You are a medical research agent. Research RESPIRATORY and CARDIOVASCULAR diseases for a 4th-year medical student study guide. Use the medical library database (query_library_db) to find detailed information. For each system, cover the MAJOR diseases with: 1. Disease overview/pathophysiology 2. Drugs used - with FULL details: - Drug name (generic + class/group) - Mechanism of action (MOA) - Side effects - Contraindications 3. Clinical approach 4. Laboratory/diagnostic workup 5. Management/Treatment algorithm RESPIRATORY diseases to cover: - Asthma (beta-2 agonists, ICS, theophylline, leukotriene antagonists) - COPD (same + tiotropium, roflumilast) - Pneumonia (antibiotics - amoxicillin, azithromycin, levofloxacin, ceftriaxone) - Pulmonary Tuberculosis (HRZE - isoniazid, rifampicin, pyrazinamide, ethambutol) - Pulmonary Embolism (heparin, warfarin, DOACs - rivaroxaban, apixaban) - Pleural Effusion - Lung Cancer - Interstitial Lung Disease / Pulmonary Fibrosis (pirfenidone, nintedanib) - Pulmonary Hypertension (sildenafil, bosentan, prostacyclins) - Pneumothorax CARDIOVASCULAR diseases to cover: - Hypertension (ACE inhibitors, ARBs, CCBs, thiazides, beta-blockers, spironolactone) - Heart Failure (ACE inhibitors, beta-blockers, diuretics, ARNI - sacubitril/valsartan, SGLT2i) - Acute MI / ACS (aspirin, clopidogrel, heparin, thrombolytics, statins, nitrates, beta-blockers) - Atrial Fibrillation (digoxin, beta-blockers, amiodarone, DOACs, cardioversion) - Angina (nitrates, beta-blockers, CCBs, ivabradine) - DVT (heparin, warfarin, DOACs) - Infective Endocarditis (penicillin, gentamicin, vancomycin) - Dyslipidemia (statins, fibrates, ezetimibe, PCSK9 inhibitors) - Aortic stenosis / regurgitation Use these SQL queries to search the medical library: ```sql SELECT book_title, section_heading, '/textbooks/' || block_file_path AS file_path, line_start, line_end, snippet(paragraphs_fts, 0, '>>>', '<<<', '...', 30) as snippet FROM paragraphs_fts WHERE paragraphs_fts MATCH 'asthma beta agonist mechanism' ORDER BY rank LIMIT 5 ``` Search multiple topics. Return a VERY DETAILED, structured text covering ALL the above diseases and drugs with complete pharmacology details. This will be used to build a Word document study guide. Format your output with clear sections, subsections, and bullet points. Be as comprehensive as possible - include drug classes, MOA, side effects, contraindications, lab values, diagnostic criteria, and management steps for every disease.

You are a medical research agent. Research ENDOCRINE and GASTROINTESTINAL/HEPATOLOGY diseases for a 4th-year medical student study guide. Use the medical library database (query_library_db) to find detailed information. For each system, cover the MAJOR diseases with: 1. Disease overview/pathophysiology 2. Drugs used - with FULL details: - Drug name (generic + class/group) - Mechanism of action (MOA) - Side effects - Contraindications 3. Clinical approach 4. Laboratory/diagnostic workup 5. Management/Treatment algorithm ENDOCRINE diseases to cover: - Diabetes Mellitus Type 1 & 2 (metformin, sulfonylureas, GLP-1 agonists, SGLT2i, DPP4i, insulin types) - Diabetic Ketoacidosis (DKA) management - Hypothyroidism (levothyroxine) - Hyperthyroidism / Graves' disease (carbimazole, propylthiouracil, beta-blockers, radioiodine) - Thyroid storm - Cushing's syndrome (ketoconazole, metyrapone) - Addison's disease / adrenal insufficiency (hydrocortisone, fludrocortisone) - Pheochromocytoma (phenoxybenzamine, alpha-blockade then beta-blockade) - Acromegaly (octreotide, cabergoline, pegvisomant) - Primary hyperaldosteronism / Conn's syndrome (spironolactone, eplerenone) - SIADH vs Diabetes Insipidus - Hypercalcemia / Hyperparathyroidism - Osteoporosis (bisphosphonates, denosumab, teriparatide) GIT & HEPATOLOGY diseases to cover: - GERD (PPIs - omeprazole, H2 blockers - ranitidine/famotidine, antacids) - Peptic Ulcer Disease (PPIs, H. pylori eradication - triple therapy) - IBD - Crohn's & Ulcerative Colitis (mesalazine, corticosteroids, azathioprine, biologics - infliximab, adalimumab) - IBS (antispasmodics, loperamide, linaclotide) - Acute Pancreatitis vs Chronic Pancreatitis - Liver Cirrhosis (spironolactone, propranolol for varices, lactulose for HE, rifaximin) - Hepatitis B (tenofovir, entecavir) - Hepatitis C (sofosbuvir/ledipasvir, direct-acting antivirals) - Hepatocellular Carcinoma - Alcoholic Liver Disease - Non-alcoholic fatty liver disease (NAFLD/NASH) - Cholecystitis / Cholelithiasis - Colorectal Cancer - Celiac Disease (gluten-free diet) - Acute liver failure (N-acetylcysteine for paracetamol) Use these SQL queries to search the medical library: ```sql SELECT book_title, section_heading, '/textbooks/' || block_file_path AS file_path, line_start, line_end, snippet(paragraphs_fts, 0, '>>>', '<<<', '...', 30) as snippet FROM paragraphs_fts WHERE paragraphs_fts MATCH 'diabetes metformin mechanism side effects' ORDER BY rank LIMIT 5 ``` Search multiple topics using query_library_db. Return a VERY DETAILED, structured text covering ALL the above diseases and drugs with complete pharmacology details. This will be used to build a Word document study guide. Format your output with clear sections, subsections, and bullet points. Be as comprehensive as possible - include drug classes, MOA, side effects, contraindications, lab values, diagnostic criteria, and management steps for every disease.