Where is pathological focus in this mark in the picture

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This is a classic gross pathology specimen. Here is a full analysis:

Specimen: Caseous Pneumonia (Казеозная Пневмония)

What you are looking at: A formalin-fixed lung section preserved in a glass jar, labeled in Russian "КАЗЕОЗНАЯ ПНЕВМОНИЯ" - Caseous Pneumonia. This is a severe form of pulmonary tuberculosis.

Location of the Pathological Focus

The pathological foci are distributed throughout the lung parenchyma, but the key changes visible in the specimen are:

Feature	Location in Specimen
Caseous necrosis (yellow-white, "cheesy" crumbling areas)	Visible as the pale/whitish-grey patches across the cut surface of the lung
Consolidation	The entire lobe is solidified - the lung is uniformly firm and hepatized
Cavitations	Dark hollowed-out areas representing liquefied necrosis that has drained, leaving cavities
Diffuse involvement	Unlike focal TB (which starts at the apex), caseous pneumonia involves entire lobes or even both lungs

Pathological Focus - Key Points

Primary site of necrosis: The gray-white to yellowish friable ("cheesy") areas represent coagulative-type caseous necrosis - the pathognomonic lesion of TB. The necrotic tissue gets its name from resembling crumbled white cheese (caseus = Latin for cheese).
What makes this "pneumonia": Unlike typical tuberculous granulomas, in caseous pneumonia the necrosis spreads confluently through entire lung segments/lobes via the airways (bronchogenic spread), filling alveolar spaces. The whole lobe loses its normal spongy texture and becomes solid.
Microscopic focus: The lesion contains:
- Central caseous necrosis (eosinophilic, amorphous, acellular debris)
- Surrounding epithelioid macrophages and Langhans giant cells
- Peripheral lymphocytic infiltrate
- No normal alveolar architecture remains
Comparison with textbook image (Robbins, Fig. 11.37): The specimen above from Robbins shows the same pattern - "the upper parts of both lungs are riddled with gray-white areas of caseation and multiple areas of softening and cavitation."

Pathogenesis

Caseous pneumonia typically occurs in:

Severely immunocompromised patients (HIV, malnutrition)
Overwhelming primary TB ("galloping consumption")
Reactivation TB with massive bronchogenic spread

The focus begins as a Ghon focus (subpleural, lower upper lobe or upper lower lobe in primary TB), but in caseous pneumonia spreads rapidly via endobronchial dissemination to involve entire lobes.

Bottom line: The pathological focus in this specimen is the lung parenchyma itself - specifically the confluent caseous necrosis occupying entire lung lobules/lobes, visible as the pale, crumbly, grayish-white areas on the cut surface of the lung, with associated cavitation where liquefied necrotic material has escaped. This pattern is caused by Mycobacterium tuberculosis and represents one of the most severe forms of pulmonary TB.

Robbins & Kumar Basic Pathology, pp. 477-478

Send me image of this focus from the image above

The textbook image I retrieved in the previous turn already shows a real gross pathology specimen of secondary pulmonary TB with caseous pneumonia - here it is again:

Secondary pulmonary tuberculosis with caseous pneumonia - gross pathology specimen showing gray-white areas of caseation and cavitation in both lungs

What to look for in this image (matching your museum specimen):

Gray-white/yellowish patches scattered across both lungs = the caseous necrosis foci (the "cheesy" crumbling material)
Dark hollowed areas = cavities where liquefied necrotic material has drained out
Upper lobe predominance = the worst involvement is in the upper portions of both lungs
Loss of normal spongy texture = the entire lobe is solidified/consolidated

This matches your jar specimen almost exactly - the same dark-brown consolidated lung tissue with pale necrotic foci and small cavities visible on the cut surface.

Robbins & Kumar Basic Pathology, Fig. 11.37 - "Secondary pulmonary tuberculosis. The upper parts of both lungs are riddled with gray-white areas of caseation and multiple areas of softening and cavitation."

In this picture mark the pathological focus and send time the labelled image of this focus don’t send text I want image with marking

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The labelled image has been created and saved. You can download it directly here:

labelled specimen

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The image marks 3 pathological foci on your specimen with colored circles and labels:

🔴 Red circle - Caseous Necrosis (the pale whitish-grey "cheesy" patch, center-right of the lung section)
🟠 Orange circle - Cavitation (dark hollow area in the lower center, where liquefied necrotic material has drained)
🟢 Green circle - Lobar Consolidation (the upper solidified/hepatized area of the lung)

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