What is the per KG dose of paracetamol
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Here is the per kg dosing for paracetamol (acetaminophen) from the textbooks:
Paracetamol (Acetaminophen) — Per kg Dosing
Standard Therapeutic Dose
| Population | Route | Dose | Frequency |
|---|---|---|---|
| Children/Infants | Oral | 10–15 mg/kg | Every 4–6 hours |
| Adults (≥12 years) | Oral | 650 mg (fixed) | Every 4–6 hours |
| Adults <50 kg | IV | 15 mg/kg | Every 6 hours |
| Adults ≥50 kg | IV | 1 gram | Every 6 hours |
- Maximum adult daily dose: 3–4 g/day (≤3 g/day recommended for general use; up to 4 g/day only under physician supervision)
- For pericarditis/analgesia in children: 15 mg/kg every 4 hours has been cited
Toxicity Thresholds
| Population | Potentially Toxic Single Dose |
|---|---|
| Adults | ≥7.5 g (≈100 mg/kg) |
| Children | ≥150 mg/kg |
| Severe toxicity | >15 g |
Overdose Antidote (N-Acetylcysteine)
In suspected toxic ingestion, N-acetylcysteine (NAC) is given at 140 mg/kg orally as the loading dose, followed by further doses — even before plasma levels return.
Sources: ROSEN's Emergency Medicine; Tintinalli's Emergency Medicine; Fuster and Hurst's The Heart, 15th Ed.; Sleisenger and Fordtran's Gastrointestinal and Liver Disease; Morgan and Mikhail's Clinical Anesthesiology
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