Research SNPs associated with two metabolic traits: glycemic_load_intolerance (T100) and refined_carb_sensitivity (T101). For each trait, find: 1. Strong, high-confidence SNPs with good evidence (GWAS hits, replicated studies, meta-analyses) 2. Gene name, SNP rsID, risk allele, effect size/OR where available 3. Functional mechanism (how the SNP affects the trait) 4. Population-specific evidence, especially Indian/South Asian cohort data where available 5. Key references Trait definitions: - T100 glycemic_load_intolerance: Sensitivity to total carbohydrate load — relates to postprandial glycemia, insulin response, HbA1c, type 2 diabetes risk - T101 refined_carb_sensitivity: Sensitivity to processed/refined carbohydrates — relates to refined carb intake effects on blood glucose, insulin, metabolic syndrome Focus on: - TCF7L2, SLC30A8, KCNJ11, PPARG, FTO, MC4R, GIPR, GLP1R, G6PC2, ADCY5, MTNR1B, IRS1, GCKR, GCK — these are common T2D/glycemia GWAS genes - Indian-specific GWAS: Look for studies from INDIGO consortium, Chennai Urban Rural Epidemiology Study (CURES), the South Asian T2D GWAS by Unnikrishnan et al., or any South Asian specific associations - Dietary carbohydrate interaction studies (GxE) - HbA1c, fasting glucose, postprandial glucose, insulin resistance GWAS Please provide a comprehensive, well-organized response with SNP tables for each trait, noting which SNPs have South Asian/Indian evidence.