These notes cover the full Harrison's content on chest discomfort and angina across 11 major sections with 15+ detailed tables. Here's what's included:
Part 1-2 - Overview and complete differential diagnosis table (all causes: cardiac, vascular, pulmonary, GI, musculoskeletal, psychiatric) with quality, location, and features for each.
Part 3 - Pathophysiology of ischemia - the O2 supply-demand equation, and a classification table distinguishing stable angina, unstable angina, NSTEMI, STEMI, Type 1 vs Type 2 MI.
Part 4 - Detailed characteristics of ischemic discomfort - quality, Levine's sign, all radiation sites, duration per syndrome, precipitants, relief, and atypical presentations.
Part 5 - Stable angina in depth - epidemiology, fixed vs. variable threshold, CCS classification (I-IV), and NYHA classification tables.
Part 6-7 - Physical examination findings (vital signs, cardiac exam during/between episodes, musculoskeletal caveats) + investigations (ECG patterns, biomarkers, all stress test types, imaging modalities).
Part 8 - Full drug therapy with dosage tables - nitrates (with the 10-12 hour nitrate-free interval rule), beta-blockers with selectivity, CCBs, ranolazine, ivabradine, antiplatelet/statin therapy.
Part 9-11 - Clinical approach (red flags, history framework), special syndromes (Prinzmetal, microvascular, ANOCA/MINOCA), conditions exacerbating angina, and revascularization (PCI vs. CABG comparison).
Final summary table - Side-by-side comparison of stable angina, unstable angina, NSTEMI, and STEMI for rapid review.