PLEASE FIND CORRELATION BETWEEN TC TG HDL LDL VLDL BOTH RATIO WITH CYC C E GFR AND SAME PARAMETERS WITH CREATININE E GFR
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Correlation of Lipid Parameters with eGFR
- eGFR (Creatinine) = MDRD: 175 × Creat^-1.154 × Age^-0.203 (×0.742 for females)
- eGFR (Cystatin C) = Hoek: 127.7 × CysC^-1.17 × Age^-0.13 (×0.91 for females)
Table: Pearson Correlation (r) and p-values
| Parameter | r (CysC eGFR) | p-value | Significance | r (Creatinine eGFR) | p-value | Significance |
|---|---|---|---|---|---|---|
| TC | -0.1603 | 0.2661 | NS | +0.0039 | 0.9785 | NS |
| TG | +0.1098 | 0.4480 | NS | +0.0727 | 0.6161 | NS |
| HDL | -0.0418 | 0.7733 | NS | +0.0221 | 0.8788 | NS |
| LDL | -0.1913 | 0.1832 | NS | -0.0207 | 0.8868 | NS |
| VLDL | +0.1098 | 0.4480 | NS | +0.0727 | 0.6161 | NS |
| TC/HDL | -0.1399 | 0.3325 | NS | -0.0097 | 0.9465 | NS |
| LDL/HDL | -0.1855 | 0.1971 | NS | -0.0327 | 0.8217 | NS |
Interpretation
- LDL showed the strongest (though non-significant) negative correlation with CysC-eGFR (r = -0.1913, p = 0.183), suggesting higher LDL tends weakly toward lower eGFR by this measure.
- TC also had a weak negative correlation with CysC-eGFR (r = -0.1603) but none with creatinine-eGFR.
- TG and VLDL showed identical weak positive correlations (r = +0.1098 for CysC-eGFR; they are mathematically linked since VLDL = TG/5).
- Correlations with creatinine-based eGFR were all extremely weak (|r| < 0.08), suggesting lipid levels have little relationship with creatinine clearance in this cohort.
- The discrepancy in direction between CysC-eGFR and creatinine-eGFR correlations for TC (r = -0.16 vs +0.004) reflects the different sensitivities of the two GFR estimation methods.
ARTICLE SMITA GFR Correlations
Spreadsheet · XLSX