The S wave decreases from V1 to V6 because the chest leads progressively move from the right side of the heart toward the left ventricle.
This reflects the fact that the
left ventricle has much greater muscle mass than the right ventricle and therefore dominates the net QRS vector. A persistent deep S wave in V5-V6 can indicate an abnormality such as right bundle branch block, right ventricular hypertrophy, or abnormal lead placement, but must be interpreted with the full ECG.
ECG progression overview