Jaundice (visible yellowing) typically appears when total bilirubin exceeds 2.5 - 3.0 mg/dL.
In neonates, ranges differ significantly - physiologic neonatal jaundice peaks around day 3-5, with total bilirubin up to ~12 mg/dL considered acceptable in term infants (treatment thresholds vary by age in hours and gestational age).
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