Create an Anki card for [Definition of inflammation, difference between acute and chronic inflammation, cardinal signs of inflammation, the steps of acute inflammation, the vascular events, which includes early transient vasoconstriction, vasodilation, increased vascular permeability, difference between exudate and transudate, stasis, then cellular events, which includes margination or pavementing, then rolling, then the mediators, which are the selectins, L-selectin, R-selectin, P-selectin, their distribution and the ligands. Then comes adhesion, the mediators, which includes integrins, the integrins on leukocytes and the ligands on endothelium. Then comes transmigration or diapedesis, the mediators, then comes chemotaxis, its mechanism and the mediators, the exogenous and endogenous, its source and chemoattractants. Then comes opsonization and the various opsonins, then phagocytosis, its mechanism, then about frustrated phagocytosis. Next is leukocyte function defects, which includes leukocyte adhesion deficiency type 1 and type 2, the differences based on inheritance, clinical presentation and pathogenesis. Then comes chronic granulomatous disease, its inheritance, clinical presentation, pathogenesis and screening test. Then comes Celiac Hegasi syndrome, its inheritance, pathogenesis and clinical presentation. And then comes neutrophil extracellular traps, its goal, mechanism. Then finally, emperiopoiesis, its difference from phagocytosis and conditions where you see emperiopoiesis. ] for NEET PG 2027 exam (pathology focus). Output a downloadable .txt file with exactly one line in this format: Front[TAB]Back. The Front should contain only the topic name. The Back should contain a comprehensive summary covering 100% of exam-relevant content, formatted using HTML bold tags for section headings and <br><br> between sections for spacing and readability. Do not use any newlines, pipes, or semicolons in the file — only commas, colons, dashes, and HTML tags. Confirm the file is exactly 1 line using wc -l before delivering it.

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The file is confirmed to be exactly 1 line, with 1 tab separator, 0 semicolons, 0 pipes, and no newlines in content. Here is your Anki card file:

inflammation anki

Text File · TXT


File verified: wc -l = 1 line | TAB-separated | 0 pipes | 0 semicolons | ~18,900 characters

Here's a summary of what's packed into the Back of the card (all 100% NEET PG-relevant):
SectionKey Content
DefinitionVascularized tissue response, protective, -itis suffix
Acute vs ChronicDuration, cell types, morphology, causes of chronic
Cardinal SignsRubor, Calor, Tumor, Dolor, Functio laesa + who described them
Vascular EventsVasoconstriction (transient) → vasodilation (mediators) → increased permeability (mechanisms)
Exudate vs TransudateProtein content, SG, mechanism, examples
StasisMechanism, consequence (margination)
Margination/PavementingDefinition, mechanism
RollingMediated by selectins, weak reversible interactions
SelectinsL (leukocytes/tips of microvilli/GlyCAM-1,CD34), E (endothelium/induced TNF-IL1/Sialyl-LewisX), P (platelets+endothelium/Weibel-Palade bodies/PSGL-1)
Adhesion/IntegrinsLFA-1→ICAM-1, MAC-1→ICAM-1, VLA-4→VCAM-1, high/low affinity states
TransmigrationPECAM-1 (CD31), CD99, collagenase, neutrophils first then monocytes
ChemotaxisG-protein receptors, actin polymerization, exogenous (fMLP), endogenous (C5a, LTB4, IL-8/CXCL8)
OpsonizationIgG (FcγR), C3b (CR1/CR3), lectins (MBL)
PhagocytosisRecognition→engulfment→killing (NADPH oxidase, MPO, HOCl, iNOS/NO)
Frustrated PhagocytosisLarge particles, extracellular enzyme release, examples (gout, SLE, Goodpasture)
LAD-1AR, CD18/beta-2 integrin defect, delayed cord separation, neutrophilia, no pus
LAD-2AR, GDP-fucose transporter/fucosylation defect, absent sialyl-LewisX, Bombay blood group, milder, intellectual disability
CGDX-linked (gp91phox) or AR (p22/p47/p67phox), NADPH oxidase defect, catalase-positive organisms, granulomas, DHR flow cytometry and NBT tests
Chediak-HigashiAR, LYST gene, giant granules, albinism, neuropathy, accelerated HLH phase, impaired degranulation/chemotaxis
NETsGoal: trap microbes, mechanism: PAD4, citrullination, chromatin decondensation, NETosis, role in thrombosis and SLE
EmperipolesisIntact viable cell inside macrophage (NOT killed), vs phagocytosis (digested), Rosai-Dorfman disease (S100+, CD68+, CD1a-)
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