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Generate an exam oriented notes on the chapter ANS and autacoids under following heading..cholinergic and anticholinergic drugs , adrenergic and anti adrenegic drugs, autacoid : serotonin and drugs acting or serotonergic system , autacoids : histamine and antihistamine and treatment of migraine..make a simple , concise and easily understandable notes in TABLE format a

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ANS Autacoids Exam Notes

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Here is a summary of what is covered inside, all in table format:

What's Inside the Document

Section 1 — Cholinergic & Anticholinergic Drugs

  • Cholinergic drugs table: Direct-acting (ACh, Bethanechol, Carbachol, Pilocarpine, Muscarine) and Indirect-acting (Physostigmine, Neostigmine, Pyridostigmine, Edrophonium, Organophosphates, Donepezil/Rivastigmine) with MOA, uses, and adverse effects
  • Atropine actions table: Organ-wise effects (heart, eye, glands, GIT, bladder, bronchi, CNS)
  • Atropine substitutes table: Scopolamine, Tropicamide, Homatropine, Ipratropium, Pirenzepine, Oxybutynin, Benztropine — with selectivity and uses
  • Key mnemonics: SLUDGE for cholinergic toxicity; HOT-DRY-RED-BLIND-MAD for atropine poisoning

Section 2 — Adrenergic & Anti-Adrenergic Drugs

  • Adrenergic agonists: Catecholamines (Adrenaline, NA, Dopamine, Dobutamine, Isoprenaline) with dose-dependent receptor actions
  • Selective β2 agonists: SABAs (Salbutamol, Terbutaline) and LABAs (Salmeterol, Formoterol)
  • Alpha agonists: Phenylephrine, Clonidine, Methyldopa
  • Alpha blockers: Phentolamine, Phenoxybenzamine, Prazosin, Tamsulosin — with phaeochromocytoma management
  • Beta blockers: Full table with Propranolol (prototype), cardioselective agents, Carvedilol, Labetalol, Esmolol — uses, AEs, and contraindications table

Section 3 — Autacoids: Serotonin

  • 5-HT receptor subtypes table: 5-HT1A/1B/1D/2A/3/4 — location, effect, and drug targets
  • 5-HT agonists: Triptans (Sumatriptan as DOC), Buspirone, SSRIs
  • 5-HT antagonists: Ondansetron/Granisetron (CINV), Cyproheptadine (dual H1+5HT2A), Ketanserin, Methysergide
  • Ergot alkaloids table: Ergotamine, Ergometrine, Bromocriptine

Section 4 — Histamine, Antihistamines & Migraine

  • Histamine receptor table: H1/H2/H3/H4 — location, effects, pharmacological significance
  • 1st vs 2nd generation antihistamine comparison table
  • Individual drug tables: Diphenhydramine, Promethazine, Chlorpheniramine, Cyclizine, Cinnarizine, Cyproheptadine (1st gen) and Cetirizine, Levocetirizine, Loratadine, Fexofenadine, Azelastine, Rupatadine (2nd gen)
  • Migraine acute treatment table: Triptans (DOC), Ergotamine, NSAIDs, Antiemetics, Opioids
  • Migraine prophylaxis table with mnemonic ABCD: Amitriptyline, Beta-blockers (Propranolol), Calcium channel blockers (Flunarizine), Drugs (Valproate, Topiramate) + newer CGRP antibodies
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