ID Trait Meaning T040 satiety_signal_strength Effectiveness of signals that create fullness. T041 sweet_drive_tendency Inclination toward sugary foods. T117 craving_drive Baseline intensity of food cravings. T051 stress_eating_liability Likelihood of eating more under stress. E. Neuroendocrine & Circadian ID Trait Meaning T050 cortisol_reactivity Sensitivity of stress hormone response. T052 circadian_alignment_stability Stability of internal biological rhythms. T118 stress_disruption Degree to which stress disrupts metabolic control. F. Metabolic Flexibility & Energy Handling ID Trait Meaning T060 metabolic_flexibility Ability to switch between fat and glucose as fuel. T061 fasting_tolerance Ability to maintain stability during fasting. Can you identify snps for these traits? High confidence snps with evidence focusing on Indian studies where available please.

general-purpose

You are a genomics research expert. The user wants high-confidence SNPs for the following metabolic/behavioral traits, with preference for evidence from Indian population studies where available. Traits to research: **Appetite & Craving:** - T040: satiety_signal_strength — Effectiveness of signals that create fullness - T041: sweet_drive_tendency — Inclination toward sugary foods - T117: craving_drive — Baseline intensity of food cravings - T051: stress_eating_liability — Likelihood of eating more under stress **Neuroendocrine & Circadian:** - T050: cortisol_reactivity — Sensitivity of stress hormone response - T052: circadian_alignment_stability — Stability of internal biological rhythms - T118: stress_disruption — Degree to which stress disrupts metabolic control **Metabolic Flexibility & Energy Handling:** - T060: metabolic_flexibility — Ability to switch between fat and glucose as fuel - T061: fasting_tolerance — Ability to maintain stability during fasting For each trait, provide: 1. The top 3–5 high-confidence SNPs (rsID, gene, chromosome, alleles) 2. Effect: what the risk/effect allele does to the trait 3. Evidence quality (GWAS, meta-analysis, functional study, etc.) 4. Indian population evidence if available (e.g., studies in South Asian cohorts, Indian GWAS, etc.) 5. Biological mechanism linking the SNP/gene to the trait Focus on well-replicated SNPs with strong evidence. Prioritize: - Published GWAS hits (p < 5×10⁻⁸) - Replicated in multiple cohorts - Functional validation where possible - South Asian / Indian specific allele frequencies or studies Format the output as a structured table or well-organized text per trait group, suitable for a clinical genomics report.

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