Orris

Can u check whether this has been publishes anywhere before

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Browsing Directory

~/

Running Command

mkdir -p "/tmp/workspace/publication-check" && python3 -c "from docx import Document; p='/tmp/workspace/attachments/43ee2461-8e4d-40ec-8fb3-fc0141673d1e/Trigger_Exposure_Data_Reference.docx'; d=Document(p); out='/tmp/workspace/publication-check/extracted.txt'; f=open(out,'w',encoding='utf-8'); [f.write(x.text+'\n') for x in d.paragraphs if x.text.strip()]; [f.write('\n[TABLE]\n'+'\n'.join(' | '.join(c.text for c in row.cells) for row in t.rows)+'\n') for t in d.tables]; f.close(); print(out)" && python3 -c "from docx import Document; p='/tmp/workspace/attachments/43ee2461-8e4d-40ec-8fb3-fc0141673d1e/Trigger_Exposure_Data_Reference.docx'; d=Document(p); print('paragraphs',len(d.paragraphs),'tables',len(d.tables))"

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Searching the Web

"Trigger-Exposure Data Reference Sheet"

Searching the Web

"SEM = C(functional activation)"

Searching the Web

"plasma-vs-local-graft-concentration proxy issue"

Searching PubMed

"Tet-On" AND doxycycline

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Searching PubMed

"Trigger Exposure"

Searching PubMed

"super-sensitive AID"

Searching PubMed

"CreERT2" AND endoxifen

I found no evidence that this exact document, title, formula, or wording has been published online before.
What I checked:
  • Exact title: “Trigger-Exposure Data Reference Sheet”
  • Distinctive wording, including the custom SEM definition: SEM = C(functional activation) ÷ C(maximum plausible human exposure)
  • Another distinctive sentence: “Plasma-vs-local-graft-concentration proxy issue applies to every row”
  • PubMed searches for the core topic combinations
The searches did identify the underlying published studies cited in the sheet, such as the super-sensitive AID study and work on tamoxifen metabolites and CreERT2 control. But I did not find a paper, preprint, web page, or indexed record that presents this particular cross-system comparison, its “SEM” framework, table structure, grading system, or wording.
Assessment: it appears to be an unpublished compiled reference sheet or original synthesis, rather than a previously published document.
Limit: this is not proof of worldwide originality. A document could still exist in a private repository, non-indexed webpage, unpublished thesis, internal report, or database not discoverable through public web and PubMed searches. Also, several cited sources are published, so the sheet should cite them carefully and verify every extracted value against the primary papers before treating it as publication-ready.

Ok I have to take some for this what to uk do something that has never been done here

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Do you mean you need to turn this into a research project or paper with a genuinely new contribution, rather than just a reference sheet?
If yes, I can help you choose a feasible novel angle, for example:
  1. Validate all trigger thresholds and human exposure values from primary sources.
  2. Build a standardized, reproducible “exposure-to-activation margin” method.
  3. Test whether common medicines can unintentionally activate engineered cell-control systems.
  4. Identify a safer trigger system based on real-world exposure and pharmacokinetics.
Tell me what you need it for: a paper, university project, grant/proposal, or patent idea.
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