Orris

Hifenac p

Reading File
Reading File
Finding Sources
Searching PubMed

aceclofenac AND paracetamol

Searching the Web

Hifenac-P aceclofenac 100 mg paracetamol 325 mg tablet uses side effects dosage

Hifenac-P is a brand of fixed-dose combination tablet. Each tablet contains aceclofenac 100 mg (an NSAID) and paracetamol 325 mg (an analgesic and antipyretic). It is sold in India.
What it's used for
  • Short-term relief of mild to moderate pain with inflammation.
  • Typical uses are osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, back pain, muscle strain, and dental or post-procedure pain. Product listings such as Apollo Pharmacy give similar uses.
How it works
  • Aceclofenac inhibits cyclooxygenase, which lowers prostaglandin-mediated pain and inflammation. A rheumatology textbook lists it among the NSAIDs studied in axial spondyloarthritis (Rheumatology, 2-Volume Set, Elsevier 2022). A Yamada's gastroenterology trial used it at 100 mg twice daily.
  • Paracetamol acts mainly centrally, giving analgesia and antipyresis with little anti-inflammatory effect.
Usual dose
  • The usual label dose is one tablet twice daily after food, for the shortest time needed. Your doctor sets the actual dose.
  • The maximum aceclofenac dose is 200 mg/day. Do not take other paracetamol-containing products or other NSAIDs at the same time.
Common side effects
  • Nausea, heartburn, indigestion, stomach pain, diarrhoea or constipation, and dizziness.
  • Seek urgent care for black or tarry stools, vomiting blood, yellow eyes or skin, swelling, or breathlessness.
Cautions and avoid if
  • Peptic ulcer or GI bleeding.
  • Significant kidney, liver or heart disease, or uncontrolled hypertension.
  • Aspirin or NSAID-induced asthma or allergy.
  • Pregnancy, especially the third trimester.
  • Regular heavy alcohol use, because of the liver risk with paracetamol.
  • Concurrent anticoagulants, other NSAIDs, steroids, lithium, methotrexate, or ACE inhibitors/diuretics. These can raise bleeding, kidney or toxicity risk.
  • Older adults need extra care. NSAID-related GI and kidney risks are higher, and the dose should be kept low and short.
Evidence note
  • A 2024 systematic review and meta-analysis of paracetamol combination therapy for back pain and osteoarthritis is relevant to combinations like this (Drugs, 2024). I only saw its title, not its findings, so I can't say what it concluded for aceclofenac plus paracetamol specifically.
  • The library textbooks I searched covered aceclofenac only as an NSAID. They had nothing on this brand combination.
Do you want a comparison with other NSAID-paracetamol combinations, or are you asking about a specific situation such as a dose, a drug interaction, or use in pregnancy? This is general information and doesn't replace advice from your doctor or pharmacist.
This is a shared conversation. Sign in to Orris to start your own chat.