY   = "F5F5F5";
const RED    = "B71C1C";
const LRED   = "FFEBEE";
const GREEN  = "1B5E20";
const TEAL   = "004D40";
const ORANGE = "E65100";
const PURPLE = "4A148C";

function bg(sl, color) {
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}
function hbar(sl, title, c) {
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}
// Simple line-by-line renderer — avoids text overflow
function L(sl, items, x, startY, w, fs, gap) {
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      fontSize: fs, bold, color,
      fontFace:"Calibri", valign:"top", wrap:true, italic:!!item.italic,
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    y += lineH + g;
  });
}

// ── SLIDE 1 — TITLE ──────────────────────────────────────────────
{
  const sl = pres.addSlide();
  bg(sl, LBLUE);
  sl.addShape(pres.ShapeType.rect,{x:0,y:0,w:10,h:3.05,fill:{color:BLUE},line:{color:BLUE,width:0}});
  sl.addShape(pres.ShapeType.rect,{x:0,y:3.05,w:10,h:0.08,fill:{color:"42A5F5"},line:{color:"42A5F5",width:0}});
  sl.addText("CASTOR POISONING",{x:0.5,y:0.18,w:9,h:1.55,fontSize:54,bold:true,color:WHITE,fontFace:"Calibri",align:"center"});
  sl.addText("Ricinus communis — Ricin Toxicology",{x:0.5,y:1.75,w:9,h:0.58,fontSize:20,color:"BBDEFB",fontFace:"Calibri",italic:true,align:"center"});
  sl.addText("Forensic Medicine & Toxicology",{x:0.5,y:2.45,w:9,h:0.4,fontSize:14,color:"BBDEFB",fontFace:"Calibri",align:"center"});
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  sl.addText("Guided by:",{x:0.5,y:3.35,w:4.5,h:0.42,fontSize:17,bold:true,color:BLUE,fontFace:"Calibri"});
  sl.addText("Resp. Dr. R.K. Singh Sir",{x:0.5,y:3.75,w:4.5,h:0.45,fontSize:20,bold:true,color:BLACK,fontFace:"Calibri"});
  sl.addText("Head of Department\nForensic Medicine & Toxicology",{x:0.5,y:4.2,w:4.5,h:0.65,fontSize:16,color:"37474F",fontFace:"Calibri"});
  sl.addText("Presented by:",{x:5.4,y:3.35,w:4.2,h:0.42,fontSize:17,bold:true,color:BLUE,fontFace:"Calibri"});
  sl.addText("Komal Rathore",{x:5.4,y:3.75,w:4.2,h:0.45,fontSize:24,bold:true,color:BLACK,fontFace:"Calibri"});
  sl.addText("Roll No. 106",{x:5.4,y:4.2,w:4.2,h:0.4,fontSize:17,color:"37474F",fontFace:"Calibri"});
}

// ── SLIDE 2 — INTRODUCTION (corrected) ───────────────────────────
// REMOVED: "Ricin is derived..." and "It belongs to the category..."
// REMOVED "Arand" from common names
{
  const sl = pres.addSlide();
  bg(sl, GRAY);
  hbar(sl, "Introduction", BLUE);
  L(sl, [
    {text:"Botanical Name:", bold:true, color:BLUE},
    {text:"Ricinus communis", sub:true, italic:true},
    "",
    {text:"Common Names:", bold:true, color:BLUE},
    {text:"Castor, Arandi", sub:true},
    "",
    {text:"The plant is widely distributed across India and found in tropical regions worldwide."},
    {text:"It is commonly found growing in wastelands, roadsides, and uncultivated lands."},
    {text:"It is an organic poisonous plant and belongs to the category of Gastrointestinal Irritants."},
  ], 0.4, 1.12, 9.2, 19);
}

// ── SLIDE 3 — FEATURES: PLANT ────────────────────────────────────
{
  const sl = pres.addSlide();
  bg(sl, GRAY);
  hbar(sl, "Features of the Plant", TEAL);
  L(sl, [
    {text:"Tall plant that grows all over India."},
    {text:"Especially found in wastelands and uncultivated areas."},
    {text:"Also seen along roadsides and open fields."},
  ], 0.4, 1.12, 5.0, 19);
  sl.addImage({data:IMGS.plant, x:5.55,y:1.1,w:4.1,h:3.9,sizing:{type:"contain",w:4.1,h:3.9}});
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  sl.addText("Ricinus communis — Castor Plant",{x:5.55,y:5.0,w:4.1,h:0.42,fontSize:12,bold:true,color:WHITE,fontFace:"Calibri",align:"center",valign:"middle"});
}

// ── SLIDE 4 — LEAVES (two images: green + reddish-purple) ─────────
// REMOVED: "Large, alternate leaves with long petioles."
// Two images side by side
{
  const sl = pres.addSlide();
  bg(sl, GRAY);
  hbar(sl, "Leaves", TEAL);
  L(sl, [
    {text:"Lobate (palm-shaped) with toothed (serrated) margins."},
    {text:"Green to reddish-purple in colour depending on variety."},
  ], 0.4, 1.12, 9.2, 20);

  // Two images side by side below the text
  sl.addImage({data:IMGS.leaf_green, x:0.4, y:2.3, w:4.4, h:2.85, sizing:{type:"contain",w:4.4,h:2.85}});
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  sl.addText("Green Castor Leaf",{x:0.4,y:5.15,w:4.4,h:0.38,fontSize:12,bold:true,color:WHITE,fontFace:"Calibri",align:"center",valign:"middle"});

  sl.addImage({data:IMGS.leaf_red, x:5.2, y:2.3, w:4.4, h:2.85, sizing:{type:"contain",w:4.4,h:2.85}});
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  sl.addText("Reddish-Purple Castor Leaf",{x:5.2,y:5.15,w:4.4,h:0.38,fontSize:12,bold:true,color:WHITE,fontFace:"Calibri",align:"center",valign:"middle"});
}

// ── SLIDE 5 — FRUIT ───────────────────────────────────────────────
{
  const sl = pres.addSlide();
  bg(sl, GRAY);
  hbar(sl, "Fruit", TEAL);
  L(sl, [
    {text:"1.2 to 2.5 cm long."},
    {text:"Globular in shape, three-lobed."},
    {text:"Softly spiny on the outer surface."},
    {text:"Blue-green or rose-red in colour when immature."},
    {text:"Turns brown and bristly when ripe and dry."},
  ], 0.4, 1.12, 9.2, 21);
}

// ── SLIDE 6 — SEEDS (corrected: removed "variable smooth flattened-oval", added close-up image) ──
{
  const sl = pres.addSlide();
  bg(sl, GRAY);
  hbar(sl, "Seeds", TEAL);
  L(sl, [
    {text:"Seeds are flattened-oval in shape and available in 2 sizes."},
    "",
    {text:"Large Seeds:", bold:true, color:BLUE},
    {text:"Mottled, dark-brown in colour.", sub:true},
    {text:"Shiny hard seed coat — called Pericarp.", sub:true},
    "",
    {text:"Small Seeds:", bold:true, color:GREEN},
    {text:"1 to 2 cm long and 0.8 cm broad in size.", sub:true},
    {text:"Closely resemble Croton seeds.", sub:true},
  ], 0.4, 1.12, 5.0, 18);
  sl.addImage({data:IMGS.seeds, x:5.55,y:1.1,w:4.1,h:3.9,sizing:{type:"contain",w:4.1,h:3.9}});
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}

// ── SLIDE 7 — TOXIC PRINCIPLE ─────────────────────────────────────
// Banner updated: added "and a powerful allergen"
// REMOVED: "The oil extract of seeds contains Ricinoleic Acid."
{
  const sl = pres.addSlide();
  bg(sl, GRAY);
  hbar(sl, "Toxic Principle", GREEN);
  sl.addShape(pres.ShapeType.rect,{x:0.35,y:1.08,w:9.3,h:0.58,fill:{color:LRED},line:{color:RED,width:1.5}});
  sl.addText("Entire plant is toxic — Seeds are the most toxic part (contain Ricin, a water-soluble glycoprotein) and a powerful allergen",{
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  });
  L(sl, [
    {text:"Seeds are rich in a purgative oil — pale-yellow with a faint odour and acrid taste."},
    {text:"The leftover seed cake after oil extraction contains the toxalbumin Ricin."},
    "",
    {text:"Important — Which forms are poisonous?", bold:true, color:GREEN},
    {text:"Unbroken seeds — Non-poisonous when swallowed or cooked.", sub:true},
    {text:"Castor oil — Non-poisonous.", sub:true},
    {text:"Crushed seeds — Poisonous.", sub:true},
    {text:"Ricin can exist in the form of powder, mist, or pellet.", sub:true},
  ], 0.4, 1.78, 9.2, 18);
}

// ── SLIDE 8 — TOXALBUMIN PROPERTIES ──────────────────────────────
// REMOVED: "Comparison with Other Toxins" section entirely
{
  const sl = pres.addSlide();
  bg(sl, GRAY);
  hbar(sl, "Toxalbumin (Ricin) — Properties", GREEN);
  L(sl, [
    {text:"Toxalbumin (Phytotoxin) is a toxic protein found in plants such as Castor, Croton, and Rati (Abrus precatorius)."},
    "",
    {text:"Properties:", bold:true, color:GREEN},
    {text:"Disables ribosomes and thereby inhibits protein synthesis.", sub:true},
    {text:"Antigenic in nature — capable of stimulating immune response.", sub:true},
    {text:"Agglutinates (clumps) red blood cells (RBCs).", sub:true},
    {text:"Causes haemolysis (destruction of RBCs) and cell destruction.", sub:true},
  ], 0.4, 1.12, 9.2, 19);
}

// ── SLIDE 9 — MECHANISM: STRUCTURE ───────────────────────────────
// REMOVED: "Effect of Chain A" heading + both bullets under it
{
  const sl = pres.addSlide();
  bg(sl, GRAY);
  hbar(sl, "Mechanism of Action — Structure of Ricin", PURPLE);
  sl.addShape(pres.ShapeType.rect,{x:0.35,y:1.08,w:9.3,h:0.58,fill:{color:"EDE7F6"},line:{color:PURPLE,width:1.5}});
  sl.addText("Ricin = Chain A (Toxic / Active)  +  Chain B (Binding)  —  connected by a Disulfide Bond",{
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  });
  L(sl, [
    {text:"In the Gastrointestinal Tract:", bold:true, color:PURPLE},
    {text:"Chain B binds to galactose-containing receptors on cell membrane (glycoproteins and glycolipids).", sub:true},
    {text:"Chain A enters into the cytoplasm of the cell.", sub:true},
  ], 0.4, 1.78, 9.2, 19);
}

// ── SLIDE 10 — MECHANISM: STEP BY STEP ───────────────────────────
{
  const sl = pres.addSlide();
  bg(sl, GRAY);
  hbar(sl, "Mechanism of Action — Step by Step", PURPLE);
  const steps = [
    {num:"1",title:"Binding",      color:"4527A0", desc:"Chain B binds to galactose receptors on cell membrane."},
    {num:"2",title:"Cell Entry",   color:"283593", desc:"Endocytosis → Endosomes → Golgi Apparatus → Endoplasmic Reticulum."},
    {num:"3",title:"Translocation",color:"0277BD", desc:"Chain A separates in the ER and moves into the cytosol."},
    {num:"4",title:"Ribosome Damage",color:RED,    desc:"Chain A inactivates 28S rRNA of 60S ribosomal subunit → irreversible inhibition of protein synthesis."},
    {num:"5",title:"Cell Death",   color:RED,      desc:"Failure of protein synthesis → cell cannot survive → cytotoxic cell death."},
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// ── SLIDE 11 — CLINICAL: ROUTES & DUST ───────────────────────────
{
  const sl = pres.addSlide();
  bg(sl, GRAY);
  hbar(sl, "Clinical Features — Routes & Dust", ORANGE);
  L(sl, [
    {text:"Routes of Absorption:", bold:true, color:ORANGE},
    {text:"Inhalation", sub:true},
    {text:"Ingestion", sub:true},
    {text:"Injection", sub:true},
    {text:"Skin Contact", sub:true},
    "",
    {text:"Dust of Seeds:", bold:true, color:ORANGE},
    {text:"Watering of the eyes (Lacrimation)", sub:true},
    {text:"Conjunctivitis", sub:true},
    {text:"Sneezing", sub:true},
    {text:"Acute nasal inflammation (Rhinitis)", sub:true},
    {text:"Headache", sub:true},
    {text:"Pharyngitis (throat inflammation)", sub:true},
    {text:"Asthmatic bronchitis", sub:true},
    {text:"Dermatitis (skin inflammation)", sub:true},
    {text:"Gastric upset", sub:true},
  ], 0.4, 1.12, 9.2, 17);
}

// ── SLIDE 12 — INHALATION ────────────────────────────────────────
{
  const sl = pres.addSlide();
  bg(sl, GRAY);
  hbar(sl, "Inhalation Exposure", ORANGE);
  L(sl, [
    {text:"Redness and pain in the eyes and throat"},
    {text:"Dyspnoea (difficulty in breathing)"},
    {text:"Wheezing"},
    {text:"Respiratory distress"},
    {text:"Fever"},
    {text:"Cough"},
    {text:"Tightness in the chest"},
    {text:"Sweating"},
    {text:"Pulmonary Oedema (fluid accumulation in the lungs)"},
  ], 0.4, 1.12, 9.2, 19);
}

// ── SLIDE 13 — ORAL INGESTION Part 1 ─────────────────────────────
{
  const sl = pres.addSlide();
  bg(sl, GRAY);
  hbar(sl, "Oral Ingestion — Crushed Seeds", RED);
  sl.addText("When crushed seeds are ingested, the following clinical features are produced:",{
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  });
  L(sl, [
    {text:"Abdominal pain"},
    {text:"Vomiting and diarrhoea with or without blood"},
    {text:"Haematemesis (vomiting blood) and Melaena (black stools)"},
    {text:"Dehydration"},
    {text:"Circulatory collapse"},
    {text:"Muscular pain and cramps in the limbs"},
    {text:"Convulsions"},
  ], 0.4, 1.6, 9.2, 18);
}

// ── SLIDE 14 — ORAL INGESTION Part 2 (with handwritten additions) ─
{
  const sl = pres.addSlide();
  bg(sl, GRAY);
  hbar(sl, "Oral Ingestion — continued", RED);
  L(sl, [
    {text:"Drowsiness and Delirium"},
    {text:"Jaundice"},
    {text:"Hepatic failure (liver failure)"},
    {text:"Oliguria (reduced urine output)"},
    {text:"Uraemia (accumulation of waste products in blood)"},
    "",
    {text:"Death may be due to Multiorgan Failure or Cardiovascular Collapse.", bold:true, color:RED},
  ], 0.4, 1.12, 9.2, 20);
}

// ── SLIDE 15 — INJECTION ─────────────────────────────────────────
{
  const sl = pres.addSlide();
  bg(sl, GRAY);
  hbar(sl, "Injection Exposure", RED);
  L(sl, [
    {text:"Injection Manifestations:", bold:true, color:RED},
    {text:"Pain at the injection site", sub:true},
    {text:"Erythema (redness) and induration", sub:true},
    {text:"Localised necrosis at injection site", sub:true},
    {text:"Muscular pain", sub:true},
    {text:"Capillary leak syndrome", sub:true},
    {text:"Circulatory collapse", sub:true},
    {text:"Convulsions", sub:true},
    {text:"Multiorgan failure", sub:true},
    {text:"Respiratory failure", sub:true},
  ], 0.4, 1.12, 9.2, 19);
}

// ── SLIDE 16 — FATAL DOSE (corrected from handwriting) ───────────
{
  const sl = pres.addSlide();
  bg(sl, GRAY);
  hbar(sl, "Fatal Dose", RED);
  L(sl, [
    {text:"5 to 10 seeds", bold:true, color:RED},
    {text:"1 mg/kg body weight", bold:true, color:RED},
    {text:"Fatal Period: 2 days to a few days", bold:true, color:RED},
  ], 0.4, 1.12, 9.2, 26);
}

// ── SLIDE 17 — MANAGEMENT (corrected) ────────────────────────────
// REMOVED: "2 to 5g Sodium Bicarbonate", "Blood transfusion", "Gastric lavage followed by..."
// REMOVED: "Supportive Treatment" + "Management of shock"
// ADDED: "and administration of activated charcoal" after gastric lavage line
{
  const sl = pres.addSlide();
  bg(sl, GRAY);
  hbar(sl, "Management", BLUE);
  sl.addShape(pres.ShapeType.rect,{x:0.35,y:1.08,w:9.3,h:0.5,fill:{color:LRED},line:{color:RED,width:1.5}});
  sl.addText("NO SPECIFIC ANTIDOTE AVAILABLE — Treatment is purely supportive",{
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  });
  L(sl, [
    {text:"In Case of Ingestion:", bold:true, color:BLUE},
    {text:"Gastric lavage (stomach wash) and administration of activated charcoal.", sub:true},
    {text:"Administration of Emetics and Demulcents.", sub:true},
    {text:"Administration of Glucose and Saline intravenously.", sub:true},
    "",
    {text:"Supportive Treatment:", bold:true, color:BLUE},
    {text:"Correction of electrolyte abnormalities.", sub:true},
    {text:"Treatment of convulsions.", sub:true},
  ], 0.4, 1.7, 9.2, 19);
}

// ── SLIDE 18 — AUTOPSY FINDINGS ──────────────────────────────────
// Organ heading corrected to "Lung, Liver, Kidney, Spleen"
{
  const sl = pres.addSlide();
  bg(sl, GRAY);
  hbar(sl, "Autopsy Findings", "37474F");
  L(sl, [
    {text:"Gastrointestinal Tract:", bold:true, color:"37474F"},
    {text:"The mucosa is congested, softened, and inflamed.", sub:true},
    {text:"Occasional erosions and submucous haemorrhages are present.", sub:true},
    {text:"Fragments of seeds may be found in the stomach and intestines.", sub:true},
    "",
    {text:"Heart:", bold:true, color:"37474F"},
    {text:"Dilation of the heart chambers is observed.", sub:true},
    {text:"Haemorrhages are present in the pleura.", sub:true},
    "",
    {text:"Lung, Liver, Kidney, Spleen:", bold:true, color:"37474F"},
    {text:"Oedema (swelling) and congestion of all these organs.", sub:true},
    {text:"Reflects multiorgan involvement as a result of systemic ricin toxicity.", sub:true},
  ], 0.4, 1.12, 9.2, 17);
}

// ── SLIDE 19 — MEDICOLEGAL IMPORTANCE ────────────────────────────
// Homicidal Use: replaced old text with "Rarely the powdered seeds are given for homicide."
// Added new bullet: "Ricin can be used as an agent of biological warfare or a weapon of mass destruction."
// Anaphylactic: added "Conjunctivitis" at end
{
  const sl = pres.addSlide();
  bg(sl, GRAY);
  hbar(sl, "Medicolegal Importance", "880E4F");
  L(sl, [
    {text:"Accidental Poisoning:", bold:true, color:"880E4F"},
    {text:"Common in children while playing or exploring the plant and its seeds.", sub:true},
    "",
    {text:"Homicidal Use:", bold:true, color:RED},
    {text:"Rarely the powdered seeds are given for homicide.", sub:true},
    "",
    {text:"Criminal Abortion:", bold:true, color:RED},
    {text:"Seed pulp has been used to procure criminal abortion.", sub:true},
    "",
    {text:"Ricin can be used as an agent of biological warfare or a weapon of mass destruction.", bold:true, color:RED},
    "",
    {text:"Anaphylactic Hypersensitivity:", bold:true, color:"880E4F"},
    {text:"Can cause anaphylactic type of hypersensitivity reactions in humans.", sub:true},
    {text:"Allergenic glycoprotein causes Dermatitis, Rhinitis, Asthma, and Conjunctivitis.", sub:true},
  ], 0.4, 1.12, 9.2, 17);
}

// ── SLIDE 20 — GEORGI MARKOV CASE ────────────────────────────────
// Title word before "Case" crossed out — title is now "Case — Georgi Markov (1978)"
{
  const sl = pres.addSlide();
  bg(sl, GRAY);
  hbar(sl, "Case — Georgi Markov (1978)", "880E4F");
  sl.addShape(pres.ShapeType.rect,{x:0.35,y:1.15,w:9.3,h:4.2,fill:{color:"FCE4EC"},line:{color:"E91E63",width:1.5}});
  sl.addText([
    {text:"Georgi Markov",options:{bold:true,color:RED}},
    {text:" was a Bulgarian dissident and journalist.\n\n",options:{color:BLACK,breakLine:true}},
    {text:"In 1978 in London, he was attacked by a man with a specially rigged ",options:{color:BLACK}},
    {text:"umbrella",options:{bold:true,color:RED}},
    {text:" that injected a tiny ",options:{color:BLACK}},
    {text:"ricin-laced pellet",options:{bold:true,color:RED}},
    {text:" under the skin of his thigh.\n\n",options:{color:BLACK,breakLine:true}},
    {text:"He died 3 days after the attack.\n\n",options:{bold:true,color:RED,breakLine:true}},
    {text:"This case remains one of the most documented examples of ricin being used as a covert assassination weapon.",options:{color:BLACK}},
  ],{x:0.6,y:1.25,w:8.9,h:4.0,fontSize:16,fontFace:"Calibri",valign:"top",paraSpaceAfter:4});
}

// ── SLIDE 21 — LABORATORY DIAGNOSIS (corrected) ──────────────────
// "Ricinine Detection" — first bullet removed (alkaloid description)
{
  const sl = pres.addSlide();
  bg(sl, GRAY);
  hbar(sl, "Laboratory Diagnosis", TEAL);
  L(sl, [
    {text:"Liquid Chromatography-Mass Spectrometry (LC-MS):", bold:true, color:TEAL},
    {text:"Gold-standard confirmatory test for detection of Ricin.", sub:true},
    "",
    {text:"Immunoassays:", bold:true, color:TEAL},
    {text:"ELISA and similar immunological tests are used.", sub:true},
    "",
    {text:"Ricinine Detection:", bold:true, color:TEAL},
    {text:"Can be detected in both serum and urine samples.", sub:true},
    {text:"Comprehensive untargeted urine drug screening is highly valuable for diagnosis.", sub:true},
    "",
    {text:"Ricin-Antibody Conjugates:", bold:true, color:TEAL},
    {text:"Detectable in surviving patients approximately 2 weeks after exposure.", sub:true},
  ], 0.4, 1.12, 9.2, 18);
}

// ── SLIDE 22 — REFERENCES (publishers removed) ───────────────────
// All publisher names crossed out → removed
// Bardale: "Principles" added (handwritten)
{
  const sl = pres.addSlide();
  bg(sl, LBLUE);
  sl.addShape(pres.ShapeType.rect,{x:0,y:0,w:10,h:1.2,fill:{color:BLUE},line:{color:BLUE,width:0}});
  sl.addShape(pres.ShapeType.rect,{x:0,y:1.2,w:10,h:0.07,fill:{color:"42A5F5"},line:{color:"42A5F5",width:0}});
  sl.addText("REFERENCES",{x:0.5,y:0,w:9,h:1.2,fontSize:38,bold:true,color:WHITE,fontFace:"Calibri",align:"center",valign:"middle"});

  const refs = [
    {num:"1.", author:"Gautam Biswas",        title:"Textbook of Forensic Medicine & Toxicology"},
    {num:"2.", author:"K.S. Narayan Reddy",   title:"The Essentials of Forensic Medicine & Toxicology"},
    {num:"3.", author:"Rajesh Bardale",        title:"Principles of Forensic Medicine & Toxicology"},
  ];
  refs.forEach((ref,i) => {
    const y = 1.45 + i*1.35;
    sl.addShape(pres.ShapeType.rect,{x:0.4,y,w:9.2,h:0.04,fill:{color:BLUE},line:{color:BLUE,width:0}});
    sl.addText(ref.num+"  "+ref.author,{x:0.4,y:y+0.1,w:9.2,h:0.52,fontSize:22,bold:true,color:BLUE,fontFace:"Calibri"});
    sl.addText(ref.title,{x:0.4,y:y+0.62,w:9.2,h:0.42,fontSize:17,color:"37474F",fontFace:"Calibri",italic:true});
  });
}

// ── SLIDE 23 — THANK YOU (only — all crossed-out text removed) ────
{
  const sl = pres.addSlide();
  bg(sl, BLUE);
  sl.addText("THANK YOU",{
    x:0,y:1.5,w:10,h:2.6,
    fontSize:72,bold:true,color:WHITE,fontFace:"Calibri",align:"center",valign:"middle"
  });
}

pres.writeFile({fileName:"/home/daytona/workspace/ricin-ppt/Castor_Poisoning_v8.pptx"})
  .then(()=>console.log("SUCCESS"))
  .catch(err=>{console.error(err);process.exit(1);});

cd /home/daytona/workspace/ricin-ppt && node build_v8.js 2>&1

curl -L -s --max-time 25 "https://upload.wikimedia.org/wikipedia/commons/9/91/Ri…

# Red leaf and seeds returning 1967 bytes (blocked by Wikimedia). Try alternate …

node -e " const fs = require('fs'); const out = { plant: 'image/jpeg;base…

cd /home/daytona/workspace/ricin-ppt && node build_v8.js 2>&1

cp /home/daytona/workspace/ricin-ppt/Castor_Poisoning_v8.pptx /tmp/v8.pptx && li…