Orris

Craeye a mind map that cannot be forgeteb for antiadrenergic drugs

Reading File
Now let me search the medical library for comprehensive antiadrenergic drug information in parallel:
Finding Sources
Finding Sources
Finding Sources
Finding Sources
Finding Sources
Finding Sources
Finding Sources
Finding Sources
The medical library doesn't have a dedicated antiadrenergic section. I have strong pharmacology knowledge on this topic - let me now create the mind map using the PPTX skill for a visually memorable output.
Reading File
Reading File
Now I have everything I need to create an unforgettable mind map for antiadrenergic drugs. Let me build it as a visually rich PPTX presentation.
Running Command

ls -la /home/daytona/workspace/ 2>/dev/null && mkdir -p /home/daytona/workspace/antiadrenergic-mindmap

Writing File

~/antiadrenergic-mindmap/build.js

const pptxgen = require("pptxgenjs");
const pres = new pptxgen();
pres.layout = "LAYOUT_WIDE"; // 13.3" x 7.5"
pres.title = "Antiadrenergic Drugs Mind Map";

// ─── COLOUR PALETTE ───────────────────────────────────────────────────────────
const C = {
  bg:        "0D1117",   // near-black background
  bgCard:    "161B22",   // card background
  accent:    "58A6FF",   // vivid blue – central hub
  alpha:     "FF7B72",   // coral-red – alpha blockers
  beta:      "3FB950",   // green – beta blockers
  central:   "D2A8FF",   // lavender – centrally acting
  pregang:   "FFA657",   // amber – ganglionic / presynaptic
  text:      "E6EDF3",   // light text
  textDim:   "8B949E",   // dim secondary text
  gold:      "F8E45C",   // mnemonic highlights
  white:     "FFFFFF",
};

// ─── HELPER ───────────────────────────────────────────────────────────────────
function pill(slide, txt, x, y, w, h, fillColor, textColor, fontSize = 9, bold = false) {
  slide.addShape(pres.ShapeType.roundRect, {
    x, y, w, h,
    fill: { color: fillColor },
    line: { color: fillColor },
    rectRadius: 0.08,
  });
  slide.addText(txt, {
    x, y, w, h,
    fontSize, color: textColor, bold,
    align: "center", valign: "middle", margin: 4,
  });
}

function connector(slide, x1, y1, x2, y2, color = "4D5662") {
  slide.addShape(pres.ShapeType.line, {
    x: x1, y: y1, w: x2 - x1, h: y2 - y1,
    line: { color, width: 1.2, dashType: "solid" },
  });
}

// ══════════════════════════════════════════════════════════════════════════════
// SLIDE 1 β€” MASTER OVERVIEW MIND MAP
// ══════════════════════════════════════════════════════════════════════════════
{
  const slide = pres.addSlide();

  // ── Background ──────────────────────────────────────────────────────────────
  slide.addShape(pres.ShapeType.rect, {
    x: 0, y: 0, w: 13.3, h: 7.5,
    fill: { color: C.bg },
    line: { color: C.bg },
  });

  // ── Title banner ────────────────────────────────────────────────────────────
  slide.addShape(pres.ShapeType.rect, {
    x: 3.5, y: 0.08, w: 6.3, h: 0.6,
    fill: { color: "161B22" },
    line: { color: C.accent, width: 1.5 },
  });
  slide.addText("ANTIADRENERGIC DRUGS  β€”  MASTER MIND MAP", {
    x: 3.5, y: 0.08, w: 6.3, h: 0.6,
    fontSize: 13, color: C.accent, bold: true,
    align: "center", valign: "middle",
  });

  // ── Centre hub ──────────────────────────────────────────────────────────────
  const cx = 6.65, cy = 3.75;
  slide.addShape(pres.ShapeType.ellipse, {
    x: cx - 0.85, y: cy - 0.42, w: 1.7, h: 0.84,
    fill: { color: C.accent },
    line: { color: C.white, width: 1.5 },
  });
  slide.addText("ANTI-\nADRENERGIC", {
    x: cx - 0.85, y: cy - 0.42, w: 1.7, h: 0.84,
    fontSize: 10, color: C.bg, bold: true,
    align: "center", valign: "middle",
  });

  // ─────────────────────────────────────────────────────────────────────────
  // BRANCH 1 β€” Ξ± BLOCKERS  (top-left)
  // ─────────────────────────────────────────────────────────────────────────
  pill(slide, "Ξ±-BLOCKERS", 0.25, 0.78, 2.0, 0.45, C.alpha, C.white, 11, true);
  connector(slide, 2.25, 1.0, cx - 0.85, cy - 0.1, C.alpha);

  // Non-selective
  pill(slide, "Non-Selective  Ξ±1+Ξ±2", 0.15, 1.42, 2.2, 0.36, "3D1A19", C.alpha, 8.5, true);
  slide.addText([
    { text: "Phentolamine", options: { breakLine: true } },
    { text: "Phenoxybenzamine (irreversible)", options: { breakLine: true } },
  ], { x: 0.2, y: 1.84, w: 2.1, h: 0.55, fontSize: 8, color: C.text });

  // Selective Ξ±1
  pill(slide, "Selective  Ξ±1  Blockers", 0.15, 2.46, 2.2, 0.36, "3D1A19", C.alpha, 8.5, true);
  slide.addText([
    { text: "Prazosin  (prototype, 1st gen)", options: { breakLine: true } },
    { text: "Terazosin, Doxazosin (long-acting)", options: { breakLine: true } },
    { text: "Tamsulosin, Alfuzosin (uroselective)", options: { breakLine: true } },
    { text: "Silodosin (most uroselective)", options: {} },
  ], { x: 0.2, y: 2.88, w: 2.1, h: 0.72, fontSize: 7.8, color: C.text });

  // Uses
  pill(slide, "Uses", 0.15, 3.68, 1.1, 0.3, "2A1717", C.gold, 8, true);
  slide.addText("HTN β€’ BPH β€’ Pheochromocytoma\nRaynaud β€’ PTSD (prazosin)", {
    x: 1.32, y: 3.68, w: 1.1, h: 0.42, fontSize: 7.5, color: C.textDim,
  });

  // ADRs
  pill(slide, "ADRs", 0.15, 4.18, 1.1, 0.3, "2A1717", C.gold, 8, true);
  slide.addText("1st-dose syncope β€’ Reflex tachycardia\nNasal congestion β€’ Sexual dysfunction", {
    x: 1.32, y: 4.18, w: 1.1, h: 0.42, fontSize: 7.5, color: C.textDim,
  });

  // ─────────────────────────────────────────────────────────────────────────
  // BRANCH 2 β€” Ξ² BLOCKERS  (top-right)
  // ─────────────────────────────────────────────────────────────────────────
  pill(slide, "Ξ²-BLOCKERS", 11.1, 0.78, 2.0, 0.45, C.beta, C.white, 11, true);
  connector(slide, 11.1, 1.0, cx + 0.85, cy - 0.1, C.beta);

  // Non-selective
  pill(slide, "Non-Selective  Ξ²1+Ξ²2", 11.0, 1.42, 2.2, 0.36, "162618", C.beta, 8.5, true);
  slide.addText("Propranolol, Nadolol, Timolol\nPindolol (+ ISA)", {
    x: 11.05, y: 1.84, w: 2.15, h: 0.42, fontSize: 8, color: C.text,
  });

  // Cardioselective
  pill(slide, "Cardioselective  Ξ²1", 11.0, 2.34, 2.2, 0.36, "162618", C.beta, 8.5, true);
  slide.addText("Metoprolol, Atenolol\nBisoprolol, Esmolol (IV, ultra-short)\nBetaxolol", {
    x: 11.05, y: 2.76, w: 2.15, h: 0.5, fontSize: 8, color: C.text,
  });

  // Mixed Ξ±+Ξ²
  pill(slide, "Mixed Ξ±+Ξ²  Blockers", 11.0, 3.34, 2.2, 0.36, "162618", C.beta, 8.5, true);
  slide.addText("Labetalol (IV in HTN emergency)\nCarvedilol (HF, anti-oxidant)", {
    x: 11.05, y: 3.76, w: 2.15, h: 0.4, fontSize: 8, color: C.text,
  });

  // Uses
  pill(slide, "Uses", 11.0, 4.24, 1.1, 0.3, "0E1F0E", C.gold, 8, true);
  slide.addText("HTN β€’ Angina β€’ MI (mortality ↓)\nHF β€’ Arrhythmia β€’ Glaucoma\nHyperthyroidism β€’ Migraine prophylaxis", {
    x: 12.15, y: 4.24, w: 1.0, h: 0.55, fontSize: 7.5, color: C.textDim,
  });

  // ADRs
  pill(slide, "ADRs", 11.0, 4.88, 1.1, 0.3, "0E1F0E", C.gold, 8, true);
  slide.addText("Bronchoconstriction (Ξ²2)\nMask hypoglycaemia\nFatigue β€’ Cold extremities\nAbrupt withdrawal β†’ rebound", {
    x: 12.15, y: 4.88, w: 1.0, h: 0.55, fontSize: 7.5, color: C.textDim,
  });

  // ─────────────────────────────────────────────────────────────────────────
  // BRANCH 3 β€” CENTRALLY ACTING  (bottom-left)
  // ─────────────────────────────────────────────────────────────────────────
  pill(slide, "CENTRALLY ACTING", 0.2, 5.65, 2.4, 0.45, C.central, C.bg, 10, true);
  connector(slide, 2.6, 5.88, cx - 0.85, cy + 0.42, C.central);

  slide.addText([
    { text: "Clonidine", options: { bold: true, color: C.central, breakLine: true } },
    { text: "Ξ±2 agonist ↓ central sympathetic outflow", options: { breakLine: true } },
    { text: "Uses: HTN, opioid withdrawal, ADHD", options: { breakLine: true } },
    { text: "ADR: Rebound HTN on withdrawal", options: { breakLine: true, color: "FF6B6B" } },
  ], { x: 0.2, y: 6.16, w: 2.5, h: 0.9, fontSize: 7.8, color: C.textDim });

  slide.addText([
    { text: "Methyldopa", options: { bold: true, color: C.central, breakLine: true } },
    { text: "β†’ Ξ±-methylnorepinephrine (false TX)", options: { breakLine: true } },
    { text: "Drug of choice: Pregnancy HTN", options: { breakLine: true } },
    { text: "ADR: Haemolytic anaemia, sedation", options: { color: "FF6B6B" } },
  ], { x: 2.85, y: 6.16, w: 2.4, h: 0.9, fontSize: 7.8, color: C.textDim });

  // ─────────────────────────────────────────────────────────────────────────
  // BRANCH 4 β€” GANGLIONIC + PRESYNAPTIC  (bottom-right)
  // ─────────────────────────────────────────────────────────────────────────
  pill(slide, "GANGLIONIC / PRESYNAPTIC", 10.4, 5.65, 2.8, 0.45, C.pregang, C.bg, 10, true);
  connector(slide, 10.4, 5.88, cx + 0.85, cy + 0.42, C.pregang);

  slide.addText([
    { text: "Reserpine", options: { bold: true, color: C.pregang, breakLine: true } },
    { text: "Depletes NE/DA/5-HT from vesicles", options: { breakLine: true } },
    { text: "ADR: Depression, Parkinsonism, Sedation", options: { breakLine: true, color: "FF6B6B" } },
  ], { x: 10.4, y: 6.16, w: 2.4, h: 0.75, fontSize: 7.8, color: C.textDim });

  slide.addText([
    { text: "Guanethidine", options: { bold: true, color: C.pregang, breakLine: true } },
    { text: "Blocks NE release from sympathetic terminals", options: { breakLine: true } },
    { text: "ADR: Orthostatic hypotension, diarrhoea", options: { color: "FF6B6B" } },
  ], { x: 10.4, y: 6.92, w: 2.7, h: 0.52, fontSize: 7.8, color: C.textDim });

  // ─────────────────────────────────────────────────────────────────────────
  // MNEMONIC STRIP (centre-bottom)
  // ─────────────────────────────────────────────────────────────────────────
  slide.addShape(pres.ShapeType.rect, {
    x: 3.5, y: 6.86, w: 6.3, h: 0.55,
    fill: { color: "1C2130" },
    line: { color: C.gold, width: 1 },
  });
  slide.addText([
    { text: "✦ MNEMONIC  ", options: { bold: true, color: C.gold } },
    { text: '"A', options: { bold: true, color: C.alpha } },
    { text: "lpha blocks β†’ ", options: { color: C.text } },
    { text: "A", options: { bold: true, color: C.gold } },
    { text: "ction on vessels (vasoD) | ", options: { color: C.text } },
    { text: "B", options: { bold: true, color: C.beta } },
    { text: "eta blocks β†’ ", options: { color: C.text } },
    { text: "B", options: { bold: true, color: C.gold } },
    { text: 'eat & BP ↓"', options: { color: C.text } },
  ], {
    x: 3.5, y: 6.86, w: 6.3, h: 0.55,
    fontSize: 9, align: "center", valign: "middle",
  });

  // ─────────────────────────────────────────────────────────────────────────
  // Legend dots
  // ─────────────────────────────────────────────────────────────────────────
  const legend = [
    [C.alpha, "Ξ±-Blockers"],
    [C.beta, "Ξ²-Blockers"],
    [C.central, "Centrally Acting"],
    [C.pregang, "Ganglionic/Presynaptic"],
  ];
  legend.forEach(([col, lbl], i) => {
    const lx = 3.6 + i * 1.58;
    slide.addShape(pres.ShapeType.ellipse, { x: lx, y: 0.83, w: 0.15, h: 0.15, fill: { color: col }, line: { color: col } });
    slide.addText(lbl, { x: lx + 0.2, y: 0.8, w: 1.35, h: 0.22, fontSize: 7.5, color: C.textDim });
  });
}

// ══════════════════════════════════════════════════════════════════════════════
// SLIDE 2 β€” Ξ²-BLOCKERS  DEEP-DIVE
// ══════════════════════════════════════════════════════════════════════════════
{
  const slide = pres.addSlide();
  slide.addShape(pres.ShapeType.rect, { x:0, y:0, w:13.3, h:7.5, fill:{color:C.bg}, line:{color:C.bg} });

  // Header
  slide.addShape(pres.ShapeType.rect, { x:0, y:0, w:13.3, h:0.72, fill:{color:C.beta}, line:{color:C.beta} });
  slide.addText("Ξ²-BLOCKERS  β€”  DEEP DIVE", {
    x:0, y:0, w:13.3, h:0.72, fontSize:18, color:C.bg, bold:true, align:"center", valign:"middle",
  });

  // ── Column helper ──────────────────────────────────────────────────────────
  function col(slide, title, x, w, items, titleColor) {
    slide.addShape(pres.ShapeType.rect, { x, y:0.82, w, h:0.38, fill:{color:"1F2933"}, line:{color:titleColor, width:1} });
    slide.addText(title, { x, y:0.82, w, h:0.38, fontSize:9.5, color:titleColor, bold:true, align:"center", valign:"middle" });
    items.forEach(([label, val, accent], idx) => {
      const iy = 1.32 + idx * 0.52;
      slide.addShape(pres.ShapeType.rect, { x, y:iy, w, h:0.46, fill:{color:"161B22"}, line:{color:"2D333B"} });
      slide.addText([
        { text: label + "  ", options: { bold: true, color: accent || titleColor } },
        { text: val, options: { color: C.text } },
      ], { x:x+0.08, y:iy+0.04, w:w-0.16, h:0.38, fontSize:8, valign:"top" });
    });
  }

  col(slide, "NON-SELECTIVE (Ξ²1+Ξ²2)", 0.2, 3.9, [
    ["Propranolol", "Prototype β€’ Lipophilic (crosses BBB)\nMetabolism: Hepatic (high first-pass)", C.beta],
    ["Nadolol", "Long-acting β€’ Hydrophilic\nRenal excretion", C.beta],
    ["Timolol", "Glaucoma (topical) β€’ Used post-MI", C.beta],
    ["Pindolol", "Has ISA (intrinsic sympathomimetic activity)\n→ Less bradycardia", C.beta],
    ["Sotalol", "Class II + III antiarrhythmic\nProlongs QT interval", C.beta],
    ["Carteolol", "Has ISA β€’ Topical glaucoma", C.beta],
  ], C.beta);

  col(slide, "CARDIOSELECTIVE (Ξ²1)", 4.3, 3.9, [
    ["Metoprolol", "Most used β€’ Tartrate (IR) / Succinate (XL)\nFor HF: Succinate only (MERIT-HF trial)", C.beta],
    ["Atenolol", "Hydrophilic β€’ Renal excretion\nNo CNS effects", C.beta],
    ["Bisoprolol", "Highly selective Ξ²1\nFor HF (CIBIS-II trial)", C.beta],
    ["Esmolol", "IV only β€’ Ultra-short tΒ½ 9 min\nIntra-op HTN, SVT", C.beta],
    ["Nebivolol", "Highest β1 selectivity + NO release\n→ Vasodilation", C.beta],
    ["Betaxolol", "Selective Ξ²1 β€’ Topical (glaucoma)", C.beta],
  ], C.beta);

  col(slide, "MIXED Ξ±+Ξ²", 8.4, 2.3, [
    ["Labetalol", "Ξ±1:Ξ² ratio 1:3 (oral) / 1:7 (IV)\nHypertensive emergency in pregnancy", C.beta],
    ["Carvedilol", "Ξ±1+Ξ²1+Ξ²2 + antioxidant\nHF (COPERNICUS trial)", C.beta],
  ], C.beta);

  // Selectivity spectrum
  slide.addShape(pres.ShapeType.rect, { x:8.4, y:2.9, w:2.3, h:0.35, fill:{color:"1C2130"}, line:{color:C.beta, width:1} });
  slide.addText("Ξ²1 SELECTIVITY SPECTRUM", { x:8.4, y:2.9, w:2.3, h:0.35, fontSize:8, color:C.gold, bold:true, align:"center", valign:"middle" });
  slide.addText("Less selective ←→ More selective\nPropranolol < Metoprolol < Bisoprolol < Nebivolol", {
    x:8.4, y:3.3, w:4.7, h:0.55, fontSize:8, color:C.textDim, align:"center",
  });

  // Properties table
  const propX = 0.2, propY = 5.05, propW = 12.9, propH = 0.32;
  slide.addShape(pres.ShapeType.rect, { x:propX, y:propY, w:propW, h:propH, fill:{color:"1F2933"}, line:{color:C.beta} });
  slide.addText("KEY PROPERTIES TO REMEMBER", { x:propX, y:propY, w:propW, h:propH, fontSize:9, color:C.beta, bold:true, align:"center", valign:"middle" });

  const props = [
    ["Lipophilic (CNS effects)", "Propranolol, Metoprolol, Carvedilol, Labetalol"],
    ["Hydrophilic (no CNS)", "Atenolol, Nadolol, Esmolol"],
    ["Has ISA", "Pindolol, Acebutolol, Carteolol"],
    ["Class III also", "Sotalol (↑ QT β†’ torsades risk)"],
    ["Ultra-short tΒ½", "Esmolol (IV, 9 min)"],
    ["Vasodilating Ξ²-blockers", "Nebivolol (NO↑), Carvedilol (Ξ±1 block)"],
  ];
  props.forEach(([k, v], i) => {
    const row = Math.floor(i / 3), colIdx = i % 3;
    const rx = propX + colIdx * 4.3, ry = propY + propH + 0.05 + row * 0.55;
    slide.addShape(pres.ShapeType.rect, { x:rx, y:ry, w:4.25, h:0.48, fill:{color:"161B22"}, line:{color:"2D333B"} });
    slide.addText([
      { text: k + ": ", options: { bold:true, color:C.gold } },
      { text: v, options: { color:C.text } },
    ], { x:rx+0.08, y:ry+0.06, w:4.1, h:0.36, fontSize:8, valign:"middle" });
  });

  // CI / ADR strip
  slide.addShape(pres.ShapeType.rect, { x:0.2, y:7.0, w:12.9, h:0.42, fill:{color:"2D1B1B"}, line:{color:"FF6B6B"} });
  slide.addText([
    { text: "⚠ CONTRAINDICATIONS: ", options:{ bold:true, color:"FF6B6B" } },
    { text: "Asthma/COPD (Ξ²2 block)  β€’  2nd/3rd degree AV block  β€’  Severe bradycardia  β€’  Severe peripheral arterial disease  |  ", options:{ color:C.text } },
    { text: "NEVER stop abruptly!", options:{ bold:true, color:"FF6B6B" } },
  ], { x:0.2, y:7.0, w:12.9, h:0.42, fontSize:8.5, align:"center", valign:"middle" });
}

// ══════════════════════════════════════════════════════════════════════════════
// SLIDE 3 β€” Ξ±-BLOCKERS  DEEP-DIVE
// ══════════════════════════════════════════════════════════════════════════════
{
  const slide = pres.addSlide();
  slide.addShape(pres.ShapeType.rect, { x:0, y:0, w:13.3, h:7.5, fill:{color:C.bg}, line:{color:C.bg} });

  // Header
  slide.addShape(pres.ShapeType.rect, { x:0, y:0, w:13.3, h:0.72, fill:{color:C.alpha}, line:{color:C.alpha} });
  slide.addText("Ξ±-BLOCKERS  β€”  DEEP DIVE", {
    x:0, y:0, w:13.3, h:0.72, fontSize:18, color:C.white, bold:true, align:"center", valign:"middle",
  });

  // ── Non-selective panel ────────────────────────────────────────────────────
  slide.addShape(pres.ShapeType.rect, { x:0.2, y:0.82, w:4.0, h:0.38, fill:{color:"2A1717"}, line:{color:C.alpha, width:1} });
  slide.addText("NON-SELECTIVE  Ξ±1 + Ξ±2", { x:0.2, y:0.82, w:4.0, h:0.38, fontSize:10, color:C.alpha, bold:true, align:"center", valign:"middle" });

  const nsData = [
    ["Phentolamine", "Competitive reversible block β€’ Short-acting IV\nDx: Pheochromocytoma (phentolamine test)\nTx: Hypertensive crisis in pheo\nNote: Reflex tachycardia (Ξ±2 block β†’ NE↑)"],
    ["Phenoxybenzamine", "NON-COMPETITIVE (covalent, irreversible)\nLong-acting oral β€’ Pre-op pheo preparation\nNote: Full receptor recovery needs new receptors"],
  ];
  nsData.forEach(([name, desc], i) => {
    const iy = 1.32 + i * 1.45;
    slide.addShape(pres.ShapeType.rect, { x:0.2, y:iy, w:4.0, h:1.35, fill:{color:"1A0F0F"}, line:{color:"4D2020"} });
    slide.addText([
      { text: name + "\n", options: { bold:true, color:C.alpha } },
      { text: desc, options: { color:C.text } },
    ], { x:0.3, y:iy+0.1, w:3.8, h:1.15, fontSize:8.2, valign:"top" });
  });

  // ── Selective Ξ±1 panel ─────────────────────────────────────────────────────
  slide.addShape(pres.ShapeType.rect, { x:4.4, y:0.82, w:5.0, h:0.38, fill:{color:"2A1717"}, line:{color:C.alpha, width:1} });
  slide.addText("SELECTIVE  Ξ±1  BLOCKERS", { x:4.4, y:0.82, w:5.0, h:0.38, fontSize:10, color:C.alpha, bold:true, align:"center", valign:"middle" });

  const selData = [
    ["Prazosin", "1st gen β€’ Prototype\nShort tΒ½ (BID-TID)\nFirst-dose phenomenon (orthostatic hypotension)\nUses: HTN, BPH, Raynaud, PTSD nightmares\nNote: No reflex tachycardia (Ξ±2 intact)"],
    ["Terazosin", "2nd gen β€’ Longer tΒ½ (once daily)\nUses: HTN + BPH"],
    ["Doxazosin", "2nd gen β€’ Longest tΒ½ (once daily)\nAllhat trial: less favoured for HTN alone"],
    ["Tamsulosin", "Highly uroselective (Ξ±1A/Ξ±1D > Ξ±1B)\nBPH first-line (little BP effect)\nComplication: Floppy iris syndrome (cataract surgery!)"],
    ["Alfuzosin", "Uroselective Ξ±1A\nBPH β€’ Less BP drop than prazosin"],
    ["Silodosin", "MOST uroselective Ξ±1A\nBPH β€’ Retrograde ejaculation common"],
  ];
  selData.forEach(([name, desc], i) => {
    const row = Math.floor(i / 2), col2 = i % 2;
    const sx = 4.4 + col2 * 2.5, sy = 1.32 + row * 1.55;
    slide.addShape(pres.ShapeType.rect, { x:sx, y:sy, w:2.4, h:1.45, fill:{color:"1A0F0F"}, line:{color:"4D2020"} });
    slide.addText([
      { text: name + "\n", options: { bold:true, color:C.alpha } },
      { text: desc, options: { color:C.text } },
    ], { x:sx+0.08, y:sy+0.08, w:2.24, h:1.28, fontSize:7.5, valign:"top" });
  });

  // ── Receptor pharmacology panel ────────────────────────────────────────────
  slide.addShape(pres.ShapeType.rect, { x:9.6, y:0.82, w:3.5, h:0.38, fill:{color:"2A1717"}, line:{color:C.alpha, width:1} });
  slide.addText("Ξ±-RECEPTOR PHARMACOLOGY", { x:9.6, y:0.82, w:3.5, h:0.38, fontSize:9, color:C.alpha, bold:true, align:"center", valign:"middle" });

  const recData = [
    ["Ξ±1 (postsynaptic)", "Vasoconstriction (skin, GIT, renal)\nMydriasis β€’ Urethral sphincter contraction"],
    ["Ξ±2 (presynaptic)", "↓ NE release (autoreceptor)\nInhibit insulin release\nPlatelet aggregation"],
    ["Ξ±1 blockade β†’", "Vasodilation (↓ SVR, ↓ BP)\nNasal congestion β€’ Ejaculatory dysfunction"],
    ["Ξ±2 blockade β†’", "↑ NE release β†’ reflex tachycardia\n(Why non-selectives cause more tachycardia)"],
  ];
  recData.forEach(([k, v], i) => {
    const ry = 1.32 + i * 1.15;
    slide.addShape(pres.ShapeType.rect, { x:9.6, y:ry, w:3.5, h:1.05, fill:{color:"1A0F0F"}, line:{color:"4D2020"} });
    slide.addText([
      { text: k + "\n", options: { bold:true, color:C.gold } },
      { text: v, options: { color:C.text } },
    ], { x:9.7, y:ry+0.06, w:3.3, h:0.93, fontSize:7.8, valign:"top" });
  });

  // ── Uses summary ───────────────────────────────────────────────────────────
  slide.addShape(pres.ShapeType.rect, { x:0.2, y:5.62, w:13.1, h:0.3, fill:{color:"1F2933"}, line:{color:C.alpha} });
  slide.addText("CLINICAL USES SUMMARY", { x:0.2, y:5.62, w:13.1, h:0.3, fontSize:9, color:C.alpha, bold:true, align:"center", valign:"middle" });

  const uses = [
    ["Hypertension", "Prazosin, Terazosin, Doxazosin\n(not first-line per JNC)"],
    ["BPH", "Tamsulosin, Alfuzosin,\nSilodosin (uroselective)"],
    ["Pheo crisis", "Phentolamine IV\n(then phenoxybenzamine pre-op)"],
    ["Raynaud's", "Prazosin (off-label)"],
    ["PTSD nightmares", "Prazosin (blocks Ξ±1 in brain)"],
  ];
  uses.forEach(([title2, desc], i) => {
    const ux = 0.2 + i * 2.62, uy = 5.98;
    slide.addShape(pres.ShapeType.rect, { x:ux, y:uy, w:2.55, h:1.4, fill:{color:"1A0F0F"}, line:{color:"4D2020"} });
    slide.addText([
      { text: title2 + "\n", options: { bold:true, color:C.alpha } },
      { text: desc, options: { color:C.text } },
    ], { x:ux+0.08, y:uy+0.08, w:2.39, h:1.24, fontSize:8, valign:"top", align:"center" });
  });
}

// ══════════════════════════════════════════════════════════════════════════════
// SLIDE 4 β€” CENTRALLY ACTING + PRESYNAPTIC
// ══════════════════════════════════════════════════════════════════════════════
{
  const slide = pres.addSlide();
  slide.addShape(pres.ShapeType.rect, { x:0, y:0, w:13.3, h:7.5, fill:{color:C.bg}, line:{color:C.bg} });

  // Split header
  slide.addShape(pres.ShapeType.rect, { x:0, y:0, w:6.65, h:0.72, fill:{color:C.central}, line:{color:C.central} });
  slide.addText("CENTRALLY ACTING  ANTIADRENERGICS", { x:0, y:0, w:6.65, h:0.72, fontSize:13, color:C.bg, bold:true, align:"center", valign:"middle" });
  slide.addShape(pres.ShapeType.rect, { x:6.65, y:0, w:6.65, h:0.72, fill:{color:C.pregang}, line:{color:C.pregang} });
  slide.addText("PRESYNAPTIC / GANGLIONIC", { x:6.65, y:0, w:6.65, h:0.72, fontSize:13, color:C.bg, bold:true, align:"center", valign:"middle" });

  // ── Centrally acting drugs ──────────────────────────────────────────────────
  const centralDrugs = [
    {
      name: "Clonidine",
      moa: "Ξ±2 agonist in brainstem (locus coeruleus)\nβ†’ ↓ sympathetic outflow β†’ ↓ NE release",
      uses: "Hypertension (2nd line)\nOpioid/alcohol withdrawal\nADHD (off-label)\nMigraine prophylaxis\nMenopausal flushing",
      adr: "Sedation, dry mouth\nConstipation\nRebound HTN (abrupt stop)\nBradycardia",
      pk: "Both oral & transdermal patch\nExcreted renally",
      color: C.central,
    },
    {
      name: "Methyldopa",
      moa: "Prodrug → α-methyldopamine\n→ α-methylnorepinephrine (false TX)\n→ α2 agonist in CNS",
      uses: "HTN in PREGNANCY (drug of choice)\nHypertensive emergencies (IV)\nHypertension (older patients)",
      adr: "Sedation, depression\nPositive Coombs test (20%)\nHaemolytic anaemia (0.5%)\nHepatotoxicity β€’ Drug fever\nSodium retention",
      pk: "Oral; crosses placenta safely\nProbe of choice in pregnancy",
      color: C.central,
    },
    {
      name: "Moxonidine",
      moa: "Imidazoline I1-receptor agonist\n(+ weak Ξ±2 agonist)\nβ†’ ↓ central sympathetic tone",
      uses: "Mild-moderate HTN\nFewer CNS side effects than clonidine",
      adr: "Dry mouth, dizziness\nLess sedation than clonidine",
      pk: "Oral, once daily\nImidazoline selectivity = less sedation",
      color: C.central,
    },
    {
      name: "Rilmenidine",
      moa: "Selective imidazoline I1 agonist\nMinimal Ξ±2 activity",
      uses: "Hypertension\nMetabolic neutral (no lipid/glucose effect)",
      adr: "Well tolerated β€’ Dry mouth",
      pk: "Oral, once daily",
      color: C.central,
    },
  ];

  centralDrugs.forEach((d, i) => {
    const col2 = i % 2, row = Math.floor(i / 2);
    const dx = 0.2 + col2 * 3.25, dy = 0.9 + row * 3.0;
    slide.addShape(pres.ShapeType.rect, { x:dx, y:dy, w:3.15, h:2.75, fill:{color:"1A1A2E"}, line:{color:d.color, width:1.2} });
    slide.addText(d.name, { x:dx, y:dy, w:3.15, h:0.35, fontSize:10, color:d.color, bold:true, align:"center", valign:"middle" });
    const rows2 = [
      { label: "MOA: ", val: d.moa },
      { label: "Uses: ", val: d.uses },
      { label: "ADRs: ", val: d.adr },
      { label: "PK: ", val: d.pk },
    ];
    rows2.forEach((r, ri) => {
      slide.addText([
        { text: r.label, options: { bold:true, color:C.gold } },
        { text: r.val, options: { color:C.text } },
      ], { x:dx+0.1, y:dy + 0.38 + ri * 0.57, w:2.95, h:0.52, fontSize:7.5, valign:"top" });
    });
  });

  // ── Presynaptic / ganglionic ────────────────────────────────────────────────
  const preDrugs = [
    {
      name: "Reserpine",
      moa: "Inhibits VMAT (vesicular monoamine transporter)\n→ Depletes NE, DA, 5-HT from storage vesicles\n→ Long-lasting effect (days-weeks)",
      uses: "Rarely used (historical)\nSevere HTN in combination\nAntipsychotic (old)",
      adr: "DEPRESSION (↓ monoamines)\nParkinsonism (↓ DA)\nSedation, nasal congestion\nPeptic ulcer (↑ ACh effect)\nDiarrhoea",
      pk: "Long-acting (irreversible)\nReserves deplete slowly",
      color: C.pregang,
    },
    {
      name: "Guanethidine",
      moa: "Enters sympathetic terminals via NE transporter\n→ Displaces NE from vesicles\n→ Blocks exocytosis of NE",
      uses: "Severe HTN (rarely used now)\nTopical: Glaucoma",
      adr: "Severe orthostatic hypotension\nRetrograde ejaculation\nDiarrhoea (unopposed PNS)\nNasal congestion\nFluid retention",
      pk: "Poor CNS penetration (does NOT cross BBB)\nBlocked by TCAs (uptake competition)",
      color: C.pregang,
    },
    {
      name: "Bretylium",
      moa: "Blocks NE release from adrenergic neurons\nAccumulates in nerve terminal",
      uses: "Ventricular fibrillation (refractory)\nVentricular tachycardia (historical use)",
      adr: "Orthostatic hypotension\nNausea, vomiting\nTransient HTN (initial NE release)",
      pk: "IV only β€’ Renally excreted\nLargely replaced by amiodarone",
      color: C.pregang,
    },
    {
      name: "Ganglionic Blockers",
      moa: "Block nicotinic ACh receptors\n(N_N) at autonomic ganglia\n→ Block both SNS and PNS",
      uses: "Trimethaphan: Hypertensive crisis,\naortic dissection (historical)\nMecamylamine: Smoking cessation",
      adr: "Orthostatic hypotension\nConstipation, urinary retention\nDry mouth, sexual dysfunction\n(Block all ganglia indiscriminately)",
      pk: "Trimethaphan: IV infusion\nMecamylamine: Oral",
      color: C.pregang,
    },
  ];

  preDrugs.forEach((d, i) => {
    const col2 = i % 2, row = Math.floor(i / 2);
    const dx = 6.85 + col2 * 3.2, dy = 0.9 + row * 3.0;
    slide.addShape(pres.ShapeType.rect, { x:dx, y:dy, w:3.1, h:2.75, fill:{color:"1A1710"}, line:{color:d.color, width:1.2} });
    slide.addText(d.name, { x:dx, y:dy, w:3.1, h:0.35, fontSize:10, color:d.color, bold:true, align:"center", valign:"middle" });
    const rows2 = [
      { label: "MOA: ", val: d.moa },
      { label: "Uses: ", val: d.uses },
      { label: "ADRs: ", val: d.adr },
      { label: "PK: ", val: d.pk },
    ];
    rows2.forEach((r, ri) => {
      slide.addText([
        { text: r.label, options: { bold:true, color:C.gold } },
        { text: r.val, options: { color:C.text } },
      ], { x:dx+0.1, y:dy + 0.38 + ri * 0.57, w:2.9, h:0.52, fontSize:7.5, valign:"top" });
    });
  });

  // Divider line
  slide.addShape(pres.ShapeType.line, { x:6.65, y:0.72, w:0, h:6.78, line:{color:"4D5662", width:1.5, dashType:"dash"} });
}

// ══════════════════════════════════════════════════════════════════════════════
// SLIDE 5 β€” CLINICAL PEARLS, MNEMONICS & COMPARISON TABLE
// ══════════════════════════════════════════════════════════════════════════════
{
  const slide = pres.addSlide();
  slide.addShape(pres.ShapeType.rect, { x:0, y:0, w:13.3, h:7.5, fill:{color:C.bg}, line:{color:C.bg} });

  // Header
  slide.addShape(pres.ShapeType.rect, { x:0, y:0, w:13.3, h:0.65, fill:{color:"1C2130"}, line:{color:C.gold, width:2} });
  slide.addText("⚑ CLINICAL PEARLS, MNEMONICS & MUST-KNOW COMPARISONS", {
    x:0, y:0, w:13.3, h:0.65, fontSize:15, color:C.gold, bold:true, align:"center", valign:"middle",
  });

  // ── Mnemonic boxes ─────────────────────────────────────────────────────────
  const mnemonics = [
    {
      title: "Ξ²-blocker ABCDEs",
      color: C.beta,
      content: "A β€” Angina / After MI / Arrhythmias\nB β€” Blood pressure (HTN)\nC β€” Cardiac failure (bisoprolol, carvedilol, metoprolol)\nD β€” Dissection (labetalol)\nE β€” Extra: glaucoma, migraine, tremor",
    },
    {
      title: "Ξ±-blocker BLAST",
      color: C.alpha,
      content: "B β€” BPH (tamsulosin, silodosin)\nL β€” Lower BP (prazosin, doxazosin)\nA β€” Alpha pheo (phentolamine, phenoxybenzamine)\nS β€” Syncope first-dose (warn patients!)\nT β€” Tamsulosin β†’ floppy iris (tell ophthalmologist!)",
    },
    {
      title: "Centrally Acting CMM",
      color: C.central,
      content: "C β€” Clonidine β†’ rebound if stopped abruptly\nM β€” Methyldopa β†’ Mums (pregnancy safe)\nM β€” Moxonidine β†’ Mild, less sedation (imidazoline)",
    },
    {
      title: "Presynaptic DRAG",
      color: C.pregang,
      content: "D β€” Depletes monoamines (Reserpine β†’ Depression!)\nR β€” Releases NE initially then blocks (Bretylium)\nA β€” Autonomic ganglion blockers (block everything)\nG β€” Guanethidine β†’ Gut effects + orthostatic hypotension",
    },
  ];
  mnemonics.forEach((m, i) => {
    const col2 = i % 2, row = Math.floor(i / 2);
    const mx = 0.2 + col2 * 6.5, my = 0.78 + row * 2.05;
    slide.addShape(pres.ShapeType.rect, { x:mx, y:my, w:6.35, h:1.9, fill:{color:"161B22"}, line:{color:m.color, width:1.5} });
    slide.addShape(pres.ShapeType.rect, { x:mx, y:my, w:6.35, h:0.35, fill:{color:m.color}, line:{color:m.color} });
    slide.addText(m.title, { x:mx, y:my, w:6.35, h:0.35, fontSize:10, color:C.bg, bold:true, align:"center", valign:"middle" });
    slide.addText(m.content, { x:mx+0.15, y:my+0.42, w:6.05, h:1.4, fontSize:8.5, color:C.text, valign:"top" });
  });

  // ── Comparison table ────────────────────────────────────────────────────────
  const tableY = 4.95;
  slide.addShape(pres.ShapeType.rect, { x:0.2, y:tableY, w:12.9, h:0.35, fill:{color:"1F2933"}, line:{color:"4D5662"} });
  slide.addText("QUICK COMPARISON", { x:0.2, y:tableY, w:12.9, h:0.35, fontSize:10, color:C.text, bold:true, align:"center", valign:"middle" });

  const headers = ["Drug Class", "Site of Action", "Main Uses", "Key ADR", "Contraindication"];
  const rows = [
    [C.alpha,   "Ξ±1 Blockers",        "Post-synaptic Ξ±1",        "HTN, BPH, Pheo",         "1st-dose syncope",             "Caution in HF"],
    [C.beta,    "Ξ² Blockers (non-sel)","Ξ²1 + Ξ²2 receptors",       "HTN, angina, arrhythmia", "Bronchoconstriction",          "Asthma, COPD"],
    [C.beta,    "Ξ² Blockers (cardio)", "Ξ²1 > Ξ²2",                 "HTN, HF, post-MI",        "Bradycardia, fatigue",         "2nd/3rd AV block"],
    [C.central, "Clonidine",           "CNS Ξ±2 agonist",          "HTN, withdrawal",         "Rebound HTN (stop abruptly)",  "Must taper off"],
    [C.central, "Methyldopa",          "CNS β†’ false TX",          "Pregnancy HTN",           "Haemolytic anaemia",           "Pheochromocytoma"],
    [C.pregang, "Reserpine",           "VMAT inhibitor",          "Severe HTN (historical)",  "Depression, Parkinsonism",     "History of depression"],
    [C.pregang, "Guanethidine",        "Nerve terminal",          "Severe HTN (historical)",  "Orthostatic hypotension",      "TCAs block its uptake"],
  ];

  const colWidths = [1.8, 2.0, 1.9, 2.3, 2.3, 2.4];
  const colX = [0.2, 2.0, 4.0, 5.9, 8.2, 10.5];

  // Header row
  headers.forEach((h, ci) => {
    slide.addShape(pres.ShapeType.rect, { x:colX[ci], y:tableY+0.35, w:colWidths[ci], h:0.32, fill:{color:"2D333B"}, line:{color:"4D5662"} });
    slide.addText(h, { x:colX[ci]+0.05, y:tableY+0.35, w:colWidths[ci]-0.1, h:0.32, fontSize:7.8, color:C.gold, bold:true, valign:"middle" });
  });

  rows.forEach(([rowColor, ...cells], ri) => {
    const ry = tableY + 0.67 + ri * 0.32;
    cells.forEach((cell, ci) => {
      slide.addShape(pres.ShapeType.rect, { x:colX[ci], y:ry, w:colWidths[ci], h:0.3, fill:{color: ri%2===0 ? "161B22" : "111318"}, line:{color:"2D333B"} });
      slide.addText(cell, { x:colX[ci]+0.05, y:ry+0.02, w:colWidths[ci]-0.1, h:0.26, fontSize:7.5, color: ci===0 ? rowColor : C.text, bold: ci===0, valign:"middle" });
    });
  });
}

// ══════════════════════════════════════════════════════════════════════════════
// WRITE FILE
// ══════════════════════════════════════════════════════════════════════════════
pres.writeFile({ fileName: "/home/daytona/workspace/antiadrenergic-mindmap/Antiadrenergic_Drugs_MindMap.pptx" })
  .then(() => console.log("βœ…  Done: /home/daytona/workspace/antiadrenergic-mindmap/Antiadrenergic_Drugs_MindMap.pptx"))
  .catch(e => { console.error("❌ Error:", e); process.exit(1); });
Running Command

cd /home/daytona/workspace/antiadrenergic-mindmap && node build.js 2>&1

Your mind map is ready! Here's what's inside:

Antiadrenergic Drugs MindMap

Presentation Β· PPTX

What's in the 5-Slide Mind Map

The presentation uses a dark theme (near-black background) with color-coded branches so each drug class is instantly recognizable:
ColorClass
πŸ”΅ BlueCentral Hub
πŸ”΄ Coral-RedΞ±-Blockers
🟒 Greenβ-Blockers
🟣 LavenderCentrally Acting
🟠 AmberGanglionic / Presynaptic

Slide 1 - Master Overview Mind Map

A radial mind map with the central hub branching into all 4 classes, each showing key drugs, uses, and ADRs at a glance. Includes a bottom mnemonic strip.

Slide 2 - Ξ²-Blockers Deep Dive

Three columns: Non-Selective, Cardioselective, Mixed Ξ±+Ξ². Includes a selectivity spectrum (Propranolol β†’ Metoprolol β†’ Bisoprolol β†’ Nebivolol), lipophilicity table, ISA drugs, and a red contraindications strip at the bottom.

Slide 3 - Ξ±-Blockers Deep Dive

Non-selective (Phentolamine vs Phenoxybenzamine - reversible vs irreversible highlighted), all 6 selective Ξ±1 blockers with their quirks (Tamsulosin floppy iris!, Silodosin retrograde ejaculation), receptor pharmacology panel, and 5 clinical use cards.

Slide 4 - Centrally Acting + Presynaptic

Side-by-side: Clonidine, Methyldopa, Moxonidine, Rilmenidine vs Reserpine, Guanethidine, Bretylium, Ganglionic Blockers - each with MOA, Uses, ADRs, PK.

Slide 5 - Pearls, Mnemonics & Comparison Table

Four mnemonic boxes:
  • Ξ²-blocker ABCDEs (Angina, BP, Cardiac failure, Dissection, Extras)
  • Ξ±-blocker BLAST (BPH, Lower BP, Alpha pheo, Syncope, Tamsulosin iris)
  • Centrally Acting CMM
  • Presynaptic DRAG
Plus a full comparison table across all classes.

Create a quick-reference PDF cheat sheet for exam prep

Reading File
The skill recommends ReportLab for rich PDF creation. Let me build a dense, beautifully formatted cheat sheet now.
Writing File

~/antiadrenergic-mindmap/cheatsheet.py

"""
Antiadrenergic Drugs β€” Exam Prep Cheat Sheet
2-page A4 PDF using ReportLab
"""
from reportlab.lib.pagesizes import A4
from reportlab.lib import colors
from reportlab.lib.units import mm, cm
from reportlab.lib.styles import ParagraphStyle
from reportlab.platypus import (
    SimpleDocTemplate, Paragraph, Spacer, Table, TableStyle,
    HRFlowable, KeepTogether
)
from reportlab.platypus.flowables import BalancedColumns
from reportlab.lib.enums import TA_CENTER, TA_LEFT, TA_RIGHT
from reportlab.pdfbase.ttfonts import TTFont
from reportlab.pdfbase import pdfmetrics
import os

OUT = "/home/daytona/workspace/antiadrenergic-mindmap/Antiadrenergic_CheatSheet.pdf"

# ── Colour palette ────────────────────────────────────────────────────────────
BG       = colors.HexColor("#0D1117")
PANEL    = colors.HexColor("#161B22")
BORDER   = colors.HexColor("#2D333B")
ACCENT   = colors.HexColor("#58A6FF")   # blue – headers
ALPHA_C  = colors.HexColor("#FF7B72")   # coral – alpha
BETA_C   = colors.HexColor("#3FB950")   # green – beta
CENT_C   = colors.HexColor("#D2A8FF")   # lavender – central
PRE_C    = colors.HexColor("#FFA657")   # amber – presynaptic
GOLD     = colors.HexColor("#F8E45C")
WHITE    = colors.white
DIM      = colors.HexColor("#8B949E")
TEXT     = colors.HexColor("#E6EDF3")
RED      = colors.HexColor("#FF6B6B")

# ── Doc setup ─────────────────────────────────────────────────────────────────
doc = SimpleDocTemplate(
    OUT,
    pagesize=A4,
    leftMargin=10*mm, rightMargin=10*mm,
    topMargin=8*mm, bottomMargin=8*mm,
    title="Antiadrenergic Drugs Cheat Sheet",
    author="Orris Medical"
)
W, H = A4
CW = W - 20*mm   # content width

story = []

# ── Style helpers ─────────────────────────────────────────────────────────────
def S(name, base=None, **kw):
    s = ParagraphStyle(name, **kw)
    return s

BODY = S("body", fontSize=7, textColor=TEXT, leading=9.5, fontName="Helvetica")
BODY_BOLD = S("body_bold", fontSize=7, textColor=TEXT, leading=9.5, fontName="Helvetica-Bold")
TINY  = S("tiny", fontSize=6, textColor=DIM, leading=8, fontName="Helvetica")
LABEL = S("label", fontSize=7, textColor=GOLD, leading=9, fontName="Helvetica-Bold")
HEAD  = S("head", fontSize=7.5, textColor=WHITE, leading=9, fontName="Helvetica-Bold", alignment=TA_CENTER)
RED_S = S("red_s", fontSize=6.5, textColor=RED, leading=8.5, fontName="Helvetica")
ALPHA_S = S("alpha_s", fontSize=7, textColor=ALPHA_C, leading=9, fontName="Helvetica-Bold")
BETA_S  = S("beta_s",  fontSize=7, textColor=BETA_C,  leading=9, fontName="Helvetica-Bold")
CENT_S  = S("cent_s",  fontSize=7, textColor=CENT_C,  leading=9, fontName="Helvetica-Bold")
PRE_S   = S("pre_s",   fontSize=7, textColor=PRE_C,   leading=9, fontName="Helvetica-Bold")

def p(txt, style=None): return Paragraph(txt, style or BODY)
def pb(txt): return Paragraph(f"<b>{txt}</b>", BODY)

def hr(col=BORDER, thick=0.5): return HRFlowable(width="100%", thickness=thick, color=col, spaceAfter=1, spaceBefore=1)

# ─────────────────────────────────────────────────────────────────────────────
# PAGE BACKGROUND  (drawn via canvas callback)
# ─────────────────────────────────────────────────────────────────────────────
def bg_canvas(canvas, doc):
    canvas.saveState()
    canvas.setFillColor(BG)
    canvas.rect(0, 0, W, H, fill=1, stroke=0)
    canvas.restoreState()

# ─────────────────────────────────────────────────────────────────────────────
# TITLE BANNER
# ─────────────────────────────────────────────────────────────────────────────
title_data = [[
    Paragraph(
        '<font color="#58A6FF"><b>ANTIADRENERGIC DRUGS</b></font>  '
        '<font color="#8B949E">|  Exam Quick-Reference Cheat Sheet</font>',
        S("t", fontSize=13, textColor=WHITE, leading=16, fontName="Helvetica-Bold")
    )
]]
title_tbl = Table(title_data, colWidths=[CW])
title_tbl.setStyle(TableStyle([
    ("BACKGROUND", (0,0), (-1,-1), PANEL),
    ("BOX",        (0,0), (-1,-1), 1, ACCENT),
    ("TOPPADDING", (0,0), (-1,-1), 5),
    ("BOTTOMPADDING",(0,0),(-1,-1),5),
    ("LEFTPADDING",(0,0),(-1,-1),8),
]))
story.append(title_tbl)
story.append(Spacer(1, 3*mm))

# ─────────────────────────────────────────────────────────────────────────────
# HELPER: section header
# ─────────────────────────────────────────────────────────────────────────────
def section_hdr(txt, col):
    tbl = Table([[Paragraph(f"<b>{txt}</b>", S("sh", fontSize=9, textColor=colors.HexColor("#0D1117"), leading=11, fontName="Helvetica-Bold", alignment=TA_CENTER))]],
                colWidths=[CW])
    tbl.setStyle(TableStyle([
        ("BACKGROUND", (0,0),(-1,-1), col),
        ("TOPPADDING",    (0,0),(-1,-1), 3),
        ("BOTTOMPADDING", (0,0),(-1,-1), 3),
    ]))
    return tbl

# ─────────────────────────────────────────────────────────────────────────────
# HELPER: drug card row  [name, moa, uses, adr, note]
# ─────────────────────────────────────────────────────────────────────────────
def drug_table(rows, col_color, col_widths=None):
    if col_widths is None:
        col_widths = [28*mm, 40*mm, 42*mm, 42*mm, 35*mm]
    header = [
        Paragraph("<b>Drug</b>",              S("h", fontSize=7, textColor=col_color, leading=9, fontName="Helvetica-Bold")),
        Paragraph("<b>Mechanism</b>",         S("h", fontSize=7, textColor=col_color, leading=9, fontName="Helvetica-Bold")),
        Paragraph("<b>Uses</b>",              S("h", fontSize=7, textColor=col_color, leading=9, fontName="Helvetica-Bold")),
        Paragraph("<b>Key ADRs</b>",          S("h", fontSize=7, textColor=GOLD,      leading=9, fontName="Helvetica-Bold")),
        Paragraph("<b>Pearl / Note</b>",      S("h", fontSize=7, textColor=GOLD,      leading=9, fontName="Helvetica-Bold")),
    ]
    data = [header]
    for r in rows:
        data.append([p(c) for c in r])
    tbl = Table(data, colWidths=col_widths, repeatRows=1)
    tbl.setStyle(TableStyle([
        ("BACKGROUND",  (0,0), (-1,0),  colors.HexColor("#1F2933")),
        ("BACKGROUND",  (0,1), (-1,-1), PANEL),
        ("ROWBACKGROUNDS",(0,1),(-1,-1),[PANEL, colors.HexColor("#111318")]),
        ("GRID",        (0,0), (-1,-1), 0.4, BORDER),
        ("TOPPADDING",  (0,0), (-1,-1), 2),
        ("BOTTOMPADDING",(0,0),(-1,-1),2),
        ("LEFTPADDING", (0,0), (-1,-1), 3),
        ("RIGHTPADDING",(0,0), (-1,-1), 3),
        ("VALIGN",      (0,0), (-1,-1), "TOP"),
    ]))
    return tbl

# ─────────────────────────────────────────────────────────────────────────────
# β‘  Ξ±-BLOCKERS
# ─────────────────────────────────────────────────────────────────────────────
story.append(section_hdr("β‘  Ξ±-BLOCKERS", ALPHA_C))
story.append(Spacer(1, 1*mm))

alpha_rows = [
    # Drug | MOA | Uses | ADRs | Pearl
    ["Phentolamine",
     "Competitive reversible Ξ±1+Ξ±2 block",
     "Pheo hypertensive crisis\nDx: phentolamine test",
     "Reflex tachycardia (Ξ±2 blockβ†’NE↑)\nOrtho hypotension",
     "IV only; short-acting\nReversal: norepinephrine"],
    ["Phenoxybenzamine",
     "Non-competitive IRREVERSIBLE Ξ±1+Ξ±2 block",
     "Pre-op pheo prep\nPheo long-term",
     "Reflex tachycardia\nNasal stuffiness\nEjaculatory dysfunction",
     "Covalent bond β†’ effect lasts days\nPre-op: start 1-2 wks before surgery"],
    ["Prazosin",
     "Selective Ξ±1 block (post-synaptic)\nΞ±2 intact β†’ less tachycardia",
     "HTN β€’ BPH\nRaynaud β€’ PTSD nightmares",
     "1st-dose syncope!\nOrthostatic hypotension\nPalpitations",
     "PROTOTYPE Ξ±1 blocker\nTake 1st dose at bedtime!"],
    ["Terazosin",
     "Selective Ξ±1 block",
     "HTN + BPH",
     "Orthostatic hypotension\nDizziness",
     "Longer tΒ½ than prazosin\nOnce daily"],
    ["Doxazosin",
     "Selective Ξ±1 block",
     "HTN + BPH",
     "Orthostatic hypotension\nPeripheral edema",
     "Longest tΒ½ in class\nALLHAT trial: avoid for HTN alone"],
    ["Tamsulosin",
     "Uroselective Ξ±1A > Ξ±1B block",
     "BPH (1st line)\nKidney stone passage",
     "Retrograde ejaculation\nOrthostasis (less)",
     "⚠ FLOPPY IRIS syndrome\n(tell ophthalmologist before cataract sx!)"],
    ["Alfuzosin",
     "Uroselective Ξ±1A block",
     "BPH",
     "Dizziness, GI upset",
     "Less BP effect than prazosin"],
    ["Silodosin",
     "MOST uroselective Ξ±1A",
     "BPH",
     "Retrograde ejaculation (most common)\nDiarrhea",
     "Highest uroselectivity in class"],
]
story.append(drug_table(alpha_rows, ALPHA_C, [30*mm, 38*mm, 35*mm, 42*mm, 42*mm]))
story.append(Spacer(1, 2*mm))

# ─────────────────────────────────────────────────────────────────────────────
# β‘‘ Ξ²-BLOCKERS
# ─────────────────────────────────────────────────────────────────────────────
story.append(section_hdr("β‘‘ Ξ²-BLOCKERS", BETA_C))
story.append(Spacer(1, 1*mm))

beta_rows = [
    ["Propranolol",
     "Non-selective Ξ²1+Ξ²2 block\nLipophilic (crosses BBB)",
     "HTN β€’ Angina β€’ MI prophylaxis\nArrhythmias β€’ Hyperthyroidism\nMigraine prophylaxis β€’ Tremor\nPortal HTN (varices)\nGlaucoma (topical timolol)",
     "Bronchoconstriction (Ξ²2↓)\nMasks hypoglycemia sx\nCold extremities\nFatigue, depression",
     "PROTOTYPE Ξ²-blocker\nHighest first-pass metabolism\nDo NOT stop abruptly!"],
    ["Metoprolol",
     "Cardioselective Ξ²1 > Ξ²2\nLipophilic",
     "HTN β€’ Angina β€’ HF (succinate XL)\nMI β€’ Arrhythmia",
     "Bradycardia β€’ Fatigue\nWorse glucose tolerance",
     "Tartrate (IR) vs Succinate (XL)\nFor HF: SUCCINATE only (MERIT-HF)\nMost widely used Ξ²-blocker"],
    ["Atenolol",
     "Cardioselective Ξ²1\nHydrophilic (no CNS effects)",
     "HTN β€’ Angina β€’ Post-MI",
     "Bradycardia\nRenal excretion (dose-adjust in CKD)",
     "No CNS ADRs (hydrophilic)\nOld standard for HTN"],
    ["Bisoprolol",
     "Highly selective Ξ²1 (most selective after nebivolol)",
     "HTN β€’ HF (CIBIS-II trial)\nAngina",
     "Bradycardia β€’ Fatigue",
     "One of three Ξ²-blockers proven for HF mortality\n(bisoprolol, carvedilol, metoprolol succinate)"],
    ["Esmolol",
     "Ultra-short acting Ξ²1 selective\nHydrophilic; IV only",
     "Intra-op HTN & tachycardia\nSVT (acute control)\nAortic dissection",
     "Bradycardia β€’ Hypotension",
     "tΒ½ = 9 MIN (metabolized by plasma esterases)\nTitrated by infusion"],
    ["Nebivolol",
     "Highest β1 selectivity + releases NO\n→ vasodilation (unique!)",
     "HTN β€’ HF (adjunct)",
     "Headache (vasodilation)\nBradycardia",
     "VASODILATING Ξ²-blocker via NO\nBest metabolic profile"],
    ["Pindolol",
     "Non-selective Ξ²1+Ξ²2 + ISA\n(partial agonist)",
     "HTN",
     "Less bradycardia than propranolol\nCan worsen angina",
     "ISA = intrinsic sympathomimetic activity\nLess bradycardia at rest"],
    ["Sotalol",
     "Non-selective Ξ²-block + K+ channel block\n(Class II + III antiarrhythmic)",
     "Ventricular arrhythmias\nAtrial fibrillation",
     "QT prolongation β†’ Torsades de Pointes!\nBradycardia",
     "Monitor QTc carefully\nHydrophilic; renally cleared"],
    ["Labetalol",
     "Ξ±1 + Ξ²1 + Ξ²2 block\nΞ±1:Ξ² ratio 1:3 (oral) / 1:7 (IV)",
     "HTN emergency in pregnancy\nHypertensive urgency/emergency\nAortic dissection",
     "Orthostatic hypotension\nBronchospasm (Ξ²2 block)",
     "Drug of choice: Hypertensive\nemergency in PREGNANCY\n(Methyldopa = chronic; Labetalol = acute)"],
    ["Carvedilol",
     "Ξ±1 + Ξ²1 + Ξ²2 block + antioxidant\nNon-selective",
     "HF (COPERNICUS trial)\nPost-MI LV dysfunction\nHTN",
     "Dizziness β€’ Hypotension\nWeight gain",
     "One of 3 mortality-reducing Ξ²-blockers in HF\nAntioxidant property: unique"],
    ["Timolol",
     "Non-selective Ξ²1+Ξ²2 block",
     "Glaucoma (topical)\nPost-MI β€’ Migraine prophylaxis",
     "Bronchoconstriction (topical absorption!)\nBradycardia",
     "Topical: systemic absorption still occurs\nWarn asthmatic patients!"],
]
story.append(drug_table(beta_rows, BETA_C, [28*mm, 42*mm, 35*mm, 40*mm, 42*mm]))
story.append(Spacer(1, 2*mm))

# ─────────────────────────────────────────────────────────────────────────────
# β‘’ CENTRALLY ACTING
# ─────────────────────────────────────────────────────────────────────────────
story.append(section_hdr("β‘’ CENTRALLY ACTING ANTIADRENERGICS", CENT_C))
story.append(Spacer(1, 1*mm))

central_rows = [
    ["Clonidine",
     "Ξ±2 agonist in brainstem (NTS + locus coeruleus)\nβ†’ ↓ sympathetic outflow β†’ ↓NE, ↓HR, ↓BP",
     "Hypertension (2nd line)\nOpioid withdrawal\nAlcohol withdrawal\nADHD (off-label)\nMigraine prophylaxis\nMenopausal flushing",
     "Sedation β€’ Dry mouth\nConstipation β€’ Bradycardia\n⚠ Rebound HTN (abrupt stop)\nSexual dysfunction",
     "Available oral + transdermal patch\nNEVER stop abruptly (rebound HTN crisis)\nOpioid withdrawal: clonidine covers autonomic sx\nbut not craving/pain"],
    ["Methyldopa",
     "Prodrug β†’ Ξ±-methyldopamine\nβ†’ Ξ±-methylnorepinephrine (false TX)\nβ†’ Stimulates Ξ±2 in CNS β†’ ↓ sympathetic outflow",
     "HTN in PREGNANCY (drug of choice!)\nHypertensive emergencies (IV)\nGeneral HTN (older patients)",
     "Sedation, depression\n+ve Coombs test (20%)\nHaemolytic anaemia (0.5%)\nHepatotoxicity β€’ Drug fever\nSodium/water retention",
     "DOC for chronic HTN in PREGNANCY\nFalse TX concept: competes with DOPA\nIV form available for HTN emergency"],
    ["Moxonidine",
     "Selective imidazoline I1 receptor agonist\n(+ weak Ξ±2 agonist)\nβ†’ ↓ central sympathetic tone",
     "Mild-moderate hypertension",
     "Dry mouth β€’ Dizziness\nLess sedation than clonidine",
     "Imidazoline selectivity = fewer CNS ADRs\nMetabolic neutral (no lipid/glucose effects)"],
    ["Rilmenidine",
     "Selective imidazoline I1 agonist\nMinimal Ξ±2 activity",
     "Hypertension",
     "Well tolerated β€’ Dry mouth",
     "Best tolerated centrally acting drug\nOnce daily dosing"],
]
story.append(drug_table(central_rows, CENT_C, [25*mm, 42*mm, 35*mm, 40*mm, 45*mm]))
story.append(Spacer(1, 2*mm))

# ─────────────────────────────────────────────────────────────────────────────
# β‘£ PRESYNAPTIC / GANGLIONIC
# ─────────────────────────────────────────────────────────────────────────────
story.append(section_hdr("β‘£ PRESYNAPTIC & GANGLIONIC BLOCKERS", PRE_C))
story.append(Spacer(1, 1*mm))

pre_rows = [
    ["Reserpine",
     "Irreversibly inhibits VMAT-2\n→ Depletes NE, DA, 5-HT\nfrom storage vesicles (presynaptic)",
     "Severe HTN (combination; historical)\nRarely used now",
     "⚠ DEPRESSION (monoamine depletion)\nParkinsonism (↓ DA)\nSedation β€’ Nasal congestion\nPeptic ulcer (↑ ACh relative)\nDiarrhea",
     "Effect lasts days-weeks (irreversible)\nHistorically important for understanding NE storage\nCI: History of depression or Parkinson's"],
    ["Guanethidine",
     "Enters via NET → taken up into nerve terminal\n→ Displaces NE from vesicles\n→ Blocks exocytosis of NE",
     "Severe hypertension (historical)\nGlaucoma (topical)",
     "Severe orthostatic hypotension\nRetrograde ejaculation\nDiarrhea (↑ GI motility)\nNasal congestion",
     "Does NOT cross BBB (no CNS effects)\n⚠ Blocked by TCAs (competes for NET)\nGuanadrel: similar drug, faster onset"],
    ["Bretylium",
     "Accumulates in adrenergic nerve terminals\n→ Initial NE release (transient HTN)\n→ Then blocks NE release",
     "Refractory VF / VT (historical)\n(largely replaced by amiodarone)",
     "Orthostatic hypotension\nTransient HTN (initial NE release)\nNausea",
     "IV only; renally excreted\nBiphasic response: HTN first, then hypotension"],
    ["Trimethaphan\n(Ganglionic blocker)",
     "Blocks nAChR (NN) at autonomic ganglia\n→ Blocks BOTH SNS and PNS",
     "Hypertensive crisis (historical)\nControlled hypotension in surgery\nAortic dissection (historical)",
     "Orthostatic hypotension\nConstipation, urinary retention\nDry mouth, blurred vision\nSexual dysfunction",
     "Non-selective: blocks all ganglia\nHistorical; largely replaced by nitroprusside\nMecamylamine (oral): smoking cessation"],
]
story.append(drug_table(pre_rows, PRE_C, [28*mm, 42*mm, 32*mm, 42*mm, 43*mm]))
story.append(Spacer(1, 3*mm))

# ─────────────────────────────────────────────────────────────────────────────
# MNEMONICS + CONTRAST BOXES  (side by side)
# ─────────────────────────────────────────────────────────────────────────────
story.append(section_hdr("⚑ MNEMONICS, PEARLS & HIGH-YIELD CONTRASTS", GOLD))
story.append(Spacer(1, 1.5*mm))

MN_W = (CW - 4*mm) / 2

def mnemonic_card(title, col, lines):
    content = []
    for l in lines:
        content.append(Paragraph(l, S("mn", fontSize=7, textColor=TEXT, leading=9.5, fontName="Helvetica")))
    hdr = Paragraph(f"<b>{title}</b>", S("mnh", fontSize=8, textColor=colors.HexColor("#0D1117"), leading=10, fontName="Helvetica-Bold", alignment=TA_CENTER))
    inner = Table([[hdr]] + [[c] for c in content], colWidths=[MN_W - 4*mm])
    inner.setStyle(TableStyle([
        ("BACKGROUND",  (0,0),(0,0), col),
        ("BACKGROUND",  (0,1),(-1,-1), PANEL),
        ("TOPPADDING",  (0,0),(-1,-1), 2),
        ("BOTTOMPADDING",(0,0),(-1,-1), 2),
        ("LEFTPADDING", (0,0),(-1,-1), 4),
        ("BOX",         (0,0),(-1,-1), 0.8, col),
    ]))
    return inner

mn1 = mnemonic_card("Ξ²-blockers: ABCDE Mnemonic", BETA_C, [
    "A β€” Angina / After MI / Arrhythmias",
    "B β€” Blood Pressure (HTN)",
    "C β€” Cardiac failure (carvedilol, bisoprolol, metoprolol-XL)",
    "D β€” Dissection / aortic (labetalol IV)",
    "E β€” Extras: glaucoma, migraine, tremor, hyperthyroidism",
])
mn2 = mnemonic_card("Ξ±-blockers: BLAST Mnemonic", ALPHA_C, [
    "B β€” BPH (tamsulosin, silodosin β€” uroselective)",
    "L β€” Lower BP (prazosin, doxazosin)",
    "A β€” Alpha pheo (phentolamine IV; phenoxybenzamine pre-op)",
    "S β€” Syncope 1st dose β†’ take at BEDTIME",
    "T β€” Tamsulosin β†’ floppy iris (warn ophthalmologist!)",
])
mn3 = mnemonic_card("Centrally Acting: CMR", CENT_C, [
    "C β€” Clonidine β†’ Can't stop (rebound HTN) β†’ taper slowly",
    "M β€” Methyldopa β†’ Mums (pregnancy DOC) β†’ +ve Coombs",
    "R β€” Rebound risk with clonidine: NEVER abrupt stop",
    "Extra: Moxonidine = imidazoline selectivity = less sedation",
])
mn4 = mnemonic_card("Presynaptic: DRAG Mnemonic", PRE_C, [
    "D β€” Depletes monoamines (Reserpine) β†’ Depression!",
    "R β€” Releases NE first, then blocks (Bretylium)",
    "A β€” Autonomic ganglion blockers (trimethaphan β€” blocks all)",
    "G β€” Guanethidine: blocked by TCAs; causes Orthostatic ↓BP",
])

mnem_tbl = Table([[mn1, mn2], [mn3, mn4]],
                 colWidths=[MN_W, MN_W],
                 spaceBefore=0, spaceAfter=0)
mnem_tbl.setStyle(TableStyle([
    ("BACKGROUND", (0,0),(-1,-1), BG),
    ("TOPPADDING",    (0,0),(-1,-1), 2),
    ("BOTTOMPADDING", (0,0),(-1,-1), 2),
    ("LEFTPADDING",   (0,0),(-1,-1), 0),
    ("RIGHTPADDING",  (0,0),(-1,-1), 2),
    ("VALIGN", (0,0),(-1,-1), "TOP"),
]))
story.append(mnem_tbl)
story.append(Spacer(1, 3*mm))

# ─────────────────────────────────────────────────────────────────────────────
# HIGH-YIELD COMPARISON TABLE
# ─────────────────────────────────────────────────────────────────────────────
story.append(section_hdr("HIGH-YIELD COMPARISONS β€” FREQUENTLY TESTED CONTRASTS", ACCENT))
story.append(Spacer(1, 1*mm))

contrast_data = [
    # Header
    [Paragraph("<b>Question</b>", S("q", fontSize=7.5, textColor=ACCENT, leading=9, fontName="Helvetica-Bold")),
     Paragraph("<b>Answer</b>",   S("a", fontSize=7.5, textColor=ACCENT, leading=9, fontName="Helvetica-Bold"))],
    # rows
    ["DOC: Pregnancy HTN (chronic)",           "Methyldopa (safe; also labetalol, nifedipine)"],
    ["DOC: Hypertensive emergency in pregnancy","Labetalol IV (or hydralazine IV)"],
    ["DOC: Pre-op pheo prep",                  "Phenoxybenzamine (irreversible Ξ±-block, 1-2 wks before surgery)"],
    ["DOC: Pheo hypertensive crisis",          "Phentolamine IV (reversible, short-acting)"],
    ["Ξ²-blocker for HF (3 proven)",            "Bisoprolol, Carvedilol, Metoprolol succinate (all ↓ mortality)"],
    ["Ξ²-blocker with ISA",                     "Pindolol, Acebutolol, Carteolol β†’ less resting bradycardia"],
    ["Ultra-short Ξ²-blocker",                  "Esmolol (tΒ½ 9 min; IV infusion; plasma esterases)"],
    ["Most uroselective Ξ±1-blocker",           "Silodosin (Ξ±1A >> Ξ±1B) β†’ for BPH, causes retrograde ejaculation"],
    ["Ξ±1-blocker that causes floppy iris",     "Tamsulosin ⚠ β€” must inform ophthalmologist before cataract surgery"],
    ["IRREVERSIBLE Ξ±-blocker",                 "Phenoxybenzamine (covalent bond to receptor)"],
    ["Ξ²-blocker CI in asthma?",                "All Ξ²-blockers worsen asthma; even cardioselective ones at high dose"],
    ["Rebound HTN risk",                       "Clonidine (central Ξ±2 agonist) β€” NEVER stop abruptly; taper over 1-2 wks"],
    ["Drug causing haemolytic anaemia",        "Methyldopa (positive Coombs test in 20%; actual haemolysis in 0.5%)"],
    ["Drug causing depression",                "Reserpine (depletes monoamines β€” NE, DA, 5-HT)"],
    ["Ξ²-blocker + QT prolongation",            "Sotalol (Class II + III) β€” risk of Torsades de Pointes"],
    ["Vasodilating Ξ²-blocker mechanism",       "Nebivolol (NO release) vs Carvedilol / Labetalol (Ξ±1 blockade)"],
    ["Ξ²-blocker blocked by TCAs",              "Guanethidine β€” TCAs block its uptake into nerve terminal β†’ no effect"],
    ["Drug for opioid withdrawal (autonomic)","Clonidine (Ξ±2 agonist) β€” covers sweating, tachycardia, HTN, anxiety"],
    ["Ξ±-blocker for PTSD nightmares",         "Prazosin (blocks Ξ±1 receptors in brain during REM sleep)"],
    ["Betablocker for glaucoma (topical)",    "Timolol (non-selective) and Betaxolol (selective Ξ²1)"],
    ["Ξ²-blocker safe in peripheral arterial disease","Nebivolol or Bisoprolol (highly cardioselective + vasodilating)"],
]

def alt_row(data):
    tbl = Table(data, colWidths=[70*mm, CW - 70*mm - 0.4*mm])
    style = [
        ("BACKGROUND",    (0,0), (-1,0),  colors.HexColor("#1F2933")),
        ("ROWBACKGROUNDS",(0,1), (-1,-1), [PANEL, colors.HexColor("#111318")]),
        ("GRID",          (0,0), (-1,-1), 0.4, BORDER),
        ("TOPPADDING",    (0,0), (-1,-1), 2),
        ("BOTTOMPADDING", (0,0), (-1,-1), 2),
        ("LEFTPADDING",   (0,0), (-1,-1), 4),
        ("RIGHTPADDING",  (0,0), (-1,-1), 4),
        ("VALIGN",        (0,0), (-1,-1), "MIDDLE"),
        ("FONTNAME",      (0,0), (-1,-1), "Helvetica"),
        ("FONTSIZE",      (0,0), (-1,-1), 7),
        ("TEXTCOLOR",     (0,1), (0,-1),  GOLD),
        ("TEXTCOLOR",     (1,1), (1,-1),  TEXT),
    ]
    tbl.setStyle(TableStyle(style))
    return tbl

story.append(alt_row(contrast_data))
story.append(Spacer(1, 3*mm))

# ─────────────────────────────────────────────────────────────────────────────
# RECEPTOR PHARMACOLOGY QUICK-REF
# ─────────────────────────────────────────────────────────────────────────────
story.append(section_hdr("RECEPTOR PHARMACOLOGY QUICK-REFERENCE", ACCENT))
story.append(Spacer(1, 1*mm))

rec_data = [
    [Paragraph("<b>Receptor</b>", S("rh", fontSize=7.5, textColor=ACCENT, leading=9, fontName="Helvetica-Bold")),
     Paragraph("<b>Location</b>", S("rh", fontSize=7.5, textColor=ACCENT, leading=9, fontName="Helvetica-Bold")),
     Paragraph("<b>Effect when stimulated</b>", S("rh", fontSize=7.5, textColor=ACCENT, leading=9, fontName="Helvetica-Bold")),
     Paragraph("<b>Effect when BLOCKED</b>", S("rh", fontSize=7.5, textColor=GOLD, leading=9, fontName="Helvetica-Bold"))],
    ["Ξ±1 (Gq)", "Vascular smooth muscle, iris dilator, urethra, GIT",
     "Vasoconstriction, mydriasis, urinary retention",
     "Vasodilation, miosis, urinary relaxation (BPH relief)"],
    ["Ξ±2 (Gi)", "Presynaptic (autoreceptor), platelets, CNS",
     "↓ NE release, platelet aggregation, ↓ insulin",
     "↑ NE release β†’ reflex tachycardia (non-selective blockers)"],
    ["Ξ²1 (Gs)", "Heart, kidney (JG cells)",
     "↑ HR, ↑ contractility, ↑ renin",
     "↓ HR, ↓ contractility, ↓ renin (β†’ ↓ BP)"],
    ["Ξ²2 (Gs)", "Bronchi, uterus, vascular SM, liver",
     "Bronchodilation, uterine relaxation, glycogenolysis",
     "Bronchoconstriction, masks hypoglycemia, uterine contraction"],
    ["Ξ²3 (Gs)", "Adipose tissue, bladder detrusor",
     "Lipolysis, bladder relaxation",
     "Rarely targeted clinically (mirabegron activates Ξ²3)"],
    ["I1 (imidazoline)", "Brainstem (RVLM)",
     "↓ Sympathetic outflow β†’ ↓ BP",
     "N/A (moxonidine/rilmenidine AGONISTS at I1)"],
]

rec_tbl = Table(rec_data, colWidths=[30*mm, 42*mm, 60*mm, 55*mm])
rec_tbl.setStyle(TableStyle([
    ("BACKGROUND",    (0,0), (-1,0),  colors.HexColor("#1F2933")),
    ("ROWBACKGROUNDS",(0,1),(-1,-1), [PANEL, colors.HexColor("#111318")]),
    ("GRID",          (0,0),(-1,-1), 0.4, BORDER),
    ("TOPPADDING",    (0,0),(-1,-1), 2),
    ("BOTTOMPADDING", (0,0),(-1,-1), 2),
    ("LEFTPADDING",   (0,0),(-1,-1), 4),
    ("RIGHTPADDING",  (0,0),(-1,-1), 4),
    ("VALIGN",        (0,0),(-1,-1), "MIDDLE"),
    ("FONTNAME",      (0,1),(-1,-1), "Helvetica"),
    ("FONTSIZE",      (0,0),(-1,-1), 7),
    ("TEXTCOLOR",     (0,1),(0,-1),  GOLD),
    ("TEXTCOLOR",     (1,1),(-1,-1), TEXT),
]))
story.append(rec_tbl)
story.append(Spacer(1, 3*mm))

# ─────────────────────────────────────────────────────────────────────────────
# CONTRAINDICATIONS STRIP
# ─────────────────────────────────────────────────────────────────────────────
ci_data = [[
    Paragraph("<b>⚠ KEY CONTRAINDICATIONS</b>", S("ci", fontSize=8, textColor=RED, leading=10, fontName="Helvetica-Bold")),
    Paragraph(
        "Ξ²-blockers: Asthma/COPD β€’ 2Β°/3Β° AV block β€’ Sick sinus syndrome β€’ Severe bradycardia β€’ Severe PAD  "
        "| Ξ±-blockers: 1st-dose hypotension (warn pt!) β€’ Caution in HF with reduced EF  "
        "| Clonidine: NEVER stop abruptly  "
        "| Methyldopa: Avoid in active hepatic disease, pheo  "
        "| Reserpine: History of depression, Parkinsonism, ulcers  "
        "| Guanethidine: TCAs block uptake β†’ renders drug ineffective",
        S("ci2", fontSize=7, textColor=TEXT, leading=9, fontName="Helvetica")
    )
]]
ci_tbl = Table(ci_data, colWidths=[38*mm, CW - 38*mm])
ci_tbl.setStyle(TableStyle([
    ("BACKGROUND", (0,0),(-1,-1), colors.HexColor("#2D1B1B")),
    ("BOX",        (0,0),(-1,-1), 1, RED),
    ("TOPPADDING",    (0,0),(-1,-1), 4),
    ("BOTTOMPADDING", (0,0),(-1,-1), 4),
    ("LEFTPADDING",   (0,0),(-1,-1), 5),
    ("RIGHTPADDING",  (0,0),(-1,-1), 5),
    ("VALIGN",        (0,0),(-1,-1), "MIDDLE"),
]))
story.append(ci_tbl)
story.append(Spacer(1, 2*mm))

# ─────────────────────────────────────────────────────────────────────────────
# Ξ²-BLOCKER SELECTIVITY SPECTRUM
# ─────────────────────────────────────────────────────────────────────────────
spec_data = [[
    Paragraph("<b>Ξ²1 Selectivity Spectrum</b>", S("sp", fontSize=7.5, textColor=BETA_C, leading=9, fontName="Helvetica-Bold")),
    Paragraph(
        "<font color='#FF7B72'>Non-selective:</font> Propranolol = Nadolol = Timolol = Sotalol = Pindolol (ISA)  "
        "<font color='#8B949E'>β†’</font>  "
        "<font color='#3FB950'>Cardioselective Ξ²1:</font> Atenolol < Metoprolol < Bisoprolol < <b>Nebivolol</b> (+ NO vasodilation)  "
        "<font color='#8B949E'>β†’</font>  "
        "<font color='#FFA657'>Mixed Ξ±+Ξ²:</font> Labetalol (Ξ±1:Ξ² = 1:3 oral, 1:7 IV)  β€’  Carvedilol (Ξ±1+Ξ²1+Ξ²2+antioxidant)",
        S("spec2", fontSize=7, textColor=TEXT, leading=9, fontName="Helvetica")
    )
]]
spec_tbl = Table(spec_data, colWidths=[35*mm, CW - 35*mm])
spec_tbl.setStyle(TableStyle([
    ("BACKGROUND", (0,0),(-1,-1), colors.HexColor("#0E1F0E")),
    ("BOX",        (0,0),(-1,-1), 1, BETA_C),
    ("TOPPADDING",    (0,0),(-1,-1), 4),
    ("BOTTOMPADDING", (0,0),(-1,-1), 4),
    ("LEFTPADDING",   (0,0),(-1,-1), 5),
    ("RIGHTPADDING",  (0,0),(-1,-1), 5),
    ("VALIGN",        (0,0),(-1,-1), "MIDDLE"),
]))
story.append(spec_tbl)
story.append(Spacer(1, 2*mm))

# ─────────────────────────────────────────────────────────────────────────────
# FOOTER
# ─────────────────────────────────────────────────────────────────────────────
footer_data = [[
    Paragraph(
        '<font color="#58A6FF"><b>Orris Medical  |  Antiadrenergic Drugs Cheat Sheet</b></font>'
        '<font color="#8B949E">  β€”  For exam preparation only. Verify all clinical decisions against current guidelines.</font>',
        S("ft", fontSize=6.5, textColor=DIM, leading=8.5, fontName="Helvetica", alignment=TA_CENTER)
    )
]]
ft_tbl = Table(footer_data, colWidths=[CW])
ft_tbl.setStyle(TableStyle([
    ("BACKGROUND", (0,0),(-1,-1), PANEL),
    ("BOX",        (0,0),(-1,-1), 0.5, BORDER),
    ("TOPPADDING",    (0,0),(-1,-1), 3),
    ("BOTTOMPADDING", (0,0),(-1,-1), 3),
    ("LEFTPADDING",   (0,0),(-1,-1), 5),
]))
story.append(footer_data[0][0])

# ─────────────────────────────────────────────────────────────────────────────
# BUILD
# ─────────────────────────────────────────────────────────────────────────────
doc.build(story, onFirstPage=bg_canvas, onLaterPages=bg_canvas)
print(f"βœ… PDF saved: {OUT}")
Running Command

cd /home/daytona/workspace/antiadrenergic-mindmap && python cheatsheet.py 2>&1

Your cheat sheet is ready:

Antiadrenergic CheatSheet

PDF Document Β· PDF

What's on the Cheat Sheet

Dark-background, color-coded A4 PDF - same palette as the mind map for instant visual association.
β‘  Ξ±-Blockers table - 8 drugs (Phentolamine, Phenoxybenzamine, Prazosin, Terazosin, Doxazosin, Tamsulosin, Alfuzosin, Silodosin) with MOA / Uses / ADRs / Key Pearl per row
β‘‘ Ξ²-Blockers table - 11 drugs (Propranolol, Metoprolol, Atenolol, Bisoprolol, Esmolol, Nebivolol, Pindolol, Sotalol, Labetalol, Carvedilol, Timolol) - the full spectrum from non-selective to mixed
β‘’ Centrally Acting table - Clonidine, Methyldopa, Moxonidine, Rilmenidine
β‘£ Presynaptic/Ganglionic table - Reserpine, Guanethidine, Bretylium, Trimethaphan
Mnemonic boxes (2x2 grid):
  • Ξ²-blocker ABCDEs
  • Ξ±-blocker BLAST
  • Centrally acting CMR
  • Presynaptic DRAG
High-Yield Contrasts table - 20 "Q β†’ A" pairs covering the most commonly tested exam questions (pregnancy DOC, pheo management, HF Ξ²-blockers, floppy iris, rebound HTN, etc.)
Receptor pharmacology quick-ref - Ξ±1/Ξ±2/Ξ²1/Ξ²2/Ξ²3/I1 with location, effect when stimulated, and effect when blocked
Contraindications strip and Ξ²1 selectivity spectrum at the bottom.
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