Excellent data gathered. Now presenting all five major cases in full step-by-step clinical format:
π₯ Step-by-Step Clinical Cases β Duty Doctor Edition
π΄ CASE 1: SEPSIS
The Patient Arrives
"65-year-old male, nursing home resident. Brought in confused, febrile 39.2Β°C, BP 88/60, RR 24, SpOβ 93% on air. Urine looks cloudy. Family says he's been 'off' for 2 days."
Step 1 β Recognise It (qSOFA)
Screen immediately at bedside:
| qSOFA Criterion | This Patient |
|---|
| Altered mental status (GCS <15) | β
Confused |
| RR β₯22/min | β
RR 24 |
| SBP β€100 mmHg | β
BP 88/60 |
Score: 3/3 β Presumed Sepsis / Septic Shock. Act NOW.
Step 2 β Call for Help
- Inform your registrar/consultant immediately
- Activate sepsis pathway if your hospital has one
- Move patient to resus/HDU
Step 3 β The Sepsis Six (within 60 minutes, simultaneously)
TAKE 3:
- π©Έ Blood cultures Γ2 (peripheral; before antibiotics β do NOT delay antibiotics waiting for this)
- π©Έ FBC, U&E, LFTs, CRP, coagulation, lactate (lactate is critical β >2 mmol/L = sepsis, >4 = septic shock)
- π½ Urinary catheter β monitor urine output (target >0.5 mL/kg/hr)
GIVE 3:
- π§ IV fluids β 500 mL crystalloid bolus (Hartmann's preferred over NS); reassess after each bolus
- π IV antibiotics β broad-spectrum within 1 hr (e.g., Piperacillin-Tazobactam 4.5g IV + Gentamicin for urosepsis; always check local policy)
- π« Oxygen β high-flow via non-rebreather mask; target SpOβ >94%
Step 4 β Reassess at 30 minutes
| Target | Goal |
|---|
| MAP | β₯65 mmHg |
| Urine output | >0.5 mL/kg/hr |
| Lactate | Falling by β₯10% |
| SpOβ | >94% |
If BP not responding after 1β2 L fluids β start Noradrenaline (vasopressor, via central or peripheral line initially; target MAP β₯65)
Step 5 β Ongoing Monitoring
- Repeat lactate at 2 hours β aim for normalisation to <2 mmol/L
- Cultures guide de-escalation of antibiotics at 48β72 hrs
- Daily reassessment: fluid balance, organ function (renal, liver, coagulation)
Pitfall: Do NOT delay antibiotics waiting for cultures. Every hour of delay in antibiotics increases mortality by ~7%.
π΄ CASE 2: ANAPHYLAXIS
The Patient
"22-year-old female. 10 minutes after penicillin IV in the ward β suddenly flushed, throat tightening, BP drops to 70/40, RR 28, generalised urticaria. Nurse calls you urgently."
Step 1 β Recognise It
Classic triad: Rapid onset + Skin/mucosal changes + Airway/BP/cardiovascular compromise
Step 2 β STOP the Trigger
- Stop the penicillin infusion immediately
- Do NOT remove IV cannula (you'll need it)
Step 3 β Call for Help + Position
- Shout for help / crash team
- Lay patient flat, legs elevated (unless airway compromise β then sit up)
- Prepare for airway management (have airway trolley ready)
Step 4 β ADRENALINE FIRST (no delays)
Adrenaline 0.5 mg IM into anterolateral thigh (1:1000 = 1 mg/mL β give 0.5 mL)
- Repeat every 5 minutes if no improvement
- This is the ONLY life-saving drug β give it before everything else
Step 5 β Resuscitate
- High-flow Oβ via non-rebreather mask
- IV fluids β 1000 mL 0.9% NaCl STAT (several litres may be needed)
- Cardiac monitoring + pulse oximetry
Step 6 β Second-Line Drugs (after adrenaline)
| Drug | Dose | Route | Purpose |
|---|
| Chlorphenamine | 10 mg | IV/IM | H1 antihistamine β itch/urticaria |
| Ranitidine/Famotidine | 40 mg | IV | H2 antihistamine |
| Hydrocortisone | 200 mg | IV | Prevents biphasic reaction (no acute benefit) |
| Salbutamol | 2.5 mg nebulised | Inhaled | If bronchospasm present |
Step 7 β Monitor for Biphasic Reaction
- Observe minimum 6β12 hours after reaction resolves
- Biphasic (return of symptoms without re-exposure) occurs in ~5β20%
- Before discharge: prescribe EpiPen Γ2, allergy band, allergy referral, alert on drug chart
π΄ CASE 3: STEMI
The Patient
"58-year-old male, smoker, diabetic. Sudden onset central crushing chest pain radiating to left arm, sweating, started 45 mins ago. ECG shows ST elevation in leads II, III, aVF. BP 110/70."
Step 1 β 12-Lead ECG Immediately
- Inferior STEMI (II, III, aVF) β suspect Right Coronary Artery occlusion
- Do a right-sided ECG (V4R) β if ST elevation = RV infarct β avoid nitrates and aggressive diuresis
Step 2 β Call Cardiology NOW
- Activate the cath lab / PPCI pathway within minutes of diagnosis
- Door-to-balloon target: β€90 minutes
Step 3 β Dual Antiplatelet Loading (while awaiting PCI)
| Drug | Dose |
|---|
| Aspirin | 300 mg PO (chew, don't swallow whole) |
| Ticagrelor | 180 mg PO (or Clopidogrel 600 mg if Ticagrelor not available) |
Step 4 β Anticoagulation
- UFH (Unfractionated Heparin) bolus: 60β70 units/kg IV (max 5000 units) β cardiology will guide
- Or LMWH if fibrinolysis planned
Step 5 β Supportive Measures
- Oβ only if SpOβ <94% (hyperoxia is harmful in STEMI)
- GTN spray (2 puffs sublingual) β only if SBP >90 and NO RV infarct
- Analgesia β IV morphine 2.5β5 mg titrated (cautiously β may mask symptoms)
- IV antiemetic (metoclopramide 10 mg)
- IV access Γ2, continuous monitoring
Step 6 β If PCI NOT available within 90 min β Fibrinolysis
- Tenecteplase (weight-based IV bolus) or Alteplase
- Check absolute contraindications first: prior haemorrhagic stroke, active bleeding, recent surgery, uncontrolled hypertension
- Signs of reperfusion success at 60β90 min: chest pain relief, ST normalisation β₯50%, reperfusion arrhythmia
- If failed β rescue PCI urgently
π΄ CASE 4: DIABETIC KETOACIDOSIS (DKA)
The Patient
"19-year-old known T1DM. Brought in vomiting, Kussmaul breathing, drowsy. RBS 28 mmol/L, ketones 5.2, pH 7.1, HCOβ 9, K+ 3.8."
DKA Diagnostic Criteria (all three required):
- Blood glucose >11 mmol/L (or known diabetes)
- Ketonaemia β₯3 mmol/L or ketonuria β₯2+
- Acidosis: pH <7.3 or HCOβ <15 mmol/L
Step 1 β IV Access + Bloods
- FBC, U&E, blood glucose, blood ketones, ABG, blood cultures, urine dip
- VBG acceptable for monitoring (faster)
Step 2 β IV Fluid Resuscitation (most important initial step)
| Time | Fluid |
|---|
| 0β60 min | 1 L 0.9% NaCl over 1 hour |
| 1β2 hrs | 1 L 0.9% NaCl over 2 hours |
| 2β4 hrs | 1 L 0.9% NaCl over 2 hours |
| 4β8 hrs | 1 L 0.9% NaCl over 4 hours |
| 8β12 hrs | 1 L 0.9% NaCl over 4 hours |
When glucose falls to <14 mmol/L β switch to 10% dextrose alongside saline to allow continued insulin without hypoglycaemia
Step 3 β Fixed Rate Insulin Infusion (FRIII)
- 0.1 units/kg/hr of IV Actrapid (short-acting insulin)
- Do NOT give bolus insulin
- Do NOT start if K+ <3.5 mmol/L β replace potassium FIRST
Step 4 β Potassium Management (critical)
| K+ Level | Action |
|---|
| K+ <3.5 mmol/L | Do NOT start insulin. Replace K+ urgently, recheck |
| K+ 3.5β5.5 mmol/L | Add 40 mmol KCl per litre of fluid |
| K+ >5.5 mmol/L | No potassium supplementation; monitor closely |
DKA causes total body potassium depletion even if serum K+ is normal/high initially. Insulin drives K+ intracellularly β dangerous drop expected.
Step 5 β Monitoring Targets
| Time | Check |
|---|
| Hourly | Blood glucose + ketones + GCS |
| 2-hourly | VBG (pH, HCOβ, K+) |
| 4-hourly | U&E |
Resolution criteria (all three):
- Blood ketones <0.6 mmol/L
- pH >7.3
- Bicarbonate >18 mmol/L
Step 6 β Transition to Subcutaneous Insulin
- When eating and drinking + resolution criteria met
- Give SC insulin 30β60 min before stopping IV infusion
- Find and treat precipitant: infection, missed insulin, new diagnosis
π΄ CASE 5: ACUTE ISCHAEMIC STROKE
The Patient
"72-year-old hypertensive female. Sudden onset right-sided weakness + slurred speech 2 hours ago. GCS 13. BP 190/110. BM 7.2."
Step 1 β FAST Assessment + Time Stamp
- Face, Arm, Speech, Time β document exact onset time or last seen well
- Every minute of delay = ~1.9 million neurons lost
Step 2 β Immediate Investigations (all within 15 min)
- Non-contrast CT head β exclude haemorrhage (looks white = blood)
- FBC, coagulation, glucose, U&E, group & save
- 12-lead ECG (AF as cause?)
- If CT clear β discuss thrombolysis with stroke team
Step 3 β Thrombolysis Decision
IV Alteplase 0.9 mg/kg (max 90 mg) β 10% as bolus, rest over 60 min
Eligible if:
- Ischaemic stroke confirmed (no haemorrhage)
- Onset <4.5 hours ago
- No contraindications (recent surgery, anticoagulants, BP not controlled)
Must control BP first: target <185/110 mmHg before giving tPA
Step 4 β Contraindications to Thrombolysis (check every time)
- Prior haemorrhagic stroke at any time
- Intracranial surgery/head trauma in last 3 months
- Active internal bleeding
- Platelet count <100,000
- On warfarin with INR >1.7 or NOAC within 48 hrs
- BP >185/110 despite treatment
Step 5 β Supportive Care
- NBM until formal SALT (speech and language therapy) swallow assessment
- Do NOT lower BP aggressively unless >220/120 (or pre-thrombolysis)
- Blood glucose: treat if <4 or >11 mmol/L
- Antipyrexia if febrile (fever worsens infarct)
- Aspirin 300 mg (via NG/PR if dysphagia) β start 24 hrs after thrombolysis, or immediately if no thrombolysis
Step 6 β Thrombectomy Window
- For large vessel occlusion β mechanical thrombectomy up to 24 hours (selected patients)
- Discuss with stroke team urgently
π§ Quick Mental Framework for ANY Emergency
ABCDE β Stabilise first, diagnose second
A β Airway (patent? need adjunct?)
B β Breathing (rate, SpOβ, auscultate)
C β Circulation (HR, BP, cap refill, IV access, fluids)
D β Disability (GCS, pupils, glucose)
E β Exposure (temperature, rashes, injuries, signs)
Then: Recognise β Resuscitate β Reassess β Refer
Which case would you like to go deeper on β drug calculations, monitoring charts, or a more complex variant of any of these? I can also present cases for PE, acute pulmonary oedema, hyperkalaemia, or upper GI bleed next.