Open Vial Policy WHO vaccine multi-dose guidelines 2024

https://www.who.int/publications/i/item/WHO-IVB-14.07

mkdir -p /home/daytona/workspace/open-vial-policy && ls /home/daytona/workspace/

~/open-vial-policy/generate_pdf.py

from reportlab.lib.pagesizes import A4
from reportlab.lib import colors
from reportlab.lib.styles import getSampleStyleSheet, ParagraphStyle
from reportlab.lib.units import cm
from reportlab.platypus import (
    SimpleDocTemplate, Paragraph, Spacer, Table, TableStyle, HRFlowable
)
from reportlab.lib.enums import TA_CENTER, TA_LEFT

OUTPUT = "/home/daytona/workspace/open-vial-policy/Open_Vial_Policy.pdf"

doc = SimpleDocTemplate(
    OUTPUT,
    pagesize=A4,
    rightMargin=2*cm, leftMargin=2*cm,
    topMargin=2*cm, bottomMargin=2*cm
)

styles = getSampleStyleSheet()

# Custom styles
title_style = ParagraphStyle(
    "Title", parent=styles["Title"],
    fontSize=22, textColor=colors.HexColor("#1a5276"),
    spaceAfter=6, alignment=TA_CENTER
)
subtitle_style = ParagraphStyle(
    "Subtitle", parent=styles["Normal"],
    fontSize=11, textColor=colors.HexColor("#555555"),
    spaceAfter=12, alignment=TA_CENTER
)
h2_style = ParagraphStyle(
    "H2", parent=styles["Heading2"],
    fontSize=13, textColor=colors.HexColor("#1a5276"),
    spaceBefore=14, spaceAfter=4,
    borderPad=3
)
body_style = ParagraphStyle(
    "Body", parent=styles["Normal"],
    fontSize=10.5, leading=16, spaceAfter=4
)
bullet_style = ParagraphStyle(
    "Bullet", parent=styles["Normal"],
    fontSize=10.5, leading=16, leftIndent=16, spaceAfter=3,
    bulletIndent=4
)
note_style = ParagraphStyle(
    "Note", parent=styles["Normal"],
    fontSize=9.5, leading=14, textColor=colors.HexColor("#7d6608"),
    leftIndent=12, spaceAfter=4
)
source_style = ParagraphStyle(
    "Source", parent=styles["Normal"],
    fontSize=9, textColor=colors.grey, alignment=TA_CENTER, spaceBefore=18
)

story = []

# ── Title ─────────────────────────────────────────────────────────────────────
story.append(Spacer(1, 0.3*cm))
story.append(Paragraph("Open Vial Policy (OVP)", title_style))
story.append(Paragraph("WHO / Universal Immunization Programme Guidelines (2015)", subtitle_style))
story.append(HRFlowable(width="100%", thickness=2, color=colors.HexColor("#1a5276")))
story.append(Spacer(1, 0.4*cm))

# ── Definition ────────────────────────────────────────────────────────────────
story.append(Paragraph("Definition", h2_style))
story.append(Paragraph(
    "The Open Vial Policy (OVP) allows reuse of partially used <b>multi-dose vaccine vials</b> "
    "across subsequent immunization sessions (both fixed and outreach) for up to <b>4 weeks (28 days)</b> "
    "after first opening, provided specific conditions are met. The primary goal is to <b>reduce vaccine wastage</b>.",
    body_style
))

# ── Vaccines Covered ───────────────────────────────────────────────────────────
story.append(Paragraph("Vaccines Covered Under OVP", h2_style))

table_data = [
    [Paragraph("<b>Applicable — Can reuse up to 28 days</b>", body_style),
     Paragraph("<b>NOT Applicable — Discard after session</b>", body_style)],
    ["DPT", "Measles / MR"],
    ["Tetanus Toxoid (TT)", "BCG"],
    ["Hepatitis B", "Japanese Encephalitis (JE)"],
    ["Oral Polio Vaccine (OPV)", "Rotavirus"],
    ["Liquid Pentavalent", ""],
    ["Pneumococcal Conjugate Vaccine (PCV)", ""],
    ["Injectable IPV", ""],
]

col_widths = [9*cm, 8*cm]
tbl = Table(table_data, colWidths=col_widths, repeatRows=1)
tbl.setStyle(TableStyle([
    ("BACKGROUND", (0, 0), (0, 0), colors.HexColor("#d6eaf8")),
    ("BACKGROUND", (1, 0), (1, 0), colors.HexColor("#fadbd8")),
    ("TEXTCOLOR", (0, 0), (-1, -1), colors.black),
    ("FONTSIZE", (0, 0), (-1, -1), 10),
    ("LEADING", (0, 0), (-1, -1), 14),
    ("ROWBACKGROUNDS", (0, 1), (-1, -1), [colors.white, colors.HexColor("#f4f6f7")]),
    ("GRID", (0, 0), (-1, -1), 0.5, colors.HexColor("#aab7b8")),
    ("VALIGN", (0, 0), (-1, -1), "MIDDLE"),
    ("TOPPADDING", (0, 0), (-1, -1), 5),
    ("BOTTOMPADDING", (0, 0), (-1, -1), 5),
    ("LEFTPADDING", (0, 0), (-1, -1), 8),
]))
story.append(tbl)
story.append(Spacer(1, 0.3*cm))
story.append(Paragraph(
    "⚠ Globally (WHO/PAHO): Reconstituted lyophilized vaccines (BCG, MMR, Yellow Fever) must be "
    "discarded within <b>6 hours</b> of reconstitution or at end of session, whichever comes first.",
    note_style
))

# ── Conditions ────────────────────────────────────────────────────────────────
story.append(Paragraph("Conditions for Reuse (ALL must be met)", h2_style))
story.append(Paragraph(
    "A vial opened at a session site can be used in more than one session up to 4 weeks, <b>provided</b>:",
    body_style
))

conditions = [
    "Expiry date has <b>not passed</b>.",
    "Vaccines are stored under <b>appropriate cold chain temperatures</b> during both transport and storage.",
    "The <b>vaccine vial septum</b> has not been submerged in water or contaminated in any way.",
    "<b>Aseptic technique</b> was used to withdraw all doses.",
    "The <b>Vaccine Vial Monitor (VVM)</b> has not reached the discard point.",
    "The vial has <b>not been exposed to direct sunlight</b>.",
]
for c in conditions:
    story.append(Paragraph(f"✓  {c}", bullet_style))

# ── Operational Rules ─────────────────────────────────────────────────────────
story.append(Paragraph("Key Operational Rules", h2_style))

ops = [
    "Record the <b>date and time of opening</b> on each open vial.",
    "Open vials should <b>never be submerged in water</b> (e.g., water accumulated in vaccine carrier) — this increases risk of septum contamination.",
    "At the end of every session, all open vials must be <b>returned to the Cold Chain Point</b>.",
    "At the Cold Chain Point, segregate vials into:<br/>"
    "&nbsp;&nbsp;&nbsp;&bull; <b>Reusable:</b> DPT, TT, Hep B, Pentavalent (if all criteria met)<br/>"
    "&nbsp;&nbsp;&nbsp;&bull; <b>Non-reusable:</b> Measles/MR, BCG, JE — destroy within 48 hours or before next session, whichever is earlier.",
]
for op in ops:
    story.append(Paragraph(f"•  {op}", bullet_style))

# ── AEFI ──────────────────────────────────────────────────────────────────────
story.append(Paragraph("In Case of AEFI (Adverse Event Following Immunization)", h2_style))
story.append(Paragraph(
    "If any AEFI is reported, <b>all open vials</b> (both usable and non-usable) must <b>not be discarded or used</b>. "
    "They must be stored under proper cold chain conditions until the investigation is complete.",
    body_style
))

# ── Historical Note ───────────────────────────────────────────────────────────
story.append(Paragraph("Historical Note", h2_style))
story.append(Paragraph(
    "The Open Vial Policy was introduced under India's Universal Immunization Programme (UIP) in "
    "<b>2012-2013</b> and updated with revised guidelines in <b>2015</b>. It is based on the "
    "<b>WHO multi-dose vial policy (2014 revision)</b>, reference WHO/IVB/14.07, which provides the global framework.",
    body_style
))

# ── Footer / Source ───────────────────────────────────────────────────────────
story.append(Spacer(1, 0.5*cm))
story.append(HRFlowable(width="100%", thickness=0.8, color=colors.HexColor("#aab7b8")))
story.append(Paragraph(
    "Source: Park's Textbook of Preventive and Social Medicine (Open Vial Policy, 2015 guidelines) · WHO/IVB/14.07 (2014 Revision)",
    source_style
))

doc.build(story)
print(f"PDF created: {OUTPUT}")

cat > /home/daytona/workspace/open-vial-policy/generate_pdf.py << 'PYEOF' from r…

A clean, colorful medical infographic titled "Open Vial Policy (OVP)" for immunization education. The infographic is divided into clear sections: 1. TOP BANNER: Bold title "Open Vial Policy (OVP)" with subtitle "Reduce Vaccine Wastage" on a deep blue background with vaccine vial icons. 2. DEFINITION BOX: Light blue box stating "Allows reuse of opened multi-dose vaccine vials across sessions for up to 28 DAYS (4 weeks)" with a calendar icon. 3. TWO-COLUMN TABLE labeled "VACCINES": - LEFT (green column, checkmark icon): "CAN Reuse up to 28 days" listing: DPT, TT, Hepatitis B, OPV, Pentavalent, PCV, IPV - RIGHT (red column, X icon): "DISCARD After Session" listing: Measles/MR, BCG, Japanese Encephalitis, Rotavirus, All Reconstituted Vaccines (6 hrs) 4. CONDITIONS CHECKLIST section titled "6 Conditions to Reuse a Vial" with green checkmark icons: ✓ Not expired ✓ Cold chain maintained ✓ Septum not submerged in water ✓ Aseptic technique used ✓ VVM not reached discard point ✓ Not exposed to sunlight 5. BOTTOM RULES strip with icons: - Clock icon: "Record date & time of opening" - Snowflake icon: "Return to Cold Chain Point after session" - Warning icon: "Never submerge vial in water" - Alert icon: "In AEFI — preserve ALL vials, do not discard" Clean white background, professional medical illustration style, bold readable fonts, icons for each point.