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The Skeletal System - Full Study Notes
Sources: Gray's Anatomy for Students; Miller's Review of Orthopaedics 9th Ed; Firestein & Kelley's Textbook of Rheumatology; Robbins & Kumar Basic Pathology; Tintinalli's Emergency Medicine
1. Introduction
The skeletal system consists of bone and cartilage. Together they form the structural framework of the entire body. The adult human skeleton contains 206 bones total:
- 80 bones in the axial skeleton
- 126 bones in the appendicular skeleton
Axial skeleton (blue) = skull, vertebral column, ribs, sternum. Appendicular skeleton (green) = limbs and girdles. - Forensic Anthropology: A Comprehensive Introduction
2. Divisions of the Skeleton
Axial Skeleton (80 bones)
| Region | Bones | Count |
|---|
| Skull | Cranium (8) + Facial bones (14) | 22 |
| Auditory ossicles | Malleus, incus, stapes (×2) | 6 |
| Hyoid | Hyoid bone | 1 |
| Vertebral column | 7C + 12T + 5L + sacrum + coccyx | 26 |
| Thoracic cage | 12 pairs ribs + sternum | 25 |
Appendicular Skeleton (126 bones)
| Region | Bones |
|---|
| Upper limb (×2) | Clavicle, scapula, humerus, radius, ulna, 8 carpals, 5 metacarpals, 14 phalanges = 32 each |
| Lower limb (×2) | Hip (os coxa), femur, patella, tibia, fibula, 7 tarsals, 5 metatarsals, 14 phalanges = 31 each |
3. Functions of Bone (mnemonic: SPRLC)
- Support - structural framework of the body
- Protection - protects viscera (skull → brain; ribs → heart/lungs; vertebrae → spinal cord)
- Reservoir - stores calcium (99% of body's Ca²⁺) and phosphorus
- Levers - muscles act on bones to produce movement
- Containers - medullary cavities house bone marrow (hematopoiesis)
4. Classification of Bones by Shape
| Type | Description | Examples |
|---|
| Long | Tubular; length > width | Femur, humerus, tibia, radius |
| Short | Cuboidal | Carpals, tarsals |
| Flat | Two cortical plates + spongy bone | Skull, sternum, scapula, ribs |
| Irregular | Complex, variable shape | Vertebrae, facial bones, hip |
| Sesamoid | Round/oval; develop within tendons | Patella (largest), sesamoids of thumb |
Clinical note: Accessory and sesamoid bones are normal variants commonly found in wrists, hands, ankles, and feet - do not mistake them for fractures on imaging.
5. Anatomy of a Long Bone
| Region | Description |
|---|
| Epiphysis | Expanded ends; covered by articular cartilage; contains spongy bone |
| Physis (growth plate) | Cartilaginous zone between epiphysis and metaphysis; site of longitudinal growth; fuses at skeletal maturity |
| Metaphysis | Flared zone between physis and diaphysis; transition region |
| Diaphysis | Midshaft; mostly compact bone; encloses medullary (marrow) cavity |
| Periosteum | Fibrous membrane covering outer bone surface; inner (cambium) layer is osteogenic |
| Endosteum | Thin membrane lining the medullary cavity; also osteogenic |
| Apophysis | Bony outgrowth serving as muscle/ligament attachment point (e.g., greater trochanter) |
- Tintinalli's Emergency Medicine, p. 946
6. Bone Tissue Types
Compact (Cortical) Bone
- Dense outer shell of all bones
- Organized in osteons (Haversian systems) - concentric lamellae around a central Haversian canal
- Haversian canals carry blood vessels and nerves; connected laterally by Volkmann's canals
- Provides tensile and compressive strength
Spongy (Cancellous/Trabecular) Bone
- Lattice-like trabeculae with interconnecting spaces filled with marrow
- Located in epiphyses of long bones and interior of flat/irregular bones
- Trabecular arrangement follows lines of mechanical stress (Wolff's Law)
- Most bone remodeling occurs here
Bone Marrow
| Type | Composition | Location |
|---|
| Red marrow | 40% water, 40% fat, 20% protein; hematopoietically active | Axial skeleton, epiphyses in children |
| Yellow marrow | 15% water, 80% fat, 5% protein; inactive | Appendicular skeleton in adults |
Red marrow converts to yellow marrow with age, starting first in the appendicular skeleton and then the axial skeleton.
- Miller's Review of Orthopaedics, 9th Ed
7. Bone Matrix Composition
| Component | % of Dry Weight | Role |
|---|
| Organic (osteoid) | 35-40% | Type I collagen (tensile strength) + proteoglycans |
| Inorganic (mineral) | 60-65% | Calcium hydroxyapatite [Ca₁₀(PO₄)₆(OH)₂] - provides compressive strength |
Two structural forms of bone matrix:
- Woven bone - disorganized collagen; produced rapidly (fetal development, fracture repair); mechanically inferior; always abnormal in adults unless repairing
- Lamellar bone - parallel collagen fibers; organized, mechanically strong; normal adult bone
8. Bone Cells
| Cell | Origin | Location | Function |
|---|
| Osteoblasts | Mesenchymal stem cells (periosteum/endosteum) | Bone surface | Synthesize osteoid; regulate mineralization |
| Osteocytes | Trapped osteoblasts | Within lacunae in matrix | Mechanosensing; Ca²⁺/PO₄ regulation; initiate remodeling signals via canalicular network |
| Osteoclasts | Monocyte/macrophage lineage (multinucleate) | Bone surface (resorption pit) | Bone resorption via acid + matrix metalloproteinases |
| Bone lining cells | Quiescent osteoblasts | Bone surface | Maintain ionic environment; regulate remodeling |
9. Bone Blood Supply
Long bones receive blood from three systems:
| System | Pressure | Supplies |
|---|
| Nutrient artery | High pressure | Inner 2/3 of cortex via Haversian system; enters through nutrient foramen → medullary canal |
| Metaphyseal-epiphyseal | Moderate | From periarticular vascular plexus |
| Periosteal | Low pressure | Outer 1/3 of cortex |
-
Arterial flow in mature bone is centrifugal (inside → outside)
-
Venous flow is centripetal (outside → inside)
-
Bones with tenuous blood supply (high avascular necrosis risk): scaphoid, talus, femoral head, odontoid
-
Miller's Review of Orthopaedics, 9th Ed
10. Cartilage
Cartilage is an avascular, alymphatic, aneural connective tissue nourished entirely by diffusion.
| Type | Matrix | Location |
|---|
| Hyaline | Moderate collagen + chondroitin sulfate | Articular surfaces, costal cartilage, trachea, growth plate |
| Elastic | Collagen + abundant elastic fibers | External ear (pinna), epiglottis, larynx |
| Fibrocartilage | Dense type I collagen; few cells | Intervertebral discs, pubic symphysis, knee menisci, TMJ disc |
Functions of cartilage:
- Supports soft tissues
- Provides smooth gliding surface at joints
- Enables growth of long bones (growth plate)
11. Bone Development (Ossification)
| Type | Process | Bones |
|---|
| Intramembranous | Bone forms directly from mesenchyme (no cartilage template) | Flat bones of skull, mandible, clavicle |
| Endochondral | Bone replaces a cartilage anlage (model) | All long bones, vertebrae, pelvis, ribs |
Endochondral ossification centers:
- Primary center - appears in diaphysis; present at birth in most bones
- Secondary centers - appear in epiphyses postnatally; important for growth; frequently the site of pediatric physeal fractures
12. Bone Remodeling
Bone is continuously remodeled throughout life. The entire adult skeleton is replaced every 7-10 years.
The remodeling cycle (Basic Multicellular Unit / BMU):
The bone remodeling cycle: Resting state → Activation → Resorption → Migration → Formation → Mineralization - Firestein & Kelley's Textbook of Rheumatology
Steps:
- Activation - osteocytes sense micro-damage; sclerostin levels fall; osteoclast precursors recruited
- Resorption - osteoclasts excavate a resorption lacuna
- Migration - mesenchymal stem cells (MSCs) migrate into the lacuna
- Formation - osteoblasts deposit new osteoid
- Mineralization - osteoid calcifies; osteoblasts become osteocytes or lining cells
- Resting state - cycle complete
Full cycle takes 3-6 months. Most remodeling occurs in trabecular bone.
Regulation:
| Factor | Effect |
|---|
| PTH (↑) | ↑ resorption (indirect via osteoblast RANKL) |
| Calcitonin | ↓ resorption |
| Vitamin D | ↑ Ca²⁺ absorption; facilitates mineralization |
| Estrogen | ↓ resorption (protective); loss at menopause → osteoporosis |
| Mechanical loading | ↑ bone formation (Wolff's Law) |
- Firestein & Kelley's Textbook of Rheumatology, p. 107
13. Joints (Arthrology)
Joints are classified by degree of movement:
| Class | Type | Structure | Movement | Example |
|---|
| Synarthrosis | Fibrous | Fibrous tissue | None | Skull sutures, tooth sockets (gomphosis) |
| Amphiarthrosis | Cartilaginous | Hyaline cartilage (synchondrosis) or fibrocartilage (symphysis) | Limited | Pubic symphysis, intervertebral discs, sternal joints |
| Diarthrosis | Synovial | Joint capsule + synovial membrane + fluid | Full range | Hip, knee, shoulder, elbow |
Synovial Joint Structure
- Articular cartilage - hyaline cartilage on bone ends; no nerve supply
- Joint capsule - fibrous outer layer + inner synovial membrane
- Synovial membrane - secretes synovial fluid (lubricant + nutrient supply to cartilage)
- Ligaments - reinforce capsule; guide/limit movement
- Bursae - fluid-filled sacs that reduce friction near joints
- Menisci/discs - fibrocartilage structures that improve joint congruity (e.g., knee)
Synovial Joint Subtypes
| Type | Movement | Example |
|---|
| Hinge | Flexion/extension (uniaxial) | Elbow, knee, ankle, interphalangeal |
| Pivot | Rotation only | Atlantoaxial (C1-C2), proximal radioulnar |
| Ball-and-socket | Multiaxial (widest ROM) | Hip, shoulder (glenohumeral) |
| Condyloid/Ellipsoid | Biaxial (flex/ext + abd/add) | Wrist (radiocarpal), MCP joints |
| Saddle | Biaxial + opposition | 1st carpometacarpal (thumb) |
| Plane/Gliding | Sliding/translational | Acromioclavicular, intertarsal, intercarpal |
14. Fracture Healing
Indirect (Secondary) Healing - most common
| Stage | Events | Timing |
|---|
| Inflammatory | Fracture hematoma; neutrophils, macrophages, T/B cells; debridement of devitalized tissue | Days 1-7 |
| Fibrovascular | Angiogenesis; MSC recruitment; soft tissue bridging | Days 7-14 |
| Soft callus | Fibrocartilaginous callus from periosteum/endosteum cells | Weeks 2-6 |
| Hard callus | Callus mineralization; woven bone | Weeks 6-8 |
| Remodeling | Woven bone → lamellar bone | Months to years |
Direct (Primary) Healing
- Requires surgical fixation + fracture gap ≤ 0.5 mm
- No cartilage callus; osteonal bridging directly crosses the fracture
- Rarely achieved without anatomic reduction and rigid fixation
Key complication: Pseudarthrosis = failure of bone union after 6 months (from excessive movement or poor vascularity)
15. Common Skeletal Conditions (Summary)
| Condition | Pathology | Key Features |
|---|
| Osteoporosis | ↓ bone mass (normal mineralization) | T-score ≤ -2.5; fragility fractures (vertebra, hip, wrist) |
| Osteomalacia / Rickets | ↓ mineralization (Vit D deficiency) | Bone pain; bowing in children; pseudofractures |
| Osteoarthritis | Articular cartilage degeneration | Joint pain, crepitus, ↓ ROM, osteophytes |
| Rheumatoid Arthritis | Autoimmune synovitis | Symmetric joint swelling, morning stiffness >1 hr |
| Osteomyelitis | Bone infection (Staph aureus #1) | Local pain, warmth, swelling; fever; ↑ ESR/CRP |
| Paget's Disease | Abnormal remodeling (↑ osteoclasts then ↑ osteoblasts) | Bone enlargement, pain, deformity; ↑ ALP |
| Osteonecrosis (AVN) | Infarction of bone | Pain; collapse of femoral head most common |
Quick Summary Table
| Feature | Detail |
|---|
| Total adult bones | 206 |
| Axial skeleton | 80 bones (skull, spine, thorax) |
| Appendicular skeleton | 126 bones (limbs + girdles) |
| Bone matrix organic | 35% - type I collagen (flexibility) |
| Bone matrix inorganic | 65% - hydroxyapatite (hardness) |
| Bone remodeling cycle | 3-6 months; skeleton fully renewed every 7-10 years |
| Avascular cartilage types | All 3 (hyaline, elastic, fibrocartilage) |
| Ossification types | Intramembranous (skull) vs. Endochondral (long bones) |
Let me know if you want to go deeper on any specific area - joints, individual regions (spine, upper/lower limb), bone diseases, or fracture types.