Hepatitis b vaccine dose in ml
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Hepatitis B vaccine dose ml schedule adults children
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Here is a summary of Hepatitis B vaccine dosing by age group and product:
Hepatitis B Vaccine Doses
Standard Products: Engerix-B & Recombivax HB
| Age Group | Engerix-B (GlaxoSmithKline) | Recombivax HB (Merck) |
|---|---|---|
| Neonates / Infants (0–19 yrs) | 0.5 mL (10 mcg) | 0.5 mL (5 mcg) |
| Adults (≥20 yrs) | 1.0 mL (20 mcg) | 1.0 mL (10 mcg) |
| Immunocompromised / Dialysis patients (adults) | 2.0 mL (40 mcg) — special formulation | 1.0 mL (40 mcg) — dialysis formulation |
| Adolescents 11–15 yrs (2-dose schedule) | — | 1.0 mL (10 mcg) adult formulation |
Newer Product: Heplisav-B (Dynavax)
- Dose: 0.5 mL per injection
- Schedule: 2-dose series (0 and 1 month)
- Approved for: Adults ≥18 years only
Combination Vaccine: Twinrix (Hep A + Hep B)
- Dose: 1.0 mL per injection
- Schedule: 3-dose series at 0, 1, and 6 months
- Approved for: Adults ≥18 years
Schedules (Monovalent Vaccines — Adults)
- 3-dose: 0, 1, 6 months (most common)
- 3-dose alternatives: 0, 1, 4 months or 0, 2, 4 months
- 4-dose (Engerix-B): 0, 1, 2, 12 months
(STI Guidelines, p. 119)
Key point: The dose in mL depends on age and brand — the most commonly used dose is 0.5 mL for children/infants and 1.0 mL for adults, administered intramuscularly into the anterolateral thigh (infants) or deltoid muscle (older children/adults).
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