from reportlab.lib.pagesizes import A4
from reportlab.lib.styles import getSampleStyleSheet, ParagraphStyle
from reportlab.lib.units import cm
from reportlab.lib import colors
from reportlab.platypus import SimpleDocTemplate, Paragraph, Spacer, HRFlowable
from reportlab.lib.enums import TA_LEFT, TA_CENTER, TA_JUSTIFY

mcqs = [
    {
        "q": "1. Which of the following is NOT a function of the hypothalamus?",
        "opts": [
            "A) Regulates body temperature",
            "B) Controls hunger and thirst",
            "C) Secretes tropic hormones directly into blood",
            "D) Produces ADH and oxytocin"
        ]
    },
    {
        "q": "2. The hormone responsible for the 'fight or flight' response is:",
        "opts": [
            "A) Cortisol",
            "B) Adrenaline (Epinephrine)",
            "C) Glucagon",
            "D) Thyroxine"
        ]
    },
    {
        "q": "3. Which of the following hormones is a steroid?",
        "opts": [
            "A) Insulin",
            "B) Glucagon",
            "C) Aldosterone",
            "D) Adrenaline"
        ]
    },
    {
        "q": "4. Grave's disease is caused by:",
        "opts": [
            "A) Hyposecretion of thyroxine",
            "B) Hypersecretion of thyroxine",
            "C) Hyposecretion of parathyroid hormone",
            "D) Hypersecretion of cortisol"
        ]
    },
    {
        "q": "5. Which of the following is the correct sequence of the hypothalamo-pituitary-thyroid axis?",
        "opts": [
            "A) TSH → TRH → T3/T4",
            "B) TRH → TSH → T3/T4",
            "C) T3/T4 → TRH → TSH",
            "D) TSH → T3/T4 → TRH"
        ]
    },
    {
        "q": "6. Insulin is secreted by which cells of the pancreas?",
        "opts": [
            "A) Alpha cells",
            "B) Beta cells",
            "C) Delta cells",
            "D) PP cells"
        ]
    },
    {
        "q": "7. Which hormone raises blood calcium levels?",
        "opts": [
            "A) Calcitonin",
            "B) Parathyroid hormone (PTH)",
            "C) Aldosterone",
            "D) Cortisol"
        ]
    },
    {
        "q": "8. Diabetes insipidus is caused by deficiency of:",
        "opts": [
            "A) Insulin",
            "B) Glucagon",
            "C) ADH (Vasopressin)",
            "D) Aldosterone"
        ]
    },
    {
        "q": "9. Which part of the adrenal gland secretes mineralocorticoids?",
        "opts": [
            "A) Adrenal medulla",
            "B) Zona fasciculata",
            "C) Zona glomerulosa",
            "D) Zona reticularis"
        ]
    },
    {
        "q": "10. The hormone oxytocin is produced in the:",
        "opts": [
            "A) Anterior pituitary",
            "B) Posterior pituitary",
            "C) Hypothalamus",
            "D) Thyroid gland"
        ]
    },
    {
        "q": "11. Which of the following is an example of a second messenger?",
        "opts": [
            "A) Thyroxine",
            "B) Cyclic AMP (cAMP)",
            "C) Cortisol",
            "D) Testosterone"
        ]
    },
    {
        "q": "12. Acromegaly results from excess secretion of which hormone in adults?",
        "opts": [
            "A) Prolactin",
            "B) TSH",
            "C) Growth Hormone",
            "D) ACTH"
        ]
    },
    {
        "q": "13. Which hormone is called the 'emergency hormone'?",
        "opts": [
            "A) Cortisol",
            "B) Aldosterone",
            "C) Adrenaline",
            "D) Thyroxine"
        ]
    },
    {
        "q": "14. Goitre is associated with deficiency of which element?",
        "opts": [
            "A) Iron",
            "B) Calcium",
            "C) Iodine",
            "D) Zinc"
        ]
    },
    {
        "q": "15. Which of the following is a tropic hormone?",
        "opts": [
            "A) GH (Growth Hormone)",
            "B) Prolactin",
            "C) FSH (Follicle Stimulating Hormone)",
            "D) MSH (Melanocyte Stimulating Hormone)"
        ]
    },
    {
        "q": "16. The pineal gland secretes:",
        "opts": [
            "A) Melatonin",
            "B) Serotonin",
            "C) Dopamine",
            "D) Thyroxine"
        ]
    },
    {
        "q": "17. Which of the following hormones stimulates milk ejection?",
        "opts": [
            "A) Prolactin",
            "B) Oxytocin",
            "C) Estrogen",
            "D) FSH"
        ]
    },
    {
        "q": "18. Steroid hormones act by:",
        "opts": [
            "A) Binding to cell surface receptors",
            "B) Activating adenylate cyclase",
            "C) Entering the cell and binding to nuclear receptors",
            "D) Using cAMP as second messenger"
        ]
    },
    {
        "q": "19. Cretinism in children is caused by:",
        "opts": [
            "A) Excess thyroxine",
            "B) Deficiency of thyroxine",
            "C) Excess growth hormone",
            "D) Deficiency of cortisol"
        ]
    },
    {
        "q": "20. Which hormone promotes sodium reabsorption in the kidneys?",
        "opts": [
            "A) ADH",
            "B) Aldosterone",
            "C) Calcitonin",
            "D) Glucagon"
        ]
    },
    {
        "q": "21. The zona reticularis of the adrenal cortex secretes:",
        "opts": [
            "A) Aldosterone",
            "B) Cortisol",
            "C) Androgens (sex corticoids)",
            "D) Adrenaline"
        ]
    },
    {
        "q": "22. Which of the following is a peptide hormone?",
        "opts": [
            "A) Estrogen",
            "B) Testosterone",
            "C) Glucagon",
            "D) Aldosterone"
        ]
    },
    {
        "q": "23. Addison's disease is caused by:",
        "opts": [
            "A) Hypersecretion of aldosterone",
            "B) Hyposecretion of adrenocortical hormones",
            "C) Hypersecretion of adrenaline",
            "D) Hyposecretion of insulin"
        ]
    },
    {
        "q": "24. Which cells of the islets of Langerhans secrete glucagon?",
        "opts": [
            "A) Beta cells",
            "B) Alpha cells",
            "C) Delta cells",
            "D) F cells"
        ]
    },
    {
        "q": "25. The hormone that inhibits growth hormone secretion is:",
        "opts": [
            "A) GHRH",
            "B) TRH",
            "C) Somatostatin",
            "D) CRH"
        ]
    },
    {
        "q": "26. Which of the following is the master endocrine gland?",
        "opts": [
            "A) Thyroid gland",
            "B) Adrenal gland",
            "C) Pituitary gland",
            "D) Pineal gland"
        ]
    },
    {
        "q": "27. Calcitonin is secreted by:",
        "opts": [
            "A) Parathyroid gland",
            "B) Parafollicular (C) cells of thyroid",
            "C) Adrenal cortex",
            "D) Anterior pituitary"
        ]
    },
    {
        "q": "28. Which hormone is responsible for the 'biological clock' and regulates sleep-wake cycles?",
        "opts": [
            "A) Cortisol",
            "B) Thyroxine",
            "C) Melatonin",
            "D) Prolactin"
        ]
    },
    {
        "q": "29. Cushing's syndrome results from hypersecretion of:",
        "opts": [
            "A) Aldosterone",
            "B) Adrenaline",
            "C) Cortisol",
            "D) Thyroxine"
        ]
    },
    {
        "q": "30. Which of the following correctly matches the hormone with its chemical nature?",
        "opts": [
            "A) Insulin – Steroid",
            "B) Testosterone – Protein",
            "C) Thyroxine – Amino acid derivative",
            "D) Aldosterone – Peptide"
        ]
    },
]

output_path = "/tmp/workspace/neet-mcq/Chemical_Coordination_MCQs.pdf"

doc = SimpleDocTemplate(
    output_path,
    pagesize=A4,
    rightMargin=2*cm,
    leftMargin=2*cm,
    topMargin=2*cm,
    bottomMargin=2*cm
)

styles = getSampleStyleSheet()

title_style = ParagraphStyle(
    "Title",
    parent=styles["Title"],
    fontSize=16,
    textColor=colors.HexColor("#1a237e"),
    spaceAfter=4,
    alignment=TA_CENTER,
    fontName="Helvetica-Bold"
)

subtitle_style = ParagraphStyle(
    "Subtitle",
    parent=styles["Normal"],
    fontSize=11,
    textColor=colors.HexColor("#37474f"),
    spaceAfter=2,
    alignment=TA_CENTER,
    fontName="Helvetica"
)

info_style = ParagraphStyle(
    "Info",
    parent=styles["Normal"],
    fontSize=10,
    textColor=colors.HexColor("#546e7a"),
    spaceAfter=6,
    alignment=TA_CENTER,
    fontName="Helvetica-Oblique"
)

q_style = ParagraphStyle(
    "Question",
    parent=styles["Normal"],
    fontSize=11,
    textColor=colors.HexColor("#1a237e"),
    spaceBefore=10,
    spaceAfter=4,
    leading=16,
    fontName="Helvetica-Bold"
)

opt_style = ParagraphStyle(
    "Option",
    parent=styles["Normal"],
    fontSize=10.5,
    textColor=colors.HexColor("#212121"),
    spaceBefore=2,
    spaceAfter=2,
    leftIndent=18,
    leading=15,
    fontName="Helvetica"
)

story = []

story.append(Paragraph("Chemical Coordination and Integration", title_style))
story.append(Paragraph("Class 11 Biology - NEET Practice MCQs", subtitle_style))
story.append(Paragraph("Chapter 22 | 30 Questions | All Single Correct Type", info_style))
story.append(Spacer(1, 0.3*cm))
story.append(HRFlowable(width="100%", thickness=1.5, color=colors.HexColor("#1a237e")))
story.append(Spacer(1, 0.4*cm))

for mcq in mcqs:
    story.append(Paragraph(mcq["q"], q_style))
    for opt in mcq["opts"]:
        story.append(Paragraph(opt, opt_style))

story.append(Spacer(1, 0.6*cm))
story.append(HRFlowable(width="100%", thickness=0.8, color=colors.HexColor("#90a4ae")))
story.append(Spacer(1, 0.2*cm))
footer_style = ParagraphStyle(
    "Footer",
    parent=styles["Normal"],
    fontSize=9,
    textColor=colors.HexColor("#78909c"),
    alignment=TA_CENTER,
    fontName="Helvetica-Oblique"
)
story.append(Paragraph("NEET Biology | Chemical Coordination & Integration | Class 11", footer_style))

doc.build(story)
print(f"PDF created: {output_path}")