A comprehensive medical education poster titled "HEART FAILURE & ITS MANAGEMENT" based on Harrison's Principles of Internal Medicine 22nd Edition. The poster should be organized in clear sections with a dark navy blue header and clean white background. Section 1 - DEFINITION: Heart failure is a clinical syndrome with symptoms/signs from structural or functional impairment of ventricular filling or ejection. Key features: breathlessness, ankle swelling, fatigue, elevated JVP, pulmonary crackles, peripheral edema. Section 2 - CLASSIFICATION (3 types in colored boxes): - HFrEF: EF < 40% (Heart Failure with Reduced Ejection Fraction) - HFmrEF: EF 40-49% (Mildly Reduced EF) - HFpEF: EF ≥ 50% (Preserved EF) Section 3 - EPIDEMIOLOGY: 6.7 million Americans affected, 56.2 million globally, >600,000 new cases/year in USA. Section 4 - PATHOPHYSIOLOGY: Neurohormonal activation diagram showing RAAS activation, sympathetic nervous system activation, ventricular remodeling leading to progressive cardiac dysfunction. Section 5 - CLINICAL FEATURES (two columns): Symptoms: Dyspnea, orthopnea, PND, fatigue, ankle swelling Signs: Elevated JVP, S3 gallop, pulmonary crackles, peripheral edema, hepatomegaly Section 6 - DIAGNOSIS: BNP/NT-proBNP elevated, Echocardiography (key), CXR (cardiomegaly, pulmonary congestion), ECG changes Section 7 - CHRONIC HFrEF MANAGEMENT - FOUR PILLARS (in colored treatment boxes with arrows showing mortality reduction): 1. ACEi/ARB or ARNI (Sacubitril-Valsartan) - 23% mortality reduction 2. Beta-Blockers (Carvedilol, Bisoprolol, Metoprolol succinate) - 35% mortality reduction 3. MRA (Spironolactone/Eplerenone) 4. SGLT-2 Inhibitors (Empagliflozin/Dapagliflozin) - newest pillar Additional: Diuretics for symptom relief, ICD for SCD prevention, CRT for dyssynchrony Section 8 - ACUTE DECOMPENSATED HF MANAGEMENT: - Typical (Hypertensive): Vasodilators - Normotensive (volume overloaded): IV Diuretics - Pulmonary Edema: O2, NIV, Vasodilators, Diuretics - Low Output: Inotropes, Hemodynamic monitoring - Cardiogenic Shock: Catecholamines, Mechanical circulatory support (IABP, VAD) Section 9 - HFpEF MANAGEMENT: BP control, Diuretics for congestion, Treat comorbidities (AF, obesity, CKD, sleep apnea), SGLT-2i beneficial Footer: Source: Harrison's Principles of Internal Medicine, 22nd Edition (2025) | Chapters 264 & 265 Use professional medical poster design with color-coded sections (blue for definition, green for pharmacotherapy, orange for acute management, purple for HFpEF), icons for each drug class, and clear hierarchy of information. Include a small heart diagram illustration.