If a UTI has reached the kidney, it is called
acute pyelonephritis. It needs medical assessment and a
urine culture before the first antibiotic dose whenever possible, so the antibiotic can be changed to match the bacteria’s susceptibility. The
NICE pyelonephritis guidance recommends this approach.
How antibiotics are given
1. Mild kidney infection, person is stable
A clinician may prescribe an oral antibiotic if the person can drink fluids and swallow tablets, has no signs of sepsis, and can be reviewed promptly. The exact choice depends on:
- Local antibiotic-resistance patterns
- Urine culture results
- Allergy history
- Pregnancy status
- Kidney function
- Recent antibiotic use
Common oral options in guidelines include certain cephalosporins, trimethoprim-sulfamethoxazole only when the organism is known to be susceptible, or a fluoroquinolone only when appropriate. Treatment is generally longer than for a simple bladder UTI, often about 7 to 14 days, depending on the medicine and clinical situation.
2. Severe illness or unable to take tablets
Hospital treatment is needed if there is high fever with marked illness, vomiting, dehydration, low blood pressure, confusion, pregnancy, suspected obstruction/stone, immune suppression, or failure to improve. Antibiotics are then given into a vein (IV), often with IV fluids. Examples used in hospitals include IV ceftriaxone, cefuroxime, or other broader agents selected for the patient and local resistance pattern. Once the person is improving and culture results are known, treatment is usually changed to an appropriate oral antibiotic.
3. If kidney function is reduced
The clinician checks creatinine/eGFR and adjusts the dose or interval for medicines cleared by the kidneys. Some agents need close monitoring because they can affect kidneys, particularly aminoglycosides such as gentamicin. Do not self-start antibiotics or use leftover tablets in this situation.
Important: antibiotics that should not be used alone for kidney infection
Nitrofurantoin and single-dose fosfomycin can be useful for some uncomplicated bladder infections, but they do not achieve adequate tissue levels in the kidney for pyelonephritis. They are not appropriate treatment for a suspected kidney infection.
When urgent care is needed
Go to urgent care or an emergency department today if there is:
- Fever or shaking chills
- Pain in the side or back below the ribs
- Vomiting or inability to keep fluids/medicine down
- Feeling faint, very weak, confused, or short of breath
- Pregnancy
- Known kidney disease, a kidney stone, catheter, transplant, diabetes with severe illness, or immune suppression
- No improvement within 48 hours after antibiotics start
Kidney infection with a blocked urinary tract is an emergency: antibiotics alone may fail until the obstruction is drained. Imaging is considered if obstruction is suspected, the person is septic, or there is no response after 48 to 72 hours, as outlined in this
clinical evidence review.