const pptxgen = require("pptxgenjs");

let pres = new pptxgen();
pres.layout = 'LAYOUT_16x9';
pres.title = 'Adverse Drug Reactions - Easy Guide';

// ─── THEME COLORS ───────────────────────────────────────────────────────────
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  green:   "27AE60",
  orange:  "E67E22",
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// ─── HELPER: add a slide background rect ────────────────────────────────────
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function lightSlide(slide) {
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// ═══════════════════════════════════════════════════════════════════════════
// SLIDE 1 — TITLE
// ═══════════════════════════════════════════════════════════════════════════
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  sl.addText("Adverse Drug\nReactions", {
    x: 0.5, y: 0.8, w: 9, h: 2.5,
    fontSize: 54, bold: true, color: C.white,
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  });

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  sl.addText("Based on Clinical Pharmacology & Drug Therapy", {
    x: 0.3, y: 5.13, w: 9.4, h: 0.45,
    fontSize: 12, color: C.white, fontFace: "Calibri", align: "left",
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}

// ═══════════════════════════════════════════════════════════════════════════
// SLIDE 2 — WHAT IS ADR?
// ═══════════════════════════════════════════════════════════════════════════
{
  let sl = pres.addSlide();
  lightSlide(sl);

  // header stripe
  sl.addShape(pres.ShapeType.rect, { x: 0, y: 0, w: 10, h: 1.0, fill: { color: C.navy } });
  sl.addText("💊 What is an Adverse Drug Reaction (ADR)?", {
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    { text: "WHO Definition:  ", options: { bold: true, fontSize: 15 } },
    { text: '"Any response to a drug which is HARMFUL, UNINTENDED, and occurs at normal doses used in humans for prevention, diagnosis, or treatment."', options: { fontSize: 14, italic: true } },
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  // simple language box
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  bullets(sl, [
    "It is a BAD or UNWANTED effect caused by a medicine",
    "It happens even when the medicine is taken correctly (right dose, right way)",
    "It is NOT the same as an overdose or medication error",
  ], 0.4, 3.3, 9.2, 2.0, { fontSize: 15 });
}

// ═══════════════════════════════════════════════════════════════════════════
// SLIDE 3 — HISTORICAL MILESTONES
// ═══════════════════════════════════════════════════════════════════════════
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  sl.addShape(pres.ShapeType.rect, { x: 0, y: 0, w: 10, h: 1.0, fill: { color: C.navy } });
  sl.addText("📜 Why Does ADR Matter? — History Tells Us!", {
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    fontSize: 22, bold: true, color: C.white, fontFace: "Calibri", valign: "middle",
  });

  const events = [
    { year: "1922", text: "Jaundice linked to SALVARSAN (used for syphilis)" },
    { year: "1937", text: "107 people DIED from Elixir of Sulfanilamide → FDA was born!" },
    { year: "1961", text: "THALIDOMIDE caused limb deformities in newborns → worldwide regulations" },
  ];

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    sl.addShape(pres.ShapeType.roundRect, {
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    sl.addText(ev.year, {
      x: 0.3, y: y + 0.28, w: 1.1, h: 0.55,
      fontSize: 20, bold: true, color: C.white,
      fontFace: "Calibri", align: "center",
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    sl.addText(ev.text, {
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      fontSize: 15, color: C.darkText, fontFace: "Calibri", valign: "middle",
    });
  });
}

// ═══════════════════════════════════════════════════════════════════════════
// SLIDE 4 — HOW COMMON ARE ADRs?
// ═══════════════════════════════════════════════════════════════════════════
{
  let sl = pres.addSlide();
  darkSlide(sl);

  sl.addText("📊 How Common Are ADRs?", {
    x: 0.4, y: 0.2, w: 9.2, h: 0.7,
    fontSize: 26, bold: true, color: C.amber, fontFace: "Calibri",
  });

  const stats = [
    { num: "10–20%", label: "Hospital patients get an ADR", icon: "🏥" },
    { num: "0.24–2.9%", label: "Hospital deaths are caused by ADRs", icon: "⚠️" },
    { num: "0.3–5%", label: "Hospital admissions are due to ADRs", icon: "🚑" },
  ];

  stats.forEach((s, i) => {
    const x = 0.4 + i * 3.15;
    sl.addShape(pres.ShapeType.roundRect, {
      x, y: 1.2, w: 2.9, h: 3.6,
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    sl.addText(s.icon, { x, y: 1.4, w: 2.9, h: 0.7, fontSize: 32, align: "center" });
    sl.addText(s.num, {
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      fontSize: 26, bold: true, color: C.amber, fontFace: "Calibri", align: "center",
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    sl.addText(s.label, {
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      fontSize: 14, color: C.white, fontFace: "Calibri",
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  sl.addText("⚡ These numbers show that ADRs are a SERIOUS public health problem!", {
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    fontSize: 13, color: C.amber, italic: true, fontFace: "Calibri", align: "center",
  });
}

// ═══════════════════════════════════════════════════════════════════════════
// SLIDE 5 — CLASSIFICATION OVERVIEW
// ═══════════════════════════════════════════════════════════════════════════
{
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  lightSlide(sl);

  sl.addShape(pres.ShapeType.rect, { x: 0, y: 0, w: 10, h: 1.0, fill: { color: C.navy } });
  sl.addText("🗂️ Types of ADRs — The Big Picture", {
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    fontSize: 22, bold: true, color: C.white, fontFace: "Calibri", valign: "middle",
  });

  // TYPE A
  sl.addShape(pres.ShapeType.roundRect, {
    x: 0.3, y: 1.15, w: 4.45, h: 3.9,
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  });
  sl.addShape(pres.ShapeType.roundRect, {
    x: 0.3, y: 1.15, w: 4.45, h: 0.55,
    fill: { color: C.green }, line: { color: C.green }, rectRadius: 0.1,
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    fontSize: 14, bold: true, color: C.white, fontFace: "Calibri", valign: "middle",
  });
  bullets(sl, [
    "Related to the DOSE of the drug",
    "Common & expected",
    "Side effects (e.g. drowsiness from antihistamines)",
    "Toxic effects (too much drug)",
    "Secondary effects (indirect harm)",
    "Can be prevented by adjusting dose",
  ], 0.42, 1.85, 4.15, 3.1, { fontSize: 13, color: C.darkText });

  // TYPE B
  sl.addShape(pres.ShapeType.roundRect, {
    x: 5.25, y: 1.15, w: 4.45, h: 3.9,
    fill: { color: "FFF3E0" }, line: { color: C.orange, pt: 2 }, rectRadius: 0.1,
  });
  sl.addShape(pres.ShapeType.roundRect, {
    x: 5.25, y: 1.15, w: 4.45, h: 0.55,
    fill: { color: C.orange }, line: { color: C.orange }, rectRadius: 0.1,
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    x: 5.35, y: 1.17, w: 4.25, h: 0.5,
    fontSize: 14, bold: true, color: C.white, fontFace: "Calibri", valign: "middle",
  });
  bullets(sl, [
    "NOT related to dose",
    "Rare & unexpected",
    "Allergic / immune reactions",
    "Genetic factors cause them",
    "Hard to predict before they happen",
    "Often require stopping the drug",
  ], 5.37, 1.85, 4.15, 3.1, { fontSize: 13, color: C.darkText });
}

// ═══════════════════════════════════════════════════════════════════════════
// SLIDE 6 — THERAPEUTIC INDEX
// ═══════════════════════════════════════════════════════════════════════════
{
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  lightSlide(sl);

  sl.addShape(pres.ShapeType.rect, { x: 0, y: 0, w: 10, h: 1.0, fill: { color: C.navy } });
  sl.addText("⚖️ Therapeutic Index — Safety Margin of a Drug", {
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    fontSize: 22, bold: true, color: C.white, fontFace: "Calibri", valign: "middle",
  });

  sl.addText("Therapeutic Index = Toxic Dose ÷ Effective Dose", {
    x: 0.5, y: 1.15, w: 9.0, h: 0.6,
    fontSize: 18, bold: true, color: C.teal, fontFace: "Calibri", align: "center",
  });

  sl.addText("👉 The BIGGER the index → the SAFER the drug!\nSmall index = drug needs careful monitoring!", {
    x: 0.5, y: 1.8, w: 9.0, h: 0.75,
    fontSize: 14, color: C.darkText, fontFace: "Calibri", align: "center", italic: true,
  });

  const narrowDrugs = [
    "Warfarin / Heparin (blood thinners)",
    "Insulin / Sulfonylureas (diabetes)",
    "Digoxin (heart)",
    "Aminoglycosides (antibiotics like Gentamicin)",
    "Antiepileptics (Phenytoin)",
    "Cytotoxic drugs (Methotrexate, Cyclosporine)",
    "Lithium (mood stabilizer)",
    "Antiarrhythmics (Lidocaine, Amiodarone)",
  ];

  sl.addShape(pres.ShapeType.roundRect, {
    x: 0.4, y: 2.7, w: 9.2, h: 2.65,
    fill: { color: "FEE8E8" }, line: { color: C.red, pt: 2 }, rectRadius: 0.1,
  });
  sl.addText("⚠️ Drugs with a NARROW Therapeutic Index (need careful monitoring):", {
    x: 0.55, y: 2.8, w: 9.0, h: 0.4,
    fontSize: 13, bold: true, color: C.red, fontFace: "Calibri",
  });

  const col1 = narrowDrugs.slice(0, 4);
  const col2 = narrowDrugs.slice(4);
  bullets(sl, col1, 0.55, 3.25, 4.5, 1.9, { fontSize: 12, color: C.darkText });
  bullets(sl, col2, 5.15, 3.25, 4.5, 1.9, { fontSize: 12, color: C.darkText });
}

// ═══════════════════════════════════════════════════════════════════════════
// SLIDE 7 — PHARMACOKINETIC VARIATION
// ═══════════════════════════════════════════════════════════════════════════
{
  let sl = pres.addSlide();
  lightSlide(sl);

  sl.addShape(pres.ShapeType.rect, { x: 0, y: 0, w: 10, h: 1.0, fill: { color: C.navy } });
  sl.addText("🔬 Why Do People React Differently to the Same Drug?", {
    x: 0.3, y: 0.05, w: 9.4, h: 0.9,
    fontSize: 21, bold: true, color: C.white, fontFace: "Calibri", valign: "middle",
  });

  const reasons = [
    { icon: "💊", title: "Pharmaceutical Variation", body: "Problem in the tablet/capsule itself\nE.g. Phenytoin toxicity when its capsule excipient changed from calcium sulfate → lactose (more absorbed!)" },
    { icon: "🧬", title: "Pharmacogenetic Variation", body: "Genes affect how fast you break down drugs\nFast vs Slow acetylators of Isoniazid → slow ones get nerve damage (neuropathy)" },
    { icon: "🫀", title: "Organ Disease", body: "Liver disease → drug not broken down → toxicity\nKidney disease → drug not excreted → builds up\nHeart failure → poor blood flow → slow drug clearance" },
  ];

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    const y = 1.2 + i * 1.38;
    sl.addShape(pres.ShapeType.roundRect, {
      x: 0.3, y, w: 9.4, h: 1.22,
      fill: { color: C.soft }, line: { color: C.teal, pt: 1 }, rectRadius: 0.08,
    });
    sl.addText(r.icon, { x: 0.4, y: y + 0.15, w: 0.9, h: 0.9, fontSize: 28, align: "center" });
    sl.addText(r.title, {
      x: 1.4, y: y + 0.08, w: 8.1, h: 0.38,
      fontSize: 14, bold: true, color: C.teal, fontFace: "Calibri",
    });
    sl.addText(r.body, {
      x: 1.4, y: y + 0.48, w: 8.1, h: 0.7,
      fontSize: 12.5, color: C.darkText, fontFace: "Calibri", lineSpacingMultiple: 1.2,
    });
  });
}

// ═══════════════════════════════════════════════════════════════════════════
// SLIDE 8 — GENETIC VARIATION (ACETYLATION & OXIDATION)
// ═══════════════════════════════════════════════════════════════════════════
{
  let sl = pres.addSlide();
  lightSlide(sl);

  sl.addShape(pres.ShapeType.rect, { x: 0, y: 0, w: 10, h: 1.0, fill: { color: C.navy } });
  sl.addText("🧬 Genetic Reasons for ADR", {
    x: 0.3, y: 0.05, w: 9.4, h: 0.9,
    fontSize: 24, bold: true, color: C.white, fontFace: "Calibri", valign: "middle",
  });

  // Acetylation
  sl.addShape(pres.ShapeType.roundRect, {
    x: 0.3, y: 1.1, w: 4.5, h: 4.2,
    fill: { color: "E8F4FB" }, line: { color: C.teal, pt: 2 }, rectRadius: 0.1,
  });
  sl.addText("💊 Acetylation (NAT enzyme)", {
    x: 0.45, y: 1.2, w: 4.2, h: 0.45,
    fontSize: 14, bold: true, color: C.teal, fontFace: "Calibri",
  });
  sl.addText("Some people are FAST, some are SLOW acetylators.\n\nSlow acetylators taking ISONIAZID (TB drug) → get PERIPHERAL NEUROPATHY (nerve pain).\n\nOther drugs affected:\nIsoniazid • Hydralazine • Procainamide • Dapsone", {
    x: 0.45, y: 1.72, w: 4.25, h: 3.4,
    fontSize: 13, color: C.darkText, fontFace: "Calibri", lineSpacingMultiple: 1.3, valign: "top",
  });

  // Succinylcholine
  sl.addShape(pres.ShapeType.roundRect, {
    x: 5.2, y: 1.1, w: 4.5, h: 4.2,
    fill: { color: "FFF8E1" }, line: { color: C.amber, pt: 2 }, rectRadius: 0.1,
  });
  sl.addText("💉 Succinylcholine Apnoea", {
    x: 5.35, y: 1.2, w: 4.2, h: 0.45,
    fontSize: 14, bold: true, color: C.orange, fontFace: "Calibri",
  });
  sl.addText("Succinylcholine is a muscle relaxant used in surgery.\n\nNormally broken down by PSEUDOCHOLINESTERASE enzyme.\n\nIn some people this enzyme is ABNORMAL → drug stays in body too long → Prolonged muscle paralysis → SCOLINE APNOEA (can't breathe!)\n\nInherited as autosomal recessive.", {
    x: 5.35, y: 1.72, w: 4.25, h: 3.4,
    fontSize: 12.5, color: C.darkText, fontFace: "Calibri", lineSpacingMultiple: 1.3, valign: "top",
  });
}

// ═══════════════════════════════════════════════════════════════════════════
// SLIDE 9 — ALLERGIC / IMMUNE REACTIONS
// ═══════════════════════════════════════════════════════════════════════════
{
  let sl = pres.addSlide();
  darkSlide(sl);

  sl.addText("🤧 Allergic Drug Reactions — 4 Types", {
    x: 0.3, y: 0.15, w: 9.4, h: 0.7,
    fontSize: 24, bold: true, color: C.amber, fontFace: "Calibri",
  });

  const types = [
    {
      type: "Type I — Anaphylaxis",
      color: C.red,
      text: "IgE → histamine release → Urticaria, Asthma, Anaphylactic Shock\n⚠️ Drugs: Penicillin, Streptomycin, Local Anesthetics",
    },
    {
      type: "Type II — Cytotoxic",
      color: "8E44AD",
      text: "IgG/IgM antibodies destroy blood cells\n⚠️ Causes: Hemolytic Anemia, Thrombocytopenia",
    },
    {
      type: "Type III — Immune Complex",
      color: C.orange,
      text: "Antibody + antigen form complexes → damage capillaries → Serum Sickness\n⚠️ Drugs: Penicillin, Sulfonamides",
    },
    {
      type: "Type IV — Cell Mediated",
      color: C.teal,
      text: "T-lymphocytes react to drug → Contact Dermatitis\n⚠️ Drugs: Topical antibiotics, antifungal creams",
    },
  ];

  types.forEach((t, i) => {
    const col = i % 2;
    const row = Math.floor(i / 2);
    const x = 0.3 + col * 4.85;
    const y = 1.05 + row * 2.1;
    sl.addShape(pres.ShapeType.roundRect, {
      x, y, w: 4.55, h: 1.9,
      fill: { color: "0D3B52" }, line: { color: t.color, pt: 2 }, rectRadius: 0.1,
    });
    sl.addShape(pres.ShapeType.roundRect, {
      x, y, w: 4.55, h: 0.45,
      fill: { color: t.color }, line: { color: t.color }, rectRadius: 0.1,
    });
    sl.addText(t.type, {
      x: x + 0.1, y: y + 0.02, w: 4.35, h: 0.42,
      fontSize: 13, bold: true, color: C.white, fontFace: "Calibri", valign: "middle",
    });
    sl.addText(t.text, {
      x: x + 0.1, y: y + 0.5, w: 4.35, h: 1.35,
      fontSize: 12, color: "D0ECF5", fontFace: "Calibri", lineSpacingMultiple: 1.3, valign: "top",
    });
  });

  sl.addText("🔸 Pseudo-Allergic: Looks like allergy but NO immune mechanism found (e.g. Aspirin → Asthma/Rash)", {
    x: 0.3, y: 5.25, w: 9.4, h: 0.28,
    fontSize: 11.5, color: C.amber, fontFace: "Calibri", italic: true,
  });
}

// ═══════════════════════════════════════════════════════════════════════════
// SLIDE 10 — SKIN RASHES
// ═══════════════════════════════════════════════════════════════════════════
{
  let sl = pres.addSlide();
  lightSlide(sl);

  sl.addShape(pres.ShapeType.rect, { x: 0, y: 0, w: 10, h: 1.0, fill: { color: C.navy } });
  sl.addText("🩺 Common Skin Reactions from Drugs", {
    x: 0.3, y: 0.05, w: 9.4, h: 0.9,
    fontSize: 22, bold: true, color: C.white, fontFace: "Calibri", valign: "middle",
  });

  const rashes = [
    { name: "Erythema Multiforme", desc: "Target-like lesions on arms/legs", drugs: "Penicillin, Sulfonamides" },
    { name: "Erythema Nodosum", desc: "Tender red nodules on shins", drugs: "Phenobarbital, OCP" },
    { name: "Exfoliative Dermatitis", desc: "Red, scaly skin over large areas", drugs: "Carbamazepine, Gold salts" },
    { name: "Pemphigus", desc: "Widespread fluid-filled blisters", drugs: "Penicillamine, Rifampicin" },
    { name: "Urticaria (Hives)", desc: "Raised, red itchy patches", drugs: "Codeine, Penicillin, Dextrans" },
  ];

  rashes.forEach((r, i) => {
    const y = 1.15 + i * 0.85;
    sl.addShape(pres.ShapeType.roundRect, {
      x: 0.3, y, w: 9.4, h: 0.75,
      fill: { color: i % 2 === 0 ? C.soft : C.white }, line: { color: C.teal, pt: 1 }, rectRadius: 0.06,
    });
    sl.addText(r.name, {
      x: 0.45, y: y + 0.1, w: 2.8, h: 0.5,
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    });
    sl.addText(r.desc, {
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    });
    sl.addText("💊 " + r.drugs, {
      x: 6.9, y: y + 0.1, w: 2.7, h: 0.5,
      fontSize: 11.5, color: C.orange, fontFace: "Calibri", valign: "middle", italic: true,
    });
  });
}

// ═══════════════════════════════════════════════════════════════════════════
// SLIDE 11 — GENETIC / ENZYME DEFECTS
// ═══════════════════════════════════════════════════════════════════════════
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  sl.addText("🧬 Genetic Enzyme Defects Causing ADR", {
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    fontSize: 22, bold: true, color: C.white, fontFace: "Calibri", valign: "middle",
  });

  const defs = [
    {
      title: "G6PD Deficiency", icon: "🔴",
      body: "G6PD enzyme is missing → Red blood cells BURST (haemolysis) when exposed to oxidizing drugs\nMore common in Africans & Mediterranean people\nDrugs to avoid: Primaquine, Dapsone, Nitrofurantoin",
      color: C.red,
    },
    {
      title: "Glutathione Reductase Deficiency", icon: "🟠",
      body: "Without this enzyme, red cell defense against oxidants fails → haemolysis\nAutosomal dominant inheritance",
      color: C.orange,
    },
    {
      title: "Methaemoglobin Reductase Deficiency", icon: "🔵",
      body: "Methaemoglobin builds up → cannot carry oxygen → HYPOXAEMIA (low blood oxygen)\nAutosomal recessive inheritance",
      color: C.teal,
    },
  ];

  defs.forEach((d, i) => {
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    });
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}

// ═══════════════════════════════════════════════════════════════════════════
// SLIDE 12 — PORPHYRIA & MALIGNANT HYPERTHERMIA
// ═══════════════════════════════════════════════════════════════════════════
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  lightSlide(sl);

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  sl.addText("⚠️ Special Genetic Conditions & Drug Reactions", {
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  sl.addText("Porphyrias = group of disorders in HAEM making pathway.\n\nCertain drugs trigger acute attacks.\n\nSymptoms: Abdominal pain, Neurological problems, Skin blistering.\n\n🚫 Avoid in Porphyria:\nBarbiturates • Dapsone • Chloramphenicol • Diclofenac", {
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    fontSize: 12.5, color: C.darkText, fontFace: "Calibri", lineSpacingMultiple: 1.3, valign: "top",
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  sl.addText("Autosomal dominant genetic condition of SKELETAL MUSCLES.\n\nTriggered by: Inhaled anaesthetics (halogenated) + Succinylcholine during surgery.\n\nWhat happens: Uncontrolled calcium release → Muscle spasms + Very HIGH body temperature (hyperthermia).\n\n✅ Treatment: DANTROLENE (life-saving drug!)", {
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  });
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// ═══════════════════════════════════════════════════════════════════════════
// SLIDE 13 — LONG-TERM & WITHDRAWAL REACTIONS
// ═══════════════════════════════════════════════════════════════════════════
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    fontSize: 24, bold: true, color: C.amber, fontFace: "Calibri",
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  sl.addText("Using a drug for a LONG TIME or STOPPING it SUDDENLY can cause serious problems!", {
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    { icon: "🔁", title: "Tolerance", text: "Body gets used to drug → needs MORE for same effect\nExample: Narcotic analgesics (morphine, codeine)" },
    { icon: "😵", title: "Tardive Dyskinesia", text: "Long-term antipsychotics (schizophrenia drugs) → involuntary repetitive movements" },
    { icon: "💔", title: "Beta-Blocker Withdrawal", text: "Sudden stop → REBOUND TACHYCARDIA → can trigger heart attack (myocardial ischemia)" },
    { icon: "🧠", title: "Barbiturate Withdrawal", text: "Sudden stop → Restlessness, Mental confusion, Convulsions" },
    { icon: "⚗️", title: "Steroid Withdrawal", text: "Sudden stop → ADRENAL INSUFFICIENCY (life-threatening!)" },
    { icon: "🍺", title: "Alcohol Withdrawal", text: "Sudden stop → DELIRIUM TREMENS (hallucinations, seizures)" },
  ];

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      fill: { color: "0D3B52" }, line: { color: C.teal, pt: 1 }, rectRadius: 0.08,
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}

// ═══════════════════════════════════════════════════════════════════════════
// SLIDE 14 — CARCINOGENESIS & REPRODUCTIVE EFFECTS
// ═══════════════════════════════════════════════════════════════════════════
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  sl.addText("🧪 Delayed Adverse Effects — Cancer & Reproduction", {
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    fontSize: 21, bold: true, color: C.white, fontFace: "Calibri", valign: "middle",
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  const cancers = [
    { mech: "Hormonal", example: "HRT > 5 years → 50% higher breast cancer risk; Stilboestrol in pregnancy → vaginal cancer in daughters" },
    { mech: "Gene Toxicity", example: "Cyclophosphamide → Bladder cancer; Melphalan → Leukemia; Phenacetin → Renal pelvis cancer" },
    { mech: "Immune Suppression", example: "Azathioprine + Corticosteroids → Lymphoma" },
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  cancers.forEach((c, i) => {
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    "Impaired Fertility: Cytotoxic drugs → ovarian failure in women; Sulfasalazine → reduced sperm in men",
    "Teratogenesis: Drug taken in early pregnancy → birth defects in baby",
    "Most dangerous period: 18–55 days of pregnancy (organogenesis — when organs are forming)",
    "Key teratogenic drugs: Thalidomide, Warfarin, Phenytoin, Valproate, Methotrexate, Lithium",
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}

// ═══════════════════════════════════════════════════════════════════════════
// SLIDE 15 — SUMMARY / KEY TAKEAWAYS
// ═══════════════════════════════════════════════════════════════════════════
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  darkSlide(sl);

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  sl.addText("✅ Key Takeaways — ADR in a Nutshell", {
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    "ADR = Harmful, unintended effect at NORMAL doses — not the patient's fault!",
    "Type A (Predictable) = Dose-related, common, preventable by adjusting dose",
    "Type B (Unpredictable) = Rare, immune/genetic, harder to prevent",
    "Narrow TI drugs (Warfarin, Digoxin, Insulin) need careful monitoring",
    "Genes matter — Fast/Slow acetylators and enzyme deficiencies cause different reactions",
    "Organ disease (liver, kidney, heart) significantly changes how drugs behave",
    "Allergy Types I–IV: from anaphylaxis to contact dermatitis",
    "Never stop long-term drugs suddenly — withdrawal can be life-threatening",
    "Certain drugs cause cancer or birth defects — especially in pregnancy",
    "If unsure, ALWAYS check drug history and inform your doctor / pharmacist",
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// ─── WRITE FILE ──────────────────────────────────────────────────────────────
pres.writeFile({ fileName: "/home/daytona/workspace/adr-ppt/Adverse_Drug_Reactions.pptx" })
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  .catch(err => console.error("❌ Error:", err));