Cancer: Definition, Treatment & Classification of Anticancer Drugs

mkdir -p /home/daytona/workspace/cancer-presentation

~/cancer-presentation/cancer_pptx.js

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pres.layout = "LAYOUT_16x9";
pres.title = "Cancer - Definition, Treatment & Anticancer Drug Classification";
pres.author = "Orris Medical Education";

// ─── THEME ───────────────────────────────────────────────────────────────────
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// ─── HELPER ──────────────────────────────────────────────────────────────────
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// ─── SLIDE 1 — TITLE ─────────────────────────────────────────────────────────
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// ─── SLIDE 2 — AGENDA ────────────────────────────────────────────────────────
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    { n: "02", title: "Cancer vs Normal Cell", sub: "Benign vs malignant comparison" },
    { n: "03", title: "Treatment Modalities", sub: "Surgery, Radiation, Chemo, Immunotherapy & more" },
    { n: "04", title: "Classification of Anticancer Drugs", sub: "7 major classes with mechanisms & examples" },
    { n: "05", title: "Cell Cycle Specificity", sub: "Which drugs act at which phase" },
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// ─── SLIDE 3 — DEFINITION ────────────────────────────────────────────────────
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    { text: " is a group of diseases characterized by ", options: { color: C.white } },
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    { text: " of cells that have escaped normal regulatory mechanisms of growth and division.", options: { color: C.white } }
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    { icon: "🚫", label: "Evades\nGrowth Inhibitors" },
    { icon: "💀", label: "Resists\nApoptosis" },
    { icon: "♾️", label: "Limitless\nReplication" },
    { icon: "🩸", label: "Sustained\nAngiogenesis" },
    { icon: "🌐", label: "Invasion &\nMetastasis" },
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// ─── SLIDE 4 — BENIGN vs MALIGNANT ───────────────────────────────────────────
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    ["Differentiation", "Well-differentiated", "Poorly differentiated"],
    ["Capsule", "Usually present", "Absent"],
    ["Recurrence", "Rare after removal", "Common"],
    ["Threat to life", "Usually not", "Often fatal if untreated"],
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// ─── SLIDE 5 — TREATMENT ─────────────────────────────────────────────────────
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  footerBar(s);

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      desc: "Ionizing radiation\nDamages tumor DNA\nExternal or brachytherapy" },
    { icon: "💊", label: "Chemo-\ntherapy", color: C.teal,
      desc: "Systemic cytotoxic drugs\nTargets rapidly dividing cells\nAdjuvant or neoadjuvant" },
    { icon: "🎯", label: "Targeted\nTherapy", color: C.purple,
      desc: "TKIs, monoclonal Abs\nHits specific molecular targets\nFewer side effects" },
    { icon: "🛡️", label: "Immuno-\ntherapy", color: C.green,
      desc: "PD-1/CTLA-4 inhibitors\nCAR-T cell therapy\nRestores immune attack" },
    { icon: "⚗️", label: "Hormonal\nTherapy", color: C.orange,
      desc: "Blocks hormone receptors\nBreast & prostate cancer\nTamoxifen, Leuprolide" },
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// ─── SLIDE 6 — ANTICANCER DRUG OVERVIEW ──────────────────────────────────────
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  slideHeader(s, "Classification of Anticancer Drugs", "Overview — 7 Major Classes");
  footerBar(s);

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    { num: "II",  label: "Antimetabolites",          color: C.teal,   icon: "🔬", phase: "S phase" },
    { num: "III", label: "Natural Products",         color: C.steel,  icon: "🌿", phase: "M / S / G2" },
    { num: "IV",  label: "Hormonal Agents",          color: C.purple, icon: "⚗️", phase: "Non-specific" },
    { num: "V",   label: "Targeted / Biologicals",   color: C.green,  icon: "🎯", phase: "Non-specific" },
    { num: "VI",  label: "Immunotherapy",            color: C.orange, icon: "🛡️", phase: "Non-specific" },
    { num: "VII", label: "Miscellaneous",             color: C.gray,   icon: "💡", phase: "Varies" },
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// ─── SLIDE 7 — CLASS I ALKYLATING ────────────────────────────────────────────
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  slideHeader(s, "Class I — Alkylating Agents", "Cell Cycle Non-Specific");
  footerBar(s);

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    { text: "Cell cycle NON-specific.", options: { bold: true, color: C.teal } }
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    { name: "Nitrosoureas", examples: "Carmustine (BCNU)\nLomustine (CCNU)\n(Cross BBB ✓)", color: C.steel },
    { name: "Alkyl Sulfonates", examples: "Busulfan", color: C.teal },
    { name: "Triazines", examples: "Dacarbazine\nTemozolomide", color: C.purple },
    { name: "Platinum Analogs", examples: "Cisplatin\nCarboplatin\nOxaliplatin", color: C.green },
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  s.addText("⚠️ Key Toxicities: Myelosuppression • Alopecia • Nausea/Vomiting • Hemorrhagic cystitis (Cyclophosphamide) • Nephrotoxicity (Cisplatin)", {
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// ─── SLIDE 8 — CLASS II ANTIMETABOLITES ──────────────────────────────────────
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  slideHeader(s, "Class II — Antimetabolites", "S Phase Specific");
  footerBar(s);

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    { text: "S phase specific.", options: { bold: true, color: C.navy } }
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    {
      name: "Folate Antagonists", color: C.navy,
      items: ["Methotrexate — inhibits DHFR", "Pemetrexed — multi-enzyme inhibitor"],
      use: "ALL, Choriocarcinoma, NSCLC, RA"
    },
    {
      name: "Pyrimidine Antagonists", color: C.steel,
      items: ["5-Fluorouracil (5-FU) — inhibits thymidylate synthase", "Capecitabine — oral prodrug of 5-FU", "Cytarabine (Ara-C) — AML", "Gemcitabine — pancreatic, lung, breast"],
      use: "Colon, breast, pancreatic cancers"
    },
    {
      name: "Purine Antagonists", color: C.purple,
      items: ["6-Mercaptopurine — ALL", "6-Thioguanine — AML", "Fludarabine — CLL", "Cladribine — Hairy cell leukemia"],
      use: "Leukemias, Lymphomas"
    },
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    const x = 0.25 + i * 3.18;
    s.addShape(pres.shapes.ROUNDED_RECTANGLE, {
      x, y: 1.88, w: 3.05, h: 3.2,
      fill: { color: g.color }, line: { color: g.color }, rectRadius: 0.1
    });
    s.addText(g.name, {
      x, y: 1.95, w: 3.05, h: 0.38, margin: 0,
      fontSize: 11, bold: true, color: C.gold, fontFace: "Calibri", align: "center"
    });
    g.items.forEach((item, j) => {
      s.addText("▸ " + item, {
        x: x + 0.15, y: 2.38 + j * 0.52, w: 2.75, h: 0.48, margin: 0,
        fontSize: 9, color: C.white, fontFace: "Calibri", wrap: true
      });
    });
    s.addShape(pres.shapes.RECTANGLE, {
      x, y: 4.72, w: 3.05, h: 0.02,
      fill: { color: C.gold }, line: { color: C.gold }
    });
    s.addText("Use: " + g.use, {
      x: x + 0.1, y: 4.76, w: 2.85, h: 0.25,
      fontSize: 8, color: C.mid, fontFace: "Calibri", italic: true
    });
  });
}

// ─── SLIDE 9 — CLASS III NATURAL PRODUCTS ────────────────────────────────────
{
  const s = pres.addSlide();
  slideHeader(s, "Class III — Natural Product Drugs", "Vinca Alkaloids | Taxanes | Topo Inhibitors | Antitumor Antibiotics");
  footerBar(s);

  const groups = [
    {
      name: "Vinca Alkaloids\n(M phase)", color: C.navy, x: 0.2, y: 1.1,
      items: ["Vinblastine — Hodgkin lymphoma, breast", "Vincristine — ALL, lymphoma", "Vinorelbine — NSCLC"],
      mech: "↓ Tubulin polymerization → mitotic arrest in metaphase"
    },
    {
      name: "Taxanes\n(M phase)", color: C.teal, x: 5.1, y: 1.1,
      items: ["Paclitaxel — ovarian, breast, lung", "Docetaxel — breast, NSCLC, prostate"],
      mech: "Stabilize microtubules → prevent depolymerization"
    },
    {
      name: "Topo I Inhibitors\n(Camptothecins)", color: C.steel, x: 0.2, y: 3.1,
      items: ["Irinotecan — CRC (FOLFIRI regimen)", "Topotecan — ovarian, SCLC"],
      mech: "Irinotecan prodrug → SN-38 (1000× more potent)"
    },
    {
      name: "Antitumor Antibiotics\n(Streptomyces)", color: C.purple, x: 5.1, y: 3.1,
      items: ["Doxorubicin — breast, lymphoma, sarcoma", "Bleomycin — Hodgkin, germ cell → pulm. fibrosis", "Mitomycin C — GI cancers"],
      mech: "DNA intercalation, Topo II inhibition, free radicals"
    },
  ];

  groups.forEach(g => {
    s.addShape(pres.shapes.ROUNDED_RECTANGLE, {
      x: g.x, y: g.y, w: 4.7, h: 1.85,
      fill: { color: g.color }, line: { color: g.color }, rectRadius: 0.1,
      shadow: { type: "outer", color: "000000", blur: 5, offset: 2, angle: 135, opacity: 0.12 }
    });
    s.addText(g.name, {
      x: g.x + 0.1, y: g.y + 0.05, w: 4.5, h: 0.5, margin: 0,
      fontSize: 11, bold: true, color: C.gold, fontFace: "Calibri"
    });
    s.addText("⚙️ " + g.mech, {
      x: g.x + 0.1, y: g.y + 0.55, w: 4.5, h: 0.35, margin: 0,
      fontSize: 8.5, color: C.mid, fontFace: "Calibri", italic: true, wrap: true
    });
    g.items.forEach((item, j) => {
      s.addText("▸ " + item, {
        x: g.x + 0.15, y: g.y + 0.92 + j * 0.28, w: 4.4, h: 0.28, margin: 0,
        fontSize: 9, color: C.white, fontFace: "Calibri"
      });
    });
  });
}

// ─── SLIDE 10 — CLASS IV HORMONAL ────────────────────────────────────────────
{
  const s = pres.addSlide();
  slideHeader(s, "Class IV — Hormonal Agents", "Hormone-sensitive Cancers: Breast & Prostate");
  footerBar(s);

  const table = [
    ["Drug / Class", "Mechanism", "Key Use"],
    ["Tamoxifen", "ER antagonist (SERM)", "Breast cancer (ER+)"],
    ["Fulvestrant", "ER degrader", "ER+ breast cancer"],
    ["Letrozole / Anastrozole", "Aromatase inhibitor → ↓ estrogen", "Postmenopausal breast cancer"],
    ["Leuprolide", "GnRH agonist → ↓ LH/FSH → ↓ androgens", "Prostate cancer"],
    ["Flutamide / Enzalutamide", "Androgen receptor blocker", "Prostate cancer"],
    ["Prednisone / Dexamethasone", "Lympholytic corticosteroid", "Lymphoma, leukemia, myeloma"],
  ];

  const colWidths = [2.8, 4.0, 2.8];
  const rowHeight = 0.52;
  const startY = 1.1;
  const startX = 0.22;

  table.forEach((row, ri) => {
    row.forEach((cell, ci) => {
      const x = startX + colWidths.slice(0, ci).reduce((a, b) => a + b, 0) + ci * 0.05;
      const y = startY + ri * rowHeight;
      const isHeader = ri === 0;
      s.addShape(pres.shapes.RECTANGLE, {
        x, y, w: colWidths[ci], h: rowHeight,
        fill: { color: isHeader ? C.navy : (ri % 2 === 0 ? "EFF4F9" : C.white) },
        line: { color: C.mid }
      });
      s.addText(cell, {
        x, y, w: colWidths[ci], h: rowHeight, margin: 5,
        fontSize: isHeader ? 11 : 10,
        bold: isHeader || ci === 0,
        color: isHeader ? C.white : (ci === 0 ? C.navy : C.gray),
        fontFace: "Calibri", valign: "middle",
        align: isHeader ? "center" : "left", wrap: true
      });
    });
  });

  s.addText("💡 Hormonal therapy blocks hormone-dependent signaling that drives tumor growth in breast and prostate cancers.", {
    x: 0.22, y: 4.9, w: 9.5, h: 0.4,
    fontSize: 10, color: C.navy, fontFace: "Calibri",
    fill: { color: "E8F4FD" }, italic: true
  });
}

// ─── SLIDE 11 — CLASS V TARGETED ─────────────────────────────────────────────
{
  const s = pres.addSlide();
  slideHeader(s, "Class V — Targeted & Biological Agents", "Monoclonal Antibodies | TKIs | ADCs");
  footerBar(s);

  // Monoclonal Abs
  s.addShape(pres.shapes.ROUNDED_RECTANGLE, {
    x: 0.2, y: 1.05, w: 4.75, h: 2.0,
    fill: { color: C.navy }, line: { color: C.navy }, rectRadius: 0.1
  });
  s.addText("🔬 Monoclonal Antibodies", {
    x: 0.3, y: 1.08, w: 4.5, h: 0.38, margin: 0,
    fontSize: 12, bold: true, color: C.gold, fontFace: "Calibri"
  });
  [
    "Trastuzumab — HER2 | Breast cancer",
    "Rituximab — CD20 | B-cell lymphoma",
    "Cetuximab — EGFR | CRC, head/neck",
    "Bevacizumab — VEGF-A | CRC, NSCLC, GBM",
    "Ramucirumab — VEGFR2 | Gastric, NSCLC",
  ].forEach((item, i) => {
    s.addText("▸ " + item, {
      x: 0.35, y: 1.5 + i * 0.3, w: 4.5, h: 0.3, margin: 0,
      fontSize: 9.5, color: C.white, fontFace: "Calibri"
    });
  });

  // TKIs
  s.addShape(pres.shapes.ROUNDED_RECTANGLE, {
    x: 5.1, y: 1.05, w: 4.75, h: 2.0,
    fill: { color: C.steel }, line: { color: C.steel }, rectRadius: 0.1
  });
  s.addText("🎯 Tyrosine Kinase Inhibitors (TKIs)", {
    x: 5.2, y: 1.08, w: 4.5, h: 0.38, margin: 0,
    fontSize: 12, bold: true, color: C.gold, fontFace: "Calibri"
  });
  [
    "Imatinib — BCR-ABL, c-kit | CML, GIST",
    "Erlotinib / Gefitinib — EGFR | NSCLC",
    "Sorafenib — VEGFR2/3, Raf | RCC, HCC",
    "Sunitinib — VEGFR, PDGFR | RCC, GIST",
    "Pazopanib — VEGFR, PDGFR | RCC",
  ].forEach((item, i) => {
    s.addText("▸ " + item, {
      x: 5.2, y: 1.5 + i * 0.3, w: 4.5, h: 0.3, margin: 0,
      fontSize: 9.5, color: C.white, fontFace: "Calibri"
    });
  });

  // ADC + VEGF note
  s.addShape(pres.shapes.ROUNDED_RECTANGLE, {
    x: 0.2, y: 3.18, w: 9.65, h: 0.92,
    fill: { color: C.purple }, line: { color: C.purple }, rectRadius: 0.1
  });
  s.addText("💉 Antibody-Drug Conjugate (ADC):", {
    x: 0.3, y: 3.22, w: 4.5, h: 0.35, margin: 0,
    fontSize: 11, bold: true, color: C.gold, fontFace: "Calibri"
  });
  s.addText("Trastuzumab-Deruxtecan — HER2-expressing tumors | Deruxtecan: Topo I inhibitor 10× more potent than SN-38 (Katzung 16e)", {
    x: 0.3, y: 3.6, w: 9.3, h: 0.42, margin: 0,
    fontSize: 9.5, color: C.white, fontFace: "Calibri"
  });

  s.addText("⚠️ Anti-VEGF agents (Bevacizumab, Sorafenib, Sunitinib): Risk of HTN, thromboembolism, GI perforation, poor wound healing. Metabolised by CYP3A4.", {
    x: 0.2, y: 4.2, w: 9.65, h: 0.42,
    fontSize: 8.5, color: C.red, fontFace: "Calibri", bold: true
  });
}

// ─── SLIDE 12 — CLASS VI IMMUNOTHERAPY ───────────────────────────────────────
{
  const s = pres.addSlide();
  slideHeader(s, "Class VI — Immunotherapy", "Checkpoint Inhibitors | CAR-T | Cytokines");
  footerBar(s);

  const cards = [
    { icon: "🔓", title: "PD-1 / PD-L1\nInhibitors", color: C.navy,
      items: ["Pembrolizumab (Keytruda)", "Nivolumab (Opdivo)", "Atezolizumab (anti-PD-L1)"],
      mech: "Block PD-1/PD-L1 interaction → restore T-cell cytotoxic activity",
      use: "Melanoma, NSCLC, bladder, HNSCC" },
    { icon: "🚧", title: "CTLA-4\nInhibitors", color: C.teal,
      items: ["Ipilimumab (Yervoy)"],
      mech: "Remove CTLA-4 inhibitory brake → enhance T-cell priming",
      use: "Melanoma (± nivolumab combination)" },
    { icon: "🧬", title: "CAR-T Cell\nTherapy", color: C.purple,
      items: ["Tisagenlecleucel (anti-CD19)", "Axicabtagene ciloleucel"],
      mech: "Engineered T cells with chimeric antigen receptor targeting tumor antigens",
      use: "Relapsed/refractory ALL, B-cell lymphoma" },
    { icon: "⚡", title: "Cytokines &\nOther", color: C.steel,
      items: ["IL-2 (Aldesleukin)", "Interferon-α (IFN-α)"],
      mech: "Stimulate proliferation of T cells and NK cells",
      use: "RCC, melanoma, hairy cell leukemia" },
  ];

  cards.forEach((c, i) => {
    const x = 0.2 + (i % 2) * 4.9;
    const y = 1.08 + Math.floor(i / 2) * 2.15;
    s.addShape(pres.shapes.ROUNDED_RECTANGLE, {
      x, y, w: 4.65, h: 2.0,
      fill: { color: c.color }, line: { color: c.color }, rectRadius: 0.1,
      shadow: { type: "outer", color: "000000", blur: 5, offset: 2, angle: 135, opacity: 0.12 }
    });
    s.addText(c.icon + " " + c.title, {
      x: x + 0.1, y: y + 0.05, w: 4.4, h: 0.5, margin: 0,
      fontSize: 11, bold: true, color: C.gold, fontFace: "Calibri"
    });
    s.addText("⚙️ " + c.mech, {
      x: x + 0.1, y: y + 0.55, w: 4.4, h: 0.35, margin: 0,
      fontSize: 8.5, color: C.mid, fontFace: "Calibri", italic: true, wrap: true
    });
    c.items.forEach((item, j) => {
      s.addText("▸ " + item, {
        x: x + 0.15, y: y + 0.92 + j * 0.26, w: 4.3, h: 0.26, margin: 0,
        fontSize: 9, color: C.white, fontFace: "Calibri"
      });
    });
    s.addText("Use: " + c.use, {
      x: x + 0.1, y: y + 1.7, w: 4.4, h: 0.26, margin: 0,
      fontSize: 8.5, color: C.gold, fontFace: "Calibri", italic: true
    });
  });
}

// ─── SLIDE 13 — CLASS VII + CELL CYCLE ───────────────────────────────────────
{
  const s = pres.addSlide();
  slideHeader(s, "Class VII — Miscellaneous  |  Cell Cycle Specificity", "");
  footerBar(s);

  // Misc table
  const misc = [
    ["Drug", "Mechanism", "Use"],
    ["Hydroxyurea", "Inhibits ribonucleotide reductase (S phase)", "CML, sickle cell"],
    ["L-Asparaginase", "Depletes asparagine → ↓ protein synthesis", "ALL"],
    ["Procarbazine", "Alkylating + MAOI activity", "Hodgkin lymphoma (MOPP)"],
    ["Thalidomide /\nLenalidomide", "Antiangiogenic + immunomodulatory", "Multiple myeloma"],
  ];

  misc.forEach((row, ri) => {
    row.forEach((cell, ci) => {
      const colW = [2.2, 4.5, 2.7];
      const x = 0.2 + colW.slice(0, ci).reduce((a, b) => a + b, 0) + ci * 0.05;
      const y = 1.05 + ri * 0.5;
      s.addShape(pres.shapes.RECTANGLE, {
        x, y, w: colW[ci], h: 0.5,
        fill: { color: ri === 0 ? C.navy : (ri % 2 === 0 ? "EFF4F9" : C.white) },
        line: { color: C.mid }
      });
      s.addText(cell, {
        x, y, w: colW[ci], h: 0.5, margin: 4,
        fontSize: ri === 0 ? 11 : 9.5,
        bold: ri === 0 || ci === 0,
        color: ri === 0 ? C.white : (ci === 0 ? C.navy : C.gray),
        fontFace: "Calibri", valign: "middle", wrap: true
      });
    });
  });

  // Cell cycle chart
  s.addShape(pres.shapes.ROUNDED_RECTANGLE, {
    x: 0.2, y: 3.6, w: 9.65, h: 1.6,
    fill: { color: C.navy }, line: { color: C.navy }, rectRadius: 0.1
  });
  s.addText("Cell Cycle Phase Specificity Summary", {
    x: 0.3, y: 3.64, w: 9.4, h: 0.35, margin: 0,
    fontSize: 12, bold: true, color: C.gold, fontFace: "Calibri", align: "center"
  });

  const phases = [
    { phase: "S Phase", drugs: "Antimetabolites\nHydroxyurea\nCamptothecins", color: C.teal },
    { phase: "M Phase", drugs: "Vinca Alkaloids\nTaxanes", color: C.steel },
    { phase: "G2 / M", drugs: "Bleomycin\nEtoposide", color: C.purple },
    { phase: "Non-Specific", drugs: "Alkylating Agents\nAnthracyclines\nHormonal agents", color: C.green },
  ];

  phases.forEach((p, i) => {
    const x = 0.35 + i * 2.37;
    s.addShape(pres.shapes.ROUNDED_RECTANGLE, {
      x, y: 4.02, w: 2.2, h: 1.1,
      fill: { color: p.color }, line: { color: p.color }, rectRadius: 0.08
    });
    s.addText(p.phase, {
      x, y: 4.05, w: 2.2, h: 0.33, margin: 0,
      fontSize: 10, bold: true, color: C.gold, fontFace: "Calibri", align: "center"
    });
    s.addText(p.drugs, {
      x, y: 4.38, w: 2.2, h: 0.72, margin: 0,
      fontSize: 8.5, color: C.white, fontFace: "Calibri", align: "center", wrap: true
    });
  });
}

// ─── SLIDE 14 — SUMMARY ──────────────────────────────────────────────────────
{
  const s = pres.addSlide();
  s.background = { color: C.navy };

  s.addShape(pres.shapes.RECTANGLE, {
    x: 0, y: 0, w: 10, h: 0.07,
    fill: { color: C.gold }, line: { color: C.gold }
  });
  s.addShape(pres.shapes.RECTANGLE, {
    x: 0, y: 5.555, w: 10, h: 0.07,
    fill: { color: C.gold }, line: { color: C.gold }
  });

  s.addText("Key Takeaways", {
    x: 0.5, y: 0.15, w: 9, h: 0.6,
    fontSize: 28, bold: true, color: C.gold, fontFace: "Calibri", align: "center"
  });

  const points = [
    ["🔬 Cancer", "Uncontrolled autonomous cell proliferation escaping normal growth regulation; classified as carcinoma, sarcoma, leukemia, lymphoma, myeloma."],
    ["💊 Treatment", "Surgery · Radiation · Chemotherapy · Targeted therapy · Immunotherapy · Hormonal therapy — often combined for best outcomes."],
    ["🧪 Alkylating (I)", "Cell cycle non-specific; cross-link DNA. Cisplatin, Cyclophosphamide, Temozolomide."],
    ["🔬 Antimetabolites (II)", "S-phase specific; structural analogs. MTX (DHFR inhibitor), 5-FU, Gemcitabine, Cladribine."],
    ["🌿 Natural Products (III)", "Vinca alkaloids (M phase) · Taxanes (M phase) · Topo inhibitors · Antitumor antibiotics (Doxorubicin → cardiotoxicity)."],
    ["⚗️ Hormonal (IV)", "ER antagonists, aromatase inhibitors, GnRH agonists, androgen blockers — breast & prostate cancer."],
    ["🎯 Targeted/Immuno (V-VI)", "Monoclonal Abs (Trastuzumab, Bevacizumab), TKIs (Imatinib, Sorafenib), Checkpoint inhibitors (Pembrolizumab), CAR-T."],
  ];

  points.forEach((p, i) => {
    const col = i % 2;
    const row = Math.floor(i / 2);
    const x = 0.25 + col * 5.0;
    const y = 0.88 + row * 1.1;
    s.addShape(pres.shapes.ROUNDED_RECTANGLE, {
      x, y, w: 4.75, h: 1.0,
      fill: { color: "1A2E5A" }, line: { color: C.teal }, rectRadius: 0.08
    });
    s.addText([
      { text: p[0] + "  ", options: { bold: true, color: C.gold, fontSize: 10 } },
      { text: p[1], options: { color: C.mid, fontSize: 9 } }
    ], {
      x: x + 0.12, y, w: 4.5, h: 1.0, margin: 6,
      fontFace: "Calibri", valign: "middle", wrap: true
    });
  });

  s.addText("Orris Medical Education  |  Based on Katzung's Pharmacology 16e & Goldman-Cecil Medicine", {
    x: 0.5, y: 5.3, w: 9, h: 0.25,
    fontSize: 8.5, color: C.gray, fontFace: "Calibri", align: "center"
  });
}

// ─── SAVE ─────────────────────────────────────────────────────────────────────
pres.writeFile({ fileName: "/home/daytona/workspace/cancer-presentation/Cancer_Anticancer_Drugs.pptx" })
  .then(() => console.log("✅ Saved: Cancer_Anticancer_Drugs.pptx"))
  .catch(e => { console.error("❌ Error:", e); process.exit(1); });

cd /home/daytona/workspace/cancer-presentation && node cancer_pptx.js

ls -lh /home/daytona/workspace/cancer-presentation/Cancer_Anticancer_Drugs.pptx