You are answering a USMLE-style medical question. Question: During a Mycobacterium tuberculosis infection, Th1 cells secrete a factor capable of stimulating phagosome-lysosome fusion within macrophages. In addition, the secreted factors help activate macrophages to produce mediators such as NO, which are capable of destroying the invading pathogen. Furthermore, activation of the macrophages by the secreted factor eventually leads to the formation of a tubercle. Which of the following factors is secreted by Th1 cells and responsible for these actions? Options: A) IL-4 B) TNF-alpha C) IFN-gamma D) Histamine Reply with ONLY the letter of the correct answer (A, B, C, or D). No explanation.