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Poster Summary
Title: Successfully Conducted Autologous Bone Marrow Transplant (BMT) in Relapsed/Refractory Classical Hodgkin Lymphoma - A New Journey Started at the Regional Cancer Centre, Gwalior, Madhya Pradesh
Authors: Dr. Anil Sharma, Dr. Gunjan Shrivastava, Dr. Nirmal Jain, Dr. Pankaj Gandotra, Dr. B.R. Shrivastava
Institution: Department of Medical Oncology & BMT, Cancer Hospital & Research Institute, Gwalior, Madhya Pradesh
Introduction
The Cancer Hospital & Research Institute, Gwalior is a Government of India-funded Regional Cancer Centre, established in 1977. It handles nearly 10,000 new cancer registrations annually, with approximately 50-60 patients requiring BMT every year. A dedicated BMT unit was set up in October 2023. This poster reports the first successful autologous hematopoietic stem cell transplantation (HSCT) performed there in a patient with relapsed/refractory classical Hodgkin lymphoma.
Methodology
- A dedicated two-room BMT unit with trained physicians and nursing staff was established.
- Patient: 42-year-old male with relapsed/refractory classical Hodgkin lymphoma.
- Received 3 cycles of GDP chemotherapy prior to transplant.
- Stem cell mobilization performed using G-CSF.
- Stem cell collection and cryopreservation achieved successfully:
- Collection volume: 342 mL
- CD34+ count: 9.21 million/kg
- BEAM conditioning regimen administered:
- BCNU 300 mg/m²
- Cytarabine 400 mg/m²
- Etoposide 200 mg/m²
- Melphalan 140 mg/m²
- Standard supportive care and transplant protocols followed.
Results
- Successful stem cell infusion on Day 0
- CD34+ infused: 8.79 million/kg
- Febrile neutropenia developed between Day +5 and Day +15 - managed successfully per protocol.
- Neutrophil engraftment achieved on Day +13
- Platelet engraftment achieved on Day +17
- Brentuximab vedotin maintenance initiated from Day +60 post-transplant
- Patient remains disease-free at 30 months follow-up
Discussion
Autologous HSCT remains an effective therapeutic strategy for relapsed/refractory Hodgkin lymphoma responsive to salvage chemotherapy. The successful completion of this first transplant demonstrates the feasibility of establishing advanced BMT services in regional cancer centres, making accessible and cost-effective transplant care available to nearly 7.5 million people in and around the region.
Venue: Cancer Hospital and Research Institute, Gwalior